RTECS:KG7350000 The Registry of Toxic Effects of Chemical Substances

Estra - 1,3,5 (10) - triene - 3,17 - diol (17 - beta) - , 3 - (bis (2 - chloroethyl) carbamate) 17 - (dihydrogenphosphate) , disodium salt

RTECS #: KG7350000

CAS #: 52205-73-9

UPDATE: August 2007 MW: 566.41 MF: C₂₃H₃₂Cl₂NO₆P•2Na

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

REPRODUCTIVE EFFECTS DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

REFERENCES:

SYNONYMS:

Emcyt

Estra - 1,3,5 (10) - triene - 3,17 - beta - diol 3 - (bis (2 - chloroethyl) carbamate) 17 - disodium phosphate

Estracyt sodium

Estramustine phosphate sodium

Estramustine phosphate disodium

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 30 mg/kg (60 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct OYYAA2 20,1211,1980
oral
rat lowest published toxic dose: 5,500 µg/kg (7-17 day pregnant) Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Physical OYYAA2 20,1219,1980
oral
rat lowest published toxic dose: 22 mg/kg (7-17 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) OYYAA2 20,1219,1980
oral
rat lowest published toxic dose: 44 mg/kg (7-17 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) OYYAA2 20,1219,1980
oral
rabbit lowest published toxic dose: 650 µg/kg (6-18 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) OYYAA2 21,41,1981
oral
rabbit lowest published toxic dose: 2,600 µg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) OYYAA2 21,41,1981
oral
rabbit lowest published toxic dose: 1,300 µg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Other measures of fertility OYYAA2 21,41,1981

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intravenous
mouse lethal dose (50 percent kill): 380 mg/kg Lung, Thorax, or Respiration: Respiratory depression OYYAA2 20,1141,1980
intravenous
rat lethal dose (50 percent kill): 208 mg/kg Lung, Thorax, or Respiration: Respiratory depression OYYAA2 20,1141,1980
oral
dog lethal dose (50 percent kill): >3 gm/kg Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Hematuria OYYAA2 20,1141,1980
oral
mouse lethal dose (50 percent kill): >12 gm/kg N/R OYYAA2 20,1141,1980
oral
rat lethal dose (50 percent kill): 5,400 mg/kg Gastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Hematuria OYYAA2 20,1141,1980
oral
rabbit lethal dose (50 percent kill): 5,655 mg/kg Gastrointestinal: Hypermotility, diarrhea

Kidney, Ureter, and Bladder: Hematuria OYYAA2 20,1141,1980
subcutaneous
mouse lethal dose (50 percent kill): 5,200 mg/kg Skin: After systemic exposure: Dermatitis, other

Skin and Appendages: Other: Hair OYYAA2 20,1141,1980
subcutaneous
rat lethal dose (50 percent kill): 9 gm/kg Skin: After systemic exposure: Dermatitis, other

Skin and Appendages: Other: Hair OYYAA2 20,1141,1980

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lowest published toxic dose: 500 mg/kg/5 day- intermittent Gastrointestinal: Colon tumors

Tumorigenic: Active as anti-cancer agent EJCAAH 38,194,2002
oral
dog lowest published toxic dose: 320 mg/kg/32 day- intermittent Blood: Hemorrhage

Blood: Normocytic anemia

Related to Chronic Data: Changes in uterine weight OYYAA2 20,1161,1980
oral
monkey lowest published toxic dose: 1,274 mg/kg/13 week- intermittent Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Related to Chronic Data: Changes in uterine weight OYYAA2 20,757,1980
oral
rat lowest published toxic dose: 3,500 mg/kg/5 week- continuous Liver: Changes in liver weight

Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) OYYAA2 21,211,1981
oral
rat lowest published toxic dose: 3,640 mg/kg/26 week- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) OYYAA2 21,549,1981

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
ENTOX* -,384,2005

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5435;
Number of Industries 1;
Total Number of Facilities 9;
Number of Occupations 1;
Total Number of Employees Exposed 63;
Total Number of Female Employees Exposed 9

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

EJCAAH European Journal of Cancer (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V. 1- 1965-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-

Used as an antiprostatic agent

FDA-proprietary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Reproductive Effector
   Hormone

