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Ethylamine, N,N - dimethyl - 2 - ( (o - methyl - alpha - phenylbenzyl) oxy) -

RTECS #: KR6120000

CAS #: 83-98-7

UPDATE: May 2005 MW: 269.42 MF: C18H23NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. REFERENCES:

SYNONYMS:

  1. 2 - Methyldiphenhydramine
  2. Brocadisipal
  3. Orphenadine
  4. Orphenadrin
  1. Orphenadrine
  2. WS 2434
  3. beta - Dimethylaminoethyl - 2 - methylbenzhydryl ether
  4. o - Methyldiphenhydramine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 80 mg/kg Behavioral: Change in motor activity (specific assay) AIPTAK 138,62,1962
intravenous
mouse 		lethal dose (50 percent kill): 33 mg/kg Behavioral: Change in motor activity (specific assay) AIPTAK 138,62,1962
oral
human 		lowest published toxic dose: 14 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Cardiac: Arrythmias (indlucing changes in conduction) 		APTSAI 41(2),137,1977
oral
human 		lowest published toxic dose: 7,143 mg/kg Behavioral: Coma

Cardiac: Pulse rate increased without fall in BP

Vascular: BP elevation not characterized in autonomic section 		ATSUDG 4,425,1980
oral
mouse 		lethal dose (50 percent kill): 125 mg/kg Behavioral: Change in motor activity (specific assay) AIPTAK 138,62,1962
subcutaneous
mouse 		lethal dose (50 percent kill): 150 mg/kg Behavioral: Change in motor activity (specific assay) AIPTAK 138,62,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 180 mg/kg/3 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) BJPCBM 139,787,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 488,151,2001


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84469;
Number of Industries 1;
Total Number of Facilities 14;
Number of Occupations 2;
Total Number of Employees Exposed 1,092
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84469;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 1;
Total Number of Employees Exposed 103;
Total Number of Female Employees Exposed 52


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
APTSAI Acta Pharmacologica et Toxicologica, Supplementun. (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) No.1- 1947-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-

RTECS Compound Description:
   Drug
   Human Data

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