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Digoxin

RTECS #: IH6125000

CAS #: 20830-75-5

UPDATE: May 2009 MW: 781.05 MF: C41H64O14


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Chloroformic digitalin
  2. Cordioxil
  3. Davoxin
  4. Digacin
  5. Digitalis glycoside
  6. Digoksyna (Polish)
  7. Digosin
  8. Digoxigenin - tridigitoxosid (German)
  1. Digoxine
  2. Dilanacin
  3. Homolle's digitalin
  4. Lanicor
  5. Lanocardin
  6. Lanoxin
  7. Rougoxin
  8. SK - Digoxin


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
domestic animal 		lowest published toxic dose: 810 µg/kg (1-18 week pregnant) Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) AJOGAH 121,1100,1975


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
mouse 		lethal dose (50 percent kill): 124 µg/kg Behavioral: Convulsions or effect on seizure threshold PLRCAT 6,417,1974
intraduodenal
cat 		lowest published lethal dose: 441 µg/kg N/R ARZNAD 20,1765,1970
intraduodenal
guinea pig 		lethal dose (50 percent kill): 3,200 µg/kg Cardiac: Cardiomyopathy including infarction

Cardiac: Arrythmias (indlucing changes in conduction) 		ARZNAD 21,225,1971
intraduodenal
pig 		lowest published lethal dose: 1,580 µg/kg N/R ARZNAD 20,229,1970
intramuscular
guinea pig 		lethal dose (50 percent kill): 630 µg/kg N/R NIIRDN 6,316,1982
intramuscular
infant 		lowest published toxic dose: 0.17 mg/kg Cardiac: Change in rate

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Respiratory obstruction 		JTCTDW 42,729,2004
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 800 µg/kg N/R OYYAA2 7,373,1973
intraperitoneal
mouse 		lethal dose (50 percent kill): 3,964 µg/kg N/R CHTHBK 16,371,1971
intraperitoneal
rat 		lethal dose (50 percent kill): 4 mg/kg N/R JDGRAX 17,247,1987
intravenous
cat 		lowest published lethal dose: 159 µg/kg N/R ARZNAD 19,657,1969
intravenous
dog 		lowest published lethal dose: 200 µg/kg N/R CRSBAW 109,279,1932
intravenous
dog 		lowest published lethal dose: 60 µg/kg Cardiac: Arrythmias (indlucing changes in conduction)

Cardiac: Change in force of contraction

Cardiac: Change in rate 		JPETAB 303,592,2002
intravenous
guinea pig 		lowest published lethal dose: 468 µg/kg Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes 		AIPTAK 153,436,1965
intravenous
guinea pig 		lowest published toxic dose: 0.32 mg/kg Cardiac: Change in force of contraction JPETAB 303,592,2002
intravenous
guinea pig 		lowest published lethal dose: 1.07 mg/kg Cardiac: Arrythmias (indlucing changes in conduction)

Cardiac: Change in force of contraction 		JPETAB 303,592,2002
intravenous
guinea pig 		lowest published toxic dose: 240.4 µg/kg Cardiac: Cardiomyopathy including infarction

Cardiac: Arrythmias (indlucing changes in conduction)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Proteases 		EJPHAZ 566,34,2007
intravenous
human 		lowest published toxic dose: 0.17 mg/kg/1 hour Vascular: Regional or general arteriolar or venous dilation

Vascular: Measurement of regional blood flow

Vascular: Other changes 		CEXPB9 28,381,2001
intravenous
infant 		lowest published lethal dose: 200 µg/kg Cardiac: Pulse rate decreased with fall in BP PEDIAU 77,848,1986
intravenous
infant 		lowest published toxic dose: 50 µg/kg Cardiac: Pulse rate decreased with fall in BP AFPYAE 34(1),137,1986
intravenous
mouse 		lethal dose (50 percent kill): 7,670 µg/kg N/R PLRCAT 6,417,1974
intravenous
pigeon 		lowest published lethal dose: 337 µg/kg Cardiac: Arrythmias (indlucing changes in conduction)

Cardiac: Change in rate

Gastrointestinal: Nausea or vomiting 		AIPTAK 126,412,1960
intravenous
pig 		lowest published lethal dose: 230 µg/kg N/R ARZNAD 20,229,1970
intravenous
pig 		lowest published toxic dose: 0.125 mg/kg Cardiac: EKG changes not diagnostic of above

