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2 - Furaldehyde, 5 - nitro - , semicarbazone

RTECS #: LT7700000

CAS #: 59-87-0

UPDATE: May 2009 MW: 198.16 MF: C6H6N4O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. (5 - Nitro - 2 - furfurylideneamino) urea
  2. 1 - (5 - Nitro - 2 - furfurylidene) semicarbazide
  3. 2 ( (5 - Nitro - 2 - furanyl) methylene) hydrazinecarboxamide
  4. 2 - ( (5 - Nitro - 2 - furanyl) methylene) hydrazine carboximide
  5. 5 - Nitro - 2 - furaldehyde semicarbazone
  6. 5 - Nitro - 2 - furancarboxaldehyde semicarbazone
  7. 5 - Nitro - 2 - furfural semicarbazone
  8. 5 - Nitro - 2 - furfuraldehyde semicarbazone
  9. 5 - Nitrofuraldehyde semicarbazide
  10. 5 - Nitrofuran - 2 - aldehyde semicarbazone
  11. 5 - Nitrofurfural semicarbazone
  12. 6 - Nitrofuraldehyde semicarbazide
  13. Acutol
  14. Aldomycin
  15. Alfucin
  16. Amifur
  17. Babrocid
  18. Becafurazone
  19. Biofuracina
  20. Biofurea
  21. Chemofuran
  22. Chixin
  23. Cocafurin
  24. Coxistat
  25. Dermofural
  26. Dynazone
  27. Eldezol
  28. Eldezol F - 6
  29. Fedacin
  30. Flavazone
  31. Fracine
  32. Furacilin
  33. Furacillin
  34. Furacin
  35. Furacin - E
  36. Furacin - HC
  37. Furacine
  38. Furacinetten
  39. Furacoccid
  40. Furacort
  41. Furacycline
  42. Furaldon
  43. Furalone
  1. Furametral
  2. Furan - ofteno
  3. Furaplast
  4. Furaseptyl
  5. Furaskin
  6. Furaziline
  7. Furazin
  8. Furazina
  9. Furazol W
  10. Furazone
  11. Furesol
  12. Furfurin
  13. Furosem
  14. Fuvacillin
  15. Hemofuran
  16. Hydrazinecarboxamide, 2 - ( (5 - nitro - 2 - furanyl) methylene) -
  17. Ibiofural
  18. Mammex
  19. Mastofuran
  20. Monofuracin
  21. NCI - C56064
  22. NF - 7
  23. NFS
  24. NFZ
  25. NSC - 2100
  26. Nefco
  27. Nifucin
  28. Nifuzon
  29. Nitrofural
  30. Nitrofuraldehyde semicarbazone
  31. Nitrofurazan
  32. Nitrofurazone
  33. Nitrozone
  34. Otofuran
  35. Semikarbazon 5 - nitrofurfuralu (Polish)
  36. Spray - dermis
  37. Spray - foral
  38. U - 6421
  39. USAF EA - 4
  40. Vabrocid
  41. Veterinary nitrofurazone
  42. Yatrocin


