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Guanidine, 1 - methyl - 3 - nitro - 1 - nitroso -

RTECS #: MF4200000

CAS #: 70-25-7

UPDATE: May 2009 MW: 147.12 MF: C2H5N5O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1 - Methyl - 1 - nitroso - 3 - nitroguanidine
  2. 1 - Methyl - 3 - nitro - 1 - nitrosoguanidine
  3. Guanidine, N - methyl - N' - nitro - N - nitroso - (9CI)
  4. MNNG
  5. Methylnitronitrosoguanidine
  6. N' - Nitro - N - nitroso - N - methylguanidine
  7. N - Methyl - N' - nitro - N - nitrosoguanidine
  8. N - Methyl - N - nitro - N - nitrosoguanidine
  1. N - Methyl - N - nitroso - N' - nitroguanidine
  2. N - Methyl - N - nitrosonitroguanidin (German)
  3. N - Metylo - N' - nitro - N - nitrozoguanidyny (Polish)
  4. N - Nitroso - N - methylnitroguanidine
  5. NSC 9369
  6. Nitrosoguanidine
  7. RCRA waste number U163


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
body fluid assay rat
ovary 		150 mg/kg MUREAV 143,263,1985
cytogenetic analysis domestic animal other cell types 1 mg/L ITCSAF 16,791,1980
cytogenetic analysis grasshopper other cell types 1,250 nmol/L ENMUDM 4,279,1982
cytogenetic analysis hamster fibroblast 4 mg/L ICHUDW 6(6),26,1984
cytogenetic analysis hamster lung 500 µg/L JNCIAM 59,289,1977
cytogenetic analysis hamster ovary 100 µg/L MUREAV 141,95,1984
cytogenetic analysis hamster ovary 0.6 mg/L/20 hour (-enzymatic activation step) JAPTO* 20,491,2000
cytogenetic analysis hamster ovary 0.5 mg/L/2 hour FCTOD7 45,928,2007
cytogenetic analysis human other cell types 700 nmol/L TIVIEQ 5,353,1991
cytogenetic analysis human lung 1 mg/L MUREAV 12,183,1971
cytogenetic analysis human fibroblast 6,800 nmol/L/24 hour MUREAV 46,297,1977
cytogenetic analysis human leukocyte 100 µg/L BJCAAI 30,103,1974
cytogenetic analysis human lymphocyte 340 nmol/L/24 hour ARTODN 46,61,1980
cytogenetic analysis human HeLa cell 100 µg/L MUREAV 57,369,1978
cytogenetic analysis human sperm 1 mg/L/120 minute (-enzymatic activation step) MUTAEX 504,183,2002
cytogenetic analysis human other cell types 0.4 mg/L MUREAV 563,139,2004
cytogenetic analysis intravenous
mouse 		50 mg/kg MUREAV 60,329,1979
cytogenetic analysis other fish other cell types 200 µg/L/24 hour ENMUDM 4,181,1982
cytogenetic analysis oral
rat 		50 mg/kg ZKKOBW 86,47,1976
cytogenetic analysis rat liver 10 µmol/L CRNGDP 8,1077,1987
dominant lethal test intraperitoneal
mouse 		50 mg/kg MUREAV 21,155,1973
DNA damage Bacillus subtilis 240 nmol/L CNREA8 41,4368,1981
DNA damage Escherichia coli 3,400 µmol/L MUREAV 52,161,1978
DNA damage oral
guinea pig 		14,700 µg/kg CRNGDP 3,1443,1982
DNA damage hamster lung 3 µmol/L/30 minute BBRCA9 72,732,1976
DNA damage hamster fibroblast 50 µmol/L ENMUDM 4,143,1982
DNA damage hamster mammary gland 1 gm/L/2 hour EMMUEG 41,28,2003
DNA damage hamster lung 1 mg/L/1 hour MUREAV 629,40,2007
DNA damage Haemophilus influenzae 1,700 µmol/L/10 minute MUREAV 13,289,1971
DNA damage human leukocyte 1 µmol/L MUREAV 346,49,1995
DNA damage human fibroblast 20 µmol/L ENMUDM 7,267,1985
DNA damage human HeLa cell 300 µg/L/1 hour ECREAL 103,175,1976
DNA damage human lymphocyte 50 µmol/L CBINA8 38,87,1981
DNA damage human other cell types 33 µmol/L/30 minute MUREAV 497,185,2001
DNA damage human other cell types 10 mg/L/60 minute EMMUEG 35,9,2000
DNA damage human lymphocyte 0.7 mmol/L/60 minute TCMUD8 21,189,2001
DNA damage human lymphocyte 0.5 mmol/L/1 hour MUREAV 535,25,2003
DNA damage human other cell types 0.5 mmol/L/1 hour MUREAV 535,25,2003
DNA damage human lymphocyte 0.2 mmol/L/30 minute MUREAV 535,127,2003
DNA damage human other cell types 50 µmol/L/5 hour ONGEN* 23,307,2004
DNA damage human embryo 0.7 mmol/L/1 hour MUREAV 561,63,2004
DNA damage human other cell types 5 µmol/L/1 hour MUREAV 577S,1,2005
DNA damage human other cell types 5 µmol/L/1 hour MUREAV 577S,1,2005
DNA damage human other cell types 33 µmol/L MUREAV 577S,1,2005
DNA damage human embryo 1 mg/L/1 hour MUREAV 629,40,2007
DNA damage human other cell types 1 mg/L/1 hour MUREAV 629,40,2007
DNA damage human sperm 1 mg/L/1 hour MUREAV 629,40,2007
DNA damage human lymphocyte 5.0 mg/L/48 hour MUREAV 607,160,2006
DNA damage human other cell types 0.2 µmol/l/50 hour MUREAV 544,167,2003
DNA damage human other cell types 0.5 µmol/l/30 hour MUREAV 544,167,2003
DNA damage human other cell types 0.4 mg/L MUREAV 563,139,2004
DNA damage mammal (species unspecified) kidney 100 µmol/L JTEHD6 6,333,1980
DNA damage mammal (species unspecified) lymphocyte 8 µmol/L CRNGDP 3,327,1982
DNA damage monkey kidney 0.2 µmol/L/60 minute MUREAV 528,29,2003
DNA damage mouse fibroblast 50 µmol/L ENMUDM 4,143,1982
DNA damage mouse leukocyte 6 mg/L MUREAV 23,387,1974
DNA damage oral
mouse 		15 mg/kg IJCNAW 17,765,1976
DNA damage intraperitoneal
