CDC logo, Safer Healthier People CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us




Estradiol

RTECS #: KG2975000

CAS #: 50-28-2

UPDATE: May 2009 MW: 272.42 MF: C18H24O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 1,3,5 - Estratriene - 3,17 - beta - diol
  2. 17 - beta - Estra - 1,3,5 (10) - triene - 3,17 - diol
  3. 17 - beta - Estradiol
  4. 17 - beta - OH - estradiol
  5. 17 - beta - OH - oestradiol
  6. 17 - beta - Oestra - 1,3,5 (10) - triene - 3,17 - diol
  7. 17 - beta - Oestradiol
  8. 3,17 - Epidihydroxyestratriene
  9. 3,17 - beta - Dihydroxy - 1,3,5 (10) - estratriene
  10. 3,17 - beta - Dihydroxy - 1,3,5 (10) - oestratriene
  11. 3,17 - beta - Dihydroxyestra - 1,3,5 (10) - triene
  12. 3,17 - beta - Dihydroxyoestra - 1,3,5 - triene
  13. 3,17 - beta - Estradiol
  14. 3,17 - beta - Oestradiol
  15. Altrad
  16. Bardiol
  17. D - 3,17 - beta - Estradiol
  18. D - 3,17 - beta - Oestradiol
  19. Dihydrofollicular hormone
  20. Dihydrofolliculin
  21. Dihydromenformon
  22. Dihydrotheelin
  23. Dihydroxyestrin
  24. Dihydroxyoestrin
  25. Dimenformon
  26. Dimenformon prolongatum
  27. Diogyn
  28. Diogynets
  29. E (sub 2)
  30. Estra - 1,3,5 (10) - triene - 3,17 - beta - diol
  31. Estraderm TTS
  32. Estradiol - 17 - beta
  33. Estraldine
  34. Estrovite
  35. Femestral
  36. Femogen
  37. Gynergon
  1. Gynestrel
  2. Gynoestryl
  3. Lamdiol
  4. Macrodiol
  5. Macrol
  6. Microdiol
  7. NSC - 9895
  8. Nordicol
  9. Oestergon
  10. Oestra - 1,3,5 (10) - triene - 3,17 - beta - diol
  11. Oestradiol
  12. Oestradiol R
  13. Oestradiol - 17 - beta
  14. Oestroglandol
  15. Oestrogynal
  16. Ovahormon
  17. Ovasterol
  18. Ovastevol
  19. Ovociclina
  20. Ovocyclin
  21. Ovocycline
  22. Ovocylin
  23. Primofol
  24. Profoliol
  25. Progynon
  26. Progynon - DH
  27. Syndiol
  28. Theelin, dihydro -
  29. alpha - Estradiol
  30. alpha - Oestradiol
  31. beta - Estradiol
  32. beta - Oestradiol
  33. cis - Estradiol
  34. cis - Oestradiol
  35. d - Estradiol
  36. d - Oestradiol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 50 µmol/L TOLED5 29,201,1985
cytogenetic analysis subcutaneous
hamster 		160 mg/kg/20 week- continuous MUREAV 311,191,1994
cytogenetic analysis hamster ovary 0.25 mmol/L/3 hour MUREAV 649,114,2008
cytogenetic analysis human lymphocyte 1 mg/L MUREAV 345,87,1995
cytogenetic analysis human other cell types 2 mg/L MUREAV 504,119,2002
cytogenetic analysis human lymphocyte 2 mg/L/22 hour MUREAV 651,40,2008
cytogenetic analysis mouse embryo 1 mg/L DANKAS 282,173,1985
cytogenetic analysis parenteral
rat 		10 mg/kg NATWAY 54,98,1967
DNA adduct guinea pig kidney 52 nmol/L BIREBV 19,338,1978
DNA adduct guinea pig lung 52 nmol/L BIREBV 19,338,1978
DNA adduct mammal (species unspecified) lymphocyte 5 nmol/L FEBLAL 61,223,1976
DNA adduct rat other cell types 10 nmol/L CELLB5 14,857,1978
DNA damage subcutaneous
hamster 		200 mg/kg/2 week- continuous CRNGDP 15,997,1994
DNA damage intraperitoneal
hamster 		75 mg/kg EXBME* 226,707,2001
DNA damage human lymphocyte 50 µmol/L/30 minute MUREAV 544,173,2003
DNA damage human sperm 50 µmol/L/1 hour MUREAV 544,173,2003
DNA damage human mammary gland 100 nmol/L/24 hour EMMUEG 45,397,2005
DNA damage human Ascites tumor 100 nmol/L/24 hour EMMUEG 45,397,2005
DNA inhibition human lymphocyte 10 µmol/L PSEBAA 146,401,1974
DNA inhibition oral
mouse 		40 µg/kg JOENAK 61,117,1974
unscheduled DNA synthesis parenteral
frog 		40 mg/kg DEBIAO 108,332,1985
unscheduled DNA synthesis human mammary gland 10 nmol/L CNREA8 45,1644,1985
unscheduled DNA synthesis subcutaneous
mouse 		1,190 µg/kg CTSRCS 156,551,1975
unscheduled DNA synthesis non-mammalian species liver 1 µmol/L ICDBEO 22,457,1986
unscheduled DNA synthesis rat liver 100 mmol/L CNREA8 42,3010,1982
unscheduled DNA synthesis subcutaneous
rat 		18,500 µg/kg/5 day- intermittent BBACAQ 656,45,1981
unscheduled DNA synthesis parenteral
rat 		10 µg/kg ACHCBO 18,213,1985
unscheduled DNA synthesis intraperitoneal
rat 		40 µg/kg BCPCA6 29,1469,1980
unscheduled DNA synthesis rabbit other cell types 100 nmol/L CRNGDP 3,703,1982
micronucleus test domestic animal other cell types 10 µmol/L MUREAV 311,85,1994
micronucleus test hamster embryo 10 µmol/L MUREAV 311,85,1994
micronucleus test human lymphocyte 5 µmol/L MUREAV 156,199,1985
micronucleus test human other cell types 8 mg/L MUREAV 504,119,2002
micronucleus test human Ascites tumor 0.1 nmol/L/30 hour MOCAT* 18,243,2003
micronucleus test human lymphocyte 8 mg/L/22 hour MUREAV 651,40,2008
micronucleus test human fibroblast 2 mg/L MUREAV 651,40,2008
micronucleus test mouse other cell types 100 nmol/L MUREAV 261,181,1991
micronucleus test intraperitoneal
mouse 		10 mg/kg MUREAV 345,87,1995
micronucleus test subcutaneous
mouse 		0.82 mg/kg/3 day- intermittent REPTED 17,79,2003
morphological transform hamster embryo 3 mg/L CRNGDP 8,1715,1987
morphological transform hamster embryo 6,800 µg/L/7 day TOSCF2 65,177,2002
morphological transform mouse fibroblast 20 µmol/L CNREA8 47,2583,1987
morphological transform mouse fibroblast 0.1 mg/L/21 day (-enzymatic activation step) EMMUEG 37,231,2001
morphological transform oral
rat 		21 mg/kg/6 week- continuous CALEDQ 46,195,1989
other mutation test systems intramuscular
chicken 		25 mg/kg BBRCA9 112,425,1983
other mutation test systems hamster embryo 6 mg/kg TIVIEQ 4,75,1990
other mutation test systems human fibroblast 20 mg/kg TIVIEQ 4,75,1990
other mutation test systems subcutaneous
rat 		10,500 ng/kg BBACAQ 656,45,1981
other mutation test systems subcutaneous
rat 		800 ng/kg/4 day BIREBV 19,385,1978
sister chromatid exchange hamster ovary 10 µmol/L EXPEAM 44,62,1988
sister chromatid exchange human lymphocyte 1 mg/L MUREAV 345,87,1995
sister chromatid exchange mouse other cell types 10 µmol/L TCMUD8 9,97,1989
sister chromatid exchange subcutaneous
mouse 		200 mg/L TCMUD8 11,135,1991
sister chromatid exchange intraperitoneal
mouse 		10 mg/kg MUREAV 345,87,1995
sex chromosome loss and nondisjunction hamster embryo 10 mg/L PAACA3 27,39,1986
sex chromosome loss and nondisjunction hamster fibroblast 50 µmol/L MUREAV 171,31,1986
sex chromosome loss and nondisjunction hamster lung 40 µmol/L MUREAV 431,105,1999
sex chromosome loss and nondisjunction human fibroblast 20 mg/L MUREAV 240,241,1990
specific locus test human mammary gland 1 mmol/L/2 week EMMUEG 39,254,2002
sperm morphology subcutaneous
mouse 		250 mg/kg MUREAV 261,181,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
monkey 		lowest published toxic concentration: 30 µg/kg/30 minute (60 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		BIREBV 22,935,1980
implant
cattle 		lowest published toxic dose: 900 µg/kg (26 week male) Reproductive: Paternal effects: Testes, epididymis, sperm duct FAATDF 10,73,1988
implant
cattle 		lowest published toxic dose: 1 mg/kg (26-47 day after birth) Reproductive: Maternal effects: Menstrual cycle changes or disorders JANSAG 66,1,1988
implant
cattle 		lowest published toxic dose: 147 mg/kg (82 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Other effects on male 		JRPFA4 94,57,1992
implant
hamster 		lowest published toxic dose: 160 mg/kg (50 week male) Reproductive: Paternal effects: Testes, epididymis, sperm duct ENDOAO 57,255,1955
implant
mouse 		lowest published toxic dose: 1,720 µg/kg (16-21 day pregnant) Reproductive: Maternal effects: Parturition

