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1,2 - Dithiolane - 3 - valeric acid

RTECS #: JP1190000

CAS #: 62-46-4

UPDATE: November 2008 MW: 206.34 MF: C8H14O2S2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. REFERENCES:

SYNONYMS:

  1. 5 - (1,2 - Dithiolan - 3 - yl) valeric acid
  2. 6,8 - Dithiooctanoic acid
  3. 6,8 - Thioctic acid
  4. 6,8 - Thiotic acid
  5. 6 - Thioctic acid
  6. 6 - Thiotic acid
  7. Acetate - replacing factor
  8. Biletan
  9. Heparlipon
  10. Lipoic acid
  11. Liposan
  12. Lipothion
  1. Thioctacid
  2. Thioctic acid
  3. Thioctidase
  4. Thioctsan
  5. Thioktsaeure (German)
  6. Thiooctanoic acid
  7. Tioctacid
  8. Tioctidasi
  9. Tioctidasi acetate replacing factor
  10. alpha - Lipoic acid
  11. alpha - Liponic acid
  12. alpha - Liponsaeure (German)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
rat 		lowest published toxic dose: 480 mg/kg (30 day male) Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands NYKZAU 68,265,1972


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 160 mg/kg N/R NIIRDN 6,454,1982
intraperitoneal
mouse 		lowest published toxic dose: 25 mg/kg Liver: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TOPADD 32,527,2004
intraperitoneal
rat 		lethal dose (50 percent kill): 200 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression 		NYKZAU 68,265,1972
intravenous
mouse 		lethal dose (50 percent kill): 197 mg/kg N/R NYKZAU 60,278,1964
intravenous
rat 		lethal dose (50 percent kill): 180 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression 		NYKZAU 68,265,1972
intravenous
rat 		lowest published toxic dose: 60 mg/kg Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Other proteins 		JPHPH* 58,541,2007
oral
human 		lowest published toxic dose: 0.83 mg/kg Blood: Change in clotting factors FATOAO 53,47,1990
oral
mouse 		lethal dose (50 percent kill): 502 mg/kg N/R ARTODN 41,79,1978
oral
rat 		lethal dose (50 percent kill): 1,130 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression 		NYKZAU 68,265,1972
oral
rat 		lowest published toxic dose: 100 mg/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		TXCYAC 243,261,2008
subcutaneous
mouse 		lethal dose (50 percent kill): 200 mg/kg N/R NIIRDN 6,454,1982
subcutaneous
rat 		lethal dose (50 percent kill): 230 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression 		NYKZAU 68,265,1972


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 50 mg/kg/5 day- intermittent Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes

Biochemical: Metabolism (intermediary): Other proteins 		TXCYAC 177,187,2002
oral
human 		lowest published toxic dose: 543.2 mg/kg/8 week- intermittent Gastrointestinal: Nausea or vomiting

Gastrointestinal: Other changes 		JDUCO* 18,79,2004
oral
human 		lowest published toxic dose: 240.8 mg/kg/4 week- intermittent Nutritional and Gross Metabolic: Conditioned vitamin deficiency EJCPAS (),A52,1999
oral
rat 		lowest published toxic dose: 1,000 mg/kg/10 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		JAPTO* 24,21,2004
oral
rat 		: 250 mg/kg/10 day- intermittent Cardiac: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport 		EJPHAZ 543,92,2006
oral
rat 		lowest published toxic dose: 175 mg/kg/7 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		TXCYAC 243,261,2008


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
CTOXAO 40,715,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 5 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9998;
Number of Industries 2;
Total Number of Facilities 138;
Number of Occupations 2;
Total Number of Employees Exposed 429;
Total Number of Female Employees Exposed 141


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
EJCPAS European Journal of Clinical Pharmacology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1970-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JDUCO* Journal of Diabetes and Its Complications (Elsevier) V.6- 1992-
JPHPH*
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944-
TOPADD Toxicologic Pathology. (c/o Dr. F.A. de la Iglesia, Warner-Lambert Co., Pharmaceutical Research Div., POB 1047, Ann Arbor, MI 48106) V.6(3/4)- 1978-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

RTECS Compound Description:
   Drug
   Reproductive Effector
   Human Data
   Natural Product

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