mouse 		400 µmol/kg 33AQAA -,165,1976
DNA damage mouse embryo 2 µmol/L CNREA8 39,131,1979
DNA damage mouse other cell types 100 µmol/L CALEDQ 10,223,1980
DNA damage mouse Ascites tumor 50 mg/L BBACAQ 192,191,1969
DNA damage intraperitoneal
mouse 		100 mg/kg MUREAV 493,39,2001
DNA damage mouse other cell types 0.5 mmol/L/1 hour MUREAV 535,25,2003
DNA damage mouse embryo 0.5 mg/L MUREAV 561,23,2004
DNA damage mouse fibroblast 10 mg/L/1 hour MUTAEX 14,339,1999
DNA damage mouse other cell types 10 µmol/L/20 minute TOLED5 170,203,2007
DNA damage other microorganisms 4 mmol/L ZKKOBW 90,37,1977
DNA damage other microorganisms 125 gm/L MUREAV 25,235,1974
DNA damage rat lung 10 mg/L CALEDQ 58,57,1991
DNA damage oral
rat 		1 mg/kg MUREAV 213,227,1989
DNA damage rat liver 30 µmol/L MUREAV 189,69,1987
DNA damage intraperitoneal
rat 		25 mg/kg ECEBDI 47,92,1979
DNA damage Salmonella typhimurium 8 µmol/L CRNGDP 3,327,1982
DNA damage Salmonella typhimurium 20 µmol/L/2 hour EMMUEG 46,126,2005
DNA damage Salmonella typhimurium 2.23 µmol/L/135 minute (-enzymatic activation step) EMMUEG 43,10,2004
DNA inhibition hamster lung 20 µmol/L CNREA8 40,682,1980
DNA inhibition human HeLa cell 2 µmol/L/30 minute- continuous JEPTDQ 2(1),65,1978
DNA inhibition human lung 1 mg/L/3 hour- continuous MUREAV 12,183,1971
DNA inhibition human fibroblast 10 mg/L CNREA8 40,984,1980
DNA inhibition human lymphocyte 3 µmol/L CBINA8 38,87,1981
DNA inhibition mouse lymphocyte 2 µmol/L MOPMA3 28,560,1985
DNA inhibition mouse embryo 2 µmol/L CNREA8 40,682,1980
DNA inhibition intraperitoneal
mouse 		100 mg/kg MUREAV 46,305,1977
DNA inhibition mouse other cell types 500 µmol/L JJIND8 68,1015,1982
DNA inhibition other microorganisms 100 µmol/L MUREAV 85,275,1981
DNA inhibition oral
rat 		8,183 mg/kg/70 week- continuous GANNA2 64,373,1973
DNA repair Bacillus subtilis 20 µg/disc MUREAV 97,1,1982
DNA repair Escherichia coli 10 µg/plate MUREAV 54,101,1978
DNA repair Escherichia coli 2 µmol/L/2 hour MUREAV 603,164,2006
DNA repair human fibroblast 5 µmol/L/2 hour COINAV 256,175,1977
DNA repair other microorganisms 100 µg/plate BIZNAT 95,463,1976
DNA repair Saccharomyes cerevisiae 2 µmol/well IDZAAW 50,403,1975
DNA repair Schizosaccharomyces pombe 180 nmol/L CNJGA8 24,771,1982
unscheduled DNA synthesis Escherichia coli 2 mmol/L ZKKOBW 92,177,1978
unscheduled DNA synthesis frog fibroblast 1 µmol/L MUREAV 49,407,1978
unscheduled DNA synthesis hamster lung 20 µmol/L/1 hour CBINA8 3,49,1971
unscheduled DNA synthesis hamster embryo 10 µmol/L JTEHD6 6,333,1980
unscheduled DNA synthesis hamster kidney 500 µmol/L CBINA8 3,49,1971
unscheduled DNA synthesis hamster ovary 1 µmol/L ENMUDM 5,515,1983
unscheduled DNA synthesis human other cell types 100 µmol/L JJIND8 69,557,1982
unscheduled DNA synthesis human lung 100 µg/L JCLBA3 39,72a,1968
unscheduled DNA synthesis human fibroblast 10 µmol/L/3 hour IJCNAW 16,284,1975
unscheduled DNA synthesis human HeLa cell 10 µmol/L CNREA8 38,2621,1978
unscheduled DNA synthesis human leukocyte 90 µmol/L CBINA8 38,87,1981
unscheduled DNA synthesis human lymphocyte 140 µmol/L CBINA8 38,87,1981
unscheduled DNA synthesis human liver 10 µmol/L TSITAQ 22,1346,1980
unscheduled DNA synthesis human kidney 100 µmol/L VOONAW 28(11),53,1982
unscheduled DNA synthesis human other cell types 100 µmol/L CCLCDY 13,90,1991
unscheduled DNA synthesis mammal (species unspecified) kidney 50 µmol/L JTEHD6 6,333,1980
unscheduled DNA synthesis mouse testis 1 µmol/L/3 hour ARTODN 37,195,1977
unscheduled DNA synthesis mouse embryo 500 µmol/L CBINA8 3,49,1971
unscheduled DNA synthesis mouse fibroblast 10 µmol/L TSITAQ 22,1346,1980
unscheduled DNA synthesis mouse liver 1 µmol/L TOPADD 12,119,1984
unscheduled DNA synthesis other microorganisms 1 mg/L CRNGDP 2,417,1981
unscheduled DNA synthesis oral
rat 		12,500 µg/kg CRNGDP 10,1425,1989
unscheduled DNA synthesis oral
rat 		50 mg/kg ENMUDM 4,553,1982
unscheduled DNA synthesis rat liver 147 µg/L PMRSDJ 5,381,1985
unscheduled DNA synthesis rat other cell types 3,200 µmol/L SHKKAN 22,300,1980
host-mediated assay mouse
Serratia marcescens 		60 mg/kg/2 hour MGGEAE 117,197,1972
host-mediated assay mouse
Salmonella typhimurium 		5 mg/kg JJIND8 62,911,1979
host-mediated assay mouse
Escherichia coli 		60 mg/kg MGGEAE 117,197,1972
host-mediated assay mouse
Saccharomyes cerevisiae 		2 mmol/kg AGACBH 3,99,1973
host-mediated assay mouse
leukocyte 		25 mg/kg CNREA8 34,3073,1974
host-mediated assay multiple
other fish 		30 mg/L/2 hour MUREAV 577S,1,2005
host-mediated assay rat
Saccharomyes cerevisiae 		412 mg/kg TCMUD8 3,41,1983
mutation in microorganisms Aspergillus nidulans 50 mmol/L (-enzymatic activation step) GENTAE 63,317,1969
mutation in microorganisms Bacillus subtilis 20 mg/L (-enzymatic activation step) CMMUAO 9,165,1984
