The Registry of Toxic Effects of Chemical Substances
Ethyl alcohol RTECS #: KQ6300000
CAS #: 64-17-5
The Registry of Toxic Effects of Chemical Substances
Ethyl alcohol |
| UPDATE: February 2008 | MW: 46.08 | MF: C2H6O |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
eye | rabbit
500 mg
|
severe
|
AJOPAA 29,1363,1946
|
eye | rabbit
500 mg/24 hour
|
mild
|
85JCAE -,189,1986
|
eye | rabbit
100 mg/4S rinse
|
moderate
|
FCTOD7 20,573,1982
|
skin | rabbit
400 mg open irritation test
|
mild
|
UCDS** 7/22/1970
|
skin | rabbit
20 mg/24 hour
|
moderate
|
85JCAE -,189,1986
|
| |||
MUTATION DATA AND REFERENCES:
SYSTEM TEST
|
ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
|
cytogenetic analysis
|
parenteral | grasshopper
500 mmol/L
|
NATWAY 51,646,1964
|
cytogenetic analysis
|
hamster
ovary
|
100 ppm
|
ENMUDM 8(Suppl 6),72,1986
|
cytogenetic analysis
|
hamster
embryo
|
1 pph
|
MUTAEX 3,207,1988
|
cytogenetic analysis
|
hamster
ovary
|
160 mmol/L
|
BIZNAT 106,169,1987
|
cytogenetic analysis
|
human
lymphocyte
|
1,160 gm/L
|
AEMBAP 85A,25,1977
|
cytogenetic analysis
|
human
fibroblast
|
12,000 ppm
|
ACYTAN 16,41,1972
|
cytogenetic analysis
|
human
leukocyte
|
1 pph/72 hour- continuous
|
TSITAQ 20,421,1978
|
cytogenetic analysis
|
human
lymphocyte
|
2.5 pph/24 hour
|
MUREAV 537,117,2003
|
cytogenetic analysis
|
oral | human
49,014 gm/kg/25 year
|
MUREAV 560,187,2004
|
cytogenetic analysis
|
oral | mouse
40 gm/kg
|
NATUAS 302,258,1983
|
cytogenetic analysis
|
intramuscular | other fish
1 pph
|
MUREAV 542,1,2003
|
cytogenetic analysis
|
oral | rat
2 gm/kg
|
TGANAK 14(5),48,1980
|
dominant lethal test
|
oral | mouse
3,720 mg/kg/3 day
|
AEMBAP 85A,25,1977
|
DNA adduct
|
oral | rat
5 gm/kg
|
MUREAV 479,81,2001
|
DNA adduct
|
oral | rat
3 gm/kg/7 day
|
MUREAV 479,81,2001
|
DNA damage
|
oral | rat
4 gm/kg
|
MUREAV 345,191,1995
|
DNA damage
|
Salmonella typhimurium
|
15 pph/120 minute
|
MUREAV 575,34,2005
|
DNA damage
|
Saccharomyes cerevisiae
|
850 mmol/L
|
MUREAV 326,165,1995
|
DNA inhibition
|
human
lymphocyte
|
220 mmol/L
|
PNASA6 79,1171,1982
|
DNA repair
|
Escherichia coli
|
5 mg/well
|
MUREAV 133,161,1984
|
DNA repair
|
Salmonella typhimurium
|
15 pph/120 minute
|
MUREAV 575,34,2005
|
mutation in microorganisms
|
Aspergillus nidulans
|
20 pph (-enzymatic activation step)
|
MUREAV 48,51,1977
|
mutation in microorganisms
|
Escherichia coli
|
140 gm/L (-enzymatic activation step)
|
MUREAV 130,97,1984
|
mutation in microorganisms
|
Salmonella typhimurium
|
11 pph (+enzymatic activation step)
|
ENVRAL 52,225,1990
|
mutation in microorganisms
|
Saccharomyes cerevisiae
|
24 pph (-enzymatic activation step)
|
GNKAA5 15,927,1979
|
micronucleus test
|
dog
lymphocyte
|
400 µmol/L
|
NTIS** AD-A075-605
|
micronucleus test
|
human
liver
|
15 mmol/L/24 hour
|
TXCYAC 198,315,2004
|
micronucleus test
|
oral | human
817.6 gm/kg/6 year- intermittent
|
MUREAV 615,134,2007
|
micronucleus test
|
intraperitoneal | mouse
1,240 mg/kg/2 day
|
AEMBAP 85A,25,1977
|
micronucleus test
|
intramuscular | other fish
1 pph
|
MUREAV 542,1,2003
|
gene conversion and mitotic recombination
|
Aspergillus nidulans
|
5 pph
|
MUREAV 48,51,1977
|
other mutation test systems
|
intraperitoneal | rat
250 gm/kg/16 day- continuous
|
CYTBAI 56,195,1988
|
other mutation test systems
|
oral | rat
3 gm/kg
|
APTOA6 49,125,1981
|
sister chromatid exchange
|
hamster
ovary
|
3,900 mg/L
|
MUREAV 124,85,1983
|
sister chromatid exchange
|
human
lymphocyte
|
500 ppm/72 hour- continuous
|
CGCGBR 27,66,1980
|
sister chromatid exchange
|
oral | mouse
420 mg/kg/3 week
|
MUREAV 68,291,1979
|
sex chromosome loss and nondisjunction
|
Aspergillus nidulans
|
30 gm/L
|
EVHPAZ 31,81,1979
|
sex chromosome loss and nondisjunction
|
oral | Drosophila melanogaster
10 pph
|
MUREAV 268,95,1992
|
sex chromosome loss and nondisjunction
|
oral | mouse
5 gm/kg
|
CGCGBR 44,7,1987
|
specific locus test
|
oral | rat
56 gm/kg/4 week
|
MUREAV 577S,1,2005
|
sperm morphology
|
oral | mouse
1,500 mg/kg/50 day
|
MUREAV 65,229,1979
|
| |||
REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
intracerebral | rat
lowest published toxic dose: 5 mg/kg (1 day prior to copulation)
|
Reproductive: Effects on fertility: Other measures of fertility
|
JRPFA4 42,199,1975
|
inhalation | rat
lowest published toxic concentration: 20,000 ppm/7 hour (1-22 day pregnant)
|
Reproductive: Other developmental abnormalities
|
TJADAB 29(2),48A,1984
|
intraperitoneal | mouse
lowest published toxic dose: 5,800 mg/kg (10 day pregnant)
|
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | Reproductive: Specific developmental abnormalities: Musculoskeletal system
TJADAB 27,231,1983
|
intraperitoneal | mouse
lowest published toxic dose: 5,800 mg/kg (7 day pregnant)
|
Reproductive: Specific developmental abnormalities: Central nervous system | Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
TJADAB 27,231,1983
|
intraperitoneal | mouse
lowest published toxic dose: 5,622 µg/kg (10 day pregnant)
|
Reproductive: Effects on embryo or fetus: Fetal death | Reproductive: Specific developmental abnormalities: Eye, ear Reproductive: Specific developmental abnormalities: Musculoskeletal system
AJOGAH 124,676,1976
|
intraperitoneal | mouse
lowest published toxic dose: 4 mg/kg (10 day pregnant)
|
Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)
|
ANREAK 193,515,1979
|
intraperitoneal | mouse
lowest published toxic dose: 4,300 mg/kg (10 day pregnant)
|
Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
|
NETOD7 2,227,1980
|
intraperitoneal | mouse
lowest published toxic dose: 2.9 gm/kg (8 day pregnant)
|
Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)
|
TOXID9 72,171,2003
|
intraperitoneal | mouse
lowest published toxic dose: 15 mg/kg (6-8 day pregnant)
|
Reproductive: Specific developmental abnormalities: Eye, ear | Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Other developmental abnormalities
REPTED 17,475,2003
|
intraperitoneal | mouse
lowest published toxic dose: 22.8 gm/kg (6-8 day pregnant)
|
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
REPTED 20,453,2005
|
intraperitoneal | mouse
lowest published toxic dose: 22.8 gm/kg (6-8 day pregnant)
|
Reproductive: Other effects to embryo or fetus | Reproductive: Specific developmental abnormalities: Eye, ear
REPTED 20,453,2005
|
intraperitoneal | mouse
lowest published toxic dose: 22.8 gm/kg (6-8 day pregnant)
|
Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) | Reproductive: Other developmental abnormalities
REPTED 22,263,2006
|
intraperitoneal | rat
lowest published toxic dose: 15 gm/kg (8-13 day pregnant)
|
Reproductive: Effects on newborn: Behavioral | Reproductive: Effects on newborn: Physical
TJADAB 36,31A,1987
|
intraperitoneal | rat
lowest published toxic dose: 2,240 mg/kg (9-12 day pregnant)
|
Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)
|
DABBBA 38,5835,1978
|
intraperitoneal | rat
lowest published toxic dose: 600 mg/kg (8-15 day pregnant)
|
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
|
TJADAB 26(1),12A,1982
|
intraperitoneal | rat
lowest published toxic dose: 600 mg/kg (8-15 day pregnant)
|
Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
IJEBA6 21,108,1983
|
intraperitoneal | rat
lowest published toxic dose: 600 mg/kg (8-15 day pregnant)
|
Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) | Reproductive: Specific developmental abnormalities: Musculoskeletal system
IJEBA6 21,108,1983
|
intraperitoneal | rat
lowest published toxic dose: 3,600 mg/kg (7-8 day pregnant)
|
Reproductive: Effects on newborn: Behavioral
|
NELED5 289,13,2000
|
intraperitoneal | rat
lowest published toxic dose: 11.25 mg/kg (7-9 day pregnant)
|
Reproductive: Specific developmental abnormalities: Central nervous system | Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) Reproductive: Other developmental abnormalities
REPTED 17,475,2003
|
intratesticular | dog
lowest published toxic dose: 100 mg/kg (1 day male)
|
Reproductive: Paternal effects: Testes, epididymis, sperm duct
|
FESTAS 24,884,1973
|
intratesticular | rat
lowest published toxic dose: 400 mg/kg (1 day male)
|
Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)
|
FESTAS 24,884,1973
|
intrauterine | rat
lowest published toxic dose: 2,400 mg/kg (10 day pregnant)
|
Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
|
IJEBA6 14,316,1976
|
intrauterine | woman
lowest published toxic dose: 200 mg/kg (5 day prior to copulation)
|
Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)
|
INJFA3 14,280,1969
|
intravenous | domestic animal
lowest published toxic dose: 94 gm/kg (14-21 week pregnant)
|
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
|
PBBHAU 12,329,1980
|
intravenous | domestic animal
lowest published toxic dose: 40 gm/kg (14-17 week pregnant)
|
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | Reproductive: Effects on newborn: Biochemical and metabolic
NTOTDY 3,105,1981
|
intravenous | domestic animal
lowest published toxic dose: 1 gm/kg (18 week pregnant)
|
Reproductive: Specific developmental abnormalities: Respiratory system
|
AJOGAH 151,859,1985
|
intravenous | domestic animal
lowest published toxic dose: 29,000 mg/kg (106-134 day pregnant)
|
Reproductive: Other effects on female | Reproductive: Effects on newborn: Other neonatal measures or effects Reproductive: Effects on newborn: Behavioral
NETEEC 22,205,2000
|
intravenous | rat
lowest published toxic dose: 4 gm/kg (6-7 day pregnant)
|
Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) | Reproductive: Other effects to embryo or fetus Reproductive: Specific developmental abnormalities: Musculoskeletal system
RECYAR 8,105,1971
|
intravenous | rat
lowest published toxic dose: 3 gm/kg (6-7 day pregnant)
|
Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
|
RECYAR 8,105,1971
|
intravenous | rat
lowest published toxic dose: 4 gm/kg (6-7 day pregnant)
|
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | Reproductive: Specific developmental abnormalities: Musculoskeletal system Reproductive: Other developmental abnormalities
RECYAR 8,105,1971
|
intravenous | rabbit
lowest published toxic dose: 15 mg/kg (15-29 day pregnant)
|