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SYNONYMS:
Emcyt Estra - 1,3,5 (10) - triene - 3,17 - beta - diol 3 - (bis (2 - chloroethyl) carbamate) 17 - disodium phosphate Estracyt sodium	Estramustine phosphate sodium Estramustine phosphate disodium

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral rat	lowest published toxic dose: 30 mg/kg (60 day male)	Reproductive: Paternal effects: Testes, epididymis, sperm duct	OYYAA2 20,1211,1980
oral rat	lowest published toxic dose: 5,500 µg/kg (7-17 day pregnant)	Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Physical	OYYAA2 20,1219,1980
oral rat	lowest published toxic dose: 22 mg/kg (7-17 day pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)	OYYAA2 20,1219,1980
oral rat	lowest published toxic dose: 44 mg/kg (7-17 day pregnant)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)	OYYAA2 20,1219,1980
oral rabbit	lowest published toxic dose: 650 µg/kg (6-18 day pregnant)	Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)	OYYAA2 21,41,1981
oral rabbit	lowest published toxic dose: 2,600 µg/kg (6-15 day pregnant)	Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)	OYYAA2 21,41,1981
oral rabbit	lowest published toxic dose: 1,300 µg/kg (6-15 day pregnant)	Reproductive: Effects on fertility: Other measures of fertility	OYYAA2 21,41,1981

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intravenous mouse	lethal dose (50 percent kill): 380 mg/kg	Lung, Thorax, or Respiration: Respiratory depression	OYYAA2 20,1141,1980
intravenous rat	lethal dose (50 percent kill): 208 mg/kg	Lung, Thorax, or Respiration: Respiratory depression	OYYAA2 20,1141,1980
oral dog	lethal dose (50 percent kill): >3 gm/kg	Gastrointestinal: Changes in structure or function of salivary glands Gastrointestinal: Hypermotility, diarrhea Kidney, Ureter, and Bladder: Hematuria	OYYAA2 20,1141,1980
oral mouse	lethal dose (50 percent kill): >12 gm/kg	N/R	OYYAA2 20,1141,1980
oral rat	lethal dose (50 percent kill): 5,400 mg/kg	Gastrointestinal: Hypermotility, diarrhea Kidney, Ureter, and Bladder: Hematuria	OYYAA2 20,1141,1980
oral rabbit	lethal dose (50 percent kill): 5,655 mg/kg	Gastrointestinal: Hypermotility, diarrhea Kidney, Ureter, and Bladder: Hematuria	OYYAA2 20,1141,1980
subcutaneous mouse	lethal dose (50 percent kill): 5,200 mg/kg	Skin: After systemic exposure: Dermatitis, other Skin and Appendages: Other: Hair	OYYAA2 20,1141,1980
subcutaneous rat	lethal dose (50 percent kill): 9 gm/kg	Skin: After systemic exposure: Dermatitis, other Skin and Appendages: Other: Hair	OYYAA2 20,1141,1980

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lowest published toxic dose: 500 mg/kg/5 day- intermittent	Gastrointestinal: Colon tumors Tumorigenic: Active as anti-cancer agent	EJCAAH 38,194,2002
oral dog	lowest published toxic dose: 320 mg/kg/32 day- intermittent	Blood: Hemorrhage Blood: Normocytic anemia Related to Chronic Data: Changes in uterine weight	OYYAA2 20,1161,1980
oral monkey	lowest published toxic dose: 1,274 mg/kg/13 week- intermittent	Endocrine: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) Related to Chronic Data: Changes in uterine weight	OYYAA2 20,757,1980
oral rat	lowest published toxic dose: 3,500 mg/kg/5 week- continuous	Liver: Changes in liver weight Endocrine: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	OYYAA2 21,211,1981
oral rat	lowest published toxic dose: 3,640 mg/kg/26 week- continuous	Kidney, Ureter, and Bladder: Other changes in urine composition Endocrine: Other changes Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)	OYYAA2 21,549,1981

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		ENTOX* -,384,2005

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X5435; Number of Industries 1; Total Number of Facilities 9; Number of Occupations 1; Total Number of Employees Exposed 63; Total Number of Female Employees Exposed 9

REFERENCES:
CODEN	REFERENCE
EJCAAH	European Journal of Cancer (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V. 1- 1965-
ENTOX*	Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
OYYAA2	Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-