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		JRPFA4 22,509,1970
implant
rat 		lowest published toxic dose: 3,600 ng/kg (90 day male) Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands NATUAS 269,409,1977
implant
rat 		lowest published toxic dose: 437 µg/kg (91 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		BIREBV 21,455,1979
implant
rat 		lowest published toxic dose: 262 µg/kg (91 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) 		BIREBV 37,327,1987
intramuscular
rat 		lowest published toxic dose: 2 µg/kg (4 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina PBPSDY 1,215,1977
intramuscular
rat 		lowest published toxic dose: 60 mg/kg (15-16 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system JCEMAZ 28,231,1968
intramuscular
rat 		lowest published toxic dose: 60 mg/kg (19-20 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system JCEMAZ 28,231,1968
intramuscular
rat 		lowest published toxic dose: 1,800 mg/kg (15-20 day pregnant) Reproductive: Maternal effects: Ovaries, fallopian tubes JCEMAZ 29,30,1969
intramuscular
rat 		lowest published toxic dose: 6,720 ng/kg (14 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands 		IJEBA6 15,16,1977
intramuscular
rat 		lowest published toxic dose: 70 µg/kg (14 day prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders

Reproductive: Other effects on female 		NFGZAD 30,1,1985
intramuscular
rabbit 		lowest published toxic dose: 30 µg/kg (18-20 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetal death 		JRPFA4 53,237,1978
intramuscular
rabbit 		lowest published toxic dose: 5 µg/kg (1-3 day pregnant) Reproductive: Effects on fertility: Other measures of fertility FESTAS 10,155,1959
intraperitoneal
mouse 		lowest published toxic dose: 4 mg/kg (5 day prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders PSEBAA 160,94,1979
intraperitoneal
non-mammalian species 		lowest published toxic dose: 3 mg/kg (10 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) CBCPAI 139,1,2004
intraperitoneal
rat 		lowest published toxic dose: 1,280 ng/kg (8 day male) Reproductive: Other effects on male

Endocrine: Change in LH 		ANDRDQ 23,339,1991
intrauterine
rat 		lowest published toxic dose: 25 ng/kg (1 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina BIREBV 31,705,1984
intravenous
rat 		lowest published toxic dose: 10 µg/kg (1 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina EXPEAM 42,165,1986
oral
monkey 		lowest published toxic dose: 10 mg/kg (1-6 day pregnant) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) AJOGAH 115,101,1973
oral
mouse 		lowest published toxic dose: 219 mg/kg (52 week prior to copulation) Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Uterus, cervix, vagina 		JEPTDQ 1(1),1,1977
oral
mouse 		lowest published toxic dose: 667 ng/kg (3 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina JTEHD6 20,37,1987
oral
rat 		lowest published toxic dose: 1 gm/kg (4-8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Abortion 		FESTAS 22,735,1971
oral
rat 		lowest published toxic dose: 750 µg/kg (3 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina JRPFA4 13,101,1967
oral
rat 		lowest published toxic dose: 875 µg/kg (7 day prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) JRPFA4 10,105,1965
oral
rat 		lowest published toxic dose: 4,195 ng/kg (1 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina JMCMAR 23,329,1980
oral
rat 		lowest published toxic dose: 0.225 mg/kg (multigeneration) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system 		TOSCF2 44,143,1998
oral
rat 		lowest published toxic dose: 99 mg/kg (multigeneration) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Breast development

Reproductive: Maternal effects: Breasts, lactation (prior to or during pregnancy) 		TOSCF2 44,116,1998
oral
rat 		lowest published toxic dose: 99 mg/kg (multigeneration) Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) 		TOSCF2 44,116,1998
oral
rat 		lowest published toxic dose: 99 mg/kg (multigeneration) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		TOSCF2 44,155,1998
oral
rat 		lowest published toxic dose: 24.75 mg/kg (multigeneration) Reproductive: Specific developmental abnormalities: Urogenital system TOSCF2 44,155,1998
oral
rat 		lowest published toxic dose: 31.5 mg/kg (84 day male/84 day prior to copulation-3 week after birth) Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) 		TOSCF2 92,295,2006
oral
rat 		lowest published toxic dose: 31.5 mg/kg (84 day male/84 day prior to copulation-3 week after birth) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on fertility: Other measures of fertility

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) 		TOSCF2 92,295,2006
oral
rat 		lowest published toxic dose: 31.5 mg/kg (84 day male/84 day prior to copulation-3 week after birth) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Other neonatal measures or effects

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		TOSCF2 92,295,2006
oral
rat 		lowest published toxic dose: 31.5 mg/kg (84 day male/84 day prior to copulation-3 week after birth) Reproductive: Effects on newborn: Other postnatal measures or effects TOSCF2 92,295,2006
oral
rat 		lowest published toxic dose: 0.15 mg/kg (multigeneration) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Other effects on male

Reproductive: Maternal effects: Ovaries, fallopian tubes 		TOSCF2 92,295,2006
oral
rat 		lowest published toxic dose: 0.15 mg/kg (multigeneration) Reproductive: Other effects on female

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		TOSCF2 92,295,2006
oral
rat 		lowest published toxic dose: 0.15 mg/kg (multigeneration) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		TOSCF2 92,295,2006
oral
rat 		lowest published toxic dose: 0.15 mg/kg (multigeneration) Reproductive: Effects on newborn: Physical TOSCF2 92,295,2006
oral
rabbit 		lowest published toxic dose: 60 µg/kg (8 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands 		TXAPA9 21,55,1972
oral
rabbit 		lowest published toxic dose: 50 µg/kg (1 day prior to copulation) Reproductive: Effects on fertility: Other measures of fertility 13OPAL -,37,1961
oral
woman 		lowest published toxic dose: 4,400 µg/kg (31 week prior to copulation) Reproductive: Effects on fertility: Other measures of fertility ACEDAB 105,7,1966
parenteral
mouse 		lowest published toxic dose: 9,600 µg/kg (4-6 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) JOENAK 20,299,1960
parenteral
mouse 		lowest published toxic dose: 4,800 µg/kg (4-6 day pregnant) Reproductive: Effects on fertility: Other measures of fertility JOENAK 20,299,1960
parenteral
mouse 		lowest published toxic dose: 4 µg/kg (1 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina FEPRA7 25,252,1966
parenteral
pig 		lowest published toxic dose: 7,692 ng/kg (9-10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) JANSAG 63,1208,1986
parenteral
rat 		lowest published toxic dose: 4 µg/kg (14-17 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) NAGZAC 33,1678,1958
parenteral
rat 		lowest published toxic dose: 1,600 µg/kg (3 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		85GRAA -,29,1965
subcutaneous
cattle 		lowest published toxic dose: 126 µg/kg (48 week prior to copulation/1-28 day pregnant) Reproductive: Maternal effects: Menstrual cycle changes or disorders