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 100 mg/L FCTOD7 23,1091,1985
cytogenetic analysis hamster lung 100 mg/L/27 hour MUREAV 66,277,1979
DNA damage hamster kidney 250 µmol/L CNREA8 35,781,1975
DNA damage human other cell types 250 µmol/L CNREA8 35,781,1975
DNA damage human other cell types 5 mg/L/3 hour (-enzymatic activation step) MUTAEX 20,193,2005
DNA damage mouse Ascites tumor 80 mg/kg CNREA8 35,781,1975
DNA damage mouse lymphocyte 500 µmol/L/90 minute- continuous BJCAAI 40,94,1979
DNA damage mouse fibroblast 250 µmol/L CNREA8 35,781,1975
DNA damage mouse other cell types 500 µmol/L CBINA8 16,223,1977
DNA inhibition hamster lung 10 µmol/L/6 day- continuous BJCAAI 40,94,1979
DNA inhibition mouse lymphocyte 500 µmol/L/90 minute- continuous BJCAAI 40,94,1979
DNA inhibition mouse other cell types 100 mg/L ONCODU 19,183,1980
DNA repair Bacillus subtilis 10 µg/disc KSRNAM 17,70,1983
DNA repair Escherichia coli 50 µmol/L MUREAV 67,133,1979
DNA repair Salmonella typhimurium 1 µg/disc BLLIAX 84,645,1985
mutation in microorganisms Bacillus subtilis 5 gm/L (-enzymatic activation step) MUREAV 42,19,1977
mutation in microorganisms Escherichia coli 40 µg/L (-enzymatic activation step) MUREAV 175,149,1986
mutation in microorganisms Escherichia coli 10 mg/L (+enzymatic activation step) BJCSB5 3,124,1978
mutation in microorganisms Escherichia coli 0.168 mmol/L/15 hour MUREAV 535,55,2003
mutation in microorganisms Euglena gracilis 50 mg/L (-enzymatic activation step) JPROAR 17,129,1970
mutation in microorganisms Neurospora crassa 1 mmol/L (-enzymatic activation step) MUREAV 56,13,1977
mutation in microorganisms Salmonella typhimurium 300 ng/plate (+enzymatic activation step) ENMUDM 9(Suppl 9),1,1987
mutation in microorganisms Salmonella typhimurium 2 µg/plate (-enzymatic activation step) MUREAV 192,15,1987
mutation in microorganisms Salmonella typhimurium 5 mg/L/2 hour (+/-enzymatic activation step) EMMUEG 44,329,2004
mutation in mammalian somatic cells hamster ovary 23 mg/L NTPTR* NTP-TR-337,1988
mutation in mammalian somatic cells mouse lymphocyte 100 mg/L NTPTR* NTP-TR-337,1988
other mutation test systems Escherichia coli 50 mg/L CBINA8 14,81,1976
other mutation test systems Salmonella typhimurium 300 µg/L MUREAV 272,91,1992
phage inhibition capacity Escherichia coli 1 mg/L MUREAV 26,3,1974
phage inhibition capacity other microorganisms 1 mg/L CHDDAT 272,886,1971
sister chromatid exchange hamster ovary 250 µg/L NTPTR* NTP-TR-337,1988


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 817 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		NTIS** PB86-145844
oral
mouse 		lowest published toxic dose: 800 mg/kg (6-13 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		TCMUD8 7,29,1987
oral
mouse 		lowest published toxic dose: 11,340 mg/kg (multigeneration) Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) 		FAATDF 34,56,1996
oral
mouse 		lowest published toxic dose: 12 mg/kg (multigeneration) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 12,199,1992
oral
mouse 		lowest published toxic dose: 45 mg/kg (multigeneration) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Germ cell effects (in offspring) 		TOXID9 12,199,1992
oral
mouse 		lowest published toxic dose: 45 mg/kg (multigeneration) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) 		TOXID9 12,199,1992
oral
mouse 		lowest published toxic dose: 1.73 gm/kg (7 day prior to copulation/21 day pregnant) Reproductive: Maternal effects: Parturition NTIS** #PB92-217694
oral
mouse 		lowest published toxic dose: 1.73 gm/kg (7 day prior to copulation/21 day pregnant) Reproductive: Effects on fertility: Other measures of fertility NTIS** #PB92-217694
oral
mouse 		lowest published toxic dose: 18.2 gm/kg (21 week male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) NTIS** #PB92-217694
oral
mouse 		lowest published toxic dose: 18.2 gm/kg (21 week prior to copulation) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		NTIS** #PB92-217694
oral
mouse 		lowest published toxic dose: 15 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Urogenital system NTIS** #PB92-217694
oral
mouse 		lowest published toxic dose: 61.9 mg/kg (multigenerations) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		NTIS** #PB92-217694
oral
mouse 		lowest published toxic dose: 61.9 mg/kg (multigenerations) Reproductive: Maternal effects: Parturition

Reproductive: Effects on newborn: Sex ratio 		NTIS** #PB92-217694
oral
mouse 		lowest published toxic dose: 433.3 mg/kg (7 day male) Reproductive: Effects on fertility: Other measures of fertility NTIS** #PB92-217694
oral
mouse 		lowest published toxic dose: 62.8 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetal death 		NTIS** #PB86-145844
oral
mouse 		lowest published toxic dose: 817 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** #PB86-145844
oral
rat 		lowest published toxic dose: 700 mg/kg (7 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct APJAAG 14,261,1964
oral
rat 		lowest published toxic dose: 840 mg/kg (14 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Other effects on male 		ENDOAO 53,585,1953
oral
rat 		lowest published toxic dose: 529 mg/kg (14 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct FCTOD7 27,129,1989
oral
rat 		lowest published toxic dose: 1,792 mg/kg (28 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		ANDRDQ 10,107,1978
oral
rabbit 		lowest published toxic dose: 280 mg/kg (6-19 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		NTIS** #PB88-130984
subcutaneous
mouse 		lowest published toxic dose: 300 mg/kg (10 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TJADAB 12,206,1975
unreported route
mouse 		lowest published toxic dose: 900 mg/kg (9-11 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other developmental abnormalities 		TJADAB 14,250,1976
unreported route
rat 		lowest published toxic dose: 700 mg/kg (14 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct JTSCDR 24,348,1999


