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Ephedrine sulfate (2:1) (salt) , ( - ) -

RTECS #: KB2625000

CAS #: 134-72-5

UPDATE: February 2008 MW: 428.60 MF: C20H30N2O2•H2O4S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 1 - Phenyl - 2 - methylamine - propanol - 1 - sulfate
  2. 1 - alpha - (1 - (Methylamino) ethyl) benzyl alcohol sulfate
  3. Ephedrine sulfate
  1. Isofedrol
  2. NCI - C55652
  3. l - Ephedrine sulfate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage rat liver 3 mmol/L MUREAV 368,59,1996


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rabbit 		lowest published lethal dose: 340 mg/kg Eye: Mydriasis (pupilliary dilation)

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		JPETAB 27,61,1926
intraperitoneal
mouse 		lethal dose (50 percent kill): 270 mg/kg Behavioral: Straub Tail

Gastrointestinal: Changes in structure or function of salivary glands

Skin and Appendages: Other: Hair 		TXAPA9 15,304,1969
intraperitoneal
rabbit 		lowest published lethal dose: 310 mg/kg Eye: Mydriasis (pupilliary dilation)

Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold 		JPETAB 27,61,1926
intravenous
cat 		lowest published lethal dose: 75 mg/kg Eye: Mydriasis (pupilliary dilation)

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Nausea or vomiting 		JPETAB 27,61,1926
intravenous
dog 		lowest published lethal dose: 70 mg/kg Eye: Mydriasis (pupilliary dilation)

Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Respiratory stimulation 		JPETAB 27,61,1926
intravenous
human 		lowest published toxic dose: 1 mg/kg Cardiac: Pulse rate increased without fall in BP

Vascular: BP elevation not characterized in autonomic section 		AEPPAE 120,189,1927
intravenous
mouse 		lowest published toxic dose: 10 mg/kg Cardiac: Change in rate

Vascular: BP elevation not characterized in autonomic section 		BJPCBM 150,29,2007
intravenous
rat 		lethal dose (50 percent kill): 102 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes 		JPETAB 94,150,1948
intravenous
rabbit 		lethal dose (50 percent kill): 73 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes 		JPETAB 94,150,1948
oral
mouse 		lethal dose (50 percent kill): 812 mg/kg Olfaction: Other olfaction effects

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia 		NTPTR* NTP-TR-307,1986
oral
rat 		lethal dose (50 percent kill): 404 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes 		JPETAB 94,150,1948
oral
rabbit 		lethal dose (50 percent kill): 825 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes 		JPETAB 94,150,1948
parenteral
frog 		lowest published lethal dose: 530 mg/kg Behavioral: Muscle weakness

Behavioral: Ataxia 		JPETAB 27,61,1926
subcutaneous
guinea pig 		lowest published lethal dose: 425 mg/kg Eye: Mydriasis (pupilliary dilation)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia 		JPETAB 27,61,1926
subcutaneous
rat 		lethal dose (50 percent kill): 318 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes 		JPETAB 94,150,1948
subcutaneous
rabbit 		lethal dose (50 percent kill): 383 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Other changes 		JPETAB 94,150,1948


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 8,120 mg/kg/14 day- continuous Blood: Other changes NTPTR* NTP-TR-307,1986
oral
mouse 		lowest published toxic dose: 91 gm/kg/13 week- continuous Blood: Other changes NTPTR* NTP-TR-307,1986
oral
rat 		lowest published toxic dose: 18,200 mg/kg/13 week- continuous Cardiac: Changes in heart weight

Endocrine: Changes in adrenal weight 		NTPTR* NTP-TR-307,1986
oral
rat 		lowest published toxic dose: 1,050 mg/kg/14 day- continuous Behavioral: Excitement

Behavioral: Food intake (animal)

Skin and Appendages: Other: Hair 		NTPTR* NTP-TR-307,1986


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84417;
Number of Industries 4;
Total Number of Facilities 2,470;
Number of Occupations 9;
Total Number of Employees Exposed 9,457
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84417;
Number of Industries 1;
Total Number of Facilities 233;
Number of Occupations 5;
Total Number of Employees Exposed 5,373;
Total Number of Female Employees Exposed 3,199


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);no evidence:mouse,rat


REFERENCES:

CODEN
REFERENCE
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

FDA-over the counter drug

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Human Data

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