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) 		JRPFA4 89,527,1990
subcutaneous
domestic animal 		lowest published toxic dose: 14 µg/kg (1 day prior to copulation) Reproductive: Effects on fertility: Other measures of fertility JANSAG 42,677,1976
subcutaneous
gerbil 		lowest published toxic dose: 15 mg/kg (15 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands 		JRPFA4 61,217,1981
subcutaneous
hamster 		lowest published toxic dose: 90 µg/kg (1-9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		CCPTAY 3,347,1971
subcutaneous
hamster 		lowest published toxic dose: 900 µg/kg (1-9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) CCPTAY 3,347,1971
subcutaneous
mouse 		lowest published toxic dose: 10 mg/kg (5 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) 		BIREBV 20,310,1979
subcutaneous
mouse 		lowest published toxic dose: 1 mg/kg (5 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) PSEBAA 165,17,1980
subcutaneous
mouse 		lowest published toxic dose: 20 mg/kg (19 day pregnant) Reproductive: Effects on newborn: Delayed effects CNREA8 37,1099,1977
subcutaneous
mouse 		lowest published toxic dose: 12 µg/kg (1-3 day pregnant) Reproductive: Effects on fertility: Other measures of fertility JOENAK 42,17,1968
subcutaneous
mouse 		lowest published toxic dose: 14,400 ng/kg (4-6 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) 		JRPFA4 5,239,1963
subcutaneous
mouse 		lowest published toxic dose: 204 ng/kg (3 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina FESTAS 20,211,1969
subcutaneous
mouse 		lowest published toxic dose: 2 µg/kg (1 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina FESTAS 25,636,1974
subcutaneous
mouse 		lowest published toxic dose: 0.99 mg/kg (5-7 day pregnant) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Other measures of fertility 		NETEEC 24,29,2002
subcutaneous
mouse 		lowest published toxic dose: 0.99 mg/kg (2-4 day pregnant) Reproductive: Effects on newborn: Germ cell effects (in offspring) REPTED 17,79,2003
subcutaneous
mouse 		lowest published toxic dose: 0.99 mg/kg (2-4 day pregnant) Reproductive: Maternal effects: Ovaries, fallopian tubes

Reproductive: Other developmental abnormalities

Reproductive: Effects on newborn: Germ cell effects (in offspring) 		REPTED 17,79,2003
subcutaneous
mouse 		lowest published toxic dose: 99 mg/kg (2-4 day pregnant) Reproductive: Effects on fertility: Other measures of fertility REPTED 17,79,2003
subcutaneous
mouse 		lowest published toxic dose: 0.82 mg/kg (2 day pregnant) Reproductive: Other effects to embryo or fetus

Reproductive: Other developmental abnormalities 		REPTED 17,79,2003
subcutaneous
mouse 		lowest published toxic dose: 0.33 mg/kg (2 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Physical 		REPTED 18,103,2004
subcutaneous
mouse 		lowest published toxic dose: 0.33 µg/kg (2 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system 		REPTED 21,154,2006
subcutaneous
rat 		lowest published toxic dose: 2,400 ng/kg (3 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina ENDOAO 60,519,1957
subcutaneous
rat 		lowest published toxic dose: 205 µg/kg (5 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct ENDOAO 60,519,1957
subcutaneous
rat 		lowest published toxic dose: 20 µg/kg (4 day prior to copulation) Reproductive: Effects on fertility: Other measures of fertility ACEDAB 105,7,1966
subcutaneous
rat 		lowest published toxic dose: 14,400 ng/kg (5-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) RCOCB8 7,701,1974
subcutaneous
rat 		lowest published toxic dose: 10,500 ng/kg (7 day prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) JRPFA4 10,105,1965
subcutaneous
rat 		lowest published toxic dose: 6,250 µg/kg (16-20 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system JRPFA4 59,43,1980
subcutaneous
rat 		lowest published toxic dose: 15,300 ng/kg (1-9 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		CCPTAY 3,347,1971
subcutaneous
rat 		lowest published toxic dose: 500 µg/kg (1 day prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders ARTODN 50,279,1982
subcutaneous
rabbit 		lowest published toxic dose: 90 µg/kg (6-11 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) ENDOAO 77,337,1965
subcutaneous
rabbit 		lowest published toxic dose: 45 mg/kg (1-3 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) EXMDA4 (133),406,1967
subcutaneous
rabbit 		lowest published toxic dose: 45 µg/kg (5-7 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) JRPFA4 3,246,1962
unreported route
rat 		lowest published toxic dose: 5 µg/kg (1 day prior to copulation) Reproductive: Effects on fertility: Other measures of fertility 15QWAW -,195,1965
unreported route
rabbit 		lowest published toxic dose: 190 µg/kg (1-19 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		CCPTAY 2,85,1970


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
guinea pig 		lowest published toxic dose: 1,200 µg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		RCBIAS 3,108,1944
implant
guinea pig 		toxic dose : 2,400 µg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Uterine tumors 		BSBSAS 8,142,1951
implant
guinea pig 		toxic dose : 40 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Uterine tumors 		LANCAO 1,1313,1939
implant
guinea pig 		toxic dose : 100 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Uterine tumors 		LANCAO 1,1313,1939
implant
hamster 		lowest published toxic dose: 200 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors 		CALEDQ 64,23,1992
implant
hamster 		toxic dose : 360 mg/kg/15 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors 		MOPMA3 23,278,1983
implant
hamster 		toxic dose : 160 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Lung, Thorax, or Respiration: Bronchogenic carcinoma 		CANCAR 10,757,1957
implant
mouse 		toxic dose : 30 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors 		REEBB3 16,425,1971
implant
mouse 		toxic dose : 34 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors 		EJCAAH 11,39,1975
implant
mouse 		lowest published toxic dose: 118 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Facilitates action of known carcinogens 		TOSCF2 69,42,2002
implant
rat 		lowest published toxic dose: 100 mg/kg/52 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors 		JJCREP 78,134,1987
implant
rat 		toxic dose : 62,500 µg/kg/36 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Tumors

Skin and Appendages: Tumors 		JJIND8 73,123,1984
implant
rat 		lowest published toxic dose: 10 mg/kg/36 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Other reproductive system tumors 		TOXID9 72,84,2003
implant
rat 		lowest published toxic dose: 17.54 mg/kg/28 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors 		JPETAB R60
intraperitoneal
rat 		lowest published toxic dose: 1,400 mg/kg/13 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Tumors 		NIGHAE 52,655,1983
oral
mouse 		lowest published toxic dose: 84 mg/kg/20 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Tumorigenic effects: Uterine tumors 		JJCREP 82,1391,1991
oral
mouse 		toxic dose : 58 mg/kg/82 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors 		BJCAAI 35,322,1977
oral
mouse 		toxic dose : 44 mg/kg/52 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumor types after systemic administration not seen spontaneously 		JEPTDQ 1(1),1,1977
subcutaneous
guinea pig 		lowest published toxic dose: 7 mg/kg/12 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Uterine tumors 		CRSBAW 130,9,1939


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
mouse 		lowest published toxic dose: 2 mg/kg Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation TOXID9 90,388,2006
implant
rat 		lowest published toxic dose: 5 mg/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		TXCYAC 200,103,2004
implant
rat 		lowest published toxic dose: 5 mg/kg Liver: Changes in liver weight

Endocrine: Changes in pituitary weight 		TOXID9 66,184,2002
implant
rat 		lowest published toxic dose: 15 mg/kg Reproductive: Other reproductive system tumors

