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Erythromycin, stearate (salt)

RTECS #: KF5785000

CAS #: 643-22-1

UPDATE: July 2002 MW: 1,018.59 MF: C37H67NO13•C18H36O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Bristamycin
  2. Dowmycin E
  3. Erypar
  4. Erythrocin stearate
  5. Erythromycin stearate
  6. Erythromycin stearic acid salt
  7. Erythromycin, octadecanoate (salt)
  1. Ethril
  2. Gallimycin
  3. NCI - C55674
  4. Pfizer - E
  5. Qidmycin
  6. SK - Erythromycin


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 413 mg/kg N/R NIIRDN -,211,1990
oral
mouse 		lethal dose (50 percent kill): 3,112 mg/kg N/R NIIRDN -,211,1990
oral
woman 		lowest published toxic dose: 60 mg/kg Gastrointestinal: Changes in structure or function of exocrine pancreas

Gastrointestinal: Nausea or vomiting

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		JTCTDW 34,93,1996
subcutaneous
mouse 		lethal dose (50 percent kill): >2,500 mg/kg N/R NIIRDN -,211,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 71 gm/kg/14 day- continuous Behavioral: Food intake (animal)

Gastrointestinal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-338,1988
oral
rat 		lowest published toxic dose: 13,037 mg/kg/14 day- continuous Behavioral: Food intake (animal)

Gastrointestinal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTPTR* NTP-TR-338,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0726;
Number of Industries 2;
Total Number of Facilities 592;
Number of Occupations 2;
Total Number of Employees Exposed 1,977
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0726;
Number of Industries 1;
Total Number of Facilities 78;
Number of Occupations 1;
Total Number of Employees Exposed 1,108;
Total Number of Female Employees Exposed 615


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
NCI Carcinogenesis Studies (feed);no evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-

FDA-proprietary drug

RTECS Compound Description:
   Tumorigen
   Human Data

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