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 10,094 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors 		FEPRA7 25,419,1966
oral
mouse 		lowest published toxic dose: 12,978 mg/kg/103 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Reproductive: Tumorigenic effects: Ovarian tumors 		NTIS** PB89-102388/AS
oral
rat 		lowest published toxic dose: 8,652 mg/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors 		NTPTR* NTP-TR-337,1988
oral
rat 		toxic dose : 4,500 mg/kg/27 day- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors 		CNREA8 28,924,1968
oral
rat 		toxic dose : 31 gm/kg/45 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Skin and Appendages: Tumors 		FEPRA7 25,419,1966
oral
rat 		toxic dose : 11,176 mg/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors 		FCTOD7 27,129,1989
oral
rat 		lowest published toxic dose: 26,821.2 mg/kg/103 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors 		NTIS** PB89-102388/AS
oral
rat 		lowest published toxic dose: 13,410.6 mg/kg/103 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Other reproductive system tumors 		NTIS** PB89-102388/AS
oral
rat 		lowest published toxic dose: 11,175.5 mg/kg/103 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors 		NTIS** PB89-102388/AS
subcutaneous
mouse 		lowest published toxic dose: 300 mg/kg/18 day- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		SEIJBO 15,234,1975


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 96 mg/kg N/R JMCMAR 10,530,1967
intraperitoneal
rat 		lowest published lethal dose: 150 mg/kg N/R BCPCA6 13,285,1964
oral
mouse 		lethal dose (50 percent kill): 167 µg/kg N/R PCJOAU 36,89,2002
oral
rat 		lethal dose (50 percent kill): 590 mg/kg N/R JAMAAP 133,299,1947
oral
rat 		lowest published toxic dose: 500 mg/kg Liver: Hepatitis (hepatocellular necrosis), diffuse

Liver: Other changes

Endocrine: Other changes 		JTPAE7 17,59,2004
subcutaneous
mouse 		lethal dose (50 percent kill): 753 mg/kg N/R JPETAB 102,185,1951
subcutaneous
rat 		lethal dose (50 percent kill): 3 gm/kg N/R JAMAAP 133,299,1947
skin
human 		lowest published toxic concentration: 1 pph Skin: After topical application: Dermatitis, allergic AJCDE* 13,125,2002


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 2,710 mg/kg/14 day- intermittent Behavioral: Convulsions or effect on seizure threshold

Skin: After systemic exposure: Dermatitis, other

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-337,1988
oral
mouse 		lowest published toxic dose: 6,770 mg/kg/13 week- intermittent Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-337,1988
oral
mouse 		lowest published toxic dose: 4,340 mg/kg/28 day- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in adrenal weight 		NTIS** #PB92-217694
oral
mouse 		lowest published toxic dose: 433.3 mg/kg/7 day- continuous Kidney, Ureter, and Bladder: Changes in kidney weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		NTIS** #PB92-217694
oral
mouse 		lowest published toxic dose: 525 mg/kg/7 day- continuous Reproductive: Paternal effects: Testes, epididymis, sperm duct NTIS** #PB92-217694
oral
mouse 		lowest published toxic dose: 420 mg/kg/28 day- continuous Reproductive: Maternal effects: Ovaries, fallopian tubes NTIS** #PB92-217694
oral
mouse 		lowest published toxic dose: 868 mg/kg/7 day- continuous Endocrine: Androgenic

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		NTIS** #PB92-217694
oral
mouse 		lowest published toxic dose: 1,733.2 mg/kg/28 day- continuous Reproductive: Effects on fertility: Other measures of fertility NTIS** #PB92-217694
oral
mouse 		lowest published toxic dose: 1,225.5 mg/kg/10 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTIS** #PB86-145844
oral
mouse 		lowest published toxic dose: 1,120 mg/kg/14 day- intermittent Liver: Changes in liver weight

Blood: Changes in cell count (unspecified) 		NTPTR* IMM-90011
oral
mouse 		lowest published toxic dose: 840 mg/kg/14 day- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Immunological Including Allergic: Decrease in cellular immune response 		NTPTR* IMM-90011
oral
mouse 		lowest published toxic dose: 560 mg/kg/14 day- intermittent Blood: Changes in erythrocyte (RBC) count

Immunological Including Allergic: Increase in cellular immune response 		NTPTR* IMM-90011
oral
rat 		lowest published toxic dose: 1,170 mg/kg/14 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-337,1988
oral
rat 		lowest published toxic dose: 11,375 mg/kg/13 week- intermittent Liver: Changes in liver weight