Tumorigenic: Increased incidence of tumors in susceptible strains 		TOXID9 66,184,2002
intramuscular
guinea pig 		lowest published toxic dose: 1 mg/kg Lung, Thorax, or Respiration: Bronchiolar dilation CYLPDN 23,243,2002
intraperitoneal
mouse 		lowest published toxic dose: 1.5 µg/kg Reproductive: Maternal effects: Uterus, cervix, vagina

Biochemical: Metabolism (intermediary): Effect on cyclic nucleotides

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TOSCF2 66,62,2002
intraperitoneal
mouse 		lowest published toxic dose: 50 µg/kg Liver: Other changes

Endocrine: Estrogenic

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		TXAPA9 201,137,2004
intraperitoneal
mouse 		lowest published toxic dose: 1,200 ng/kg Related to Chronic Data: Changes in uterine weight

Liver: Changes in liver weight 		TOXID9 60,249,2001
intraperitoneal
non-mammalian species 		lowest published toxic dose: 2.5 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) TOXID9 72,192,2003
intraperitoneal
rat 		lowest published toxic dose: 150 µg/kg Related to Chronic Data: Changes in uterine weight TXAPA9 14,358,1969
intraperitoneal
rat 		lowest published toxic dose: 100 µg/kg Reproductive: Maternal effects: Uterus, cervix, vagina

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Related to Chronic Data: Changes in uterine weight 		BCPCA6 39,485,1990
intraperitoneal
rat 		lowest published toxic dose: 1 mg/kg Eye: Retinal changes pigmentary deposition, retinitis, other)

Biochemical: Metabolism (intermediary): Other 		EJPHAZ 498,111,2004
parenteral
frog 		lowest published toxic dose: 60.6 µg/kg Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) REPRO* 126,83,2003
parenteral
non-mammalian species 		lowest published toxic dose: 5 mg/kg Liver: Other changes TOXID9 60,35,2001
parenteral
non-mammalian species 		lowest published toxic dose: 0.5 mg/kg Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Other 		TOXID9 60,35,2001
subcutaneous
mouse 		lowest published toxic dose: 1,090 ng/kg Vascular: Other changes

Endocrine: Estrogenic 		JRPFA4 123,235,2002
subcutaneous
mouse 		lowest published toxic dose: 400 mg/kg Behavioral: Fluid intake

Biochemical: Metabolism (intermediary): Other proteins

Related to Chronic Data: Changes in uterine weight 		TOXID9 72,12,2003
subcutaneous
mouse 		lowest published toxic dose: 1 µg/kg Reproductive: Maternal effects: Uterus, cervix, vagina TOXID9 72,134,2003
subcutaneous
mouse 		lowest published toxic dose: 10 µg/kg Reproductive: Maternal effects: Ovaries, fallopian tubes TOXID9 72,135,2003
subcutaneous
mouse 		lowest published toxic dose: 1 µg/kg Related to Chronic Data: Changes in uterine weight

Biochemical: Metabolism (intermediary): Other proteins 		TOLED5 144,257,2003
subcutaneous
mouse 		lowest published toxic dose: 400 mg/kg Related to Chronic Data: Changes in uterine weight TOXID9 72(Supp 1),12,2003
subcutaneous
mouse 		lowest published toxic dose: 60 mg/kg Blood: Change in clotting factors EJPHAZ 510,229,2005
subcutaneous
mouse 		lowest published toxic dose: 7.2 mg/kg Vascular: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Peptidases 		CNREA8 66,4789,2006
subcutaneous
rat 		lethal dose : >300 mg/kg N/R IYKEDH 26,740,1995
subcutaneous
rat 		lowest published toxic dose: 10 µg/kg Related to Chronic Data: Changes in uterine weight TXAPA9 133,313,1995
subcutaneous
rat 		lowest published toxic dose: 50 µg/kg Reproductive: Maternal effects: Uterus, cervix, vagina

Related to Chronic Data: Changes in uterine weight 		JOENAK 85,291,1980
subcutaneous
rat 		lowest published toxic dose: 5 µg/kg Reproductive: Maternal effects: Oogenesis

Reproductive: Maternal effects: Ovaries, fallopian tubes

Biochemical: Metabolism (intermediary): Other proteins 		BIREBV 65,1232,2001
subcutaneous
rat 		lowest published toxic dose: 10 µg/kg Behavioral: Change in motor activity (specific assay)

Behavioral: Change in psychophysiological tests 		PSCHDL 173,139,2004
subcutaneous
rat 		lowest published toxic dose: 25 µg/kg Behavioral: Change in psychophysiological tests NEROEW 28,830,2003
subcutaneous
rat 		lowest published toxic dose: 25 mg/kg Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands BJMRDK 38,487,2005
subcutaneous
rat 		lowest published toxic dose: 40 µg/kg Reproductive: Maternal effects: Uterus, cervix, vagina

Biochemical: Metabolism (intermediary): Other proteins 		JTEHF8 70,171,2007
subcutaneous
rat 		lowest published toxic dose: 40 mg/kg Endocrine: Other changes

Endocrine: Changes in pituitary weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		ALCOH* 9,465,1992
subcutaneous
rat 		lowest published toxic dose: 10 µg/kg Endocrine: Change in LH

Endocrine: Change in gonadotropins

Related to Chronic Data: Changes in uterine weight 		REPRO* 125,597,2003
skin
woman 		lowest published toxic dose: 4 µg/kg/36 hour Kidney, Ureter, and Bladder: Other changes in urine composition

Biochemical: Metabolism (intermediary): Effect on cyclic nucleotides 		EJCPAS (),A56,1999
unreported route
mouse 		lowest published toxic dose: 2,000 ng/kg Reproductive: Maternal effects: Uterus, cervix, vagina TOXID9 60,299,2001
unreported route
mouse 		lowest published toxic dose: 400 µg/kg Reproductive: Maternal effects: Uterus, cervix, vagina

Biochemical: Metabolism (intermediary): Other 		TXCYAC 213,236,2005


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
cattle 		lowest published toxic dose: 0.48 mg/kg/67 day- continuous Reproductive: Maternal effects: Ovaries, fallopian tubes BIREBV 65,581,2001
implant
mouse 		lowest published toxic dose: 252,000 mg/kg/12 week- intermittent Endocrine: Estrogenic

Reproductive: Maternal effects: Uterus, cervix, vagina 		EVHPAZ 105,577,1997
implant
mouse 		lowest published toxic dose: 1,800 mg/kg/90 day- continuous Biochemical: Metabolism (intermediary): Other CNREA8 65,2474,2005
implant
rat 		lowest published toxic dose: 28 µg/kg/7 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina EOGRAL 108,59,2003
implant
rat 		lowest published toxic dose: 420 µg/kg/21 day- continuous Musculoskeletal: Other changes TOXID9 44,354,2005
implant
rat 		lowest published toxic dose: 18.29 mg/kg/6 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in thymus weight 		JPETAB 317,590,2006
implant
rat 		lowest published toxic dose: 25 mg/kg/15 day- continuous Tumorigenic: Active as anti-cancer agent CRNGDP 26,1055,2005
intramuscular
rat 		lowest published toxic dose: 1,740 µg/kg/2 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) 		CBINA8 63,15,1987
intraperitoneal
frog 		lowest published toxic dose: 30 mg/kg/14 day- intermittent Reproductive: Other effects on male

Biochemical: Metabolism (intermediary): Other proteins 		AECTCV 44,247,2003
intraperitoneal
mouse 		lowest published toxic dose: 30 µg/kg/3 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Related to Chronic Data: Changes in uterine weight 		TOLED5 122,89,2001
intraperitoneal
mouse 		lowest published toxic dose: 55.5 mg/kg/5 day- intermittent Reproductive: Maternal effects: Ovaries, fallopian tubes TJADAB 34,29,1986
intraperitoneal
mouse 		lowest published toxic dose: 77.8 mg/kg/14 day- intermittent Endocrine: Effect on menstrual cycle

