RTECS:MA2275100 The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH

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Glutamine, L -

RTECS #: MA2275100

CAS #: 56-85-9

UPDATE: February 2008 MW: 146.17 MF: C₅H₁₀N₂O₃

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

MUTATION DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

(S) - 2,5 - Diamino - 5 - oxopentanoic acid

2 - Aminoglutaramic acid

Cebrogen

Glumin

Glutamic acid amide

Glutamic acid 5 - amide

Glutamine

L - (+) - Glutamine

L - 2 - Aminoglutaramidic acid

L - Glutamic acid gamma - amide

L - Glutamine (9CI)

Levoglutamid

Levoglutamide

Pentanoic acid, 2,5 - diamino - 5 - oxo - , (S) -

Stimulina

gamma - Glutamine

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
sister chromatid exchange human lymphocyte 10 mg/L MUREAV 372,75,1996

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
man lowest published toxic dose: 27 mg/kg/1 week- intermittent Behavioral: Euphoria AJPSAO 141,1302,1984
oral
mouse lethal dose (50 percent kill): 21,700 mg/kg N/R NIIRDN 6,228,1982
oral
rat lethal dose (50 percent kill): 7,500 mg/kg N/R NIIRDN 6,228,1982

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 260 mg/kg/30 day- intermittent Behavioral: Food intake (animal)

Blood: Changes in spleen

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field KSRNAM 8,902,1974
oral
rat lowest published toxic dose: 180,544 mg/kg/13 week- continuous Kidney, Ureter, and Bladder: Proteinuria

Kidney, Ureter, and Bladder: Other changes in urine composition IJTOFN 23,107,2004
rectal
rat lowest published toxic dose: 50 mg/kg/2 day- intermittent Gastrointestinal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation TXCYAC 236,217,2007

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4814;
Number of Industries 4;
Total Number of Facilities 841;
Number of Occupations 14;
Total Number of Employees Exposed 8,491;
Total Number of Female Employees Exposed 5,700

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY

REFERENCES:
CODEN
REFERENCE

AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc., Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.78- 1921-
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

RTECS Compound Description:
   Drug
   Mutagen
   Human Data

ALT CAS #: 32640-56-5
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