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | Reproductive: Other effects to embryo or fetus
JPDSA3 29,1030,1994
|
intravenous | woman
lowest published toxic dose: 8 gm/kg (32 week pregnant)
|
Reproductive: Effects on newborn: Apgar score (human only) | Reproductive: Effects on newborn: Other neonatal measures or effects
AJDCAI 134,419,1980
|
multiple | rat
lowest published toxic dose: 642 gm/kg (1-21 day pregnant/23 day after birth)
|
Reproductive: Maternal effects: Parturition | Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
DEPBA5 10,435,1977
|
multiple | rat
lowest published toxic dose: 373 gm/kg (23 day after birth)
|
Reproductive: Effects on newborn: Behavioral | Reproductive: Effects on newborn: Physical
DEPBA5 10,435,1977
|
oral | dog
lowest published toxic dose: 21,600 mg/kg (1-60 day pregnant)
|
Reproductive: Effects on newborn: Stillbirth | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
FEPRA7 36,285,1977
|
oral | dog
lowest published toxic dose: 260 gm/kg (1-62 day pregnant)
|
Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)
|
ACRSDM 4,123,1980
|
oral | dog
lowest published toxic dose: 221 gm/kg (1-47 day pregnant)
|
Reproductive: Effects on fertility: Abortion
|
ACRSDM 4,123,1980
|
oral | guinea pig
lowest published toxic dose: 90 gm/kg (1-68 day pregnant)
|
Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | Reproductive: Effects on newborn: Behavioral
ANREAK 127,438,1957
|
oral | guinea pig
lowest published toxic dose: 240 gm/kg (2-61 day pregnant)
|
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | Reproductive: Specific developmental abnormalities: Central nervous system
DBRRDB 106,39,1998
|
oral | guinea pig
lowest published toxic dose: 264 gm/kg (2-67 day pregnant)
|
Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) | Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Physical
ACRSDM 23,1816,1999
|
oral | guinea pig
lowest published toxic dose: 72 gm/kg (45-62 day pregnant)
|
Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
|
FAJOEC 14,A1447,2000
|
oral | guinea pig
lowest published toxic dose: 76,000 mg/kg (43-62 day pregnant)
|
Reproductive: Other effects on female | Reproductive: Effects on newborn: Other neonatal measures or effects Reproductive: Other effects to embryo or fetus
NETEEC 23,355,2001
|
oral | guinea pig
lowest published toxic dose: 264,000 mg/kg (2-67 day pregnant)
|
Reproductive: Other effects on female | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Effects on newborn: Physical
NETEEC 22,183,2000
|
oral | guinea pig
lowest published toxic dose: 264 gm/kg (2-67 day pregnant)
|
Reproductive: Effects on newborn: Biochemical and metabolic | Reproductive: Effects on newborn: Other postnatal measures or effects
NETEEC 25,59,2003
|
oral | guinea pig
lowest published toxic dose: 272 gm/kg (2-67 day pregnant)
|
Reproductive: Effects on newborn: Other postnatal measures or effects | Reproductive: Effects on newborn: Delayed effects
NETEEC 26,59,2004
|
oral | guinea pig
lowest published toxic dose: 57 gm/kg (43-62 day pregnant)
|
Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
|
NETEEC 26,543,2004
|
oral | guinea pig
lowest published toxic dose: 204 gm/kg (0-67 day pregnant)
|
Reproductive: Specific developmental abnormalities: Central nervous system | Reproductive: Effects on newborn: Behavioral
JPETAB 308,650,2004
|
oral | guinea pig
lowest published toxic dose: 264 gm/kg (2-67 day pregnant)
|
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | Reproductive: Effects on newborn: Behavioral
NETEEC 28,333,2006
|
oral | mammal (species unspecified)
lowest published toxic dose: 31,500 mg/kg (15-35 day pregnant)
|
Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
|
TJADAB 30,203,1984
|
oral | monkey
lowest published toxic dose: 78 gm/kg (4-23 week pregnant)
|
Reproductive: Effects on fertility: Abortion
|
TJADAB 35,345,1987
|
oral | monkey
lowest published toxic dose: 400 mg/kg (2-21 week pregnant)
|
Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
|
TJADAB 29,49,1984
|
oral | monkey
lowest published toxic dose: 206 gm/kg (90 day prior to copulation)
|
Reproductive: Maternal effects: Menstrual cycle changes or disorders
|
SCIEAS 221,677,1983
|
oral | monkey
lowest published toxic dose: 32,400 mg/kg (2-19 week pregnant)
|
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | Reproductive: Specific developmental abnormalities: Central nervous system Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)
TJADAB 44,29,1991
|
oral | monkey
lowest published toxic dose: 43,200 mg/kg (1-24 week pregnant)
|
Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)
|
TJADAB 44,29,1991
|
oral | mouse
lowest published toxic dose: 162 gm/kg (11-19 day pregnant)
|
Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord)
|
TJADAB 27,56A,1983
|
oral | mouse
lowest published toxic dose: 21 gm/kg (1-21 day pregnant)
|
Reproductive: Effects on newborn: Biochemical and metabolic | Reproductive: Effects on newborn: Behavioral
JSALDP 38,1696,1977
|
oral | mouse
lowest published toxic dose: 5,800 mg/kg (7 day pregnant)
|
Reproductive: Specific developmental abnormalities: Central nervous system | Reproductive: Specific developmental abnormalities: Eye, ear
TJADAB 27,231,1983
|
oral | mouse
lowest published toxic dose: 75,600 mg/kg (5-11 day pregnant)
|
Reproductive: Specific developmental abnormalities: Urogenital system | Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
RCOCB8 23,127,1979
|
oral | mouse
lowest published toxic dose: 5,500 mg/kg (9 day pregnant)
|
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
|
TJADAB 24(1),53A,1981
|
oral | mouse
lowest published toxic dose: 1,680 gm/kg (70 day male)
|
Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
|
FEPRA7 39,542,1980
|
oral | mouse
lowest published toxic dose: 20 gm/kg (multigenerations)
|
Reproductive: Specific developmental abnormalities: Hepatobiliary system | Reproductive: Specific developmental abnormalities: Urogenital system Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTIS** #PB85118651
|
oral | mouse
lowest published toxic dose: 20 gm/kg (multigenerations)
|
Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
|
NTIS** #PB85118651
|
oral | mouse
lowest published toxic dose: 20 gm/kg (multigenerations)
|
Reproductive: Specific developmental abnormalities: Urogenital system
|
NTIS** #PB85118651
|
oral | mouse
lowest published toxic dose: 700 gm/kg (7 day male/7 day prior to copulation/21 day pregnant)
|
Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)
|
NTIS** #PB85118651
|
oral | mouse
lowest published toxic dose: 60 gm/kg (6-15 day pregnant)
|
Reproductive: Specific developmental abnormalities: Central nervous system
|
MUREAV 577S,1,2005
|
oral | mouse
lowest published toxic dose: 50 gm/kg (6-15 day pregnant)
|
Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on embryo or fetus: Fetal death
REPTED 22,61,2006
|
oral | mouse
lowest published toxic dose: 50 gm/kg (6-15 day pregnant)
|
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | Reproductive: Specific developmental abnormalities: Musculoskeletal system
REPTED 22,61,2006
|
oral | pig
lowest published toxic dose: 2,648 gm/kg (78 week prior to copulation/1-16 week pregnant)
|
Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
NTOTDY 5,229,1983
|
oral | rat
lowest published toxic dose: 78 gm/kg (7-19 day pregnant)
|
Reproductive: Effects on newborn: Biochemical and metabolic
|
PBBHAU 59,577,1998
|
oral | rat
lowest published toxic dose: 4 gm/kg (13 day pregnant)
|
Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material)
|
CYGEDX 15(2),23,1981
|
oral | rat
lowest published toxic dose: 322 gm/kg (35 day male)
|
Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | Reproductive: Paternal effects: Testes, epididymis, sperm duct
INJFA3 23,176,1978
|
oral | rat
lowest published toxic dose: 12 gm/kg (9-12 day pregnant)
|
Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
|
PLPSAX 7,311,1979
|
oral | rat
lowest published toxic dose: 132 gm/kg (1-22 day pregnant)
|
Reproductive: Maternal effects: Parturition | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Behavioral
TJADAB 23,217,1981
|
oral | rat
lowest published toxic dose: 24 gm/kg (14-16 day pregnant)
|
Reproductive: Specific developmental abnormalities: Central nervous system | Reproductive: Other developmental abnormalities
TJADAB 23,41A,1981
|
oral | rat
lowest published toxic dose: 354 gm/kg (10 day after birth)
|
Reproductive: Effects on newborn: Biochemical and metabolic
|
RCPBDC 2,119,1977
|
oral | rat
lowest published toxic dose: 4 gm/kg (6-15 day pregnant)
|
Reproductive: Specific developmental abnormalities: Eye, ear | Reproductive: Specific developmental abnormalities: Urogenital system
JTEHD6 10,267,1982
|
oral | rat
lowest published toxic dose: 35,295 mg/kg (1-15 day pregnant)
|
Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) | Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)
ONGZAC 22(1),71,1991
|
oral | rat
lowest published toxic dose: 44 gm/kg (7-17 day pregnant)
|
Reproductive: Specific developmental abnormalities: Musculoskeletal system | Reproductive: Specific developmental abnormalities: Urogenital system
ESKHA5 (103),10,1985
|
oral | rat
lowest published toxic dose: 191,220 mg/kg (2-20 day pregnant)
|
Reproductive: Specific developmental abnormalities: Central nervous system | Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Other postnatal measures or effects
NETEEC 23,453,2001
|
oral | rat
lowest published toxic dose: 30 gm/kg (1-20 day pregnant)
|
Reproductive: Specific developmental abnormalities: Central nervous system | Reproductive: Effects on newborn: Other neonatal measures or effects
TJADAB 163,15,2001
|
oral | rat
lowest published toxic dose: 22.5 gm/kg (11-20 day pregnant)
|
Reproductive: Specific developmental abnormalities: Central nervous system | Reproductive: Effects on newborn: Other postnatal measures or effects
NETEEC 24,719,2002
|
oral | rat
lowest published toxic dose: 40 gm/kg (1-20 day pregnant)
|
Reproductive: Other developmental abnormalities | Reproductive: Specific developmental abnormalities: Central nervous system
FATOAO 45,68,1982
|
oral | rat
