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Estriol

RTECS #: KG8225000

CAS #: 50-27-1

UPDATE: May 2009 MW: 288.42 MF: C18H24O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. REFERENCES:

SYNONYMS:

  1. (16 - alpha,17 - beta) - Estra - 1,3,5 (10) - triene - 3,16,17 - triol
  2. (16 - alpha,17 - beta) - Oestra - 1,3,5 (10) - triene - 3,16,17 - triol
  3. 1,3,5 - Estratriene - 3 - beta,16 - alpha,17 - beta - triol
  4. 1,3,5 - Oestratriene - 3 - beta,16 - alpha,17 - beta - triol
  5. 16 - alpha - Hydroxyestradiol
  6. 16 - alpha - Hydroxyoestradiol
  7. 16 - alpha,17 - beta - Estriol
  8. 16 - alpha,17 - beta - Oestriol
  9. 3,16 - alpha,17 - beta - Estriol
  10. 3,16 - alpha,17 - beta - Oestriol
  11. 3,16 - alpha,17 - beta - Trihydroxy - delta - 1,3,5 - oestratriene
  12. 3,16 - alpha,17 - beta - Trihydroxyestra - 1,3,5 (10) - triene
  13. 3,16 - alpha,17 - beta - Trihydroxy - delta - 1,3,5 - estratriene
  14. 3,16 - alpha,17 - beta - Trihydroxyoestra - 1,3,5 (10) - triene
  15. Aacifemine
  16. Destriol
  17. Deuslon - A
  18. Estra - 1,3,5 (10) - triene - 3,16 - alpha, l7 - beta - triol
  19. Estratriol
  20. Estriolo (Italian)
  21. Follicular hormone hydrate
  22. Gynaesan
  1. Hemostyptanon
  2. Holin
  3. Hormomed
  4. Hormonin
  5. Klimoral
  6. NSC - 12169
  7. OE3
  8. Oestra - 1,3,5 (10) - triene - 3,16 - alpha,17 - beta - triol
  9. Oestratriol
  10. Oestriol
  11. Orgastyptin
  12. Ovestin
  13. Stiptanon
  14. Synapause
  15. Theelol
  16. Thulol
  17. Tridestrin
  18. Trihydroxyestrin
  19. Trihydroxyoestrin
  20. Triodurin
  21. Triovex


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 50 µmol/L TOLED5 29,201,1985
sister chromatid exchange hamster ovary 10 µmol/L EXPEAM 44,62,1988
sex chromosome loss and nondisjunction hamster fibroblast 75 µmol/L MUREAV 171,31,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rabbit 		lowest published toxic dose: 25 µg/kg (1-3 day pregnant) Reproductive: Effects on fertility: Other measures of fertility FESTAS 10,155,1959
intrauterine
rat 		lowest published toxic dose: 1,500 ng/kg (1 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina BIREBV 31,705,1984
intrauterine
rabbit 		lowest published toxic dose: 760 ng/kg (28 day prior to copulation/1-10 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) FESTAS 28,262,1977
oral
rat 		lowest published toxic dose: 17,500 µg/kg (35 day prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) INJFA3 10,327,1965
oral
rat 		lowest published toxic dose: 3 mg/kg (1-4 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) JRPFA4 26,363,1971
oral
rat 		lowest published toxic dose: 577 µg/kg (16-19 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system AOGMAU 96,83,1975
oral
rat 		lowest published toxic dose: 8,440 ng/kg (1 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina JMCMAR 23,329,1980
oral
rat 		lowest published toxic dose: 5 mg/kg (5 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) CCPTAY 14,487,1976
parenteral
rat 		lowest published toxic dose: 105 µg/kg (1-7 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) JRPFA4 26,143,1971
subcutaneous
hamster 		lowest published toxic dose: 3,200 µg/kg (2-5 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) JRPFA4 26,365,1971
subcutaneous
mouse 		lowest published toxic dose: 100 mg/kg (10 day male) Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) 		FESTAS 24,687,1973
subcutaneous
rat 		lowest published toxic dose: 250 µg/kg (4-8 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		ZDBEA9 (3),63,1982
subcutaneous
rat 		lowest published toxic dose: 50 µg/kg (1 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on fertility: Abortion 		FESTAS 7,301,1956
subcutaneous
rat 		lowest published toxic dose: 350 µg/kg (7 day prior to copulation) Reproductive: Effects on newborn: Stillbirth FESTAS 7,301,1956
subcutaneous
rat 		lowest published toxic dose: 500 µg/kg (1 day male) Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Other measures of fertility 		ACENA7 49,193,1965
subcutaneous
rat 		lowest published toxic dose: 400 µg/kg (1 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands 		ACENA7 49,193,1965
subcutaneous
rat 		lowest published toxic dose: 85 µg/kg (7 day prior to copulation/1-10 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) JRPFA4 26,139,1971
subcutaneous
rabbit 		lowest published toxic dose: 60 µg/kg (1-3 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) AJOGAH 117,167,1973


