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Ethanone, 1 - (5,6,7,8 - tetrahydro - 3,5,5,6,8,8 - hexamethyl - 2 - naphthalenyl) -

RTECS #: KM5805024

CAS #: 21145-77-7

UPDATE: May 2005 MW: 258.44 MF: C18H26O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REFERENCES:

SYNONYMS:

  1. 2' - Acetonaphthone, 5',6',7',8' - tetrahydro - 3',5',5',6',8',8' - hexamethyl -
  2. 6 - Acetyl - 1,1,2,4,4,7 - hexamethyltetraline
  3. AHMT (perfume)
  4. AHTN
  1. Musk tonalid
  2. Tonalid
  3. Tonalide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 18 mg/L MUREAV 446,67,1999
other mutation test systems hamster ovary 20 mg/L MUREAV 446,67,1999


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 550 mg/kg (7-17 day pregnant) Reproductive: Other effects on female TOLED5 111,69,1999


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lethal dose (50 percent kill): 570 mg/kg N/R DLRUAJ 94,268,1998
skin
rat 		lethal dose (50 percent kill): 7,940 mg/kg N/R DLRUAJ 94,268,1998
skin
rabbit 		lethal dose (50 percent kill): >5 gm/kg N/R DLRUAJ 94,268,1998


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 4,550 mg/kg/13 week- continuous Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		DLRUAJ 94,268,1998
oral
rat 		lowest published toxic dose: 448 mg/kg/14 day- continuous Liver: Changes in liver weight FCTOD7 42,791,2004
oral
rat 		lowest published toxic dose: 1,246 mg/kg/14 day- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FCTOD7 42,791,2004
oral
rat 		lowest published toxic dose: 135 mg/kg/90 day- continuous Endocrine: Hypoglycemia FCTOD7 42,791,2004
oral
rat 		lowest published toxic dose: 744.8 mg/kg/7 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) FCTOD7 42,791,2004
oral
rat 		lowest published toxic dose: 2,494.1 mg/kg/7 week- continuous Blood: Normocytic anemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		FCTOD7 42,791,2004
oral
rat 		lowest published toxic dose: 459 mg/kg/90 day- continuous Reproductive: Maternal effects: Uterus, cervix, vagina FCTOD7 42,791,2004
oral
rat 		lowest published toxic dose: 739.9 mg/kg/7 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		FCTOD7 42,791,2004
oral
rat 		lowest published toxic dose: 1,359 mg/kg/90 day- continuous Blood: Normocytic anemia FCTOD7 42,791,2004
oral
rat 		lowest published toxic dose: 4,563 mg/kg/90 day- continuous Liver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FCTOD7 42,791,2004
skin
rat 		lowest published toxic dose: 9,100 mg/kg/13 week- intermittent Liver: Other changes

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		DLRUAJ 94,268,1998
skin
rat 		lowest published toxic dose: 6,552 mg/kg/26 week- intermittent Liver: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		DLRUAJ 94,268,1998


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
DLRUAJ Deutsche Lebensmittel - Rundschau. (Wissenschaftliche Verlagsgesellschaft Postfach 101061, D-70009 Stutgart, Germany) V. 34 - 42 n.10, 1936-1944, (1944 - 1947 suspended) V 43 n.1- July 1947-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-

Used in fragrance formation

RTECS Compound Description:
   Mutagen
   Reproductive Effector

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