mutation in microorganisms Chlamydomonas reinhardi 1 mg/L (-enzymatic activation step) MGGEAE 121,99,1973
mutation in microorganisms Escherichia coli 0.5 µg/plate/20 minute MUREAV 492,91,2001
mutation in microorganisms Escherichia coli 0.25 mg/plate/90 minute (-enzymatic activation step) MUREAV 535,55,2003
mutation in microorganisms Escherichia coli 1 µg/plate/48 hour MUTAEX 15,317,2000
mutation in microorganisms Escherichia coli 2 µmol/L/1 hour (-enzymatic activation step) MUREAV 605,42,2006
mutation in microorganisms Escherichia coli 0.8 nmol/plate (-enzymatic activation step) MUTAEX 20,199,2005
mutation in microorganisms Escherichia coli 0.25 mg/L/2 hour MUREAV 631,77,2007
mutation in microorganisms Escherichia coli 0.1 nmol/plate/48 hour (-enzymatic activation step) MUTAEX 20,199,2005
mutation in microorganisms Euglena gracilis 5 mg/L (-enzymatic activation step) AMACCQ 9,682,1976
mutation in microorganisms hamster ovary 60 nmol/L (+enzymatic activation step) MOTOEX 1,217,1987
mutation in microorganisms Haemophilus influenzae 1 mmol/L (-enzymatic activation step) MUREAV 30,9,1975
mutation in microorganisms Klebsiella pneumoniae 100 mg/L (-enzymatic activation step) MGGEAE 157,189,1977
mutation in microorganisms mouse lymphocyte 200 µg/L/4 hour (+enzymatic activation step) MUREAV 59,61,1979
mutation in microorganisms Neurospora crassa 20 µg/plate (-enzymatic activation step) MUREAV 53,297,1978
mutation in microorganisms other microorganisms 160 mg/L (-enzymatic activation step) JOBAAY 137,415,1979
mutation in microorganisms other microorganisms 20 mg/L (-enzymatic activation step) JOBAAY 135,911,1978
mutation in microorganisms other microorganisms 10 mg/L (-enzymatic activation step) GENTAE 89,695,1978
mutation in microorganisms other microorganisms 4 gm/L (-enzymatic activation step) JGMIAN 128,1441,1982
mutation in microorganisms other microorganisms 250 mg/L (-enzymatic activation step) JGAMA9 19,467,1973
mutation in microorganisms other microorganisms 25 mg/L (-enzymatic activation step) JOVIAM 37,936,1981
mutation in microorganisms other microorganisms 50 mg/L (-enzymatic activation step) MUREAV 50,37,1978
mutation in microorganisms other microorganisms 4 gm/L (-enzymatic activation step) JGMIAN 98,265,1977
mutation in microorganisms other microorganisms 100 mg/L (-enzymatic activation step) MUREAV 94,1,1982
mutation in microorganisms other microorganisms 10 mg/L (-enzymatic activation step) JGMIAN 128,1401,1982
mutation in microorganisms other microorganisms 100 mg/L (-enzymatic activation step) DEBIAO 43,213,1975
mutation in microorganisms other microorganisms 1 gm/L (-enzymatic activation step) BBRCA9 59,865,1974
mutation in microorganisms other microorganisms 10 gm/L (-enzymatic activation step) MUREAV 37,1,1976
mutation in microorganisms other microorganisms 100 mg/L (-enzymatic activation step) AMACCQ 19,571,1981
mutation in microorganisms other microorganisms 5 mg/L (-enzymatic activation step) JMOBAK 35,439,1968
mutation in microorganisms other microorganisms 20 µg/plate (-enzymatic activation step) JMOBAK 35,439,1968
mutation in microorganisms other microorganisms 100 mg/L (-enzymatic activation step) JOVIAM 15,1,1975
mutation in microorganisms other microorganisms 100 mg/L (-enzymatic activation step) JOBAAY 102,784,1970
mutation in microorganisms other microorganisms 5 mg/L (-enzymatic activation step) IVRYAK 10,181,1978
mutation in microorganisms other microorganisms 1 gm/L (-enzymatic activation step) JOVIAM 15,41,1975
mutation in microorganisms other microorganisms 5 mg/L (-enzymatic activation step) VIRLAX 49,815,1972
mutation in microorganisms other microorganisms 25 mg/L (-enzymatic activation step) DBANAD 33,1401,1980
mutation in microorganisms other microorganisms 10 mg/L (-enzymatic activation step) MGGEAE 167,65,1978
mutation in microorganisms other microorganisms 30 mg/L (-enzymatic activation step) MGGEAE 167,65,1978
mutation in microorganisms other microorganisms 1 gm/L (-enzymatic activation step) MGGEAE 104,378,1969
mutation in microorganisms other microorganisms 1 gm/L (-enzymatic activation step) JANTAJ 31,662,1978
mutation in microorganisms other microorganisms 100 mg/L (-enzymatic activation step) JOBAAY 135,748,1978
mutation in microorganisms other microorganisms 100 mmol/L (-enzymatic activation step) MUREAV 73,1,1980
mutation in microorganisms other microorganisms 100 mg/L (-enzymatic activation step) JOBAAY 101,921,1970
mutation in microorganisms other microorganisms 500 ppm/72 hour- continuous (-enzymatic activation step) SOGEBZ 10,522,1974
mutation in microorganisms other microorganisms 25 mg/L (-enzymatic activation step) JOBAAY 120,106,1974
mutation in microorganisms other microorganisms 50 mg/L/30 minute- continuous (-enzymatic activation step) JGMIAN 121,349,1980
