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Fluoranthene

RTECS #: LL4025000

CAS #: 206-44-0

UPDATE: May 2009 MW: 202.26 MF: C16H10


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1,2 - (1,8 - Naphthalenediyl) benzene
  2. 1,2 - (1,8 - Naphthylene) benzene
  3. 1,2 - Benzacenaphthene
  4. Benzene, 1,2 - (1,8 - naphthylene) -
  1. Benzo (jk) fluorene
  2. Idryl
  3. RCRA waste number U120


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA adduct oral
rat 		50 µg/kg TOXID9 44,306,2005
DNA adduct rat liver 30 µmol/L/24 hour MUTAEX 22,55,2007
DNA damage Escherichia coli 34.8 µg/L/3 hour (+enzymatic activation step) MUREAV 515,85,2002
DNA damage hamster fibroblast 50 µmol/L/2 hour (-enzymatic activation step) MUREAV 650,96,2008
DNA damage human ovary 30 µmol/L MUREAV 575,17,2005
mutation in microorganisms Salmonella typhimurium 1 µg/plate (-enzymatic activation step) EMMUEG 44,304,2004
mutation in microorganisms Salmonella typhimurium 559.2 pmol/L (+enzymatic activation step) MUREAV 626,88,2007
mutation in mammalian somatic cells hamster ovary 20 mg/L ENMUDM 6,539,1984
mutation in mammalian somatic cells human lymphocyte 2 µmol/L DTESD7 10,277,1982
morphological transform rat embryo 50 mg/L JNCIAM 51,799,1973
sister chromatid exchange hamster ovary 9 mg/L MUREAV 174,125,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 280 mg/kg/58 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		JNCIAM 56,1237,1976


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
mouse 		lethal dose (50 percent kill): 100 mg/kg N/R CSLNX* NX#00205
oral
rat 		lethal dose (50 percent kill): 2 gm/kg N/R AIHAAP 23,95,1962
oral
rat 		lowest published toxic dose: 1,000 mg/kg Liver: Changes in liver weight EESADV 59,102,2004
oral
rat 		lowest published toxic dose: 1,000 mg/kg Blood: Other changes EESADV 59,102,2004
oral
rat 		lowest published toxic dose: 2,000 mg/kg Blood: Changes in leukocyte (WBC) count EESADV 59,102,2004
oral
rat 		lowest published toxic dose: 200 mg/kg Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Ataxia

Behavioral: Alteration of operant conditioning 		IJTOFN 22,263,2003
oral
rat 		lowest published toxic dose: 200 mg/kg Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Behavioral: Change in motor activity (specific assay)

Behavioral: Alteration of operant conditioning 		IJTOFN 22,263,2003
oral
rat 		lowest published toxic dose: 400 mg/kg Behavioral: Ataxia IJTOFN 22,263,2003
skin
rabbit 		lethal dose (50 percent kill): 3,180 mg/kg N/R AIHAAP 23,95,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 67,500 mg/kg/90 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Normocytic anemia

Blood: Changes in leukocyte (WBC) count 		TOXID9 36(1 Pt2),219,1997
oral
rat 		lowest published toxic dose: 135,000 mg/kg/90 day- intermittent Behavioral: Food intake (animal)

Liver: Changes in liver weight 		EESADV 59,102,2004
oral
rat 		lowest published toxic dose: 90,000 mg/kg/60 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain EESADV 59,102,2004
oral
rat 		lowest published toxic dose: 4,500 mg/kg/30 day- intermittent Blood: Other changes

Blood: Changes in erythrocyte (RBC) count

Blood: Changes in leukocyte (WBC) count 		EESADV 59,102,2004
oral
rat 		lowest published toxic dose: 135,000 mg/kg/90 day- intermittent Blood: Other changes

Blood: Changes in erythrocyte (RBC) count 		EESADV 59,102,2004
oral
rat 		lowest published toxic dose: 67,500 mg/kg/90 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in leukocyte (WBC) count 		EESADV 59,102,2004
oral
rat 		lowest published toxic dose: 90,000 mg/kg/60 day- intermittent Blood: Changes in leukocyte (WBC) count EESADV 59,102,2004
oral
rat 		lowest published toxic dose: 9,000 mg/kg/60 day- intermittent Blood: Other changes EESADV 59,102,2004
oral
rat 		lowest published toxic dose: 13,500 mg/kg/90 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) EESADV 59,102,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 32,355,1983
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 32,355,1983
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
MUREAV 558,155,2004
TOXICOLOGY REVIEW
MUREAV 558,7,2004
TOXICOLOGY REVIEW
TOLED5 140-141,353,2003
TOXICOLOGY REVIEW
MUREAV 567,401,2004
TOXICOLOGY REVIEW
MUREAV 589,208,2005
TOXICOLOGY REVIEW
MUREAV 636,95,2007
TOXICOLOGY REVIEW
MUREAV 543,17,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T0379;
Number of Industries 6;
Total Number of Facilities 90;
Number of Occupations 3;
Total Number of Employees Exposed 382
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T0379;
Number of Industries 22;
Total Number of Facilities 1,019;
Number of Occupations 17;
Total Number of Employees Exposed 21,337;
Total Number of Female Employees Exposed 2,138


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/95/264370)
EPA GENETOX PROGRAM 1988, Inconclusive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: CHO gene mutation
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Polynuclear aromatic hydrocarbons by HPLC, 5506; by GC, 5515


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
DTESD7 Developments in Toxicology and Environtal Science. (Elsevier Science, New York, NY) V.1-15, 1977-87. Discontinued
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data

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