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Guanidine, 1,3 - di - o - tolyl -

RTECS #: MF1400000

CAS #: 97-39-2

UPDATE: November 2008 MW: 239.35 MF: C15H17N3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 1,3 - Di - o - tolylguanidine
  2. DOTG accelerator
  3. Di - o - tolylguanidine
  1. Diorthotolylguanidine
  2. USAF A - 6598
  3. Vulkacit dotg/C


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 2.5 gm/kg (2 week male/2 week prior to copulation/1-22 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) 		REPTED 22,30,2006
oral
rat 		lowest published toxic dose: 2.5 gm/kg (2 week male/2 week prior to copulation/1-22 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) REPTED 22,30,2006
oral
rat 		lowest published toxic dose: 2,650 mg/kg (14 day male/14 day prior to copulation-3 day after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) REPTED 22,30,2006
oral
rat 		lowest published toxic dose: 560 mg/kg (6-19 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		REPTED 22,672,2006
oral
rat 		lowest published toxic dose: 560 mg/kg (6-19 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system REPTED 22,672,2006
oral
rat 		lowest published toxic dose: 140 mg/kg (6-19 day pregnant) Reproductive: Effects on newborn: Sex ratio REPTED 22,672,2006


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 25 mg/kg N/R NTIS** AD277-689
oral
mammal (species unspecified) 		lowest published lethal dose: 120 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis 		JIDHAN 13,87,1931
oral
rat 		lethal dose (50 percent kill): 500 mg/kg N/R JPETAB 90,260,1947
oral
rat 		lowest published toxic dose: 50 mg/kg Behavioral: General anesthetic REPTED 22,30,2006
oral
rat 		lowest published toxic dose: 50 mg/kg Peripheral Nerve and Sensation: Sensory change involving peripheral nerve

Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Somnolence (general depressed activity) 		REPTED 22,30,2006
oral
rat 		lowest published toxic dose: 20 mg/kg Behavioral: Change in motor activity (specific assay)

Behavioral: Muscle weakness

Behavioral: Ataxia 		REPTED 22,30,2006
oral
rabbit 		lowest published lethal dose: 80 mg/kg N/R IPSTB3 3,93,1976


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 40 mg/kg/2 day- intermittent Eye: Mydriasis (pupilliary dilation)

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Respiratory depression 		REPTED 22,30,2006
oral
rat 		lowest published toxic dose: 40 mg/kg/2 day- intermittent Behavioral: Alteration of classical conditioning REPTED 22,30,2006
oral
rat 		lowest published toxic dose: 140 mg/kg/7 day- intermittent Behavioral: Food intake (animal) REPTED 22,30,2006
oral
rat 		lowest published toxic dose: 140 mg/kg/7 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field REPTED 22,30,2006
oral
rat 		lowest published toxic dose: 2,450 mg/kg/9 day- intermittent Eye: Mydriasis (pupilliary dilation)

Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Respiratory depression 		REPTED 22,30,2006
oral
rat 		lowest published toxic dose: 2,450 mg/kg/49 day- intermittent Related to Chronic Data: Changes in testicular weight REPTED 22,30,2006
oral
rat 		lowest published toxic dose: 560 mg/kg/28 day- intermittent Gastrointestinal: Changes in structure or function of salivary glands REPTED 22,30,2006
oral
rat 		lowest published toxic dose: 560 mg/kg/14 day- intermittent Behavioral: Change in motor activity (specific assay)

Skin and Appendages: Other: Hair

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		REPTED 22,672,2006
oral
rat 		lowest published toxic dose: 560 mg/kg/14 day- intermittent Behavioral: Tremor

Behavioral: Food intake (animal) 		REPTED 22,672,2006
oral
rat 		lowest published toxic dose: 400 mg/kg/10 day- intermittent Lung, Thorax, or Respiration: Dyspnea REPTED 22,672,2006
oral
rat 		lowest published toxic dose: 280 mg/kg/14 day- intermittent Eye: Mydriasis (pupilliary dilation) REPTED 22,672,2006
oral
rat 		lowest published toxic dose: 200 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain REPTED 22,672,2006


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81800;
Number of Industries 5;
Total Number of Facilities 157;
Number of Occupations 23;
Total Number of Employees Exposed 3,729
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81800;
Number of Industries 7;
Total Number of Facilities 492;
Number of Occupations 18;
Total Number of Employees Exposed 22,254;
Total Number of Female Employees Exposed 4,255


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For publisher information, see AEHLAU.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-

Used as general-purpose rubber accelerator

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