lowest published toxic dose: 42 gm/kg (1-21 day pregnant)
|
Reproductive: Other developmental abnormalities
|
FATOAO 45,66,1982
|
oral | rat
lowest published toxic dose: 240 gm/kg (30 day male)
|
Reproductive: Specific developmental abnormalities: Urogenital system
|
FATOAO 47,82,1984
|
oral | rat
lowest published toxic dose: 65 gm/kg (7-19 day pregnant)
|
Reproductive: Specific developmental abnormalities: Endocrine system
|
ENDOAO 138,389,1997
|
oral | rat
lowest published toxic dose: 75 gm/kg (7-21 day pregnant)
|
Reproductive: Specific developmental abnormalities: Endocrine system
|
ENDOAO 138,389,1997
|
oral | rat
lowest published toxic dose: 112 mg/kg (14 day male)
|
Reproductive: Effects on newborn: Biochemical and metabolic
|
FATOAO 48,86,1985
|
oral | rat
lowest published toxic dose: 147 mg/kg (1-21 day pregnant)
|
Reproductive: Specific developmental abnormalities: Endocrine system | Reproductive: Effects on newborn: Delayed effects
FATOAO 47,84,1984
|
oral | rat
lowest published toxic dose: 60,000 mg/kg (1-30 day after birth)
|
Reproductive: Specific developmental abnormalities: Endocrine system | Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Delayed effects
FATOAO 48,93,1985
|
oral | rat
lowest published toxic dose: 900 mL/kg (19 day prior to copulation-21 day after birth)
|
Reproductive: Specific developmental abnormalities: Central nervous system | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Biochemical and metabolic
NETEEC 24,275,2002
|
oral | rat
lowest published toxic dose: 110 gm/kg (1-23 day pregnant)
|
Reproductive: Effects on newborn: Behavioral | Reproductive: Effects on newborn: Physical
EKFAE9 59,44,1996
|
oral | rat
lowest published toxic dose: 135 gm/kg (1 day pregnant-7 day after birth)
|
Reproductive: Effects on newborn: Behavioral | Reproductive: Effects on newborn: Physical
EKFAE9 59,44,1996
|
oral | rat
lowest published toxic dose: 210 gm/kg (6-20 day pregnant)
|
Reproductive: Effects on fertility: Abortion | Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
TOXID9 72(Suppl 1),341,2003
|
oral | rat
lowest published toxic dose: 90 mg/kg (30 day male)
|
Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | Reproductive: Other effects on male Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)
LIFSAK 71,3059,2002
|
oral | rat
lowest published toxic dose: 30 gm/kg (16-20 day pregnant)
|
Reproductive: Effects on newborn: Other postnatal measures or effects
|
NETEEC 25,447,2003
|
oral | rat
lowest published toxic dose: 120 gm/kg (1-20 day pregnant)
|
Reproductive: Effects on newborn: Other postnatal measures or effects
|
NETEEC 25,447,2003
|
oral | rat
lowest published toxic dose: 45 gm/kg (15-22 day pregnant/7 day after birth)
|
Reproductive: Effects on newborn: Behavioral
|
NEROEW 24,691,2001
|
oral | rat
lowest published toxic dose: 45 gm/kg (15-22 day pregnant/7 day after birth)
|
Reproductive: Effects on newborn: Behavioral | Reproductive: Effects on newborn: Other postnatal measures or effects
NEROEW 26,191,2002
|
oral | rat
lowest published toxic dose: 10,400 mg/kg (7-19 day pregnant)
|
Reproductive: Tumorigenic effects: Transplacental tumorigenesis | Reproductive: Effects on newborn: Delayed effects
BJCAAI 90,2225,2004
|
oral | rat
lowest published toxic dose: 110 gm/kg (10-20 day pregnant)
|
Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) | Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) Reproductive: Effects on newborn: Biochemical and metabolic
NETEEC 27,73,2005
|
oral | rat
lowest published toxic dose: 120 gm/kg (6-15 day pregnant)
|
Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)
TOXID9 44,57,2005
|
oral | rat
lowest published toxic dose: 16.25 gm/kg (7-19 day pregnant)
|
Reproductive: Other effects on female | Reproductive: Other reproductive system tumors Reproductive: Effects on newborn: Biochemical and metabolic
BJCAAI 90,2225,2004
|
oral | rat
lowest published toxic dose: 54 gm/kg (6-14 day pregnant)
|
Reproductive: Other effects on female
|
TOXID9 78,280,2004
|
oral | rat
lowest published toxic dose: 36.5 gm/kg (30 day prior to copulation-21 day after birth)
|
Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | Reproductive: Effects on newborn: Behavioral
NETEEC 27,585,2005
|
oral | rat
lowest published toxic dose: 292 gm/kg (30 day prior to copulation-21 day after birth)
|
Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) | Reproductive: Effects on newborn: Biochemical and metabolic Reproductive: Effects on newborn: Behavioral
NETEEC 27,585,2005
|
oral | rat
lowest published toxic dose: 94,500 mg/kg (1-21 day pregnant)
|
Reproductive: Effects on newborn: Stillbirth | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Behavioral
TOVEFN (5),13,2002
|
oral | rat
lowest published toxic dose: 94,500 mg/kg (1-21 day pregnant)
|
Reproductive: Effects on newborn: Physical | Reproductive: Effects on newborn: Other postnatal measures or effects
TOVEFN (5),13,2002
|
oral | rat
lowest published toxic dose: 99,000 mg/kg (multigeneration)
|
Reproductive: Effects on newborn: Biochemical and metabolic
|
NETEEC 28,238,2006
|
oral | rat
lowest published toxic dose: 1,188 gm/kg (55 day male)
|
Reproductive: Paternal effects: Impotence | Reproductive: Other effects on male Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)
REPTED 22,599,2006
|
oral | rat
lowest published toxic dose: 1,188 gm/kg (55 day male)
|
Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) | Reproductive: Paternal effects: Testes, epididymis, sperm duct Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)
REPTED 22,599,2006
|
oral | rabbit
lowest published toxic dose: 3,945 mg/kg (1 day prior to copulation)
|
Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)
|
JOENAK 34,275,1966
|
oral | rabbit
lowest published toxic dose: 3,750 mg/kg (1 day prior to copulation)
|
Reproductive: Effects on fertility: Other measures of fertility
|
IJMRAQ 58,501,1970
|
oral | woman
lowest published toxic dose: 41 gm/kg (41 week pregnant)
|
Reproductive: Effects on newborn: Apgar score (human only) | Reproductive: Effects on newborn: Other neonatal measures or effects Reproductive: Effects on newborn: Drug dependence
AJDCAI 129,1075,1975
|
oral | woman
lowest published toxic dose: 250 mg/kg (37 week pregnant)
|
Reproductive: Other effects to embryo or fetus
|
AJOGAH 145,251,1983
|
oral | woman
lowest published toxic dose: 5,860 mL/kg (3 year prior to copulation-100 day after birth)
|
Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) | Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Delayed effects
INJPD2 37,129,2005
|
unreported route | rat
lowest published toxic dose: 60 gm/kg (9-14 day pregnant)
|
Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) | Reproductive: Effects on embryo or fetus: Fetal death
FATOAO 45(1),83,1982
|
| |||
TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
oral | mouse
lowest published toxic dose: 320 mg/kg/50 week- intermittent
|
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria | Liver: Tumors Blood: Lymphoma including Hodgkin's disease
CALEDQ 13,345,1981
|
oral | mouse
toxic dose : 400 gm/kg/57 week- intermittent
|
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria | Gastrointestinal: Tumors
ZIETA2 59,203,1928
|
rectal | mouse
lowest published toxic dose: 120 gm/kg/18 week- intermittent
|
Tumorigenic: Equivocal tumorigenic agent by RTECS criteria | Gastrointestinal: Tumors Liver: Tumors
ZIETA2 59,203,1928
|
| |||
ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
intraarterial | man
lowest published toxic dose: 0.71 mL/kg
|
Vascular: Acute arterial occulsion
|
JKMSEH 18,585,2003
|
intraarterial | rat
lethal dose (50 percent kill): 11 mg/kg
|
Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion | Lung, Thorax, or Respiration: Dyspnea
TXAPA9 18,60,1971
|
intracerebral | rat
lowest published toxic dose: 363.6 µg/kg
|
Behavioral: Alteration of operant conditioning
|
PSCHDL 170,51,2003
|
intracerebral | rat
lowest published toxic dose: 106 µg/kg
|
Behavioral: Change in motor activity (specific assay)
|
PSCHDL 170,368,2003
|
inhalation | guinea pig
lowest published lethal concentration: 21,900 ppm
|
N/R
|
FAONAU 48A,99,1970
|
inhalation | guinea pig
lowest published toxic concentration: 12,000 mg/m3/8 hour
|
Behavioral: General anesthetic
|
VCVGK* -,93,1984
|
inhalation | human
lowest published toxic concentration: 2,500 mg/m3/20 minute
|
Peripheral Nerve and Sensation: Recording from afferent nerve
|
VCVGK* -,93,1984
|
inhalation | mouse
lethal concentration (50 percent kill): 39 gm/m3/4 hour
|
N/R
|
GTPZAB 26(8),53,1982
|
inhalation | mouse
lowest published lethal concentration: 117,000 mg/m3/2 hour
|
N/R
|
VCVGK* -,93,1984
|
inhalation | mouse
lowest published toxic concentration: 50,000 mg/m3/2 hour
|
Behavioral: Alteration of classical conditioning
|
VCVGK* -,93,1984
|
inhalation | mouse
lowest published toxic concentration: 2,500 mg/m3/40 minute
|
Brain and Coverings: Other degenerative changes
|
VCVGK* -,93,1984
|
inhalation | rat
lethal concentration (50 percent kill): 20,000 ppm/10 hour
|
N/R
|
NPIRI* 1,44,1974
|
inhalation | rat
lowest published toxic concentration: 12,000 mg/m3/8 hour
|
Behavioral: General anesthetic
|
VCVGK* -,93,1984
|
inhalation | rat
lowest published toxic concentration: 4,930 mg/m3
|
N/R
|
TPKVAL 15,76,1979
|
inhalation | rat
lowest published toxic concentration: 1,110 mg/m3/4 hour
|
N/R
|
TPKVAL 15,76,1979
|
inhalation | rabbit
lowest published toxic concentration: 2,500 mg/m3/40 minute
|
Brain and Coverings: Other degenerative changes
|
VCVGK* -,93,1984
|
intramuscular | non-mammalian species
lowest published toxic dose: 0.1 gm/kg
|
Cardiac: Other changes | Musculoskeletal: Other changes
MUREAV 542,1,2003
|
intraperitoneal | dog
lowest published lethal dose: 3 gm/kg
|
N/R
|
BJIMAG 1,207,1944
|
intraperitoneal | guinea pig
lethal dose (50 percent kill): 3,414 mg/kg
|
N/R
|
EVHPAZ 61,321,1985
|
intraperitoneal | hamster
lethal dose (50 percent kill): 5,068 mg/kg
|
N/R
|
EVHPAZ 61,321,1985
|
intraperitoneal | mammal (species unspecified)
lethal dose (50 percent kill): 4,300 mg/kg
|
Behavioral: Somnolence (general depressed activity) | Behavioral: Convulsions or effect on seizure threshold Behavioral: Change in motor activity (specific assay)
