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Glycyrrhiza extract

RTECS #: MD2007000

CAS #: 68916-91-6

UPDATE: May 2009 MW: N/R MF: N/R


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. REFERENCES:

SYNONYMS:

  1. Glycyrrhiza
  2. Glycyrrhizae (Latin)
  3. Kanzo (Japanese)
  4. Kanzou (Chinese)
  5. Licorice
  1. Licorice extract
  2. Licorice root
  3. Licorice root extract
  4. Licorice, roots


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA repair Bacillus subtilis 100 gm/L MUREAV 97,81,1982


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,500 mg/kg Behavioral: Convulsions or effect on seizure threshold

Blood: Changes in spleen 		OYYAA2 14,535,1977
intraperitoneal
rat 		lethal dose (50 percent kill): 1,420 mg/kg Gastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Other changes 		OYYAA2 14,535,1977
oral
man 		lowest published toxic dose: 209 gm/kg/2 year- intermittent Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Muscle weakness

Cardiac: EKG changes not diagnostic of above 		IJNSD3 4,493,1983
oral
mouse 		lethal dose (50 percent kill): >7,500 mg/kg N/R OYYAA2 14,535,1977
oral
rat 		lethal dose (50 percent kill): 14,200 mg/kg Gastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Other changes 		OYYAA2 14,535,1977
subcutaneous
mouse 		lethal dose (50 percent kill): 4 gm/kg Behavioral: Convulsions or effect on seizure threshold

Blood: Changes in spleen 		OYYAA2 14,535,1977
subcutaneous
rat 		lethal dose (50 percent kill): 4,200 mg/kg Gastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Other changes 		OYYAA2 14,535,1977


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
human 		lowest published toxic dose: 79.9 mg/kg/8 week- intermittent Kidney, Ureter, and Bladder: Proteinuria TCPHP* -,226,2000
oral
man 		lowest published toxic dose: 400 mg/kg/4 day- intermittent Endocrine: Androgenic

Endocrine: Other changes 		NEJMAG 341,1158,1999
oral
mouse 		lowest published toxic dose: 2,700 gm/kg/90 day- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		FCTOD7 31,343,1993
oral
mouse 		lowest published toxic dose: 7.5 mg/kg/15 day- intermittent Tumorigenic: Protects against induction of experimental tumors BPBLEO 30,2191,2007
oral
rat 		lowest published toxic dose: 37,500 µg/kg/30 day- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		OYYAA2 14,535,1977
oral
rat 		lowest published toxic dose: 114 mg/kg/13 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in thymus weight 		OYYAA2 14,535,1977


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
AJOPAA 138,639,2004
TOXICOLOGY REVIEW
JACCDI 39,1083,2002
TOXICOLOGY REVIEW
HETOEA 25,481,2006
TOXICOLOGY REVIEW
APLMAS 130,521,2006


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X8576;
Number of Industries 1;
Total Number of Facilities 29;
Number of Occupations 2;
Total Number of Employees Exposed 316


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
APLMAS Archives of Pathology and Laboratory Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-5(2), 1926-28; V.100- 1976-
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
HETOEA Human & Experimental Toxicology. (Macmillan Press Ltd., Brunel Road, Houndmills, Basingstoke, Hampshire, RG21 2XS, UK) V.9- 1990-
IJNSD3 Italian Journal of Neurological Sciences. (Masson Italia Periodici, Via Statuto 2/4, I-20121 Milan, Italy) V.1 n1- 1979-
JACCDI Journal of the American College of Cardiology. (Elsevier Science, P.O. Box 945 New York, NY 10159) V.1- 1983-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
TCPHP* Toxicology and Clinical Pharmacology of Herbal Products Melanie Johns Cupp ed., Humana press, 2000.

RTECS Compound Description:
   Drug
   Mutagen
   Human Data
   Natural Product

ALT CAS #: 8008-94-4
ALT CAS #: 8057-63-4
Click Here for Additional Information about RTECS

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