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1,2 - Ethanediamine, N - (2 - aminoethyl) - N' - (2 - ( (2 - aminoethyl) amino) ethyl) -

RTECS #: KH8585000

CAS #: 112-57-2

UPDATE: October 1997 MW: 189.36 MF: C8H23N5


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 1,4,7,10,13 - Pentaazatridecane
  2. DEH 26
  1. Tetraethylpentylamine
  2. Tetren


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		5 mg moderate UCDS** 3/20/1973
eye
rabbit 		100 mg/24 hour moderate 85JCAE -,446,1986
skin
rabbit 		495 mg open irritation test severe UCDS** 3/20/1973
skin
rabbit 		5 mg/24 hour severe 85JCAE -,446,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
unscheduled DNA synthesis rat liver 10 µg/L MUREAV 320,31,1994
mutation in microorganisms Salmonella typhimurium 333 µg/plate (+/-enzymatic activation step) ENMUDM 8(Suppl 7),1,1986
sister chromatid exchange hamster ovary 250 µg/L MUREAV 320,31,1994


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 205 mg/kg N/R ICHAA3 91,L51,1984
intravenous
mouse 		lethal dose (50 percent kill): 320 mg/kg N/R CSLNX* NX#03522
oral
rat 		lethal dose (50 percent kill): 3,990 mg/kg N/R UCDS** 3/20/1973
skin
rabbit 		lethal dose (50 percent kill): 660 µL/kg N/R JIHTAB 31,60,1949


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84383;
Number of Industries 25;
Total Number of Facilities 798;
Number of Occupations 25;
Total Number of Employees Exposed 17,539
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84383;
Number of Industries 45;
Total Number of Facilities 1,513;
Number of Occupations 49;
Total Number of Employees Exposed 50,358;
Total Number of Female Employees Exposed 8,280


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as intermediate for adhesives, fungicides, asphalt additives and emulsifiers
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010)
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ICHAA3 Inorganica Chimica Acta. (Elsevier Sequoia SA, POB 851, CH-1001 Lausanne 1, Switzerland) V.1- 1967-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used as intermediate for adhesives, fungicides, asphalt additives and emulsifiers

NIOSH PROFILE (AMINES, POLY), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Primary Irritant

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