Musculoskeletal: Osteoporosis 		NTPTR* NTP-TR-337,1988
oral
rat 		lowest published toxic dose: 3,325 mg/kg/19 week- continuous Related to Chronic Data: Changes in ovarian weight CALEDQ 156,177,2000
oral
rat 		lowest published toxic dose: 800 mg/kg/8 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JTSCDR 25,195,2000
oral
rat 		lowest published toxic dose: 700 mg/kg/2 week- intermittent Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		JTSCDR 25,195,2000
oral
rat 		lowest published toxic dose: 1,050 mg/kg/3 week- intermittent Behavioral: Somnolence (general depressed activity)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JTSCDR 25,195,2000
oral
rat 		lowest published toxic dose: 26,821.2 mg/kg/103 week- continuous Reproductive: Tumorigenic effects: Testicular tumors

Blood: Leukemia

Tumorigenic: Active as anti-cancer agent 		NTIS** PB89-102388/AS
oral
rat 		lowest published toxic dose: 11,175.5 mg/kg/103 week- continuous Blood: Leukemia

Tumorigenic: Active as anti-cancer agent 		NTIS** PB89-102388/AS
oral
rabbit 		lowest published toxic dose: 140 mg/kg/14 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB88-130984
oral
rabbit 		lowest published toxic dose: 280 mg/kg/14 day- intermittent Liver: Hepatitis (hepatocellular necrosis), diffuse

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** #PB88-130984
skin
human 		lowest published toxic concentration: 1 pph/48 hour- continuous Skin: After topical application: Dermatitis, allergic AJCDE* 13,59,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 50,195,1990
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 7,171,1974
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 7,171,1974
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 50,195,1990
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 50,195,1990
TOXICOLOGY REVIEW
CRTXB2 2,365,1973
TOXICOLOGY REVIEW
CCSUDL 4,171,1978
TOXICOLOGY REVIEW
JTSCDR 25,1,2000
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
REPTED 25,192,2008
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
MUREAV 654,114,2008
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84410;
Number of Industries 3;
Total Number of Facilities 305;
Number of Occupations 5;
Total Number of Employees Exposed 3,806
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2857;
Number of Industries 1;
Total Number of Facilities 697;
Number of Occupations 5;
Total Number of Employees Exposed 6,091;
Total Number of Female Employees Exposed 2,898
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84410;
Number of Industries 1;
Total Number of Facilities 978;
Number of Occupations 5;
Total Number of Employees Exposed 6,652;
Total Number of Female Employees Exposed 2,898


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: N crassa-forward mutation; N crassa-reversion
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive/dose response: TRP reversion
EPA GENETOX PROGRAM 1988, Positive/limited: Carcinogenicity-mouse/rat
EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-nonhuman bone marrow
EPA GENETOX PROGRAM 1988, Negative: Sperm morphology-mouse; In vitro UDS-human fibroblast
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an antibacterial agent, and a topical agent for burns, skin grafts and wounds
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);clear evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE
AJCDE* American Journal of Contact Dermatitis: Official Journal of the American Contact Dermatitis Society (Philadelphia, PA : W.B. Saunders, Harcourt Brace Jovanovich) V.1-14 1990-2003.
ANDRDQ Andrologia. (Grosse Verlag GmbH, Kurfuerstenstr. 112-113, D-1000 Berlin 30, Fed. Rep. Ger.) V.6- 1974-
APJAAG Acta Pathologica Japonica. (Japan Publications Trading Co., Ltd., POB 5030, Tokyo International, Tokyo 101-31, Japan) V.1- 1951-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
BJCSB5 British Journal of Cancer, Supplement. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2ZS, UK) No.1- 1973-
BLLIAX Bratislavske Lekarske Listy. (PNS-Ustredna Expedicia a Dovoz Tlace, Gottwaldovo nam. 6, 813 81 Bratislava, Czechoslovakia) V.1- 1921-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CCSUDL Carcinogenesis--A Comprehensive Survey. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) V.1- 1976-
CHDDAT Comptes Rendus des Seances de l'Academie des Sciences, Serie D: Sciences Naturelles. (Paris, France) V.262-291, 1966-80. For publisher information, see CRASEV.
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
HTOPA*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPROAR Journal of Protozoology. (Soc. of Protozoologists, P.O. Box 368, Lawrence, KS 66044) V.1- 1954-
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Used as an antibacterial agent, and a topical agent for burns, skin grafts and wounds

FDA-proprietary drug

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Hormone

 Click Here for Additional Information about RTECS

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