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Glutamic acid, N - (p - ( ( (2 - amino - 5 - formyl - 5,6,7,8 - tetrahydro - 3 - hydroxy - 6 - pteridinyl) methyl) amino) benzoyl) - , calcium salt (1:1) , L -

RTECS #: MA0600500

CAS #: 1492-18-8

UPDATE: August 2007 MW: 511.56 MF: C20H21N7O7•Ca


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. REVIEWS:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. REFERENCES:

SYNONYMS:

  1. Calcium folinate
  2. Calcium L - folinate
  3. Calcium 5 - formyltetrahydrofolate
  4. Calcium leucovorin
  1. Folinic acid, calcium salt
  2. Lederfoline
  3. Leucovorin calcium salt


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,036 mg/kg N/R IYKEDH 23,93,1992
intraperitoneal
rat 		lethal dose (50 percent kill): 1,063 mg/kg N/R IYKEDH 23,93,1992
intravenous
mouse 		lethal dose (50 percent kill): 732 mg/kg N/R NIIRDN 6,910,1982
oral
mouse 		lethal dose (50 percent kill): >7 gm/kg N/R IYKEDH 23,93,1992
oral
rat 		lethal dose (50 percent kill): >8 gm/kg N/R IYKEDH 23,93,1992


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 566,209,2004
TOXICOLOGY REVIEW
ENTOX* -,384,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6060;
Number of Industries 1;
Total Number of Facilities 103;
Number of Occupations 6;
Total Number of Employees Exposed 3,686;
Total Number of Female Employees Exposed 2,084


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)

RTECS Compound Description:
   Drug

ALT CAS #: 6035-86-5
ALT CAS #: 6209-45-6
ALT CAS #: 30771-29-0
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