Reproductive: Maternal effects: Ovaries, fallopian tubes

Related to Chronic Data: Changes in ovarian weight 		REPTED 9,379,1995
intraperitoneal
mouse 		lowest published toxic dose: 11,111.1 µg/kg/2 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina TXAPA9 49,151,1979
intraperitoneal
mouse 		lowest published toxic dose: 1,200 µg/kg/12 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Related to Chronic Data: Changes in uterine weight 		TXAPA9 180,1,2002
intraperitoneal
mouse 		lowest published toxic dose: 30 µg/kg/3 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		TOSCF2 69,354,2002
intraperitoneal
mouse 		lowest published toxic dose: 11.2 µg/kg/14 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Related to Chronic Data: Changes in uterine weight 		ARTODN 78,309,2004
intraperitoneal
mouse 		lowest published toxic dose: 11.2 µg/kg/14 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases ARTODN 78,309,2004
intraperitoneal
non-mammalian species 		lowest published toxic dose: 3 mg/kg/10 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: Ca

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion) 		CBCPAI 139,1,2004
intraperitoneal
rat 		lowest published toxic dose: 750 µg/kg/15 day- intermittent Endocrine: Change in LH

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight 		TOSCF2 44,116,1998
intraperitoneal
rat 		lowest published toxic dose: 40 µg/kg/2 day- intermittent Liver: Other changes

Related to Chronic Data: Changes in uterine weight 		EVHPAZ 102,568,1994
intraperitoneal
rat 		lowest published toxic dose: 60 µg/kg/5 day- intermittent Related to Chronic Data: Changes in uterine weight EVHPAZ 102,568,1994
intraperitoneal
rat 		lowest published toxic dose: 136 mg/kg/8 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct TICEL* 13,369,1981
intraperitoneal
rat 		lowest published toxic dose: 750 mg/kg/3 day- intermittent Behavioral: Convulsions or effect on seizure threshold EURNE* 13,257,2003
intraperitoneal
rat 		lowest published toxic dose: 828 µg/kg/12 week- intermittent Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in uterine weight 		TXCYAC 199,129,2004
intraperitoneal
rat 		lowest published toxic dose: 30 µg/kg/3 day- intermittent Endocrine: Estrogenic

Related to Chronic Data: Changes in uterine weight 		AECTCV 46,454,2004
oral
human 		lowest published toxic dose: 2.352 mg/kg/12 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Kidney, Ureter, and Bladder: Other changes

Biochemical: Metabolism (intermediary): Other proteins 		LIFSAK 72,1279,2003
oral
mouse 		lowest published toxic dose: 47.7 µg/kg/3 day- continuous Endocrine: Estrogenic

Related to Chronic Data: Changes in uterine weight 		JRPFA4 123,235,2002
oral
mouse 		lowest published toxic dose: 150 µg/kg/30 day- intermittent Liver: Other changes

Reproductive: Maternal effects: Uterus, cervix, vagina

Biochemical: Metabolism (intermediary): Other proteins 		BECTA6 71,458,2003
oral
mouse 		lowest published toxic dose: 910 mg/kg/0.5 year- intermittent Endocrine: Other changes

Endocrine: Changes in adrenal weight

Endocrine: Changes in spleen weight 		TOXID9 60,155,2001
oral
mouse 		lowest published toxic dose: 910 mg/kg/0.5 year- intermittent Blood: Changes in spleen

Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOXID9 60,155,2001
oral
mouse 		lowest published toxic dose: 910 mg/kg/0.5 year- intermittent Liver: Other changes

Liver: Changes in liver weight

Endocrine: Other changes 		TOXID9 60,155,2001
oral
mouse 		lowest published toxic dose: 910 mg/kg/0.5 year- intermittent Blood: Changes in spleen

Blood: Other changes 		TOXID9 60,155,2001
oral
mouse 		lowest published toxic dose: 18.2 mg/kg/0.5 year- intermittent Musculoskeletal: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TOXID9 60,155,2001
oral
mouse 		lowest published toxic dose: 910 mg/kg/0.5 year- intermittent Liver: Changes in liver weight TOXID9 60,155,2001
oral
mouse 		lowest published toxic dose: 910 mg/kg/0.5 year- intermittent Endocrine: Changes in spleen weight TOXID9 60,155,2001
oral
mouse 		lowest published toxic dose: 28.5 mg/kg/57 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOXID9 60,156,2001
oral
mouse 		lowest published toxic dose: 91 mg/kg/26 week- intermittent Brain and Coverings: Changes in brain weight

Liver: Changes in liver weight 		TOXID9 60,156,2001
oral
mouse 		lowest published toxic dose: 324 mg/kg/162 day- intermittent Cardiac: Changes in heart weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOXID9 60,156,2001
oral
mouse 		lowest published toxic dose: 81 mg/kg/162 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight 		TOXID9 60,156,2001
oral
rat 		lowest published toxic dose: 45 mg/kg/90 day- continuous Endocrine: Gynecomastia

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Other changes 		TOXID9 42,99,1998
oral
rat 		lowest published toxic dose: 45 mg/kg/90 day- continuous Liver: Changes in liver weight TOSCF2 44,116,1998
oral
rat 		lowest published toxic dose: 225 mg/kg/90 day- continuous Biochemical: Metabolism (intermediary): Lipids including transport TOSCF2 44,116,1998
oral
rat 		lowest published toxic dose: 45 mg/kg/90 day- continuous Endocrine: Changes in pituitary weight

Blood: Normocytic anemia

Blood: Changes in spleen 		TOSCF2 44,116,1998
oral
rat 		lowest published toxic dose: 11.25 mg/kg/90 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOSCF2 44,116,1998
oral
rat 		lowest published toxic dose: 54 mg/kg/90 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight 		TOSCF2 44,155,1998
oral
rat 		lowest published toxic dose: 1.2 mg/kg/3 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina

Related to Chronic Data: Changes in uterine weight 		CRTOEC 14,149,2001
oral
rat 		lowest published toxic dose: 3 mg/kg/15 day- intermittent Endocrine: Change in LH

Endocrine: Change in gonadotropins

Related to Chronic Data: Changes in testicular weight 		JRPFA4 118,29,2000
oral
rat 		lowest published toxic dose: 1.2 mg/kg/3 day- intermittent Related to Chronic Data: Changes in uterine weight TXAPA9 153,12,1998
oral
rat 		lowest published toxic dose: 140 µg/kg/4 day- intermittent Related to Chronic Data: Changes in uterine weight REPTED 17,421,2003
oral
rat 		lowest published toxic dose: 180 mg/kg/4 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina REPTED 17,421,2003
oral
rat 		lowest published toxic dose: 4.2 mg/kg/14 day- intermittent Cardiac: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		EJPHAZ 495,179,2004
oral
rat 		lowest published toxic dose: 20 mg/kg/10 day- intermittent Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXCYAC 195,177,2004
oral
rat 		lowest published toxic dose: 3 mg/kg/5 day- intermittent Related to Chronic Data: Changes in uterine weight TXCYAC 205,123,2004
oral
rat 		lowest published toxic dose: 0.6 mg/kg/3 day- intermittent Endocrine: Estrogenic

Reproductive: Maternal effects: Uterus, cervix, vagina

Related to Chronic Data: Changes in uterine weight 		ARTODN 76,727,2002
oral
rat 		lowest published toxic dose: 1,008 µg/kg/14 day- intermittent Behavioral: Change in psychophysiological tests TOXID9 66,251,2002
oral
rat 		lowest published toxic dose: 149.5 mg/kg/12 week- continuous Endocrine: Change in LH

