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Dodecane

RTECS #: JR2125000

CAS #: 112-40-3

UPDATE: May 2008 MW: 170.38 MF: C12H26


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Adakane 12
  2. Ba 51 - 090453
  3. Bihexyl
  1. Dihexyl
  2. n - Dodecan (German)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
pig 		1,200 µL/4 day- intermittent mild TOPADD 33,258,2005
skin
rat 		300 µL/4 day open irritation test moderate TIHEEC 20,109,2004
skin
rabbit 		0.5 mL/24 hour moderate ETOPFR 16,153,2004


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 11 gm/kg/22 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		TXAPA9 9,70,1966


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): >142 ppm/8 hour N/R PHTOEH 62,259,1988
intravenous
mouse 		lowest published lethal dose: 2,672 mg/kg Behavioral: Altered sleep time (including change in righting reflex) APTOA6 37,56,1975
skin
rabbit 		lowest published toxic dose: 0.3 mL/kg/24 hour Vascular: Measurement of regional blood flow ETOPFR 16,153,2004


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rat 		lowest published toxic dose: 1,200 µL/kg/4 day- intermittent Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation TIHEEC 20,109,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
ZKKOBW 78,99,1972
TOXICOLOGY REVIEW
PAASAH 54,171,1959
TOXICOLOGY REVIEW
TOLED5 127,111,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - SWEDEN time-weighted average 350 mg/m3;
short term exposure limit 500 mg/m3, JUN2005


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83924;
Number of Industries 1;
Total Number of Facilities 12;
Number of Occupations 1;
Total Number of Employees Exposed 12
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83924;
Number of Industries 2;
Total Number of Facilities 96;
Number of Occupations 5;
Total Number of Employees Exposed 5,451;
Total Number of Female Employees Exposed 356


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
PAASAH Publication of the American Association for the Advancement of Science. (Washington, DC) No.1-94, 1934-73. Discontinued.
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
TIHEEC Toxicology and Industrial Health. (Princeton Scientific Pub. Co., POB 2155, Princeton, NJ 08540) V.1- 1985-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
ZKKOBW Zeitschrift fuer Krebsforschung und Klinische Onkologie. (Berlin, Fed. Rep. Ger.) V.76-92, 1971-78. For publisher information, see JCROD7.

RTECS Compound Description:
   Tumorigen
   Primary Irritant

Click Here for Additional Information about RTECS

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