TXAPA9 13,358,1968
|
intraperitoneal | mouse
lethal dose (50 percent kill): 528 mg/kg
|
N/R
|
STRAAA 127,245,1965
|
intraperitoneal | mouse
lowest published toxic dose: 4.2 gm/kg
|
Nutritional and Gross Metabolic: Body temperature decrease
|
JPETAB 293,188,2000
|
intraperitoneal | mouse
lowest published toxic dose: 1.75 gm/kg
|
Behavioral: Ataxia
|
PSCHDL 153,415,2001
|
intraperitoneal | mouse
lowest published toxic dose: 0.5 gm/kg
|
Behavioral: Change in motor activity (specific assay)
|
NNAPBA 367,414,2003
|
intraperitoneal | mouse
lowest published toxic dose: 4.25 gm/kg
|
Behavioral: Sleep
|
PSCHDL 174,283,2004
|
intraperitoneal | mouse
lowest published toxic dose: 2 mg/kg
|
Brain and Coverings: Recordings from specific areas of CNS
|
TOLED5 145,69,2003
|
intraperitoneal | mouse
lowest published lethal dose: 4,000 mg/kg
|
Behavioral: Alteration of classical conditioning | Nutritional and Gross Metabolic: Body temperature decrease
EJPHAZ 499,285,2004
|
intraperitoneal | mouse
lowest published toxic dose: 1.5 mg/kg
|
Behavioral: Antianxiety
|
PSCHDL 177,84,2004
|
intraperitoneal | mouse
lowest published toxic dose: 2 gm/kg
|
Behavioral: Alteration of operant conditioning | Behavioral: Change in psychophysiological tests
PSCHDL 176,166,2004
|
intraperitoneal | mouse
lowest published toxic dose: 2.5 gm/kg
|
Behavioral: Somnolence (general depressed activity) | Behavioral: Alteration of operant conditioning Behavioral: Change in psychophysiological tests
PSCHDL 176,166,2004
|
intraperitoneal | mouse
lowest published toxic dose: 4 gm/kg
|
Behavioral: Somnolence (general depressed activity)
|
PSCHDL 174,358,2004
|
intraperitoneal | mouse
lowest published toxic dose: 2 mg/kg
|
Behavioral: Change in motor activity (specific assay) | Behavioral: Alteration of classical conditioning
PSCHDL 174,291,2004
|
intraperitoneal | mouse
lowest published toxic dose: 1 gm/kg
|
Behavioral: Antianxiety | Behavioral: Change in psychophysiological tests
HOBEAO 49,123,2006
|
intraperitoneal | mouse
lowest published toxic dose: 1,000 mg/kg
|
Liver: Other changes
|
MUREAV 577S,1,2005
|
intraperitoneal | mouse
lowest published toxic dose: 0.25 gm/kg
|
Behavioral: Analgesia
|
JPETAB 309,86,2004
|
intraperitoneal | mouse
lowest published toxic dose: 2 gm/kg
|
Behavioral: Change in psychophysiological tests
|
JPETAB 314,675,2005
|
intraperitoneal | mouse
lowest published toxic dose: 4 gm/kg
|
Behavioral: Withdrawal
|
JPETAB 319,219,2006
|
intraperitoneal | mouse
lowest published toxic dose: 2.0 gm/kg
|
Behavioral: Ataxia | Nutritional and Gross Metabolic: Body temperature decrease
JPETAB 319,219,2006
|
intraperitoneal | mouse
lowest published toxic dose: 3.8 gm/kg
|
Behavioral: Altered sleep time (including change in righting reflex)
|
JPETAB 319,219,2006
|
intraperitoneal | mouse
lowest published toxic dose: 2.25 gm/kg
|
Behavioral: Alteration of operant conditioning
|
JPETAB 319,219,2006
|
intraperitoneal | rat
lethal dose (50 percent kill): 3,600 µg/kg
|
N/R
|
PHMGBN 2,27,1969
|
intraperitoneal | rat
lowest published toxic dose: 2.45 gm/kg
|
Behavioral: Altered sleep time (including change in righting reflex)
|
JPETAB 299,698,2001
|
intraperitoneal | rat
lowest published toxic dose: 3,000 mg/kg
|
Nutritional and Gross Metabolic: Body temperature decrease
|
FATOAO 47,21,1984
|
intraperitoneal | rat
lowest published toxic dose: 3,500 mg/kg
|
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
|
FATOAO 51,92,1988
|
intraperitoneal | rat
lowest published toxic dose: 1,000 mg/kg
|
Brain and Coverings: Other degenerative changes | Liver: Other changes Biochemical: Metabolism (intermediary): Lipids including transport
EKFAE9 59,38,1996
|
intraperitoneal | rat
lowest published toxic dose: 0.5 gm/kg
|
Behavioral: Change in psychophysiological tests
|
EJPHAZ 462,115,2003
|
intraperitoneal | rat
lowest published toxic dose: 3,000 mg/kg
|
Behavioral: Sleep
|
TOSCF2 73,270,2003
|
intraperitoneal | rat
lowest published toxic dose: 2 gm/kg
|
Brain and Coverings: Other degenerative changes | Endocrine: Differential effect of sex or castration on observed toxicity Biochemical: Metabolism (intermediary): Other
EJPHAZ 484,241,2004
|
intraperitoneal | rat
lowest published toxic dose: 1 gm/kg
|
Taste: Change in function
|
PSCHDL 167,130,2003
|
intraperitoneal | rat
lowest published toxic dose: 2.4 mg/kg
|
Brain and Coverings: Other degenerative changes | Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites
PSCHDL 169,60,2003
|
intraperitoneal | rat
lowest published toxic dose: 1.5 gm/kg
|
Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
|
NEROEW 28,939,2003
|
intraperitoneal | rat
lowest published toxic dose: 1.25 mg/kg
|
Behavioral: Change in motor activity (specific assay)
|
NEROEW 28,2124,2003
|
intraperitoneal | rat
lowest published toxic dose: 2,700 mg/kg
|
Behavioral: Ataxia
|
PSCHDL 170,343,2003
|
intraperitoneal | rat
lowest published toxic dose: 500 mg/kg
|
Behavioral: Analgesia
|
PSCHDL 171,204,2004
|
intraperitoneal | rat
lowest published toxic dose: 0.25 gm/kg
|
Behavioral: Alteration of operant conditioning
|
JOPSEQ 17,293,2003
|
intraperitoneal | rat
lowest published toxic dose: 0.5 gm/kg
|
Behavioral: Change in motor activity (specific assay) | Behavioral: Alteration of operant conditioning
JOPSEQ 17,293,2003
|
intraperitoneal | rat
lowest published toxic dose: 1,000 mg/kg
|
Behavioral: Food intake (animal)
|
EJPHAZ 519,96,2005
|
intraperitoneal | rat
lowest published toxic dose: 2,000 mg/kg
|
Brain and Coverings: Other degenerative changes | Biochemical: Metabolism (intermediary): Other
EJPHAZ 520,51,2005
|
intraperitoneal | rat
lowest published toxic dose: 2 gm/kg
|
Brain and Coverings: Other degenerative changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase
JPETAB 319,1366,2006
|
intraperitoneal | rabbit
lethal dose (50 percent kill): 963 mg/kg
|
N/R
|
EVHPAZ 61,321,1985
|
intravenous | cat
lowest published lethal dose: 3,945 mg/kg
|
N/R
|
HBTXAC 1,130,1955
|
intravenous | chicken
lowest published lethal dose: 8,216 mg/kg
|
Vascular: Other changes
|
JPETAB 60,312,1937
|
intravenous | dog
lowest published lethal dose: 1,600 mg/kg
|
Behavioral: Ataxia | Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Hypermotility, diarrhea
TXAPA9 18,60,1971
|
intravenous | human
lowest published toxic dose: 1.6 gm/kg/6 hour
|
Biochemical: Metabolism (intermediary): Other
|
CLPTAT 67,591,2000
|
intravenous | human
lowest published toxic dose: 0.89 mL/kg
|
Vascular: Regional or general arteriolar constriction | Vascular: Measurement of regional blood flow
JKMSEH 19,51,2004
|
intravenous | man
lowest published toxic dose: 0.57 gm/kg
|
Behavioral: Change in psychophysiological tests
|
NEROEW 29,1527,2004
|
intravenous | mouse
lethal dose (50 percent kill): 1,973 mg/kg
|
N/R
|
HBTXAC 1,128,1955
|
intravenous | mouse
lowest published toxic dose: 3 gm/kg
|
Behavioral: Sleep
|
JPETAB 302,257,2002
|
intravenous | mouse
lowest published toxic dose: 3 gm/kg
|
Behavioral: Sleep | Behavioral: Tolerance
JPETAB 302,257,2002
|
intravenous | rat
lethal dose (50 percent kill): 1,440 mg/kg
|
Lung, Thorax, or Respiration: Dyspnea
|
TXAPA9 18,60,1971
|
intravenous | rat
lowest published toxic dose: 0.5 gm/kg
|
Brain and Coverings: Recordings from specific areas of CNS
|
NEROEW 29,530,2004
|
intravenous | rabbit
lethal dose (50 percent kill): 2,374 mg/kg
|
N/R
|
EVHPAZ 61,321,1985
|
multiple | man
lowest published toxic dose: 3,660 mg/kg
|
Endocrine: Evidence of thyroid hypofunction
|
PSCHDL 170,213,2003
|
oral | cat
lowest published lethal dose: 6 gm/kg
|
Gastrointestinal: Gastritis | Liver: Hepatitis (hepatocellular necrosis), diffuse Kidney, Ureter, and Bladder: Interstitial nephritis
JPETAB 56,117,1936
|
oral | child
lowest published lethal dose: 2 gm/kg
|
Lung, Thorax, or Respiration: Other changes | Liver: Fatty liver degeneration Blood: Other changes
ATXKA8 17,183,1958
|
oral | child
lowest published toxic dose: 14,400 mg/kg/30 minute- intermittent
|
Behavioral: Coma | Lung, Thorax, or Respiration: Dyspnea Gastrointestinal: Nausea or vomiting
APSVAM 74,977,1985
|
oral | dog
lowest published lethal dose: 5,500 mg/kg
|
N/R
|
HBTXAC 1,130,1955
|
oral | dog
lowest published toxic dose: 2 gm/kg
|
Behavioral: Change in psychophysiological tests
|
TOXID9 66,263,2002
|
oral | guinea pig
lethal dose (50 percent kill): 5,560 mg/kg
|
N/R
|
JIHTAB 23,259,1941
|
oral | human
lowest published lethal dose: 1,400 mg/kg
|
Behavioral: Sleep | Behavioral: Headache Gastrointestinal: Nausea or vomiting
NPIRI* 1,44,1974
|
oral | human
lowest published toxic dose: 0.5 gm/kg
|
Behavioral: Somnolence (general depressed activity) | Behavioral: Change in psychophysiological tests
NEROEW 28,371,2003
|
oral | human
lowest published toxic dose: 1.4 gm/kg
|
Behavioral: Euphoria | Behavioral: Change in psychophysiological tests Gastrointestinal: Nausea or vomiting
NEROEW 28,740,2003
|
oral | human
lowest published toxic dose: 400 mg/kg
|
Behavioral: Alteration of operant conditioning
|
PSCHDL 172,68,2004
|
oral | human
lowest published toxic dose: 0.5 mg/kg
|
Behavioral: Change in psychophysiological tests
|
JOPSEQ 17,379,2003
|
oral | human
lowest published toxic dose: 0.7 gm/kg/10 minute
|
Behavioral: Change in psychophysiological tests
|
JOPSEQ 19,627,2005
|
oral | infant
lowest published toxic dose: 11,712 µL/kg
|
Behavioral: General anesthetic | Cardiac: Arrythmias (indlucing changes in conduction) Lung, Thorax, or Respiration: Dyspnea
JOUOD4 9,53,1987
|
oral | mammal (species unspecified)
lowest published toxic dose: 4,000 mg/kg
|
Endocrine: Other changes | Immunological Including Allergic: Decrease in humoral immune response
TOXID9 44,184,2005
|
oral | man
lowest published toxic dose: 22,500 mg/kg/4 week- intermittent
|
Endocrine: Other changes | Blood: Other changes
CLECAP 25,143,1986
|
oral | man
lowest published toxic dose: 3,371 µL/kg
|
Behavioral: Altered sleep time (including change in righting reflex) | Behavioral: Excitement Behavioral: Coma
VHTODE 21,272,1979
|
oral | man
lowest published toxic dose: 700 mg/kg
|
Behavioral: Change in psychophysiological tests
|
