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Dimethylamine, hydrochloride

RTECS #: IQ0220000

CAS #: 506-59-2

UPDATE: January 1997 MW: 81.56 MF: C2H7N•ClH


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Dimethylammonium chloride
  2. Hydrochloric acid dimethylamine
  1. Methanamine, N - methyl - , hydrochloride (9CI)
  2. N - Methylmethanamine hydrochloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 3,825 mg/kg (1-17 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) JTEHD6 32,319,1991


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 12 gm/kg/1 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma

Liver: Tumors 		GISAAA 44(8),15,1979


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,570 mg/kg Lung, Thorax, or Respiration: Respiratory stimulation JJPAAZ 17,475,1967
intravenous
mouse 		lethal dose (50 percent kill): 1,210 mg/kg N/R AIPTAK 112,36,1957
oral
guinea pig 		lethal dose (50 percent kill): 1,600 mg/kg N/R GISAAA 32(6),12,1967
oral
mouse 		lethal dose (50 percent kill): 8,100 mg/kg N/R GISAAA 32(6),12,1967
oral
rat 		lethal dose (50 percent kill): 1,070 mg/kg N/R GISAAA 32(6),12,1967
oral
rabbit 		lethal dose (50 percent kill): 1,600 mg/kg N/R GISAAA 32(6),12,1967
subcutaneous
mouse 		lethal dose (50 percent kill): 2 gm/kg N/R AIPTAK 112,36,1957


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M2704;
Number of Industries 3;
Total Number of Facilities 50;
Number of Occupations 3;
Total Number of Employees Exposed 74
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M2704;
Number of Industries 9;
Total Number of Facilities 172;
Number of Occupations 10;
Total Number of Employees Exposed 3,429;
Total Number of Female Employees Exposed 2,153


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: In vitro cytogenetics-nonhuman
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-forward mutation
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-

Used as a chemical intermediate

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

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