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Ethylamine, 2,2' - oxybis (N,N - dimethyl -

RTECS #: KR9460000

CAS #: 3033-62-3

UPDATE: February 2009 MW: 160.30 MF: C8H20N2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 2,2' - Oxybis (N,N - dimethylethylamine)
  2. A 99 (Amine)
  3. Bis (2 - dimethylaminoethyl) ether
  4. Dabco BL 11
  5. Dabco BL 19
  6. Dabco BL 19I
  1. Kalpur PC
  2. Niax A 1
  3. Niax A 99
  4. Texacat ZF 20
  5. Toyocat ET
  6. Toyocat ETS


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		1 mg severe UCDS** 12/27/1971
eye
rabbit 		250 µg/24 hour severe 85JCAE -,721,1986
skin
rabbit 		5 mg/24 hour severe 85JCAE -,721,1986
skin
rabbit 		500 mg open irritation test severe UCDS** 12/27/1971
skin
rabbit 		100 mg/24 hour severe JTOTDO 5,3,1986
skin
rabbit 		10% JAPTO* 25,260,2005


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
sister chromatid exchange hamster ovary 0.5 pph (-enzymatic activation step) JAPTO* 25,260,2005


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		lowest published toxic dose: 650 mg/kg (6-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		JTOTDO 5,263,1986
skin
rabbit 		lowest published toxic dose: 700 µg/kg (6-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JAPTO* 25,260,2005


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 117 ppm/6 hour Eye: Corneal damage

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Other changes 		NTIS** OTS0536387
inhalation
rat 		lethal concentration (50 percent kill): 166 ppm/6 hour Behavioral: Somnolence (general depressed activity) JAPTO* 25,260,2005
inhalation
rat 		lowest published toxic concentration: 68 ppm/6 hour Eye: Conjunctiva irritation JAPTO* 25,260,2005
inhalation
rat 		lowest published lethal concentration: 149 ppm/6 hour Olfaction: Other olfaction effects

Eye: Corneal damage

Lung, Thorax, or Respiration: Respiratory depression 		JAPTO* 25,260,2005
inhalation
rat 		lowest published lethal concentration: 149 ppm/6 hour Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JAPTO* 25,260,2005
intraperitoneal
mouse 		lethal dose (50 percent kill): 171 mg/kg N/R JAPTO* 25,260,2005
intraperitoneal
mouse 		lethal dose (50 percent kill): 128 mg/kg Behavioral: Sleep JAPTO* 25,260,2005
intravenous
rat 		lethal dose (50 percent kill): 286 mg/kg N/R JAPTO* 25,260,2005
intravenous
rabbit 		lethal dose (50 percent kill): 183 mg/kg N/R JAPTO* 25,260,2005
ocular
rabbit 		lowest published toxic concentration: 10 pph Eye: Corneal damage JAPTO* 25,260,2005
ocular
rabbit 		lowest published toxic concentration: 1 pph Eye: Other eye effects JAPTO* 25,260,2005
ocular
rabbit 		lowest published toxic concentration: 4.6 ppm/2 hour Eye: Conjunctiva irritation

Eye: Corneal damage 		JAPTO* 25,260,2005
oral
rat 		lethal dose (50 percent kill): 571 mg/kg N/R NTIS** OTS0545161
oral
rat 		lethal dose (50 percent kill): 1,045 mg/kg Behavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes 		JAPTO* 25,260,2005
oral
rat 		lethal dose (50 percent kill): 1,045 mg/kg Gastrointestinal: Other changes

Liver: Other changes

Blood: Hemorrhage 		JAPTO* 25,260,2005
oral
rat 		lethal dose (50 percent kill): 1,045 mg/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain JAPTO* 25,260,2005
skin
rabbit 		lethal dose (50 percent kill): 280 µL/kg N/R AIHAAP 30,470,1969
skin
rabbit 		lethal dose (50 percent kill): 348 mg/kg/4 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Gastrointestinal: Changes in structure or function of salivary glands 		JAPTO* 25,260,2005
skin
rabbit 		lethal dose (50 percent kill): 314 mg/kg/24 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Gastrointestinal: Changes in structure or function of salivary glands 		JAPTO* 25,260,2005