NTOTDY 8,77,1986
|
oral | man
lowest published toxic dose: 50 mg/kg
|
Gastrointestinal: Alteration in gastric secretion | Gastrointestinal: Other changes
JPETAB 56,117,1936
|
oral | man
lowest published toxic dose: 1,430 µg/kg
|
Behavioral: Change in motor activity (specific assay) | Behavioral: Ataxia Behavioral: Antipsychotic
JPETAB 197,488,1976
|
oral | man
lowest published toxic dose: 0.8 gm/kg
|
Behavioral: Euphoria | Behavioral: Somnolence (general depressed activity) Behavioral: Change in psychophysiological tests
JPETAB 300,236,2002
|
oral | man
lowest published toxic dose: 0.5 gm/kg
|
Cardiac: Pulse rate increased without fall in BP | Vascular: BP elevation not characterized in autonomic section Endocrine: Other changes
NEROEW 25,537,2001
|
oral | man
lowest published toxic dose: 0.8 gm/kg
|
Brain and Coverings: Changes in surface EEG | Behavioral: Change in psychophysiological tests
NEROEW 28,747,2003
|
oral | man
lowest published toxic dose: 1.14 mL/kg
|
Behavioral: Change in psychophysiological tests
|
NEROEW 28,1366,2003
|
oral | man
lowest published toxic dose: 0.6 gm/kg
|
Behavioral: Change in psychophysiological tests | Endocrine: Other changes
NEROEW 29,1156,2004
|
oral | man
lowest published toxic dose: 625 mg/kg
|
Cardiac: Pulse rate decreased with fall in BP | Cardiac: Change in rate Nutritional and Gross Metabolic: Body temperature increase
ECPPH* 2,53,1994
|
oral | monkey
lowest published toxic dose: 4.8 mg/kg
|
Behavioral: Abuse
|
JPETAB 301,993,2002
|
oral | monkey
lowest published toxic dose: 102 mg/kg
|
Behavioral: Alteration of operant conditioning
|
PSCHDL 170,1,2003
|
oral | mouse
lethal dose (50 percent kill): 3,450 mg/kg
|
N/R
|
GISAAA 32(3),31,1967
|
oral | mouse
lowest published toxic dose: 5 gm/kg
|
Brain and Coverings: Other degenerative changes | Vascular: Other changes Liver: Other changes
JPETAB 298,737,2001
|
oral | mouse
lowest published toxic dose: 5 gm/kg
|
Blood: Other changes
|
TOXID9 72,99,2003
|
oral | mouse
lowest published toxic dose: 5 gm/kg
|
Liver: Changes in liver weight
|
TOXID9 72,98,2003
|
oral | mouse
lowest published toxic dose: 1 gm/kg
|
Behavioral: Change in motor activity (specific assay) | Behavioral: Aggression
PSCHDL 157,131,2001
|
oral | mouse
lowest published toxic dose: 6 gm/kg
|
Liver: Other changes | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)
TOXID9 72,202,2003
|
oral | mouse
lowest published toxic dose: 4 gm/kg
|
Endocrine: Other changes | Blood: Changes in spleen Immunological Including Allergic: Decrease in cellular immune response
TOXID9 72,172,2003
|
oral | mouse
lowest published toxic dose: 1,000 mg/kg
|
Behavioral: Aggression
|
PSCHDL 172,255,2004
|
oral | mouse
lowest published toxic dose: 5,000 mg/kg
|
Endocrine: Other changes | Blood: Changes in other cell count (unspecified)
TOXID9 44,184,2005
|
oral | mouse
lowest published toxic dose: 6,000 mg/kg
|
Blood: Changes in spleen
|
TOXID9 44,184,2005
|
oral | mouse
lowest published toxic dose: 5,000 mg/kg
|
Liver: Other changes
|
TOXID9 44,213,2005
|
oral | mouse
lowest published toxic dose: 6,000 mg/kg
|
Immunological Including Allergic: Decrease in cellular immune response
|
TOXID9 60,28,2001
|
oral | mouse
lowest published toxic dose: 1.5 mg/kg
|
Behavioral: Alteration of classical conditioning
|
ACPSI* 24,1137,2003
|
oral | mouse
lowest published toxic dose: 500 mg/kg
|
Liver: Other changes | Biochemical: Metabolism (intermediary): Other
TXAPA9 223,225,2007
|
oral | pigeon
lowest published toxic dose: 1 gm/kg
|
Behavioral: Change in psychophysiological tests
|
JPETAB 293,551,2000
|
oral | rat
lethal dose (50 percent kill): 7,060 mg/kg
|
Lung, Thorax, or Respiration: Other changes
|
TXAPA9 16,718,1970
|
oral | rat
lowest published toxic dose: 6.4 gm/kg
|
Gastrointestinal: Alteration in gastric secretion | Gastrointestinal: Ulceration or bleeding from stomach
LIFSAK 70,17,2001
|
oral | rat
lowest published toxic dose: 1,500 mg/kg
|
Behavioral: Ataxia
|
VCVGK* -,93,1984
|
oral | rat
lowest published toxic dose: 2.5 gm/kg
|
Gastrointestinal: Other changes
|
AEPPAE 365,17,2002
|
oral | rat
lowest published toxic dose: 8,000 mg/kg
|
Brain and Coverings: Other degenerative changes | Cardiac: Cardiomyopathy including infarction Liver: Multiple effects
FATOAO 50,52,1987
|
oral | rat
lowest published toxic dose: 3 gm/kg
|
Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
FATOAO 44,319,1981
|
oral | rat
lowest published toxic dose: 5 gm/kg
|
Behavioral: Change in motor activity (specific assay)
|
FATOAO 44,319,1981
|
oral | rat
lowest published toxic dose: 6,000 mg/kg
|
Biochemical: Metabolism (intermediary): Effect on mitochondrial function
|
FATOAO 55,18,1992
|
oral | rat
lowest published toxic dose: 4,800 mg/kg
|
Gastrointestinal: Ulceration or bleeding from stomach
|
FATOAO 51,82,1988
|
oral | rat
lowest published toxic dose: 10 mL/kg
|
Gastrointestinal: Gastritis
|
JPETAB 303,1301,2002
|
oral | rat
lowest published toxic dose: 5 mL/kg
|
Gastrointestinal: Alteration in gastric secretion | Gastrointestinal: Ulceration or bleeding from stomach
FCLPH* 16,311,2002
|
oral | rat
lowest published toxic dose: 5.25 gm/kg
|
Brain and Coverings: Other degenerative changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases
TOXID9 72,128,2003
|
oral | rat
lowest published toxic dose: 1,600 mg/kg
|
Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | Biochemical: Metabolism (intermediary): Lipids including transport
FCTOD7 41,1551,2003
|
oral | rat
lowest published toxic dose: 0.5 gm/kg
|
Brain and Coverings: Other degenerative changes
|
TOLED5 133,255,2002
|
oral | rat
lowest published toxic dose: 5,250 mg/kg
|
Nutritional and Gross Metabolic: Weight loss or decreased weight gain
|
NETEEC 26,451,2004
|
oral | rat
lethal dose (50 percent kill): 7 gm/kg
|
N/R
|
USXXAM #6696575
|
oral | rat
lowest published toxic dose: 3 gm/kg
|
Liver: Other changes | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
TXAPA9 197,206,2004
|
oral | rat
lowest published toxic dose: 5,000 mg/kg
|
Endocrine: Other changes | Blood: Changes in other cell count (unspecified)
TOXID9 44,184,2005
|
oral | rat
lowest published toxic dose: 5,000 mg/kg
|
Immunological Including Allergic: Decrease in cellular immune response
|
TOXID9 44,184,2005
|
oral | rat
lowest published toxic dose: 1,500 mg/kg
|
Behavioral: Alteration of classical conditioning
|
TOXID9 44,224,2005
|
oral | rat
lowest published toxic dose: 5 gm/kg
|
Behavioral: Anticonvulsant
|
ARTODN 79,610,2005
|
oral | rat
lowest published toxic dose: 0.72 gm/kg
|
Behavioral: Abuse | Endocrine: Differential effect of sex or castration on observed toxicity
BJMRDK 37,1511,2004
|
oral | rat
lowest published toxic dose: 10.5 gm/kg/2 hour
|
Brain and Coverings: Other degenerative changes | Biochemical: Metabolism (intermediary): Other
TOXID9 78,380,2004
|
oral | rat
lowest published toxic dose: 6 gm/kg
|
Behavioral: Alteration of classical conditioning | Nutritional and Gross Metabolic: Weight loss or decreased weight gain
PSCHDL 175,189,2004
|
oral | rat
lowest published toxic dose: 5,000 mg/kg
|
Behavioral: General anesthetic
|
TOVEFN (5),13,2002
|
oral | rat
lowest published toxic dose: 6,000 mg/kg
|
Behavioral: Change in psychophysiological tests
|
TOVEFN (5),13,2002
|
oral | rat
lowest published toxic dose: 5 mL/kg
|
Gastrointestinal: Ulceration or bleeding from stomach
|
BPBLEO 30,451,2007
|
oral | rat
lowest published toxic dose: 4 mL/kg
|
Gastrointestinal: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
BPBLEO 29,1973,2006
|
oral | rat
lowest published toxic dose: 10 mL/kg
|
Gastrointestinal: Ulceration or bleeding from stomach | Gastrointestinal: Other changes
BPBLEO 29,2206,2006
|
oral | rat
lowest published toxic dose: 10 mL/kg
|
Gastrointestinal: Other changes
|
BPBLEO 29,2206,2006
|
oral | rat
lowest published toxic dose: 4,300 mg/kg
|
Vascular: Measurement of regional blood flow
|
TXCYAC 235,141,2007
|
oral | rat
lowest published toxic dose: 6,000 mg/kg
|
Biochemical: Metabolism (intermediary): Other
|
TXCYAC 235,141,2007
|
oral | rabbit
lethal dose (50 percent kill): 6,300 mg/kg
|
N/R
|
HBTXAC 1,130,1955
|
oral | woman
lowest published toxic dose: 1,200 mg/kg/3 hour
|
Endocrine: Change in gonadotropins | Endocrine: Other changes Blood: Other changes
ACRSDM 7,289,1983
|
oral | woman
lowest published toxic dose: 256 gm/kg/12 week
|
Behavioral: Hallucinations, distorted perceptions | Endocrine: Effect on menstrual cycle
JAMAAP 238,2143,1977
|
oral | woman
lowest published toxic dose: 0.7 gm/kg
|
Behavioral: Change in psychophysiological tests
|
JOPSEQ 16,379,2002
|
parenteral | frog
lowest published lethal dose: 36 gm/kg
|
Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change | Behavioral: Somnolence (general depressed activity)
AIPTAK 50,296,1935
|
subcutaneous | chicken
lowest published lethal dose: 5 gm/kg
|
N/R
|
FDWU** -,-,1931
|
subcutaneous | dog
lowest published lethal dose: 6 gm/kg
|
N/R
|
HBTXAC 1,130,1955
|
subcutaneous | frog
lowest published lethal dose: 7,100 mg/kg
|
N/R
|
HBTXAC 1,128,1955
|
subcutaneous | infant
lowest published lethal dose: 19,440 mg/kg
|
Behavioral: Convulsions or effect on seizure threshold | Behavioral: Coma Nutritional and Gross Metabolic: Body temperature decrease
AJCPAI 5,466,1935
|
subcutaneous | mouse
lethal dose (50 percent kill): 8,285 mg/kg
|
N/R
|
FAONAU 48A,99,1970
|
subcutaneous | mouse
lowest published toxic dose: 5 gm/kg
|
Liver: Hepatitis (hepatocellular necrosis), zonal
|
TOXID9 66,119,2002
|
subcutaneous | pigeon
lowest published lethal dose: 5 gm/kg
|
N/R
|
FDWU** -,-,1931
|
subcutaneous | rabbit
lowest published lethal dose: 20 gm/kg
|
N/R
|
YAKUD5 22,651,1980
|
skin | rabbit
lowest published lethal dose: 20 gm/kg
|
N/R
|
31ZTAS -,72,1968
|
unreported route | rat
lowest published toxic dose: 3 gm/kg
|
Brain and Coverings: Other degenerative changes | Biochemical: Metabolism (intermediary): Other proteins
TOLED5 150,325,2004
|
| |||
OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | mouse
lowest published toxic concentration: 8,000 mg/m3/4 hour/17 week- intermittent
|
Brain and Coverings: Other degenerative changes | Endocrine: Other changes Immunological Including Allergic: Decreased immune response