mutation in microorganisms other microorganisms 17 mg/L (-enzymatic activation step) NEZAAQ 34,664,1979
mutation in microorganisms other microorganisms 10 mg/L (-enzymatic activation step) JOVIAM 10,760,1972
mutation in microorganisms other microorganisms 30 mg/L (-enzymatic activation step) JOVIAM 7,673,1971
mutation in microorganisms other microorganisms 10 mg/L (-enzymatic activation step) MUREAV 9,261,1970
mutation in microorganisms other microorganisms 100 mg/L (-enzymatic activation step) MGGEAE 121,57,1973
mutation in microorganisms other microorganisms 1 gm/L (-enzymatic activation step) JANTAJ 35,94,1982
mutation in microorganisms other microorganisms 30 ppm (-enzymatic activation step) SOGEBZ 11,183,1975
mutation in microorganisms other microorganisms 2,000 ppm/20 minute- continuous (-enzymatic activation step) ABCHA6 41,615,1977
mutation in microorganisms other microorganisms 100 mg/L (-enzymatic activation step) CJMIAZ 20,1479,1975
mutation in microorganisms other microorganisms 10 ng/disc (-enzymatic activation step) ISGEAK 8,82,1979
mutation in microorganisms other microorganisms 100 mg/L (-enzymatic activation step) MUREAV 8,531,1969
mutation in microorganisms other microorganisms 50 mg/L (+enzymatic activation step) KHFKDF 8,297,1980
mutation in microorganisms other microorganisms 500 ppm/20 minute- continuous (-enzymatic activation step) MIBLAO 42,265,1973
mutation in microorganisms other microorganisms 1 gm/L (-enzymatic activation step) AMACCQ 9,682,1976
mutation in microorganisms other microorganisms 10 mg/L (-enzymatic activation step) EXPEAM 25,85,1969
mutation in microorganisms other microorganisms 200 mg/L (-enzymatic activation step) ZAPOAK 17,451,1977
mutation in microorganisms other microorganisms 10 mg/L (-enzymatic activation step) GENTAE 83,489,1976
mutation in microorganisms other microorganisms 1 gm/L (-enzymatic activation step) SCINAL 37,52,1971
mutation in microorganisms other microorganisms 15 mg/L/70 minute- continuous (-enzymatic activation step) JGMIAN 55,121,1969
mutation in microorganisms other microorganisms 7 µmol/L/24 hour- continuous (-enzymatic activation step) MUREAV 33,135,1975
mutation in microorganisms other microorganisms 50 mg/L (-enzymatic activation step) JPROAR 24,313,1977
mutation in microorganisms other microorganisms 10 mg/L (-enzymatic activation step) FOMIAZ 16,197,1971
mutation in microorganisms other microorganisms 1 gm/L/30 minute- continuous (-enzymatic activation step) JANTAJ 31,247,1978
mutation in microorganisms other microorganisms 1 gm/L (-enzymatic activation step) AMACCQ 12,383,1977
mutation in microorganisms other microorganisms 1 gm/L (-enzymatic activation step) FOMIAZ 22,12,1977
mutation in microorganisms other microorganisms 1 gm/L (-enzymatic activation step) MUREAV 35,65,1976
mutation in microorganisms other microorganisms 2 gm/L (-enzymatic activation step) MUREAV 28,9,1975
mutation in microorganisms other microorganisms 1 gm/L (-enzymatic activation step) GENRA8 29,65,1977
mutation in microorganisms other microorganisms 400 µg/plate (-enzymatic activation step) CBINA8 22,297,1978
mutation in microorganisms other microorganisms 50 µg/L (-enzymatic activation step) MUREAV 74,113,1980
mutation in microorganisms other microorganisms 10 mg/L (-enzymatic activation step) JDSCAE 54,331,1970
mutation in microorganisms other microorganisms 100 mg/L (-enzymatic activation step) JOBAAY 133,631,1978
mutation in microorganisms other microorganisms 25 mg/L (-enzymatic activation step) JIDIAQ 124,179,1971
mutation in microorganisms other microorganisms 100 mg/L (-enzymatic activation step) JBCHA3 252,6294,1977
mutation in microorganisms other microorganisms 1 gm/L (-enzymatic activation step) BBRCA9 48,113,1972
mutation in microorganisms other microorganisms 50 mg/L (-enzymatic activation step) PNASA6 70,1335,1973
mutation in microorganisms other microorganisms 400 mg/L (-enzymatic activation step) AMBBBR 6,15,1974
mutation in microorganisms other microorganisms 30 mg/L (-enzymatic activation step) ABCHA6 41,1667,1977
mutation in microorganisms other microorganisms 300 mg/L (-enzymatic activation step) CYGEDX 12(5),56,1978
mutation in microorganisms other microorganisms 400 mg/L/30 minute MUREAV 649,239,2008
mutation in microorganisms Salmonella typhimurium 310 ng/plate (+enzymatic activation step) MUREAV 130,79,1984
mutation in microorganisms Salmonella typhimurium 2 µg/plate (-enzymatic activation step) PNASA6 72,5135,1975
mutation in microorganisms Salmonella typhimurium 1 µg/plate (+/-enzymatic activation step) FCTOD7 38,1,2000
mutation in microorganisms Salmonella typhimurium 5 µg/plate/20 minute (+/-enzymatic activation step) MUREAV 492,13,2001
