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Ethanol, 2,2' - (methylimino) di -

RTECS #: KL7525000

CAS #: 105-59-9

UPDATE: February 2006 MW: 119.19 MF: C5H13NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 2,2' - (Methylimino) diethanol
  2. 2 - (N - 2 - Hydroxyethyl - N - methylamino) ethanol
  3. Bis (2 - hydroxyethyl) methylamine
  4. Diethanolmethylamine
  5. Ethanol, 2,2' - (methylimino) bis -
  6. MDEA
  7. Methylbis (2 - hydroxyethyl) amine
  8. Methyldiethanolamine
  1. Methyliminodiethanol
  2. N,N - Di (2 - hydroxyethyl) - N - methylamine
  3. N - Methylaminodiglycol
  4. N - Methyldiethanolamine
  5. N - Methyldiethanolimine
  6. N - Methyliminodiethanol
  7. N - Methyl - 2,2' - iminodiethanol
  8. USAF DO - 52


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		5 µL mild VHTODE 38,422,1996
skin
rabbit 		502 mg open irritation test mild UCDS** 7/13/1971
skin
rabbit 		500 µL mild VHTODE 38,422,1996


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rat 		lowest published toxic dose: 10 gm/kg (6-15 day pregnant) Reproductive: Other effects on female JTOTDO 17,179,1990


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration : >6,500 µg/m3/6 hour N/R JTOTDO 17,179,1990
intraperitoneal
mouse 		lethal dose (50 percent kill): 500 mg/kg N/R USXXAM #6582498
oral
rat 		lethal dose (50 percent kill): 1,945 mg/kg Eye: Chromodacryorrhea

Behavioral: Ataxia

Gastrointestinal: Hypermotility, diarrhea 		VHTODE 38,422,1996
oral
rat 		lethal dose (50 percent kill): 4,780 mg/kg N/R USXXAM #6582498
skin
rabbit 		lethal dose (50 percent kill): 5,990 µL/kg N/R AMIHBC 10,61,1954


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rat 		lowest published toxic dose: 9,360 mg/kg/11 day- intermittent Behavioral: Food intake (animal)

Skin: After systemic exposure: Dermatitis, other

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JTOTDO 16,157,1997
skin
rat 		lowest published toxic dose: 16,250 mg/kg/13 week- intermittent Skin: After systemic exposure: Dermatitis, other JTOTDO 16,157,1997
skin
rat 		lowest published toxic dose: 9,360 mg/kg/9 day- intermittent Kidney, Ureter, and Bladder: Changes in bladder weight

Endocrine: Changes in adrenal weight

Blood: Methemoglobinemia- Carboxhemoglobinemia 		JTOTDO 17,179,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 82845;
Number of Industries 5;
Total Number of Facilities 59;
Number of Occupations 15;
Total Number of Employees Exposed 1,677
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 82845;
Number of Industries 5;
Total Number of Facilities 203;
Number of Occupations 6;
Total Number of Employees Exposed 6,811;
Total Number of Female Employees Exposed 1,031


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
JTOTDO Journal of Toxicology, Cutaneous and Ocular Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1982-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-

NIOSH PROFILE (ALKANOLAMINES), SRC, 5/81

RTECS Compound Description:
   Reproductive Effector
   Primary Irritant

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