VCVGK* -,93,1994
|
inhalation | rat
lowest published toxic concentration: 8,000 mg/m3/4 hour/17 week- intermittent
|
Brain and Coverings: Other degenerative changes | Endocrine: Other changes Immunological Including Allergic: Decreased immune response
VCVGK* -,93,1994
|
inhalation | rat
lowest published toxic concentration: 6,130 ppm/4 week- intermittent
|
Endocrine: Changes in thymus weight
|
JAPTO* 25,193,2005
|
inhalation | rat
lowest published toxic concentration: 6,130 ppm/4 week- intermittent
|
Brain and Coverings: Other degenerative changes | Cardiac: Changes in heart weight Endocrine: Hyperglycemia
JAPTO* 25,193,2005
|
inhalation | rat
lowest published toxic concentration: 6,130 ppm/4 week- intermittent
|
Biochemical: Metabolism (intermediary): Other
|
JAPTO* 25,193,2005
|
inhalation | rat
lowest published toxic concentration: 4,930 mg/m3/4 day- intermittent
|
Peripheral Nerve and Sensation: Recording from peripheral motor nerve | Lung, Thorax, or Respiration: Other changes
TPKVAL 15,76,1979
|
inhalation | rat
lowest published toxic concentration: 4,930 mg/m3/8 day- intermittent
|
Behavioral: Alteration of classical conditioning
|
TPKVAL 15,76,1979
|
inhalation | rat
lowest published toxic concentration: 4,930 mg/m3/14 day- intermittent
|
Behavioral: Change in motor activity (specific assay)
|
TPKVAL 15,76,1979
|
inhalation | rat
lowest published toxic concentration: 1,110 mg/m3/14 day- intermittent
|
Vascular: Other changes
|
TPKVAL 15,76,1979
|
inhalation | rabbit
lowest published toxic concentration: 8,000 mg/m3/4 hour/17 week- intermittent
|
Brain and Coverings: Other degenerative changes | Endocrine: Other changes Immunological Including Allergic: Decreased immune response
VCVGK* -,93,1994
|
intramuscular | mouse
lowest published toxic dose: 42 gm/kg/14 day- intermittent
|
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases | Liver: Other changes
FATOAO 46,103,1983
|
intramuscular | mouse
lowest published toxic dose: 63 gm/kg/21 day- intermittent
|
Liver: Fatty liver degeneration | Liver: Liver function tests impaired
FATOAO 46,103,1983
|
intramuscular | rat
lowest published toxic dose: 420 gm/kg/6 week- intermittent
|
Liver: Hepatitis (hepatocellular necrosis), diffuse | Liver: Fatty liver degeneration Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
JPETAB 299,832,2001
|
intraperitoneal | mouse
lowest published toxic dose: 12 mg/kg/3 day- intermittent
|
Behavioral: Alteration of classical conditioning
|
BJPCBM 138,9,2003
|
intraperitoneal | mouse
lowest published toxic dose: 4 gm/kg/8 day- intermittent
|
Behavioral: Alteration of classical conditioning | Behavioral: Change in psychophysiological tests
PSCHDL 176,50,2004
|
intraperitoneal | rat
lowest published toxic dose: 4.8 mg/kg/4 day- intermittent
|
Behavioral: Change in motor activity (specific assay)
|
PSCHDL 160,48,2002
|
oral | dog
lowest published toxic dose: 560 mL/kg/10 week- continuous
|
Brain and Coverings: Other degenerative changes | Cardiac: Other changes Liver: Other changes
PSEBAA 128,1021,1968
|
oral | guinea pig
lowest published toxic dose: 204 gm/kg/68 day- continuous
|
Reproductive: Other effects on female
|
JPETAB 308,644,2004
|
oral | hamster
lowest published toxic dose: 512 mg/kg/30 day- continuous
|
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
CBCPAI 129,285,2001
|
oral | hamster
lowest published toxic dose: 559 mg/kg/30 day- continuous
|
Liver: Changes in liver weight | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
CBCPAI 129,285,2001
|
oral | human
lowest published toxic dose: 149 units/kg/4 year- intermittent
|
Skin: After systemic exposure: Dermatitis, other
|
BJDEAZ 155,195,2006
|
oral | mammal (species unspecified)
lowest published toxic dose: 112,000 mg/kg/28 day- intermittent
|
Immunological Including Allergic: Decrease in cellular immune response
|
TOXID9 44,184,2005
|
oral | man
lowest published toxic dose: 4,623 gm/kg/12 year- intermittent
|
Brain and Coverings: Other degenerative changes
|
DADEDV 65,159,2002
|
oral | monkey
lowest published toxic dose: 210 gm/kg/5 week- intermittent
|
Liver: Fatty liver degeneration
|
JTSCDR 8,243,1983
|
oral | monkey
lowest published toxic dose: 260 gm/kg/2 year- intermittent
|
Behavioral: Alteration of classical conditioning | Behavioral: Aggression
PSCHDL 165,1,2002
|
oral | mouse
lowest published toxic dose: 3,500 gm/kg/10 week- continuous
|
Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)
|
JPETAB 225,479,1983
|
oral | mouse
lowest published toxic dose: 2,100 gm/kg/5 week- continuous
|
Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)
|
JPETAB 225,479,1983
|
oral | mouse
lowest published toxic dose: 1,750 gm/kg/5 week- continuous
|
Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
|
JPETAB 225,479,1983
|
oral | mouse
lowest published toxic dose: 448 gm/kg/4 week- continuous
|
Behavioral: Fluid intake
|
NTIS** #PB85118651
|
oral | mouse
lowest published toxic dose: 24,000 mL/kg/120 day- continuous
|
Kidney, Ureter, and Bladder: Other changes in urine composition
|
TOXID9 72,195,2003
|
oral | mouse
lowest published toxic dose: 36,000 mL/kg/180 day- continuous
|
Liver: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 72,195,2003
|
oral | mouse
lowest published toxic dose: 36,000 mL/kg/180 day- continuous
|
Liver: Other changes | Nutritional and Gross Metabolic: Changes in: Fe Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 72,195,2003
|
oral | mouse
lowest published toxic dose: 1,120 gm/kg/4 week- intermittent
|
Blood: Changes in spleen | Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
TOSCF2 73,72,2003
|
oral | mouse
lowest published toxic dose: 98,800 mg/kg/13 day- continuous
|
Behavioral: Withdrawal | Behavioral: Alteration of classical conditioning
EJPHAZ 499,285,2004
|
oral | mouse
lowest published toxic dose: 480,000 mg/kg/60 day- continuous
|
Gastrointestinal: Changes in structure or function of exocrine pancreas
|
TOXID9 44,318,2005
|
oral | mouse
lowest published toxic dose: 396 gm/kg/198 day- continuous
|
Liver: Other changes | Biochemical: Metabolism (intermediary): Porphyrin including bile pigments
TOXID9 78,14,2004
|
oral | mouse
lowest published toxic dose: 396 gm/kg/198 day- continuous
|
Liver: Other changes | Nutritional and Gross Metabolic: Changes in: Fe Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 78,14,2004
|
oral | mouse
lowest published toxic dose: 295.2 gm/kg/10 week- intermittent
|
Cardiac: Cardiomyopathy including infarction | Cardiac: Other changes Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphokinase
TOXID9 78,167,2004
|
oral | mouse
lowest published toxic dose: 15,000 mg/kg/2 day- intermittent
|
Liver: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases Biochemical: Metabolism (intermediary): Other
TOXID9 60,41,2001
|
oral | mouse
lowest published toxic dose: 35 gm/kg/5 week- intermittent
|
Liver: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Metabolism (intermediary): Other proteins
TXCYAC 215,234,2005
|
oral | mouse
lowest published toxic dose: 95,200 mg/kg/4 week- intermittent
|
Behavioral: Food intake (animal) | Behavioral: Fluid intake
NTPTR* TR-510
|
oral | mouse
lowest published toxic dose: 78,400 mg/kg/4 week- intermittent
|
Liver: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
NTPTR* TR-510
|
oral | mouse
lowest published toxic dose: 496,000 mg/kg/80 week- intermittent
|
Nutritional and Gross Metabolic: Weight loss or decreased weight gain
|
NTPTR* TR-510
|
oral | mouse
lowest published toxic dose: 2,920,000 mg/kg/2 year- intermittent
|
Liver: Other changes | Liver: Tumors Liver: Changes in liver weight
NTPTR* TR-510
|
oral | mouse
lowest published toxic dose: 5,256,000 mg/kg/2 year- intermittent
|
Liver: Tumors
|
NTPTR* TR-510
|
oral | mouse
lowest published toxic dose: 470,220 mg/kg/51 day- continuous
|
Musculoskeletal: Osteoporosis
|
TXAPA9 220,302,2007
|
oral | mouse
lowest published toxic dose: 284.4 gm/kg/45 day- intermittent
|
Nutritional and Gross Metabolic: Weight loss or decreased weight gain | Biochemical: Metabolism (intermediary): Lipids including transport
HETOEA 22,149,2003
|
oral | rat
lowest published toxic dose: 1,825 gm/kg/1 year- continuous
|
Liver: Fatty liver degeneration | Liver: Changes in liver weight Nutritional and Gross Metabolic: Weight loss or decreased weight gain
DDSCDJ 25,587,1980
|
oral | rat
lowest published toxic dose: 19 gm/kg/21 day- continuous
|
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)
|
TOLED5 12,265,1982
|
oral | rat
lowest published toxic dose: 280 gm/kg/5 week- intermittent
|
Cardiac: Changes in heart weight | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data: Changes in testicular weight
JTSCDR 8,243,1983
|
oral | rat
lowest published toxic dose: 851 gm/kg/10 week- continuous
|
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
APTOA6 38,260,1976
|
oral | rat
lowest published toxic dose: 7 mL/kg/7 day- intermittent
|
Liver: Other changes | Biochemical: Effect on specific coenzyme: B vitamins including folate
JDGRAX 10(1-2),25,1978
|
oral | rat
lowest published toxic dose: 6,300 mg/kg/9 week- intermittent
|
Liver: Other changes | Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases
GISAAA 64(1),46,1999
|
oral | rat
lowest published toxic dose: 45 gm/kg/30 day- intermittent
|
Behavioral: Change in psychophysiological tests
|
GISAAA -,64,1993
|
oral | rat
lowest published toxic dose: 62.5 gm/kg/5 day- continuous
|
Brain and Coverings: Other degenerative changes | Endocrine: Effect on menstrual cycle Endocrine: Change in gonadotropins
BIREBV 37,1089,1987
|
oral | rat
lowest published toxic dose: 62.5 gm/kg/6 day- continuous
|
Endocrine: Effect on menstrual cycle
|
BIREBV 37,1089,1987
|
oral | rat
lowest published toxic dose: 65 gm/kg/13 day- continuous
|
Endocrine: Other changes
|
ENDOAO 138,389,1997
|
oral | rat
lowest published toxic dose: 900 mL/kg/62 day- continuous
|
Behavioral: Fluid intake | Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NETEEC 24,275,2002
|
oral | rat
lowest published toxic dose: 240,000 mg/kg/30 day- intermittent
|
Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)
|
