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Estr - 4 - en - 3 - one, 17 - beta - hydroxy - , decanoate

RTECS #: KG7967000

CAS #: 360-70-3

UPDATE: February 2008 MW: 428.72 MF: C28H44O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. REFERENCES:

SYNONYMS:

  1. 17 - beta - Hydroxyestr - 4 - en - 3 - one decanoate
  2. 19 - Norandrostenolone decanoate
  3. 19 - Nortestosterone decanoate
  4. Deca - Durabol
  5. Deca - Durabolin
  1. Estr - 4 - en - 3 - one, 17 - ( (1 - oxodecyl) oxy) - , (17 - beta) - (9CI)
  2. Nandrolone decanoate
  3. Norandrostenolone decanoate
  4. Nortestosterone decanoate
  5. Retabolil


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rat 		lowest published toxic dose: 42 mg/kg (14 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		BCLPT* 97,214,2005
parenteral
rat 		lowest published toxic dose: 5 mg/kg (1 day prior to copulation) Reproductive: Effects on fertility: Other measures of fertility ARGYAJ 221,103,1976


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): >566 mg/kg N/R NIIRDN 6,541,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rat 		lowest published toxic dose: 42 mg/kg/14 week- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct TXAPA9 197,353,2004
intramuscular
rat 		lowest published toxic dose: 42 mg/kg/14 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight 		BCLPT* 97,214,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
ENTOX* -,121,2005
TOXICOLOGY REVIEW
TOLED5 158,167,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 0.005 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5316;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 2;
Total Number of Employees Exposed 628;
Total Number of Female Employees Exposed 314


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
ARGYAJ Archiv fuer Gynaekologie. (Munich, Fed. Rep. Ger.) V.1-225, 1870-1978. For publisher information, see ARCGDG.
BCLPT* Basic & clinical pharmacology & toxicology (Copenhagen, Denmark : Nordic Pharmacological Society Oxford, UK : Distributed by Blackwell Munksgaard) V.94- 2004-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
   Drug
   Reproductive Effector
   Hormone

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