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Ephedrine, L - ( - ) -

RTECS #: KB0700000

CAS #: 299-42-3

UPDATE: May 2008 MW: 165.26 MF: C10H15NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. ( - ) - alpha - (1 - Methylaminoethyl) benzyl alcohol
  2. 1 - Hydroxy - 2 - methylamino - 1 - phenylpropane
  3. 1 - Phenyl - 2 - methylaminopropanol
  4. Benzenemethanol, alpha - (1 - (methylamino) ethyl) - , (R - (R*,S*) ) -
  5. Biophedrin
  6. Efedrin
  7. Ephedrin
  8. Ephedrine
  9. Ephedrosan
  1. Ephedrotal
  2. L ( - ) - Ephedrine
  3. L - Ephedrine
  4. Norephedrine, N - methyl -
  5. Xenadrine
  6. alpha - Hydroxy - beta - methyl amine propylbenzene
  7. l - 2 - Methylamino - 1 - phenylpropanol
  8. l - Ephedrine
  9. l - alpha - (1 - Methylaminoethyl) benzyl alcohol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 50 mg/kg (9 day pregnant) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system TJADAB 34,469,1986


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rabbit 		lowest published lethal dose: 340 mg/kg Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes 		AEPPAE 120,189,1927
intraperitoneal
mammal (species unspecified) 		lethal dose (50 percent kill): 247 mg/kg N/R TOVEFN (1),14,2001
intraperitoneal
mouse 		lethal dose (50 percent kill): 350 mg/kg Behavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Body temperature decrease 		PCJOAU 3,203,1969
intraperitoneal
mouse 		lowest published lethal dose: 13 mg/kg N/R TOLED5 150,97,2004
intraperitoneal
rat 		lowest published lethal dose: 150 mg/kg N/R AEPPAE 195,647,1940
intraperitoneal
rat 		lowest published toxic dose: 5 mg/kg Cardiac: Other changes FATOAO 50,41,1987
intraperitoneal
rabbit 		lowest published lethal dose: 310 mg/kg Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes 		AEPPAE 120,189,1927
intravenous
cat 		lowest published lethal dose: 60 mg/kg N/R AEPPAE 120,189,1927
intravenous
dog 		lowest published lethal dose: 70 mg/kg N/R AEPPAE 120,189,1927
intravenous
mouse 		lethal dose (50 percent kill): 74 mg/kg Behavioral: Change in motor activity (specific assay) APTOA6 38,474,1976
intravenous
mouse 		lowest published lethal dose: 74 mg/kg N/R TOLED5 150,97,2004
intravenous
rat 		lowest published lethal dose: 130 mg/kg N/R AEPPAE 120,189,1927
intravenous
rat 		lowest published toxic dose: 1 mg/kg Vascular: BP elevation not characterized in autonomic section JPETAB 316,95,2006
intravenous
rabbit 		lowest published lethal dose: 50 mg/kg Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes 		AEPPAE 120,189,1927
oral
wild bird 		lethal dose (50 percent kill): 562 mg/kg N/R AECTCV 12,355,1983
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 1,508 mg/kg N/R TOVEFN (1),14,2001
oral
mouse 		lethal dose (50 percent kill): 689 mg/kg N/R JJTOEX 4,143,1991
oral
mouse 		lowest published lethal dose: 689 mg/kg N/R TOLED5 150,97,2004
oral
rat 		lethal dose (50 percent kill): 600 mg/kg N/R 27ZQAG -,341,1972
oral
rat 		lowest published lethal dose: 600 mg/kg N/R TOLED5 150,97,2004
oral
rabbit 		lowest published lethal dose: 590 mg/kg Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes 		AEPPAE 120,189,1927
oral
woman 		lowest published toxic dose: 10 mg/kg Cardiac: EKG changes not diagnostic of above

Cardiac: Pulse rate increased without fall in BP

Gastrointestinal: Nausea or vomiting 		JTCTDW 41,849,2003
parenteral
frog 		lowest published lethal dose: 530 mg/kg N/R AEPPAE 120,189,1927
parenteral
mouse 		lethal dose (50 percent kill): 170 mg/kg N/R AEPPAE 195,647,1940
subcutaneous
guinea pig 		lethal dose (50 percent kill): 420 mg/kg N/R AEPPAE 169,114,1933
subcutaneous
mouse 		lethal dose (50 percent kill): 132 mg/kg N/R ARZNAD 3,328,1953
subcutaneous
mouse 		lowest published lethal dose: 600 mg/kg N/R TOLED5 150,97,2004
subcutaneous
rat 		lethal dose (50 percent kill): 300 mg/kg N/R AIPTAK 68,339,1942
subcutaneous
rat 		lowest published toxic dose: 100 mg/kg Brain and Coverings: Other degenerative changes

Nutritional and Gross Metabolic: Body temperature increase 		TOLED5 125,151,2001
subcutaneous
rat 		lowest published lethal dose: 320 mg/kg N/R TOLED5 150,97,2004
subcutaneous
rabbit 		lowest published lethal dose: 320 mg/kg Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes 		AEPPAE 120,189,1927
unreported route
man 		lowest published lethal dose: 9 mg/kg N/R 85DCAI 2,73,1970
unreported route
mouse 		lowest published lethal dose: 600 mg/kg Autonomic Nervous System: Sympathomimetic AEPPAE 153,161,1930


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
CTOXAO 12,1,1978
TOXICOLOGY REVIEW
PISDDJ 5(3-6),-,1977
TOXICOLOGY REVIEW
MUREAV 488,151,2001
TOXICOLOGY REVIEW
PCVDI* 47,217,2005
TOXICOLOGY REVIEW
ENTOX* -,223,2005
TOXICOLOGY REVIEW
ENTOX* -,69,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84541;
Number of Industries 3;
Total Number of Facilities 256;
Number of Occupations 8;
Total Number of Employees Exposed 12,900
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84541;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 1;
Total Number of Employees Exposed 103;
Total Number of Female Employees Exposed 52


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972
85DCAI "Poisoning; Toxicology, Symptoms, Treatments," 2nd ed., Arena, J.M., Springfield, IL, C.C. Thomas, 1970
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
JJTOEX Japanese Journal of Toxicology. (Yakugyo Jihosha, Hokushin Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo, 101, Japan) V.1- 1988-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967-
PCVDI* Progress in Cardiovascular Diseases (Elsevier Inc.) V.10- 1967-
PISDDJ Pacific Information Service on Street Drugs. (J.K. Brown, School of Pharmacy, Univ. of the Pacific, Stockton, CA 95211) V.1- 1972(?)-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown

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RTECS Compound Description:
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   Reproductive Effector
   Human Data
   Natural Product

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