FATOAO 47,82,1984
|
oral | rat
lowest published toxic dose: 35,000 mg/kg/7 day- intermittent
|
Nutritional and Gross Metabolic: Weight loss or decreased weight gain
|
EKFAE9 59,44,1996
|
oral | rat
lowest published toxic dose: 115,000 mg/kg/23 day- intermittent
|
Behavioral: Alteration of classical conditioning
|
EKFAE9 59,44,1996
|
oral | rat
lowest published toxic dose: 67.5 mg/kg/15 day- continuous
|
Brain and Coverings: Other degenerative changes | Biochemical: Metabolism (intermediary): Xanthine, purine or nucleotides including urate Biochemical: Metabolism (intermediary): Other proteins
JPETAB 296,857,2001
|
oral | rat
lowest published toxic dose: 93.8 mL/kg/2 week- intermittent
|
Liver: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Biochemical: Metabolism (intermediary): Lipids including transport
JJATDK 22,207,2002
|
oral | rat
lowest published toxic dose: 882 gm/kg/75 day- intermittent
|
Musculoskeletal: Other changes
|
JPETAB 301,1132,2002
|
oral | rat
lowest published toxic dose: 72 gm/kg/7 day- continuous
|
Kidney, Ureter, and Bladder: Other changes in urine composition | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases
TOXID9 72,315,2003
|
oral | rat
lowest published toxic dose: 908 mg/kg/4 week- continuous
|
Liver: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
JAPTO* 22,207,2002
|
oral | rat
lowest published toxic dose: 1,372 gm/kg/20 week- continuous
|
Behavioral: Food intake (animal) | Vascular: Regional or general arteriolar constriction Vascular: Other changes
CEXPB9 29,707,2002
|
oral | rat
lowest published toxic dose: 8 mg/kg/4 day- intermittent
|
Brain and Coverings: Other degenerative changes | Biochemical: Metabolism (intermediary): Other proteins
TOXID9 72,127,2003
|
oral | rat
lowest published toxic dose: 9,660 gm/kg/56 week- intermittent
|
Cardiac: Change in resting or action potential | Endocrine: Differential effect of sex or castration on observed toxicity Nutritional and Gross Metabolic: Weight loss or decreased weight gain
TXAPA9 189,196,2003
|
oral | rat
lowest published toxic dose: 240 gm/kg/60 day- intermittent
|
Liver: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
TOXIA6 42,367,2003
|
oral | rat
lowest published toxic dose: 12 gm/kg/20 day- continuous
|
Behavioral: Tolerance | Behavioral: Alteration of operant conditioning
EJPHAZ 477,129,2003
|
oral | rat
lowest published toxic dose: 210 gm/kg/10 week- continuous
|
Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | Biochemical: Metabolism (intermediary): Lipids including transport
FCTOD7 41,1551,2003
|
oral | rat
lowest published toxic dose: 4,500 gm/kg/24 week- intermittent
|
Behavioral: Food intake (animal) | Cardiac: Change in force of contraction Endocrine: Differential effect of sex or castration on observed toxicity
TXAPA9 179,111,2002
|
oral | rat
lowest published toxic dose: 84 gm/kg/4 week- intermittent
|
Behavioral: Food intake (animal) | Endocrine: Other changes Nutritional and Gross Metabolic: Other changes
BJMRDK 36,125,2003
|
oral | rat
lowest published toxic dose: 14 gm/kg/7 day- intermittent
|
Brain and Coverings: Other degenerative changes
|
BJMRDK 36,503,2003
|
oral | rat
lowest published toxic dose: 28 gm/kg/7 day- intermittent
|
Brain and Coverings: Other degenerative changes | Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
BJMRDK 36,503,2003
|
oral | rat
lowest published toxic dose: 875 mg/kg/10 week- intermittent
|
Kidney, Ureter, and Bladder: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Biochemical: Metabolism (intermediary): Effect on Na-K pump
LIFSAK 71,2881,2002
|
oral | rat
lowest published toxic dose: 41.6 gm/kg/4 day- continuous
|
Behavioral: Analgesia
|
LIFSAK 73,3351,2003
|
oral | rat
lowest published toxic dose: 130 gm/kg/10 day- continuous
|
Behavioral: Tolerance | Behavioral: Withdrawal
LIFSAK 73,3351,2003
|
oral | rat
lowest published toxic dose: 36,000 mg/kg/6 day- continuous
|
Behavioral: Change in motor activity (specific assay) | Behavioral: Alteration of classical conditioning Behavioral: Alteration of operant conditioning
NETEEC 26,35,2004
|
oral | rat
lowest published toxic dose: 8 gm/kg/10 day- intermittent
|
Behavioral: Abuse
|
PSCHDL 168,208,2003
|
oral | rat
lowest published toxic dose: 300 gm/kg/12 week- intermittent
|
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases
FCTOD7 42,429,2004
|
oral | rat
lowest published toxic dose: 27,000 mg/kg/6 day- intermittent
|
Brain and Coverings: Other degenerative changes
|
NETEEC 26,353,2004
|
oral | rat
lowest published toxic dose: 31,500 mg/kg/6 day- intermittent
|
Cardiac: Change in rate
|
NETEEC 26,451,2004
|
oral | rat
lowest published toxic dose: 21,000 mg/kg/7 day- intermittent
|
Brain and Coverings: Other degenerative changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
BJPCBM 138,1376,2003
|
oral | rat
lowest published toxic dose: 15 gm/kg/15 day- intermittent
|
Endocrine: Androgenic
|
REPTED 17,641,2003
|
oral | rat
lowest published toxic dose: 30 gm/kg/15 day- intermittent
|
Endocrine: Estrogenic
|
REPTED 17,641,2003
|
oral | rat
lowest published toxic dose: 90 gm/kg/15 day- intermittent
|
Reproductive: Paternal effects: Testes, epididymis, sperm duct
|
REPTED 17,641,2003
|
oral | rat
lowest published toxic dose: 108 gm/kg/4 week- intermittent
|
Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Catalases Liver: Other changes
FCTOD7 42,2045,2004
|
oral | rat
lowest published toxic dose: 10,400 mg/kg/13 day- intermittent
|
Endocrine: Estrogenic
|
BJCAAI 90,2225,2004
|
oral | rat
lowest published toxic dose: 875 gm/kg/35 day- continuous
|
Liver: Liver function tests impaired
|
TXAPA9 197,206,2004
|
oral | rat
lowest published toxic dose: 42 gm/kg/7 day- intermittent
|
Behavioral: Change in psychophysiological tests
|
NETEEC 27,55,2005
|
oral | rat
lowest published toxic dose: 25,000 mg/kg/5 day- intermittent
|
Behavioral: Alteration of operant conditioning
|
PSCHDL 171,204,2004
|
oral | rat
lowest published toxic dose: 420 gm/kg/10 week- intermittent
|
Brain and Coverings: Other degenerative changes | Musculoskeletal: Other changes Biochemical: Metabolism (intermediary): Lipids including transport
TXCYAC 199,161,2004
|
oral | rat
lowest published toxic dose: 48,000 mg/kg/12 week- intermittent
|
Cardiac: Other changes | Vascular: BP elevation not characterized in autonomic section Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects
TOXID9 44,46,2005
|
oral | rat
lowest published toxic dose: 6,650 mL/kg/10 week- continuous
|
Liver: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)
CBCPAI 131,161,2002
|
oral | rat
lowest published toxic dose: 273,000 mg/kg/21 day- continuous
|
Musculoskeletal: Osteoporosis
|
TOXID9 44,354,2005
|
oral | rat
lowest published toxic dose: 1,428,000 mg/kg/14 day- continuous
|
Behavioral: Fluid intake | Liver: Other changes Nutritional and Gross Metabolic: Conditioned vitamin deficiency
DCTODJ 26,191,2003
|
oral | rat
lowest published toxic dose: 168 gm/kg/12 week- intermittent
|
Cardiac: Other changes | Vascular: BP elevation not characterized in autonomic section Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
TOXID9 78,168,2004
|
oral | rat
lowest published toxic dose: 270 gm/kg/90 day- intermittent
|
Brain and Coverings: Other degenerative changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects Biochemical: Metabolism (intermediary): Other proteins
ARTODN 78,276,2004
|
oral | rat
lowest published toxic dose: 54 gm/kg/9 day- intermittent
|
Endocrine: Other changes | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Musculoskeletal: Other changes
TOXID9 78,280,2004
|
oral | rat
lowest published toxic dose: 54 gm/kg/9 day- intermittent
|
Endocrine: Other changes | Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Musculoskeletal: Osteoporosis
TOXID9 78,280,2004
|
oral | rat
lowest published toxic dose: 60 gm/kg/30 day- intermittent
|
Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS | Biochemical: Neurotransmitters or modulators (putative): Dopamine in striatum
BJMRDK 37,1839,2004
|
oral | rat
lowest published toxic dose: 50 gm/kg/10 day- intermittent
|
Liver: Other changes | Biochemical: Metabolism (intermediary): Other
PSCHDL 182,58,2005
|
oral | rat
lowest published toxic dose: 600,000 mg/kg/75 day- intermittent
|
Musculoskeletal: Other changes | Nutritional and Gross Metabolic: Changes in: Ca
TOXID9 60,388,2001
|
oral | rat
lowest published toxic dose: 354,000 mg/kg/30 day- intermittent
|
Musculoskeletal: Other changes | Nutritional and Gross Metabolic: Changes in: Ca
TOXID9 60,388,2001
|
oral | rat
lowest published toxic dose: 462,000 mg/kg/6 week- intermittent
|
Musculoskeletal: Other changes
|
TOXID9 60,388,2001
|
oral | rat
lowest published toxic dose: 31.5 gm/kg/6 day- intermittent
|
Behavioral: Change in psychophysiological tests | Nutritional and Gross Metabolic: Weight loss or decreased weight gain
NETEEC 27,815,2005
|
oral | rat
lowest published toxic dose: 126 gm/kg/12 week- continuous
|
Vascular: BP lowering not characterized in autonomic section
|
JPETAB 306,271,2003
|
oral | rat
lowest published toxic dose: 400 gm/kg/8 week- intermittent
|
Brain and Coverings: Recordings from specific areas of CNS | Behavioral: Withdrawal
JPETAB 307,566,2003
|
oral | rat
lowest published toxic dose: 52,800 mg/kg/6 day- intermittent
|
Behavioral: Convulsions or effect on seizure threshold | Behavioral: Withdrawal Gastrointestinal: Other changes
TOVEFN (5),13,2002
|
oral | rat
lowest published toxic dose: 52,800 mg/kg/6 day- intermittent
|
Liver: Other changes | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TOVEFN (5),13,2002
|
oral | rat
lowest published toxic dose: 52,800 mg/kg/6 day- intermittent
|
Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
|
TOVEFN (5),13,2002
|
oral | rat
lowest published toxic dose: 30 gm/kg/3 day- continuous
|
Biochemical: Effect on specific coenzyme: Proportion of isoenzymes | Liver: Other changes
ACPSI* 24,831,2003
|
oral | rat
lowest published toxic dose: 195 gm/kg/30 day- continuous
|
Brain and Coverings: Other degenerative changes
|
ACPSI* 24,930,2003
|
oral | rat
lowest published toxic dose: 420,000 mg/kg/12 week- intermittent
|