mutation in microorganisms Salmonella typhimurium 5 µg/plate/20 minute (-enzymatic activation step) MUREAV 498,19,2001
mutation in microorganisms Salmonella typhimurium 0.1 mg/plate/45 minute (-enzymatic activation step) TCMUD8 22,285,2002
mutation in microorganisms Salmonella typhimurium 5 nmol/plate FCTOD7 40,1165,2002
mutation in microorganisms Salmonella typhimurium 1 mg/L/3 hour (-enzymatic activation step) RTOPDW 37,11,2003
mutation in microorganisms Salmonella typhimurium 0.3 µmol/L/16 hour EMMUEG 46,126,2005
mutation in microorganisms Salmonella typhimurium 3 µmol/L/48 hour EMMUEG 46,126,2005
mutation in microorganisms Salmonella typhimurium 20 µmol/L/2 hour EMMUEG 46,126,2005
mutation in microorganisms Salmonella typhimurium 0.25 mg/L/2 hour MUREAV 631,77,2007
mutation in microorganisms Salmonella typhimurium 1 µg/plate/48 hour (-enzymatic activation step) CEXPB9 32,888,2005
mutation in microorganisms Salmonella typhimurium 0.4 µg/plate/48 hour MUREAV 672,55,2009
mutation in microorganisms Saccharomyes cerevisiae 1,000 ppm (-enzymatic activation step) AGACBH 4,286,1974
mutation in microorganisms Saccharomyes cerevisiae 1 mg/L (-enzymatic activation step) MGGEAE 200,313,1985
mutation in microorganisms Saccharomyes cerevisiae 0.125 mg/L/16 hour MUTAEX 20,105,2004
mutation in microorganisms Saccharomyes cerevisiae 50 µmol/l MUREAV 547,123,2004
mutation in microorganisms Schizosaccharomyces pombe 10 µmol/L (-enzymatic activation step) MUREAV 2,312,1965
micronucleus test hamster lung 80 µg/L MUREAV 130,273,1984
micronucleus test hamster ovary 40 µg/L MUREAV 240,295,1990
micronucleus test human lung 10 µg/L TIVIEQ 4,735,1990
micronucleus test intraperitoneal
mouse 		75 mg/kg MUTAEX 2,199,1987
micronucleus test intraperitoneal
mouse 		100 mg/kg MUREAV 172,151,1986
micronucleus test skin
mouse 		0.2 pph/3 day MUREAV 513,93,2002
micronucleus test mouse mammary gland 0.1 mg/L/24 hour (-enzymatic activation step) MUREAV 540,153,2003
micronucleus test mouse embryo 0.75 mg/L/4 hour MUREAV 561,23,2004
micronucleus test oral
mouse 		40 mg/kg DCTODJ 27,15,2004
micronucleus test intraperitoneal
rat 		18,750 µg/kg/5 day- continuous MUREAV 188,45,1987
micronucleus test oral
rat 		20 mg/kg/16 hour MUTAEX 4,327,1989
micronucleus test rat liver 10 µmol/L MUREAV 292,213,1993
micronucleus test skin
rat 		0.2 pph/3 day MUREAV 513,93,2002
gene conversion and mitotic recombination Bacillus subtilis 10 mmol/L MUREAV 68,31,1979
gene conversion and mitotic recombination Saccharomyes cerevisiae 1 ppm JJIND8 62,901,1979
gene conversion and mitotic recombination Schizosaccharomyces pombe 1 mmol/L/5 minute MGGEAE 110,348,1971
mutation in mammalian somatic cells dog kidney 500 µg/L SCGTDW 4,609,1978
mutation in mammalian somatic cells hamster lung 200 µg/L/3 hour BJCAAI 39,540,1979
mutation in mammalian somatic cells hamster embryo 1 µmol/L/3 hour MUREAV 41,351,1976
mutation in mammalian somatic cells hamster ovary 500 µg/L/16 hour JCLLAX 74,245,1969
mutation in mammalian somatic cells hamster kidney 500 µg/L GENTAE 77,309,1974
mutation in mammalian somatic cells hamster fibroblast 10 µmol/L CNREA8 42,389,1982
mutation in mammalian somatic cells human fibroblast 225 nmol/L MUREAV 53,29,1978
mutation in mammalian somatic cells human embryo 40 µmol/L/3 hour- continuous JNCIAM 58,1873,1977
mutation in mammalian somatic cells human other cell types 3 µmol/L CNREA8 41,1114,1981
mutation in mammalian somatic cells human HeLa cell 1 mg/L BCPCA6 30,3039,1981
mutation in mammalian somatic cells mammal (species unspecified) liver 1 mg/L SCGTDW 4,647,1978
mutation in mammalian somatic cells mouse liver 500 µg/L SCGTDW 7,373,1981
mutation in mammalian somatic cells mouse other cell types 1 mg/L GANNA2 73,167,1982
mutation in mammalian somatic cells mouse other cell types 3 mg/L JEMEAV 152,1175,1980
mutation in mammalian somatic cells mouse mammary gland 3 mg/L CNREA8 43,125,1983
mutation in mammalian somatic cells mouse embryo 1 mg/L ENMUDM 4,332,1982
mutation in mammalian somatic cells mouse testis 3 mg/L 32YLA6 -,161,1975
mutation in mammalian somatic cells mouse other cell types 250 µg/L PAACA3 21,108,1980
mutation in mammalian somatic cells mouse lymphocyte 5 µg/L/2 hour MUREAV 59,61,1979
mutation in mammalian somatic cells mouse fibroblast 250 µg/L CRNGDP 1,215,1980
mutation in mammalian somatic cells mouse leukocyte 250 nmol/L CNREA8 34,3073,1974
mutation in mammalian somatic cells implant
mouse 		10 mg/kg/42 week- intermittent CALEDQ 182,127,2002
mutation in mammalian somatic cells other fish fibroblast 4 mg/L AECTCV 10,663,1981
mutation in mammalian somatic cells intraperitoneal
rat 		50 mg/kg MUREAV 54,159,1978
mutation in mammalian somatic cells oral
rat 		50 mg/kg MUREAV 54,159,1978
mutation in mammalian somatic cells parenteral
rat 		2,400 µg/kg MUREAV 187,99,1987
