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Fluorescein, 2',7' - dibromo - 4' - (hydroxymercurio) - , disodium salt

RTECS #: LM5250000

CAS #: 129-16-8

UPDATE: May 2009 MW: 750.67 MF: C20H8Br2HgO6•2Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2,7 - Dibromo - 4 - hydroxymercurifluoresceine disodium salt
  2. Asceptichrome
  3. Aseptichrome
  4. Chromargyre
  5. DOMF
  6. Disodium 2,7 - dibrom - 4 - hydroxy - mercuri - fluorescein
  7. Disodium 2',7' - dibromo - 4' - (hydroxymercury) fluorescein
  8. Flavurol
  9. Fluorochrome
  10. Gallochrome
  1. Gynochrome
  2. Merbromin
  3. Mercuranine
  4. Mercurochrome
  5. Mercurochrome - 220 soluble
  6. Mercurocol
  7. Mercurome
  8. Mercurophage
  9. Planochrome


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
gene conversion and mitotic recombination Saccharomyes cerevisiae 10 mg/L EVHPAZ 31,97,1979
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 50 mg/L EVHPAZ 31,97,1979


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published lethal dose: 200 mg/kg N/R JPETAB 43,71,1931
intravenous
mouse 		lethal dose (50 percent kill): 50 mg/kg N/R JPETAB 43,645,1931
intravenous
rabbit 		lowest published lethal dose: 15 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory stimulation 		JPETAB 35,343,1929
oral
woman 		lowest published toxic dose: 10 µL/kg Gastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes 		JTCTDW 35,657,1997
subcutaneous
mouse 		lowest published lethal dose: 20 mg/kg N/R MOLAAF 73,751,1939


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
human 		lowest published toxic concentration: 2 pph/48 hour- continuous Skin: After topical application: Dermatitis, allergic AJCDE* 13,3,2002


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
SDGTB3 1,177,1971
TOXICOLOGY REVIEW
HUTOX* -,515,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg(Hg)/m3, JUL2008
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg(Hg)/m3, Skin, MAR2002
Occupational Exposure Limit - HUNGARY time-weighted average 0.01 mg(Hg)/m3, short term exposure limit 0.04 mg(Hg)/m3, Skin, SEP2000
Occupational Exposure Limit - RUSSIA time-weighted average 0.05 mg(Hg)/m3, short term exposure limit 0.2 mg(Hg)/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MERCURY, ARYL AND INORGANIC-air ceiling concentration 0.1 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 44650;
Number of Industries 5;
Total Number of Facilities 586;
Number of Occupations 10;
Total Number of Employees Exposed 7,896
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 44650;
Number of Industries 3;
Total Number of Facilities 372;
Number of Occupations 6;
Total Number of Employees Exposed 5,294;
Total Number of Female Employees Exposed 3,955


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S cerevisiae-aneuploidy
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AJCDE* American Journal of Contact Dermatitis: Official Journal of the American Contact Dermatitis Society (Philadelphia, PA : W.B. Saunders, Harcourt Brace Jovanovich) V.1-14 1990-2003.
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
HUTOX*
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
MOLAAF Monatsschrift fuer Ohrenheilkunde und Laryngo-Rhinologie. (Vienna, Austria) V.1-108, 1867-1974. For publisher information, see LROTDW.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
SDGTB3 Seminars in Drug Treatment. (New York, NY) V.1-3, 1971-74. Discontinued.

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   Human Data

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