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Estr - 4 - en - 3 - one, 17 - beta - hydroxy - , hydrocinnamate

RTECS #: KG7995000

CAS #: 62-90-8

UPDATE: November 2007 MW: 406.61 MF: C27H34O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. REFERENCES:

SYNONYMS:

  1. 17 - beta - Hydroxy - estra - 4 - en - 3 - one, 17 - phenylpropionate
  2. 17 - beta - Phenylpropionyloxy - 4 - estren - 3 - one
  3. 19 - Nortestosterone phenylpropionate
  4. 19NTPP
  5. Durabolin
  6. Estr - 4 - ene - 3 - one, 17 - beta - hydroxy - , 3 - phenylpropionate
  7. Estr - 4 - en - 3 - one, 17 - (1 - oxo - 3 - phenylpropoxy) - , (17 - beta) - (9CI)
  8. Fenobolin
  9. NPP
  10. NTPP
  1. Nandrolone phenpropionate
  2. Nandrolone phenylpropionate
  3. Nerobil
  4. Nerobiolil
  5. Norandrolone phenylpropionate
  6. Norandrostenolone phenylpropionate
  7. Nortestosterone phenylpropionate
  8. Phenobolin
  9. Superanabolon


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
mouse 		lowest published toxic dose: 15 mg/kg (7-12 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) 		OYYAA2 7,723,1973
intramuscular
mouse 		lowest published toxic dose: 15 mg/kg (7-12 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) OYYAA2 7,723,1973
intramuscular
mouse 		lowest published toxic dose: 60 mg/kg (7-12 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear OYYAA2 7,723,1973
intramuscular
mouse 		lowest published toxic dose: 240 mg/kg (7-12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) 		OYYAA2 7,723,1973
intramuscular
rat 		lowest published toxic dose: 1,400 µg/kg (14 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct ARZNAD 23,907,1973
intramuscular
rat 		lowest published toxic dose: 3,750 µg/kg (9-14 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		OYYAA2 7,723,1973
intramuscular
rat 		lowest published toxic dose: 15 mg/kg (9-14 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) 		OYYAA2 7,723,1973
oral
rat 		lowest published toxic dose: 14,850 µg/kg (11 day male) Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands ARZNAD 26,1673,1976
subcutaneous
mouse 		lowest published toxic dose: 1,200 µg/kg (3 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina ARZNAD 23,907,1973
subcutaneous
rat 		lowest published toxic dose: 60 mg/kg (7-12 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) STEDAM 18,731,1971
subcutaneous
rat 		lowest published toxic dose: 600 mg/kg (17-20 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system AVBIB9 13,71,1974


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): >1 gm/kg N/R NIIRDN 6,541,1982
intraperitoneal
rat 		lethal dose (50 percent kill): 595 mg/kg N/R PCJOAU 20,143,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
BIREBV 8,259,1973
TOXICOLOGY REVIEW
TOLED5 158,167,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 0.005 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5317;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 2;
Total Number of Employees Exposed 628;
Total Number of Female Employees Exposed 314


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
AVBIB9 Advances in the Biosciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1967-
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967-
STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609) V.1- 1963-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-

FDA-proprietary drug

RTECS Compound Description:
   Reproductive Effector
   Hormone

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