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Estr - 4 - en - 3 - one, 17 - beta - hydroxy -

RTECS #: KG7964000

CAS #: 434-22-0

UPDATE: August 2007 MW: 274.44 MF: C18H26O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. REVIEWS:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. REFERENCES:

SYNONYMS:

  1. (+) - 19 - Nortestosterone
  2. 17 - beta - Hydroestr - 4 - en - 3 - one
  3. 19 - Norandrostenolone
  4. 19 - Nortestosterone
  5. Estr - 4 - en - 3 - one, 17 - hydroxy - , (17 - beta) - (9CI)
  6. Menidrabol
  7. Nandrolon
  1. Nandrolone
  2. Norandrostenolon
  3. Norandrostenolone
  4. Nortestonate
  5. Nortestosterone
  6. Oestrenolon


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravaginal
mouse 		lowest published toxic dose: 6,400 ng/kg (1 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina JOENAK 20,198,1960
subcutaneous
rat 		lowest published toxic dose: 1,200 µg/kg (3 day prior to copulation) Reproductive: Effects on fertility: Other measures of fertility ACENA7 47,444,1964
subcutaneous
rat 		lowest published toxic dose: 140 mg/kg (3-9 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) ACENA7 47,444,1964
subcutaneous
rat 		lowest published toxic dose: 1,400 µg/kg (14 day prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Effects on fertility: Other measures of fertility 		CCPTAY 5,489,1972
subcutaneous
rat 		lowest published toxic dose: 700 µg/kg (14 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina CCPTAY 5,489,1972
subcutaneous
rabbit 		lowest published toxic dose: 2 mg/kg (5 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina ANREAK 142,469,1962
skin
rat 		lowest published toxic dose: 240 mg/kg (30 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands 		STEDAM 10,687,1967


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
MUREAV 628,67,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 0.005 mg/m3, Skin, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4325;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 1;
Total Number of Employees Exposed 103;
Total Number of Female Employees Exposed 52


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948-
ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08-
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609) V.1- 1963-

RTECS Compound Description:
   Reproductive Effector
   Hormone

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