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in uterine weight 		TXAPA9 214,1,2006
oral
rat 		lowest published toxic dose: 4.2 mg/kg/28 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOSCF2 92,295,2006
oral
rat 		lowest published toxic dose: 15.75 mg/kg/15 week- continuous Kidney, Ureter, and Bladder: Changes in kidney weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOSCF2 92,295,2006
oral
rat 		lowest published toxic dose: 18.9 mg/kg/18 week- continuous Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in ovarian weight 		TOSCF2 92,295,2006
oral
rat 		lowest published toxic dose: 1,008 µg/kg/14 day- intermittent Behavioral: Alteration of classical conditioning

Endocrine: Differential effect of sex or castration on observed toxicity 		JTEHF8 66,2077,2003
oral
rat 		lowest published toxic dose: 8,173 µg/kg/60 day- intermittent Musculoskeletal: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Related to Chronic Data: Changes in uterine weight 		BMECEP 13,4880,2005
oral
woman 		lowest published toxic dose: 1.12 mg/kg/4 week- intermittent Endocrine: Change in gonadotropins

Endocrine: Estrogenic 		JCEMAZ 54,404,1982
oral
woman 		lowest published toxic dose: 0.24 mg/kg/6 day- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		APHRER 37,1610,2003
parenteral
mouse 		lowest published toxic dose: 50,000 µg/kg/5 day- intermittent Reproductive: Maternal effects: Oogenesis

Reproductive: Maternal effects: Ovaries, fallopian tubes 		TJADAB 34,29,1986
subcutaneous
mouse 		lowest published toxic dose: 0.99 µg/kg/3 day- intermittent Endocrine: Estrogenic

Related to Chronic Data: Changes in uterine weight 		FCTOD7 39,1211,2001
subcutaneous
mouse 		lowest published toxic dose: 14.5 mg/kg/5 day- intermittent Endocrine: Changes in thymus weight

Endocrine: Changes in spleen weight 		JTEHD6 60,185,2000
subcutaneous
mouse 		lowest published toxic dose: 69,444 mg/kg/5 day- intermittent Endocrine: Estrogenic

Reproductive: Maternal effects: Uterus, cervix, vagina 		EVHPAZ 105,577,1997
subcutaneous
mouse 		lowest published toxic dose: 170 µg/kg/22 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands 		REPTED 16,123,2002
subcutaneous
mouse 		lowest published toxic dose: 1,500 µg/kg/3 day- intermittent Endocrine: Estrogenic

Nutritional and Gross Metabolic: Other changes

Related to Chronic Data: Changes in uterine weight 		EVHPAZ 109,821,2001
subcutaneous
mouse 		lowest published toxic dose: 7.5 µg/kg/3 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina TOXID9 44,354,2005
subcutaneous
mouse 		lowest published toxic dose: 500 µg/kg/5 day- intermittent Behavioral: Change in psychophysiological tests PSCHDL 179,637,2005
subcutaneous
mouse 		lowest published toxic dose: 600 µg/kg/3 day- intermittent Behavioral: Change in psychophysiological tests PSCHDL 179,637,2005
subcutaneous
mouse 		lowest published toxic dose: 120 mg/kg/3 day- intermittent Endocrine: Estrogenic

Reproductive: Maternal effects: Uterus, cervix, vagina

Related to Chronic Data: Changes in uterine weight 		TXAPA9 209,226,2005
subcutaneous
mouse 		lowest published toxic dose: 0.3 µg/kg/3 day- intermittent Related to Chronic Data: Changes in uterine weight EJPHAZ 510,235,2005
subcutaneous
mouse 		lowest published toxic dose: 1,024 µg/kg/4 week- intermittent Endocrine: Other changes

Immunological Including Allergic: Hypersensitivity delayed (multiple organ involvement)

Related to Chronic Data: Changes in uterine weight 		TOLED5 166,60,2006
subcutaneous
mouse 		lowest published toxic dose: 1,024 µg/kg/4 week- intermittent Immunological Including Allergic: Hypersensitivity delayed (multiple organ involvement) TOLED5 166,60,2006
subcutaneous
mouse 		lowest published toxic dose: 30 µg/kg/3 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina

Related to Chronic Data: Changes in uterine weight 		TIHEEC 20,123,2004
subcutaneous
rat 		lowest published toxic dose: 4,200 µg/kg/12 week- intermittent Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in uterine weight 		YACHDS 20,3899,1992
subcutaneous
rat 		lowest published toxic dose: 0.7 mg/kg/14 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina TOSCF2 54,154,2000
subcutaneous
rat 		lowest published toxic dose: 0.125 mg/kg/25 day- intermittent Reproductive: Maternal effects: Menstrual cycle changes or disorders TOSCF2 54,154,2000
subcutaneous
rat 		lowest published toxic dose: 833.2 µg/kg/2 day- intermittent Endocrine: Change in gonadotropins

Endocrine: Change in LH 		JOENAK 105,211,1985
subcutaneous
rat 		lowest published toxic dose: 111.2 µg/kg/2 day- intermittent Endocrine: Change in LH

Endocrine: Change in gonadotropins

Endocrine: Androgenic 		JOENAK 105,211,1985
subcutaneous
rat 		lowest published toxic dose: 6 µg/kg/3 day- intermittent Endocrine: Estrogenic

Reproductive: Maternal effects: Uterus, cervix, vagina

Related to Chronic Data: Changes in uterine weight 		STEDAM 59,443,1994
subcutaneous
rat 		lowest published toxic dose: 1.2 mg/kg/3 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in uterine weight 		CRTOEC 14,149,2001
subcutaneous
rat 		lowest published toxic dose: 28 µg/kg/28 day- intermittent Related to Chronic Data: Changes in uterine weight PSEBAA 223,288,2000
subcutaneous
rat 		lowest published toxic dose: 2,800 µg/kg/28 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina PSEBAA 223,288,2000
subcutaneous
rat 		lowest published toxic dose: 4,000 µg/kg/15 day- intermittent Endocrine: Change in LH

Endocrine: Effect on menstrual cycle

Endocrine: Estrogenic 		BIREBV 64,1216,2001
subcutaneous
rat 		lowest published toxic dose: 3 µg/kg/3 day- intermittent Endocrine: Estrogenic

Related to Chronic Data: Changes in uterine weight 		EVHPAZ 109,821,2001
subcutaneous
rat 		lowest published toxic dose: 30 µg/kg/3 day- intermittent Endocrine: Estrogenic

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in uterine weight 		EVHPAZ 109,821,2001
subcutaneous
rat 		lowest published toxic dose: 1.26 mg/kg/6 week- intermittent Musculoskeletal: Other changes

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation 		BJMRDK 34,1015,2001
subcutaneous
rat 		lowest published toxic dose: 10,000 µg/kg/10 day- intermittent Reproductive: Maternal effects: Menstrual cycle changes or disorders

Reproductive: Effects on newborn: Physical

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		REPTED 17,283,2003
subcutaneous
rat 		lowest published toxic dose: 10,000 µg/kg/10 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina

Related to Chronic Data: Changes in ovarian weight

Related to Chronic Data: Changes in uterine weight 		REPTED 17,283,2003
subcutaneous
rat 		lowest published toxic dose: 120 µg/kg/3 day- intermittent Reproductive: Maternal effects: Uterus, cervix, vagina REPTED 17,311,2003
subcutaneous
rat 		lowest published toxic dose: 10 mg/kg/7 day- continuous Kidney, Ureter, and Bladder: Other changes in urine composition

Musculoskeletal: Other changes

Biochemical: Metabolism (intermediary): Other proteins 		JPETAB 302,205,2002
subcutaneous
rat 		lowest published toxic dose: 1,120 µg/kg/2 week- intermittent Biochemical: Metabolism (intermediary): Other proteins