mutation in mammalian somatic cells rat embryo 1 mg/L JTEHD6 4,79,1978
mutation in mammalian somatic cells rat other cell types 250 µg/L MUREAV 34,481,1976
mutation in mammalian somatic cells rat liver 50 µmol/L ENMUDM 2,259,1980
morphological transform hamster embryo 500 µg/L CNREA8 37,3508,1977
morphological transform hamster lung 68 µmol/L JNCIAM 48,1409,1972
morphological transform hamster kidney 80 µg/L BJCAAI 37,873,1978
morphological transform hamster fibroblast 500 µg/L CNREA8 42,1274,1982
morphological transform hamster embryo 0.25 mg/L/48 hour (-enzymatic activation step) MUREAV 537,183,2003
morphological transform hamster embryo 5 µg/L/24 hour MUREAV 572,45,2005
morphological transform human fibroblast 200 µg/L PNASA6 75,1334,1978
morphological transform human other cell types 400 µg/L CNREA8 41,5096,1981
morphological transform mouse embryo 300 µg/L PMRSDJ 5,659,1985
morphological transform mouse fibroblast 20 µg/L AETODY 1,133,1980
morphological transform mouse other cell types 50 µg/L PNASA6 68,1098,1971
morphological transform mouse fibroblast 0.1 mg/L/21 day (-enzymatic activation step) EMMUEG 35,300,2000
morphological transform mouse embryo 1 gm/L/2 day (-enzymatic activation step) MUREAV 588,7,2005
morphological transform oral
rat 		1 mmol/kg CBINA8 43,313,1983
morphological transform intraperitoneal
rat 		30 mg/kg CNREA8 40,1157,1980
morphological transform rat embryo 100 µg/L JTEHD6 4,79,1978
morphological transform rat liver 10 mg/L BJCAAI 28,215,1973
other mutation test systems grasshopper other cell types 1,250 nmol/L ENMUDM 4,279,1982
other mutation test systems human lung 500 µg/L JCLBA3 39,72a,1968
phage inhibition capacity Bacillus subtilis 10 mmol/L IJEBA6 22,338,1984
phage inhibition capacity Escherichia coli 20 µg/plate MUREAV 130,141,1984
phage inhibition capacity Haemophilus influenzae 68 µmol/L MUREAV 37,1,1976
phage inhibition capacity other microorganisms 10 µg/plate ZMMPAO 231,369,1975
phage inhibition capacity other microorganisms 10 µg/L BAPBAN 18,445,1970
phage inhibition capacity Salmonella typhimurium 22 nmol/plate PPTCBY 9,337,1979
sister chromatid exchange hamster ovary 180 nmol/L MOTOEX 1,217,1987
sister chromatid exchange hamster lung 100 µg/L CNREA8 44,3270,1984
sister chromatid exchange unreported route
hamster 		7 mg/kg MUREAV 74,166,1980
sister chromatid exchange hamster fibroblast 30 µg/L MUREAV 104,141,1982
sister chromatid exchange intraperitoneal
hamster 		25 mg/kg MUREAV 113,33,1983
sister chromatid exchange oral
hamster 		25 mg/kg MUREAV 113,33,1983
sister chromatid exchange human fibroblast 1 nmol/L JTEHD6 2,1387,1977
sister chromatid exchange human lymphocyte 1 µmol/L CBINA8 24,107,1979
sister chromatid exchange human other cell types 1 nmol/L IUSMDJ 7,341,1977
sister chromatid exchange human HeLa cell 300 nmol/L CRNGDP 5,593,1984
sister chromatid exchange human leukocyte 1 µmol/L MUREAV 346,49,1995
sister chromatid exchange intraperitoneal
mouse 		300 µg/kg/6 hour- intermittent HUGEDQ 35,299,1977
sister chromatid exchange intravenous
mouse 		50 mg/kg MUREAV 60,329,1979
sister chromatid exchange mouse lymphocyte 100 µg/L JCHODP 13,1,1983
sister chromatid exchange mouse fibroblast 250 µg/L HUGEDQ 63,53,1983
sister chromatid exchange mouse embryo 2,500 µmol/L CRNGDP 5,593,1984
sister chromatid exchange other fish embryo 1 nmol/L MUREAV 68,381,1979
sister chromatid exchange rat liver 400 µg/L MUREAV 91,47,1981
sex chromosome loss and nondisjunction Aspergillus nidulans 500 µg/L MUREAV 155,105,1985
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		500 ppm/24 hour MUREAV 44,145,1977
specific locus test oral
Drosophila melanogaster 		500 ppm/24 hour MUREAV 46,202,1977
specific locus test parenteral
Drosophila melanogaster 		2,500 µmol/L MUREAV 13,19,1971
specific locus test Escherichia coli 10 mg/L/30 minute MUREAV 628,123,2007
specific locus test Escherichia coli 0.5 mg/L/2 hour MUREAV 631,77,2007
specific locus test Escherichia coli 0.25 µg/plate/12 hour (-enzymatic activation step) MUREAV 535,55,2003
specific locus test hamster ovary 0.1 mg/L/9 day EMMUEG 16,260,1990
specific locus test hamster lung 2.5 mg/L/3 hour (-enzymatic activation step) MUREAV 537,183,2003
specific locus test hamster ovary 0.5 mg/L/3 hour MUREAV 602,14,2006
specific locus test intraperitoneal
mouse 		35 mg/kg ARTODN 38,87,1977
specific locus test mouse embryo 25 µg/L/4 hour MUREAV 561,23,2004
specific locus test skin
mouse 		11.77 gm/kg EMMUEG 45,62,2005
specific locus test multiple
other fish 		15 mg/L/2 hour MUREAV 577S,1,2005
specific locus test oral
rat 		0.4 mg/kg/10 day MUREAV 535,73,2003
specific locus test rat kidney 6.8 µmol/L/4 hour MOCAE8 31,37,2001
specific locus test Salmonella typhimurium 0.25 mg/L/2 hour MUREAV 631,77,2007


