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Glycolic acid, monosodium salt

RTECS #: MC5525000

CAS #: 2836-32-0

UPDATE: August 2003 MW: 98.04 MF: C2H3O3•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Acetic acid, hydroxy - , monosodium salt
  2. Glykokolan sodny (Czech)
  3. Monosodium glycolate
  4. Natriumglykolat (German)
  1. Sodium hydroxyacetate
  2. Sodium alpha - hydroxyacetate
  3. Sodium lycolate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
cat 		lowest published lethal dose: 1 gm/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness

Behavioral: Ataxia 		JAPMA8 31,306,1942
oral
cat 		lowest published lethal dose: 500 mg/kg Behavioral: Food intake (animal)

Behavioral: Muscle weakness

Behavioral: Ataxia 		JAPMA8 31,306,1942
oral
mouse 		lethal dose (50 percent kill): 6,700 mg/kg Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Changes primarily in glomeruli

Blood: Changes in spleen 		GTPZAB 29(12),53,1985
oral
rat 		lethal dose (50 percent kill): 7,110 mg/kg N/R 85JCAE -,656,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
cat 		lowest published toxic dose: 2,250 mg/kg/19 day- intermittent Nutritional and Gross Metabolic: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JAPMA8 31,306,1942
oral
cat 		lowest published toxic dose: 3 gm/kg/12 day- intermittent Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JAPMA8 34,86,1944
oral
dog 		lowest published toxic dose: 21 gm/kg/14 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JAPMA8 34,86,1944
oral
rat 		lowest published toxic dose: 78 gm/kg/78 day- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) ARZNAD 6,227,1956
oral
rat 		lowest published toxic dose: 730 gm/kg/1 year- continuous Kidney, Ureter, and Bladder: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		IJTOFN 17(Suppl 1),71,1998


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,314,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M3308;
Number of Industries 12;
Total Number of Facilities 454;
Number of Occupations 31;
Total Number of Employees Exposed 10,491
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M3308;
Number of Industries 14;
Total Number of Facilities 896;
Number of Occupations 17;
Total Number of Employees Exposed 21,831;
Total Number of Female Employees Exposed 6,316


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998

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