Liver: Other changes | Kidney, Ureter, and Bladder: Other changes in urine composition Kidney, Ureter, and Bladder: Other changes
TXCYAC 219,11,2006
|
oral | rat
lowest published toxic dose: 210 gm/kg/6 week- intermittent
|
Nutritional and Gross Metabolic: Weight loss or decreased weight gain | Liver: Changes in liver weight Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
BPBLEO 27,1636,2004
|
parenteral | rat
lowest published toxic dose: 50,000 mg/kg/50 day- intermittent
|
Liver: Hepatitis (hepatocellular necrosis), zonal | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases
TOXID9 44,15,2005
|
subcutaneous | mouse
: 5,000 mg/kg/20 day- intermittent
|
Liver: Other changes | Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes
FCTOD7 44,588,2006
|
| |||
REVIEWS:
ORGANIZATION
|
STANDARD
|
|
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
|
time-weighted average 1000 ppm
|
DTLVS* TLV/BEI,2007
|
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
|
Not classifiable as human carcinogen
|
DTLVS* TLV/BEI,2007
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Animal Inadequate Evidence
|
IMEMDT 44,35,1988
|
TOXICOLOGY REVIEW
|
|
IRXPAT 11,177,1972
|
TOXICOLOGY REVIEW
|
|
AEMBAP 56,291,1975
|
TOXICOLOGY REVIEW
|
|
AICMA2 44,874,1974
|
TOXICOLOGY REVIEW
|
|
MAEPBU 6,81,1972
|
TOXICOLOGY REVIEW
|
|
FCTXAV 8,433,1970
|
TOXICOLOGY REVIEW
|
|
CLCHAU 19,361,1973
|
TOXICOLOGY REVIEW
|
|
PAREAQ 4,1,1952
|
TOXICOLOGY REVIEW
|
|
FNSCA6 2,67,1973
|
TOXICOLOGY REVIEW
|
|
SCIEAS 209,353,1980
|
TOXICOLOGY REVIEW
|
|
JAMAAP 235,1458,1976
|
TOXICOLOGY REVIEW
|
|
NEJMAG 342,186,2000
|
TOXICOLOGY REVIEW
|
|
JFSCAS 45,7,2000
|
TOXICOLOGY REVIEW
|
|
JKMSEH 17,236,2002
|
TOXICOLOGY REVIEW
|
|
TPHSDY 23,519,2002
|
TOXICOLOGY REVIEW
|
|
CRTXB2 33,407,2003
|
TOXICOLOGY REVIEW
|
|
TOLED5 140-141,155,2003
|
TOXICOLOGY REVIEW
|
|
TOLED5 140-141,161,2003
|
TOXICOLOGY REVIEW
|
|
PSCHDL 172,352,2004
|
TOXICOLOGY REVIEW
|
|
PBBHAU 55,501,1996
|
TOXICOLOGY REVIEW
|
|
TJADAB 21,157,1980
|
TOXICOLOGY REVIEW
|
|
TPHSDY 24,55,2003
|
TOXICOLOGY REVIEW
|
|
REPTED 22,196,2006
|
TOXICOLOGY REVIEW
|
|
TJADAB 16,53,1977
|
TOXICOLOGY REVIEW
|
|
TOLED5 127,197,2002
|
TOXICOLOGY REVIEW
|
|
TOLED5 134,3,2002
|
TOXICOLOGY REVIEW
|
|
PSCHDL 174,539,2004
|
TOXICOLOGY REVIEW
|
|
ARPTDI 44,27,2004
|
TOXICOLOGY REVIEW
|
|
ARPTDI 44,87,2004
|
TOXICOLOGY REVIEW
|
|
REPTED 19,421,2005
|
TOXICOLOGY REVIEW
|
|
TPHSDY 24,41,2003
|
TOXICOLOGY REVIEW
|
|
TPHSDY 24,266,2003
|
TOXICOLOGY REVIEW
|
|
TPHSDY 24,151,2003
|
TOXICOLOGY REVIEW
|
|
TPHSDY 24,456,2003
|
TOXICOLOGY REVIEW
|
|
EMMUEG 45,271,2005
|
TOXICOLOGY REVIEW
|
|
JAPTO* 23,289,2003
|
TOXICOLOGY REVIEW
|
|
MUREAV 613,17,2006
|
TOXICOLOGY REVIEW
|
|
NETOX* 26,521,2005
|
TOXICOLOGY REVIEW
|
|
EJCCER 41,956,2005
|
TOXICOLOGY REVIEW
|
|
JPETAB 312,875,2005
|
TOXICOLOGY REVIEW
|
|
MUTAEX 19,251,2004
|
TOXICOLOGY REVIEW
|
|
EJPHAZ 526,113,2005
|
TOXICOLOGY REVIEW
|
|
EJPHAZ 526,163,2005
|
TOXICOLOGY REVIEW
|
|
JOPSEQ 20,143,2006
|
TOXICOLOGY REVIEW
|
|
AINCM* 7,63,2006
|
TOXICOLOGY REVIEW
|
|
BIPHEX 58,84,2004
|
TOXICOLOGY REVIEW
|
|
CHHSA* 9,6,2002
|
TOXICOLOGY REVIEW
|
|
ENTOX* -,62,2005
|
TOXICOLOGY REVIEW
|
|
DIMON* 39,678,1993
|
TOXICOLOGY REVIEW
|
|
MUREAV 628,67,2007
|
TOXICOLOGY REVIEW
|
|
JPETAB 318,1,2006
|
TOXICOLOGY REVIEW
|
|
ENTOX* -,742,2005
|
TOXICOLOGY REVIEW
|
|
ENTOX* -,263,2005
|
TOXICOLOGY REVIEW
|
|
ENTOX* -,387,2005
|
TOXICOLOGY REVIEW
|
|
MUREAV 584,1,2005
|
| ||
STANDARDS AND REGULATIONS:
ORGANIZATION
|
STANDARD
|
|
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988
|
PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
|
FEREAC 54,7740,1989
|
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF
|
PESTICIDES: RED Completed
|
RBREV* -,290,1998
|
Mine Safety and Health Administration (MSHA) STANDARD - air
|
time-weighted average 1000 ppm (1900 mg/m3)
|
DTLVS* 3,103,1971
|
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)
|
8 hour time-weighted average 1000 ppm (1900 mg/m3)
|
CFRGBR 29,1910.1000,1994
|
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)
|
8 hour time-weighted average 1000 ppm (1900 mg/m3)
|
CFRGBR 29,1926.55,1994
|
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)
|
8 hour time-weighted average 1000 ppm (1900 mg/m3)
|
CFRGBR 29,1915.1000,1993
|
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)
|
8 hour time-weighted average 1000 ppm (1900 mg/m3)
|
CFRGBR 41,50-204.50,1994
|
Occupational Exposure Limit - AUSTRALIA
|
time-weighted average 1000 ppm (1900 mg/m3), JAN1993
|
Occupational Exposure Limit - BELGIUM
|
time-weighted average 1000 ppm (1880 mg/m3), JAN1993
|
Occupational Exposure Limit - DENMARK
|
time-weighted average 1000 ppm (1900 mg/m3), OCT 2002
|
Occupational Exposure Limit - FINLAND
|
time-weighted average 1000 ppm (1900 mg/m3), short term exposure limit 1250 ppm (2400 mg/m3), JAN1999
|
Occupational Exposure Limit - FRANCE
|
VME 1000 ppm (1900 mg/m3), VLE 5000 ppm, JAN1999
|
Occupational Exposure Limit - GERMANY
|
MAK 960 mg/m3 (500 mL/m3), 2005
|
Occupational Exposure Limit - HUNGARY
|
time-weighted average 1000 mg/m3, short term exposure limit 3000 mg/m3, JAN1993
|
Occupational Exposure Limit - KOREA
|
time-weighted average 1000 ppm (1900 mg/m3), 2006
|
Occupational Exposure Limit - MEXICO
|
time-weighted average 1000 ppm (1900 mg/m3), 2004
|
Occupational Exposure Limit - THE NETHERLANDS
|
MAC-TGG 1000 mg/m3, 2003
|
Occupational Exposure Limit - NEW ZEALAND
|
time-weighted average 1000 ppm (1880 mg/m3), JAN2002
|
Occupational Exposure Limit - NORWAY
|
time-weighted average 500 ppm (950 mg/m3), JAN1999
|
Occupational Exposure Limit - THE PHILIPPINES
|
time-weighted average 1000 ppm (1900 mg/m3), JAN1993
|
Occupational Exposure Limit - POLAND
|
MAC(time-weighted average) 1000 mg/m3, MAC(short term exposure limit) 3000 mg/m3, JAN1999
|
Occupational Exposure Limit - RUSSIA
|
time-weighted average 1000 mg/m3, short term exposure limit 2000 mg/m3, JUN2003
|
Occupational Exposure Limit - SWEDEN
|
NGV 500 ppm (1000 mg/m3), KTV 1000ppm (1900 mg/m3), JAN1999
|
Occupational Exposure Limit - SWITZERLAND
|
MAK- week 500 ppm (960 mg/m3),KZG- week 1000 ppm (1920 mg/m3), DEC2006
|
Occupational Exposure Limit - THAILAND
|
time-weighted average 1000 ppm (1900 mg/m3), JAN1993
|
Occupational Exposure Limit - TURKEY
|
time-weighted average 1000 ppm (1900 mg/m3), JAN1993
|
Occupational Exposure Limit - UNITED KINGDOM
|
time-weighted average 1000 ppm (1920 mg/m3), 2005
|
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN
|
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; | Not classifiable as human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM
|
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value |
Not classifiable as human carcinogen | ||||||||||||||||||||||||
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
|
STANDARD or SURVEY
|
|
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO ETHYL ALCOHOL-air
|
10 hour time-weighted average 1000 ppm
|
NIOSH* DHHS #92-100,1992
|
National Occupational Hazard Survey 1974
|
National Occupational Hazard Survey 1974: Hazard Code: 31500; | Number of Industries 430; Total Number of Facilities 157,709; Number of Occupations 242; Total Number of Employees Exposed 2,088,926
National Occupational Exposure Survey 1983
|
National Occupational Exposure Survey 1983: Hazard Code: 31500 |
 ;Number of Industries 334; Total Number of Facilities 86,077; Number of Occupations 222; Total Number of Employees Exposed 2,069,125; Total Number of Female Employees Exposed 1,014,002 | ||||
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
|
|
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Rodent dominant lethal
|
EPA GENETOX PROGRAM 1988, Negative: Aspergillus-forward mutation; SHE-clonal assay
|
EPA GENETOX PROGRAM 1988, Negative: Cell transform.-RLV F344 rat embryo
|
EPA GENETOX PROGRAM 1988, Negative: In vitro cytogenetics-nonhuman; Mammalian micronucleus
|
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy; Histidine reversion-Ames test
|
EPA GENETOX PROGRAM 1988, Negative: In vitro SCE-human lymphocytes; In vitro SCE-human
|
EPA GENETOX PROGRAM 1988, Negative: In vitro SCE-nonhuman; Sperm morphology-mouse
|
EPA GENETOX PROGRAM 1988, Negative/limited: Carcinogenicity-mouse/rat
|
EPA TSCA Section 8(b) CHEMICAL INVENTORY
|
Used as a topical anti-infective agent, solvent to make beverages
|
EPA TSCA Section 8(d) unpublished health/safety studies
|
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
|
NIOSH Analytical Method, 1994: Ethanol in blood, 8002
|
NIOSH Analytical Method, 1994: Alcohols I, 1400
|
NTP Carcinogenesis studies; on test (two year studies), October 2000
|
OSHA ANALYTICAL METHOD #100
|
| |||||||||||||||||
REFERENCES:
CODEN
|
|
REFERENCE
31ZTAS
|
"Alcohols: Their Chemistry, Properties and Manufacture," Monick, J.A., New York, Reinhold
Book, 1968
|
85JCAE
|
"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia,
Avicenum, 1986
|
ACPSI*
|
Acta pharmacologica Sinica (Shanghai : Shanghai Institute of Materia Medica : Chinese Academy
of Science ; Carlton, VIC, Australia : Blackwell Publishing Asia, 2005) V.21- 2000-
|
ACRSDM
|
Alcoholism: Clinical and Experimental Research. (Williams & Wilkins Co., 428 E. Preston St.,
Baltimore, MD 21202) V.1- 1977-
|
ACYTAN
|
Acta Cytologica. (Science Printers and Pub., Inc., 2 Jacklynn Ct., St. Louis, MO 63132) V.1-
1957-
|
AEMBAP
|
Advances in Experimental Medicine and Biology. (Plenum Pub. Corp., 233 Spring St., New York,
NY 10013) V.1- 1967-
|
AEPPAE
|
Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.)
V.110-253, 1925-66. For publisher information, see NSAPCC.
|
AICMA2
|
Archivos del Instituto de Cardiologia de Mexico. (Instituto de Cardiologia de Mexico, Juan
Badiano No.1, 14080 Mexico City, Mexico) V.14- 1944-
|
AINCM*
|
Anaesthesia and Intensive Care Medicine (Abingdon: Medicine Pub. Co.) V.1- 2000-
|
AIPTAK
|
Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of
Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
|
AJCPAI
|
American Journal of Clinical Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350
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Biological and Pharmaceutical Bul | | |