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 25 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TCMUD8 3,335,1983
intraperitoneal
mouse 		lowest published toxic dose: 40 mg/kg (10 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TJADAB 18,263,1978
intraperitoneal
mouse 		lowest published toxic dose: 40 mg/kg (10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TJADAB 18,263,1978
intraperitoneal
mouse 		lowest published toxic dose: 50 mg/kg (1 day prior to copulation) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on fertility: Other measures of fertility 		MUREAV 13,171,1971
intraperitoneal
mouse 		lowest published toxic dose: 50 mg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TJADAB 25(2),60A,1982


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
rat 		lowest published toxic dose: 25 mg/kg (15 day pregnant) Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Transplacental tumorigenesis

Brain and Coverings: Tumors 		KFIZAO 84,23,1975
intravenous
rat 		lowest published toxic dose: 60 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma

Blood: Leukemia 		EJCAAH 16,395,1980
intravenous
rat 		lowest published toxic dose: 437.5 mg/kg/25 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Musculoskeletal: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains 		MUREAV 477,173,2001
oral
dog 		lowest published toxic dose: 725 mg/kg/45 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors

Blood: Lymphoma including Hodgkin's disease 		JCROD7 97,51,1980
oral
gerbil 		lowest published toxic dose: 1,400 µL/kg/20 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		JJCREP 89,97,1998
oral
hamster 		lowest published toxic dose: 592 mg/kg/27 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors 		CNREA8 30,1444,1970
oral
monkey 		lowest published toxic dose: 800 mg/kg/5 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors 		NEOLA4 36,129,1989
oral
mouse 		lowest published toxic dose: 1,984 mg/kg/70 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		CCLCDY 4,161,1982
oral
mouse 		toxic dose : 6,220 mg/kg/88 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		CCLCDY 4,161,1982
oral
rat 		lowest published toxic dose: 500 µg/kg Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		GANNA2 69,805,1978
oral
rat 		toxic dose : 697 mg/kg/12 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		CALEDQ 22,315,1984
oral
rat 		toxic dose : 280 mg/kg/8 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		CNREA8 43,1335,1983
oral
rat 		toxic dose : 107 mg/kg/35 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		JCROD7 100,1,1981
oral
rat 		toxic dose : 438 mg/kg/25 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		IJCNAW 32,253,1983
oral
rat 		toxic dose : 651 mg/kg/34 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		VOONAW 28(9),34,1982
oral
rat 		toxic dose : 13,500 mg/kg/78 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		JJIND8 70,1067,1983
oral
rat 		toxic dose : 155 mg/kg/11 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		CNREA8 35,2469,1975
oral
rat 		toxic dose : 250 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		GANNA2 75,362,1984
oral
rat 		lowest published toxic dose: 840 mg/kg/12 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		CALEDQ 145,85,1999
oral
rat 		lowest published toxic dose: 437.5 mg/kg/25 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		CALEDQ 137,131,1999
oral
rat 		lowest published toxic dose: 2,600 mg/kg/52 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		CALEDQ 138,23,1999
oral
rat 		lowest published toxic dose: 700 mg/kg/25 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		CALEDQ 141,117,1999
oral
rat 		lowest published toxic dose: 450 mg/kg/4 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors

