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Ether, 3 - iodo - 2 - propynyl 2,4,5 - trichlorophenyl

RTECS #: KO1225000

CAS #: 777-11-7

UPDATE: December 1996 MW: 361.38 MF: C9H4Cl3IO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. 2,4,5 - Trichlorophenyl iodopropargyl ether
  2. 2,4,5 - Trichlorophenyl - gamma - iodopropargyl ether
  3. 3 - Iodo - 2 - propynyl 2,4,5 - trichlorophenyl ether
  4. Haloprogin
  5. Halotex
  1. M 1028
  2. Mycanden
  3. Mycilan
  4. Polik


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		1 mg/24 hour mild TXAPA9 22,375,1972
skin
pig 		5 mg/24 hour mild TXAPA9 22,375,1972
skin
rabbit 		10 mg/72 hour mild TXAPA9 22,375,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
dog 		lethal dose (50 percent kill): 250 mg/kg Gastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes 		TXAPA9 22,375,1972
intraperitoneal
mouse 		lethal dose (50 percent kill): 89 mg/kg N/R DCTODJ 13,195,1990
intraperitoneal
rat 		lethal dose (50 percent kill): 152 mg/kg Gastrointestinal: Other changes TXAPA9 22,375,1972
intraperitoneal
rabbit 		lethal dose (50 percent kill): 137 mg/kg Gastrointestinal: Other changes TXAPA9 22,375,1972
oral
dog 		lethal dose (50 percent kill): >3 gm/kg Gastrointestinal: Nausea or vomiting TXAPA9 22,375,1972
oral
mouse 		lethal dose : >3 gm/kg N/R AACHAX -,569,1963
oral
rat 		lethal dose (50 percent kill): >5,600 mg/kg N/R TXAPA9 22,375,1972
oral
rabbit 		lethal dose (50 percent kill): 1,625 mg/kg N/R TXAPA9 22,375,1972
subcutaneous
mouse 		lethal dose : >3 gm/kg N/R AACHAX -,569,1963


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6077;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 2;
Total Number of Employees Exposed 628;
Total Number of Female Employees Exposed 314


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy


REFERENCES:

CODEN
REFERENCE
AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI) 1961-70. For publisher information, see AMACCQ.
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as an antibacterial agent

FDA-over the counter and proprietary drug

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Primary Irritant

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