CDC logo, Safer Healthier People CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us




Ethylene, 1,2 - dichloro - , (Z) -

RTECS #: KV9420000

CAS #: 156-59-2

UPDATE: February 2008 MW: 96.94 MF: C2H2Cl2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. (Z) - 1,2 - Dichloroethene
  2. 1,2 - Dichloroethylene, cis -
  3. Ethene, 1,2 - dichloro - , (Z) - (9CI)
  4. HCC 1130c
  1. R 1130c
  2. cis - 1,2 - Dichloroethene
  3. cis - 1,2 - Dichloroethylene
  4. cis - Dichloroethylene


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
unscheduled DNA synthesis rat liver 4,300 µmol/L CRNGDP 5,1629,1984
host-mediated assay mouse
Saccharomyes cerevisiae 		1,300 mg/kg TCMUD8 4,365,1984
mutation in microorganisms Saccharomyes cerevisiae 100 mmol/L (-enzymatic activation step) TCMUD8 4,365,1984
gene conversion and mitotic recombination Saccharomyes cerevisiae 40 mmol/L TCMUD8 4,365,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published lethal concentration: 20 gm/m3/6 hour Behavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold

Nutritional and Gross Metabolic: Body temperature decrease 		AHBAAM 116,131,1936
inhalation
mouse 		lowest published lethal concentration: 65 gm/m3/2 hour Behavioral: General anesthetic

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay) 		AHBAAM 116,131,1936
inhalation
rat 		lethal concentration (50 percent kill): 13,700 ppm Behavioral: Somnolence (general depressed activity)

Liver: Fatty liver degeneration 		TOXID9 54,17,2000


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 200 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - SWITZERLAND MAK- week 200 ppm (790 mg/m3),KZG- week 400 ppm (1580 mg/m3), DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5352;
Number of Industries 1;
Total Number of Facilities 3;
Number of Occupations 3;
Total Number of Employees Exposed 61;
Total Number of Female Employees Exposed 6


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as synthetic intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AHBAAM Archiv fuer Hygiene und Bakteriologie. (Munich, Fed. Rep. Ger.) V.101-154, 1929-71. For publisher information, see ZHPMAT.
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-

Used as synthetic intermediate

RTECS Compound Description:
   Mutagen

 Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us