Tumorigenic: Increased incidence of tumors in susceptible strains 		SIMEJ* 48,645,2007
oral
rabbit 		lowest published toxic dose: 743 mg/kg/26 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		HGANAO 16,321,1976
parenteral
rat 		lowest published toxic dose: 400 µg/kg Tumorigenic: Carcinogenic by RTECS criteria

Tumorigenic: Tumors at site of application 		ARTODN 45,227,1980
parenteral
rat 		toxic dose : 125 mg/kg/10 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		VOONAW 26(2),62,1980
rectal
rat 		lowest published toxic dose: 128 mg/kg/32 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Colon tumors 		JNCIAM 50,927,1973
subcutaneous
mouse 		lowest published toxic dose: 48 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		BJCAAI 23,757,1969
subcutaneous
rat 		lowest published toxic dose: 400 µg/kg Tumorigenic: Carcinogenic by RTECS criteria

Cardiac: Other changes

Kidney, Ureter, and Bladder: Kidney tumors 		ARTODN 45,227,1980
skin
mouse 		lowest published toxic dose: 54 mg/kg/30 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors 		BANRDU 12,397,1982
skin
rat 		lowest published toxic dose: 720 mg/kg/60 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		ARGEAR 55,117,1985


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 66 mg/kg N/R JJIND8 62,911,1979
intravenous
mouse 		lethal dose (50 percent kill): 37,300 µg/kg N/R NCISP* JAN1986
intravenous
rat 		lethal dose (50 percent kill): 80 mg/kg Lung, Thorax, or Respiration: Acute pulmonary edema

Behavioral: Convulsions or effect on seizure threshold 		EJCAAH 16,395,1980
oral
hamster 		lethal dose (50 percent kill): 1,070 mg/kg N/R CALEDQ 4,241,1978
oral
mouse 		lowest published toxic dose: 40 mg/kg Gastrointestinal: Other changes

Liver: Other changes

Blood: Other changes 		DCTODJ 27,15,2004
oral
mouse 		lowest published toxic dose: 40 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Lipids including transport 		DCTODJ 27,15,2004
oral
rat 		lethal dose (50 percent kill): 90 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Acute pulmonary edema

Gastrointestinal: Ulceration or bleeding from stomach 		ZKKOBW 91,183,1978
subcutaneous
rat 		lethal dose (50 percent kill): 420 mg/kg N/R ZEKBAI 69,103,1967


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 4,183,1974
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMSUDL 7,248,1987
International Agency for Research on Cancer (IARC) Cancer Review Group 2A IMSUDL 7,248,1987
TOXICOLOGY REVIEW
MUREAV 544,179,2003
TOXICOLOGY REVIEW
BLFSBY 24,129,1983
TOXICOLOGY REVIEW
NUCADQ 3,109,1981
TOXICOLOGY REVIEW
MUTAEX 14,141,1999
TOXICOLOGY REVIEW
MUREAV 588,88,2005
TOXICOLOGY REVIEW
EMMUEG 44,26,2004
TOXICOLOGY REVIEW
MUREAV 566,209,2004
TOXICOLOGY REVIEW
MUTAEX 20,389,2005
TOXICOLOGY REVIEW
MUREAV 613,76,2006
TOXICOLOGY REVIEW
FCTOD7 44,1699,2006
TOXICOLOGY REVIEW
MUREAV 627,10,2007
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
MUTAEX 20,153,2005
TOXICOLOGY REVIEW
MUTAEX 20,389,2005
TOXICOLOGY REVIEW
MUREAV 549,1,2004
TOXICOLOGY REVIEW
MUREAV 659,221,2008
TOXICOLOGY REVIEW
JTPAE7 19,111,2006
TOXICOLOGY REVIEW
JTPAE7 19,1,2006
TOXICOLOGY REVIEW
TXAPA9 231,197,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: B0070;
Number of Industries 1;
Total Number of Facilities 75;
Number of Occupations 2;
Total Number of Employees Exposed 523


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Aspergillus-recombination; Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/F344 rat; Cell transform.-BALB/c-3T3
EPA GENETOX PROGRAM 1988, Positive: SHE-focus assay; Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; In vitro cytogenetics-nonhuman
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-reciprocal translocation
EPA GENETOX PROGRAM 1988, Positive: Rodent dominant lethal; Host-mediated assay
EPA GENETOX PROGRAM 1988, Positive: L5178Y cells in vitro-TK test; Mouse spot test
EPA GENETOX PROGRAM 1988, Positive: N crassa-forward mutation; N crassa-reversion
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Positive: In vitro UDS in rat liver; V79 cell culture-gene mutation
EPA GENETOX PROGRAM 1988, Positive: TRP reversion; S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-forward mutation; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-reversion; S pombe-reversion
EPA GENETOX PROGRAM 1988, Positive/dose response: SHE-clonal assay; Cell transform.-C3H/10T1/2
EPA GENETOX PROGRAM 1988, Positive/dose response: Cell transform.-mouse prostate
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro SCE-human; In vitro SCE-nonhuman
EPA GENETOX PROGRAM 1988, Positive/dose response: In vivo SCE-nonhuman
EPA GENETOX PROGRAM 1988, Positive/dose response: In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Negative: In vitro cytogenetics-human; N crassa-aneuploidy
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse; UDS in mouse germ cells
EPA GENETOX PROGRAM 1988, Inconclusive: Cytogenetics-male germ cell; Mammalian micronucleus
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro SCE-human lymphocytes; Mouse specific locus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the preparation of DIAZOMETHANE, and as a research chemical
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


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Used in the preparation of DIAZOMETHANE, and as a research chemical

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 100234-53-5
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