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 20 ppm/6 hour/9 day- intermittent Olfaction: Other olfaction effects

Eye: Ptosis

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0536526
inhalation
rat 		lowest published toxic concentration: 47 ppm/5 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JAPTO* 25,260,2005
inhalation
rat 		lowest published toxic concentration: 90 ppm/3 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field JAPTO* 25,260,2005
inhalation
rat 		lowest published toxic concentration: 22 ppm/11 day- intermittent Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Endocrine: Hyperglycemia 		JAPTO* 25,260,2005
inhalation
rat 		lowest published toxic concentration: 22 ppm/11 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in leukocyte (WBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JAPTO* 25,260,2005
inhalation
rat 		lowest published toxic concentration: 22 ppm/11 day- intermittent Nutritional and Gross Metabolic: Dehydration

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		JAPTO* 25,260,2005
inhalation
rat 		lowest published toxic concentration: 47 ppm/11 day- intermittent Cardiac: Changes in coronary arteries

Lung, Thorax, or Respiration: Other changes

Liver: Other changes 		JAPTO* 25,260,2005
inhalation
rat 		lowest published toxic concentration: 47 ppm/11 day- intermittent Blood: Changes in spleen JAPTO* 25,260,2005
inhalation
rat 		lowest published toxic concentration: 5.8 ppm/14 week- intermittent Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JAPTO* 25,260,2005
inhalation
rat 		lowest published toxic concentration: 1.25 ppm/13 week- intermittent Eye: Corneal damage JAPTO* 25,260,2005
intraperitoneal
mouse 		lowest published toxic dose: 0.14 mg/kg/14 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JAPTO* 25,260,2005
intraperitoneal
rat 		lowest published toxic dose: 0.14 mg/kg/14 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JAPTO* 25,260,2005
oral
rat 		lowest published toxic dose: 1,540 mg/kg/7 day- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0536157
skin
rabbit 		lowest published toxic dose: 292 mg/kg/11 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Skin: After systemic exposure: Dermatitis, other

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JTOTDO 5,3,1986
skin
rabbit 		lowest published toxic dose: 391 mg/kg/13 week- intermittent Skin: After systemic exposure: Dermatitis, other JTOTDO 5,3,1986
skin
rabbit 		lowest published toxic dose: 0.225 mg/kg/11 day- intermittent Skin: After topical application: Primary irritation

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JAPTO* 25,260,2005
skin
rabbit 		lowest published toxic dose: 0.225 mg/kg/11 day- intermittent Skin: After topical application: Primary irritation

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight 		JAPTO* 25,260,2005
skin
rabbit 		lowest published toxic dose: 0.45 mg/kg/11 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JAPTO* 25,260,2005
skin
rabbit 		lowest published toxic dose: 0.45 mg/kg/11 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in kidney weight 		JAPTO* 25,260,2005
skin
rabbit 		lowest published toxic dose: 0.26 mg/kg/13 week- intermittent Skin: After topical application: Primary irritation JAPTO* 25,260,2005
skin
rabbit 		lowest published toxic dose: 0.7 mg/kg/14 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JAPTO* 25,260,2005
skin
rabbit 		lowest published toxic dose: 0.35 mg/kg/14 day- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Skin: After topical application: Primary irritation 		JAPTO* 25,260,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 ppm (skin);short term exposure limit 0.15 ppm(skin) DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - BELGIUM time-weighted average 0.05 ppm (0.33 mg/m3), MAR2002
Occupational Exposure Limit - BELGIUM short term exposure limit 0.15 ppm (1 mg/m3), Skin, MAR2002


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BIS(2-(DIMETHYlAMINO)ETHYL)ETHER-air minimize exposure NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T0015;
Number of Industries 1;
Total Number of Facilities 8;
Number of Occupations 2;
Total Number of Employees Exposed 40
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T0015;
Number of Industries 2;
Total Number of Facilities 60;
Number of Occupations 5;
Total Number of Employees Exposed 1,529;
Total Number of Female Employees Exposed 165


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the manufacture of polyurethane foams
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 26, 1978


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JTOTDO Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used in the manufacture of polyurethane foams

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Primary Irritant

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