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Ethanol, 2 - ( (2 - aminoethyl) amino) -

RTECS #: KJ6300000

CAS #: 111-41-1

UPDATE: February 2006 MW: 104.18 MF: C4H12N2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Aminoethyl ethanolamine
  2. Ethanolethylene diamine
  3. Monoethanolethylenediamine
  4. N - (2 - Hydroxyethyl) ethylenediamine
  1. N - (beta - Hydroxyethyl) ethylenediamine
  2. N - Aminoethylethanolamine
  3. N - Hydroxyethyl - 1,2 - ethanediamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		50 mg severe UCDS** 7/19/1965
skin
rabbit 		10 mg/24 hour open irritation test severe JIHTAB 26,269,1944
skin
rabbit 		445 mg open irritation test mild UCDS** 11/29/1963


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 2,800 µg/plate (-enzymatic activation step) ENMUDM 9(Suppl 9),1,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rat 		lethal dose (50 percent kill): 2 gm/kg N/R EVSSAV 2,289,1968
intraperitoneal
rat 		lethal dose (50 percent kill): 120 mg/kg N/R EVSSAV 2,289,1968
intravenous
rat 		lethal dose (50 percent kill): 417 mg/kg N/R EVSSAV 2,289,1968
oral
guinea pig 		lethal dose (50 percent kill): 1,500 mg/kg N/R EVSSAV 2,289,1968
oral
mouse 		lethal dose (50 percent kill): 3,550 mg/kg N/R EVSSAV 2,289,1968
oral
rat 		lethal dose (50 percent kill): 3 gm/kg N/R UCDS** 7/19/1965
oral
rabbit 		lethal dose (50 percent kill): 2 gm/kg N/R EVSSAV 2,289,1968
subcutaneous
rat 		lethal dose (50 percent kill): 2,250 mg/kg N/R EVSSAV 2,289,1968
skin
guinea pig 		lethal dose (50 percent kill): 1,800 µL/kg N/R JIHTAB 26,269,1944
skin
rat 		lethal dose (50 percent kill): 2,250 mg/kg N/R 85GMAT -,64,1982
skin
rabbit 		lethal dose (50 percent kill): 3,560 µL/kg N/R UCDS** 7/19/1965


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUTAEX 14,5,1999
TOXICOLOGY REVIEW
MUTAEX 14,271,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 3 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84805;
Number of Industries 3;
Total Number of Facilities 61;
Number of Occupations 12;
Total Number of Employees Exposed 1,555
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84805;
Number of Industries 14;
Total Number of Facilities 457;
Number of Occupations 18;
Total Number of Employees Exposed 8,709;
Total Number of Female Employees Exposed 823


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as chelating agent and corrosion inhibitor
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
EVSSAV Environmental Space Science. English Translation of Kosmicheskaya Biologiya Meditsina. 1967-70.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as chelating agent and corrosion inhibitor

NIOSH PROFILE (ALKANOLAMINES), SRC, 5/81

RTECS Compound Description:
   Mutagen
   Primary Irritant

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