Related to Chronic Data: Changes in uterine weight 		NEROEW 23,69,2000
subcutaneous
rat 		lowest published toxic dose: 3 µg/kg/3 day- continuous Related to Chronic Data: Changes in uterine weight EJPHAZ 502,265,2004
subcutaneous
rat 		lowest published toxic dose: 6 µg/kg/3 day- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) EJPHAZ 502,265,2004
subcutaneous
rat 		lowest published toxic dose: 0.6 µg/kg/3 day- continuous Vascular: Structural changes in vessels EJPHAZ 502,265,2004
subcutaneous
rat 		lowest published toxic dose: 0.3 µg/kg/3 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases CMSHAF 50,1167,2003
subcutaneous
rat 		lowest published toxic dose: 0.15 mg/kg/3 day- intermittent Related to Chronic Data: Changes in uterine weight TXCYAC 207,215,2005
subcutaneous
rat 		lowest published toxic dose: 15 mg/kg/6 week- continuous Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		TOXID9 78,307,2004
subcutaneous
rat 		lowest published toxic dose: 59,660 ng/kg/3 day- intermittent Endocrine: Estrogenic

Reproductive: Maternal effects: Uterus, cervix, vagina 		CRTOEC 16,741,2003
subcutaneous
rat 		lowest published toxic dose: 278,413 ng/kg/14 day- intermittent Endocrine: Estrogenic

Reproductive: Maternal effects: Uterus, cervix, vagina

Related to Chronic Data: Changes in uterine weight 		CRTOEC 16,741,2003
subcutaneous
rat 		lowest published toxic dose: 22.5 mg/kg/18 day- intermittent Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Other proteins 		TOLED5 160,196,2006
subcutaneous
rat 		lowest published toxic dose: 8.1 mg/kg/9 day- intermittent Autonomic Nervous System: Beta adrenergic blocker

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		REPTED 22,20,2006
subcutaneous
rat 		lowest published toxic dose: 8.1 mg/kg/9 day- intermittent Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)

Related to Chronic Data: Changes in prostate weight 		REPTED 22,20,2006
subcutaneous
rat 		lowest published toxic dose: 8.1 mg/kg/9 day- intermittent Related to Chronic Data: Changes in testicular weight REPTED 22,20,2006
subcutaneous
rat 		lowest published toxic dose: 0.7 mg/kg/7 day- intermittent Vascular: Structural changes in vessels JPETAB 310,135,2004
subcutaneous
rat 		lowest published toxic dose: 200 µg/kg/5 day- intermittent Blood: Change in clotting factors EJPHAZ 510,229,2005
subcutaneous
rat 		: 0.1 mg/kg/2 day- intermittent Brain and Coverings: Other degenerative changes

Endocrine: Differential effect of sex or castration on observed toxicity 		NETEEC 28,111,2006
subcutaneous
rat 		: 21 mg/kg/21 day- intermittent Vascular: BP lowering not characterized in autonomic section ACPSI* 25,313,2004
subcutaneous
rat 		lowest published toxic dose: 35 µg/kg/7 day- intermittent Endocrine: Change in gonadotropins

Endocrine: Changes in pituitary weight

Related to Chronic Data: Changes in uterine weight 		TXAPA9 217,1,2006
subcutaneous
rat 		lowest published toxic dose: 22.5 mg/kg/18 day- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		TOLED5 160,196,2006
subcutaneous
rat 		lowest published toxic dose: 510 µg/kg/5 week- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		TOLED5 166,276,2006
subcutaneous
rat 		lowest published toxic dose: 350 µg/kg/7 week- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		FCLPH* 18(Suppl 1),86,2004
subcutaneous
rat 		lowest published toxic dose: 5,980 mg/kg/13 day- intermittent Endocrine: Estrogenic

Skin and Appendages: Other: Breast

Tumorigenic: Protects against induction of experimental tumors 		CRNGDP 25,741,2004
subcutaneous
rat 		lowest published toxic dose: 600 µg/kg/5 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) REPTED 22,513,2006
subcutaneous
rat 		lowest published toxic dose: 1,920 µg/kg/16 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) REPTED 22,513,2006
subcutaneous
rabbit 		lowest published toxic dose: 15,582 µg/kg/21 day- intermittent Vascular: Regional or general arteriolar constriction

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Other proteins 		BJMRDK 38,1325,2005
skin
mouse 		lowest published toxic dose: 58.3 µg/kg/3 day- intermittent Related to Chronic Data: Changes in uterine weight MOEND* 10,923,1996
skin
mouse 		lowest published toxic dose: 571.4 µg/kg/3 day- intermittent Endocrine: Estrogenic

Related to Chronic Data: Changes in uterine weight 		JSBBEZ 62,409,1997
skin
mouse 		lowest published toxic dose: 3,000 ng/kg/3 day- continuous Related to Chronic Data: Changes in uterine weight JAPTO* 23,43,2003
skin
mouse 		lowest published toxic dose: 6,000 ng/kg/3 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain JAPTO* 23,43,2003
skin
woman 		lowest published toxic dose: 0.7 mg/kg/5 week- intermittent Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		NEROEW 27,800,2002
unreported route
mouse 		lowest published toxic dose: 1,500 mg/kg/3 day- intermittent Related to Chronic Data: Changes in uterine weight TOXID9 72,255,2003
unreported route
rat 		lowest published toxic dose: 300 mg/kg/15 day- intermittent Kidney, Ureter, and Bladder: Other changes

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands

Biochemical: Metabolism (intermediary): Other 		TOXID9 44,368,2005
unreported route
rat 		lowest published toxic dose: 3.1 mg/kg/31 day- intermittent Related to Chronic Data: Changes in uterine weight TOXID9 60,250,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 21,279,1979
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 6,99,1974
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 72,339,1999
TOXICOLOGY REVIEW
MUREAV 539,77,2003
TOXICOLOGY REVIEW
BJMRDK 36,1143,2003
TOXICOLOGY REVIEW
JJIND8 93,754,2001
TOXICOLOGY REVIEW
BJMRDK 35,271,2002
TOXICOLOGY REVIEW
CMAJAX 168,1001,2003
TOXICOLOGY REVIEW
JJIND8 94,497,2002
TOXICOLOGY REVIEW
SCIEAS 93,754,2001
TOXICOLOGY REVIEW
CRTXB2 32,113,2002
TOXICOLOGY REVIEW
TOLED5 127,225,2002
TOXICOLOGY REVIEW
TOLED5 131,75,2002
TOXICOLOGY REVIEW
TOLED5 140-141,287,2003
TOXICOLOGY REVIEW
MUREAV 526,85,2003
TOXICOLOGY REVIEW
CRTXB2 33,305,2003
TOXICOLOGY REVIEW
TPHSDY 23,527,2002
TOXICOLOGY REVIEW
MUTAEX 15,431,2000
TOXICOLOGY REVIEW
TPHSDY 24,261,2003
TOXICOLOGY REVIEW
TPHSDY 24,479,2003
TOXICOLOGY REVIEW
JPETAB 308,403,2004
TOXICOLOGY REVIEW
NETOX* 26,905,2005
TOXICOLOGY REVIEW
NETOX* 26,893,2005
TOXICOLOGY REVIEW
BPCEM* 16,105,2002
TOXICOLOGY REVIEW
BPCEM* 16,105,2002
TOXICOLOGY REVIEW
MUREAV 613,76,2006
TOXICOLOGY REVIEW
JJATDK 26,191,2006
TOXICOLOGY REVIEW
ENTOX* -,244,2005
TOXICOLOGY REVIEW
MUREAV 584,1,2005
TOXICOLOGY REVIEW
BJPCBM 144,161,2005
TOXICOLOGY REVIEW
MUREAV 651,1,2008
TOXICOLOGY REVIEW
ARPTDI 47,680,2007
TOXICOLOGY REVIEW
MUTAEX 19,169,2004
TOXICOLOGY REVIEW
REPTED 22,291,2006
TOXICOLOGY REVIEW
MUREAV 540,165,2003
TOXICOLOGY REVIEW
MUTAEX 19,423,2004
TOXICOLOGY REVIEW
JTPAE7 17,69,2004
TOXICOLOGY REVIEW
JTPAE7 19,57,2006
TOXICOLOGY REVIEW
MUREAV 672,10,2009
TOXICOLOGY REVIEW
MUREAV 672,17,2009
TOXICOLOGY REVIEW
HTOPA* 1,501,2002
TOXICOLOGY REVIEW
HTOPA* 1,501,2002
TOXICOLOGY REVIEW
MUREAV 681,3,2009


