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Fluorescein, 2',4',5',7' - tetrabromo - 4,5,6,7 - tetrachloro - , disodium salt

RTECS #: LM5900000

CAS #: 18472-87-2

UPDATE: December 1998 MW: 829.64 MF: C20H2Br4Cl4O5•2Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 11969 Red
  2. 3427 Veri Pur Pink
  3. Acid Red 92
  4. Aizen Acid Phloxine PB
  5. C.I. 45410
  6. C.I. Acid Red 92
  7. Cyanosin
  8. Cyanosin (acid dye)
  9. Cyanosin B
  10. Cyanosine
  11. D and C Red No. 28
  12. Daiwa Red 45
  13. Eosin Blue
  14. Eosine Blue
  1. Eosine bluish
  2. Food Dye Red No. 104
  3. Food Red 104
  4. Food Red No. 104
  5. Japan Red 104
  6. Japan Red 104 - 1
  7. Orient Water Pink 2
  8. Phloxin B
  9. Phloxine B
  10. Phloxine P
  11. Red 104
  12. Red No. 104
  13. Red No. 104 - 1
  14. Water Pink 2


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in mammalian somatic cells human lung 3 mg/L MUREAV 30,239,1975


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 39,600 mg/kg (6-16 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system FCTOD7 22,55,1984
oral
mouse 		lowest published toxic dose: 66 gm/kg (6-16 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) FCTOD7 22,55,1984
oral
rat 		lowest published toxic dose: 63 gm/kg (1-22 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		SKEZAP 16,34,1975


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 75,600 mg/kg/90 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Liver: Tumors

Endocrine: Tumors 		FCTOD7 32,517,1994


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
mouse 		lethal dose (50 percent kill): 310 mg/kg N/R TXAPA9 44,225,1978
oral
dog 		lethal dose (50 percent kill): >4,600 mg/kg N/R JAFCAU 46,1005,1998
oral
mouse 		lethal dose (50 percent kill): 310 mg/kg N/R JAFCAU 46,1005,1998
oral
rat 		lethal dose (50 percent kill): 8,400 mg/kg N/R JAFCAU 46,1005,1998


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M4129;
Number of Industries 2;
Total Number of Facilities 301;
Number of Occupations 5;
Total Number of Employees Exposed 1,460
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M4129;
Number of Industries 3;
Total Number of Facilities 559;
Number of Occupations 11;
Total Number of Employees Exposed 9,866;
Total Number of Female Employees Exposed 3,202
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9003;
Number of Industries 2;
Total Number of Facilities 636;
Number of Occupations 3;
Total Number of Employees Exposed 8,722;
Total Number of Female Employees Exposed 6,754


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
SKEZAP Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. (Nippon Shokuhin Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo 150, Japan) V.1- 1960-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as a food dye

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 12777-84-3
ALT CAS #: 37361-25-4
ALT CAS #: 51374-31-3
ALT CAS #: 157367-38-9
ALT CAS #: 198831-99-1
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