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
guinea pig 		lowest published toxic dose: 20 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Uterine tumors 		RBBIAL 5,1,1945
implant
hamster 		lowest published toxic dose: 480 mg/kg/64 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors 		NCIMAV 1,1,1959
implant
mouse 		lowest published toxic dose: 26 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors 		EJCAAH 11,39,1975
implant
mouse 		toxic dose : 34 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors 		EJCAAH 11,39,1975


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lethal dose (50 percent kill): >2 gm/kg N/R NIIRDN -,176,1990
subcutaneous
mouse 		lowest published toxic dose: 1,154 ng/kg Vascular: Other changes

Endocrine: Estrogenic 		JRPFA4 123,235,2002


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
rat 		lowest published toxic dose: 10 mg/kg/36 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOXID9 72,84,2003
subcutaneous
mouse 		lowest published toxic dose: 200 µg/kg/3 day- intermittent Endocrine: Estrogenic

Reproductive: Maternal effects: Uterus, cervix, vagina

Related to Chronic Data: Changes in uterine weight 		JOENAK 34,215,1966


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 21,327,1979
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 72,339,1999
TOXICOLOGY REVIEW
JJIND8 94,497,2002
TOXICOLOGY REVIEW
CLECAP 4,551,1975
TOXICOLOGY REVIEW
JPETAB 308,403,2004
TOXICOLOGY REVIEW
BPCEM* 16,105,2002
TOXICOLOGY REVIEW
ENTOX* -,244,2005
TOXICOLOGY REVIEW
MUTAEX 19,423,2004
TOXICOLOGY REVIEW
JTPAE7 17,69,2004
TOXICOLOGY REVIEW
HTOPA* 1,501,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80409;
Number of Industries 1;
Total Number of Facilities 68;
Number of Occupations 6;
Total Number of Employees Exposed 2,770
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80409;
Number of Industries 3;
Total Number of Facilities 316;
Number of Occupations 7;
Total Number of Employees Exposed 3,694;
Total Number of Female Employees Exposed 2,675


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948-
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
AOGMAU Annali di Ostetricia, Ginecologia, Medicina Perinatale. (Istiuti Clinica di Perfezionamento di Milano, Via Daverio, 6, 20122 Milan, Italy) V.93- 1972-
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969-
BPCEM* Best Practice & Research Clinical Endocrinology and Metabolism (Elsevier Ltd.) V.13- 1999-
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970-
CLECAP Clinical Endocrinology (Oxford). (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1972-
EJCAAH European Journal of Cancer (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V. 1- 1965-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945-
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950-
HTOPA*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
INJFA3 International Journal of Fertility. (Allen Press, 1041 New Hampshire, St., Lawrence, KS 66044) V.1- 1955-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NCIMAV National Cancer Institute, Monograph. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) No.1- 1959-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
RBBIAL Revista Brasileira de Biologia. Brazilian Review of Biology. (Academia Brasileira de Ciencias, Caixa Postal 229, ZC-00 Rio de Janeiro, Brazil) V.1- 1941-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
ZDBEA9 Zdravookhranenie Belorussii. Public Health Service of White Russia. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1955-

Used as a drug for the treatment of symptoms of the climacteric

NIOSH PROFILE (ESTROGENS and ANDROGENS), SRC, 12/79

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Hormone
   Natural Product

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