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80407;
Number of Industries 1;
Total Number of Facilities 68;
Number of Occupations 6;
Total Number of Employees Exposed 2,770
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80407;
Number of Industries 4;
Total Number of Facilities 151;
Number of Occupations 5;
Total Number of Employees Exposed 9,083;
Total Number of Female Employees Exposed 8,217


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; Sperm morphology-rat
EPA GENETOX PROGRAM 1988, Positive: Sperm morphology-mouse
Used as a drug for the treatment of symptoms of the climacteric
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen


REFERENCES:

CODEN
REFERENCE
13OPAL "Control of Ovulation, Proceedings of the Conference, Dedham, MA, 1960," Villee, C.A., ed., Oxford, UK, Pergamon Press Ltd., 1961
15QWAW "Agents Affecting Fertility, a Symposium, 1964," Austin, C.R., and J.S. Perry, eds., Boston, Little, Brown & Co., 1965
85GRAA "The Control of Fertility," Pincus, G., New York, Academic Press, 1965
ACEDAB Acta Endocrinologica, Supplementum (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) No.1- 1948-
ACHCBO Acta Histochemica et Cytochemica. (Japan Soc. of Histochemistry and Cytochemistry, Dept. Anatomy, Faculty of Medicine, Kyoto Univ., Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1968-
ACPSI* Acta pharmacologica Sinica (Shanghai : Shanghai Institute of Materia Medica : Chinese Academy of Science ; Carlton, VIC, Australia : Blackwell Publishing Asia, 2005) V.21- 2000-
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
ALCOH*
ANDRDQ Andrologia. (Grosse Verlag GmbH, Kurfuerstenstr. 112-113, D-1000 Berlin 30, Fed. Rep. Ger.) V.6- 1974-
APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992-
ARPTDI Annual Review of Pharmacology and Toxicology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.16- 1976-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BBACAQ Biochimica et Biophysica Acta. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1947-
BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
BIREBV Biology of Reproduction. (Soc. for the Study of Reproduction, 309 W. Clark St., Champaign, IL 61820) V.1- 1969-
BJCAAI British Journal of Cancer. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1947-
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981-
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968-
BMECEP Biorganic & Medicinal Chemistry. (Elsevier Science, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, UK) V.1 1993-
BPCEM* Best Practice & Research Clinical Endocrinology and Metabolism (Elsevier Ltd.) V.13- 1999-
BSBSAS Boletin de la Sociedad de Biologia de Santiago de Chile. (Santiago, Chile) V.1-12, 1943-55. Discontinued.
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CANCAR Cancer (Philadelphia). (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1948-
CBCPAI Comparative Biochemistry and Physiology. (Elmsford, NY) V.1-37, 1960-70. For publisher information, see CBPBB8.
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970-
CELLB5 Cell (Cambridge, Mass.). (MIT Press, 28 Carleton St., Cambridge, MA 02142) V.1- 1974-
CMAJAX Canadian Medical Association Journal. (Canadian Medical Assoc., POB 8650, Ottawa, ON K1G 0G8, Canada) V.1- 1911-
CMSHAF Chemosphere. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1972-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
CRTOEC Chemical Research in Toxicology. (American Chemical Soc., Distribution Office Dept. 223, POB 57/36, West End Station, Washington, DC 20037) V.1- 1988-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
CTSRCS Cell and Tissue Research. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.148- 1974-
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980-
DANKAS Doklady Akademii Nauk SSSR. Proceedings of the Academy of Sciences of the USSR. For English translation, see DBIOAM and DKBSAS. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1933-
DEBIAO Developmental Biology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
EJCAAH European Journal of Cancer (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V. 1- 1965-
EJCPAS European Journal of Clinical Pharmacology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1970-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
EOGRAL European Journal of Obstetrics, Gynecology and Reproductive Biology. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.3- 1973-
EURNE* European Neuropsychopharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Nov.1990-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
EXBME* Experimental biology and medicine (Maywood, N.J.) (Society for Experimental Biology and Medicine, Maywood, NJ : The Society) V. 226- 2001-
EXMDA4 International Congress Series--Excerpta Medica. (Excerpta Medica, Inc., POB 3085, Princeton, NJ 08540) No.1- 1952-
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEBLAL FEBS Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1968-
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950-
HTOPA*
ICDBEO In Vitro Cellular and Developmental Biology. (Tissue Culture Assoc., 19110 Montgomery Village Ave., Suite 300, Gaithersburg, MD 20879) V.21- 1985-
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
JANSAG Journal of Animal Science. (American Soc. of Animal Science, 309 W. Clark St., Champaign, IL 61820) V.1- 1942-
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JCEMAZ Journal of Clinical Endocrinology and Metabolism. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.12- 1952-
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
JSBBEZ Journal of Steroid Biochemistry and Molecular Biology. (Pergamon Press, c/o Elsevier Science, POB 945, New York, NY 10159) V.37- 1990-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
JTEHF8 Journal of Toxicology and Environmental Health, Part A. (Taylor & Francis, 47 Runway Rd., Suite G, Levittown, PA 19057) V.53- 1998-
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
LIFSAK Life Sciences. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1-8, 1962-69; V.14- 1974-
MOCAT* Molecular Cancer Therapeutics (Philadelphia, PA : American Association for Cancer Research) V.1- 2001-
MOEND* Molecular endocrinology. (Baltimore, MD: Endocrine Society) V.1- 1987-
MOPMA3 Molecular Pharmacology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1965-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NAGZAC Nagasaki Igakkai Zasshi. Journal of Nagasaki Medical Association. (Nagasaki Igakkai, c/o Nagasaki Daigaku Igakubu, 12-4 Sakamoto-machi, Nagasaki 852, Japan) V.1- 1923-
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NATWAY Naturwissenschaften. (Springer-Verlag, Heidelberger Platz 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.1- 1913-
NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987-
NETEEC Neurotoxicology and Teratology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.9- 1987-
NETOX* NeuroToxicology (Amsterdam : Elsevier Science) V.1- 1979-
NFGZAD Nippon Funin Gakkai Zasshi. Japanese Journal of Fertility and Sterility. (Nippon Funin Gakkai, 1-1 Sadohara-cho, Ichigaya, Shinjuku-ku, Toyko 162, Japan) V.1- 1956-
NIGHAE Archiv fuer Japanische Chirurgie. (Nippon Geka Hokan Henshushitsu, c/o Kyoto Daigaku Igakubu Geka Seikei Geka Kyoshitsu, 54 Kawara- machi, Shogoin, Sakyo-ku, Kyoto 606, Japan) V.1- 1924-
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
PBPSDY Pharmacological and Biochemical Properties of Drug Substances. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.1- 1977-
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
RCBIAS Revue Canadienne de Biologie. (Montreal, Quebec, Canada) V.1-40, 1942-81.
RCOCB8 Research Communications in Chemical Pathology and Pharmacology. (PJD Pub. Ltd., P.O. Box 966, Westbury, NY 11590) V.1- 1970-
REEBB3 Revue Europeenne d'Etudes Cliniques et Biologiques. European Journal of Clinical and Biological Research. (Paris, France) V.15-17, 1970-72. For publisher information, see BIMDB3.
REPRO*
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
STEDAM Steroids. (Holden-Day Inc., 4432 Telegraph Ave., Oakland, CA 94609) V.1- 1963-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TICEL* Tissue & cell (Edinburgh, Oliver & Boyd) V.1- 1969-
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
YACHDS Yakuri to Chiryo. Pharmacology and Therapeutics. (Raifu Saiensu Shuppan K.K., 2-5-13, Yaesu, Chuo-ku, Tokyo 104, Japan) V.1- 1972-

Used as a drug for the treatment of symptoms of the climacteric

NIOSH PROFILE (ESTROGENS and ANDROGENS), SRC, 12/79

FDA-over the counter and proprietary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Hormone
   Natural Product

 Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us