Cardiac: Change in rate 		JTCTDW 42,337,2004
intravenous
rat 		lethal dose (50 percent kill): 25 mg/kg N/R AIPTAK 155,165,1965
intravenous
rat 		lethal dose (80 percent kill): 555.6 mg/kg/30 minute N/R TXCYAC 224,238,2006
intravenous
rat 		lowest published toxic dose: 92.6 mg/kg/5 minute Cardiac: Arrythmias (indlucing changes in conduction)

Cardiac: EKG changes not diagnostic of above

Cardiac: Pulse rate decreased with fall in BP 		TXCYAC 224,238,2006
intravenous
rabbit 		lethal dose (50 percent kill): 3,560 µg/kg N/R NIIRDN 6,316,1982
intravenous
rabbit 		lowest published toxic dose: 0.1 mg/kg Brain and Coverings: Changes in circulation FATOAO 55,13,1992
oral
cat 		lethal dose (50 percent kill): 200 µg/kg N/R AIPTAK 159,1,1966
oral
child 		lowest published toxic dose: 127 µg/kg Cardiac: Pulse rate decreased with fall in BP AFPYAE 34(1),137,1986
oral
child 		lowest published toxic dose: 54 µg/kg Cardiac: Pulse rate decreased with fall in BP

Nutritional and Gross Metabolic: Changes in: K 		AJEMEN 4,364,1986
oral
dog 		lowest published lethal dose: 300 µg/kg N/R CRSBAW 109,279,1932
oral
guinea pig 		lethal dose (50 percent kill): 3,500 µg/kg N/R AIPTAK 159,1,1966
oral
man 		lowest published toxic dose: 333 µg/kg Eye: Visual field changes

Cardiac: Pulse rate decreased with fall in BP 		BMJOAE 287,392,1983
oral
man 		lowest published toxic dose: 75 µg/kg Cardiac: EKG changes not diagnostic of above

Cardiac: Pulse rate increased without fall in BP 		AJEMEN 6,465,1988
oral
mouse 		lethal dose (50 percent kill): 17,780 µg/kg Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes 		AIPTAK 153,436,1965
oral
rat 		lethal dose (50 percent kill): 28,270 µg/kg N/R AIPTAK 164,47,1966
oral
woman 		lowest published toxic dose: 500 µg/kg Cardiac: EKG changes not diagnostic of above

Cardiac: Pulse rate increased without fall in BP

Gastrointestinal: Nausea or vomiting 		CTOXAO 15,437,1979
oral
woman 		lowest published toxic dose: 165 µg/kg/33 day- intermittent Behavioral: General anesthetic

Behavioral: Muscle contraction or spasticity 		BMJOAE 296,1262,1988
oral
woman 		lowest published toxic dose: 100 µg/kg Behavioral: Anorexia (human)

Cardiac: Arrythmias (indlucing changes in conduction)

Gastrointestinal: Nausea or vomiting 		NZMJAX 84,443,1976
parenteral
cat 		lowest published lethal dose: 1,470 µg/kg N/R APPHAX 34,431,1977
parenteral
frog 		lowest published lethal dose: 1 mg/kg N/R CPBTAL 11,613,1963
parenteral
mouse 		lowest published lethal dose: 2,947 µg/kg N/R SIHSD8 4(2),32,1981
parenteral
pigeon 		lowest published lethal dose: 450 µg/kg N/R CPBTAL 11,613,1963
rectal
rat 		lowest published lethal dose: 5 mg/kg Cardiac: Pulse rate decreased with fall in BP PLMEAA 25,88,1974
subcutaneous
frog 		lethal dose (50 percent kill): 2,240 ng/kg N/R RPTOAN 53,171,1990
subcutaneous
guinea pig 		lethal dose (50 percent kill): 600 µg/kg Cardiac: Arrythmias (indlucing changes in conduction) JPPMAB 35,580,1983
subcutaneous
mouse 		lethal dose (50 percent kill): 8,150 ng/kg N/R RPTOAN 53,171,1990
subcutaneous
mouse 		lowest published toxic dose: 0.81 mg/kg Behavioral: Anticonvulsant FATOAO 54,11,1991
subcutaneous
rat 		lethal dose (50 percent kill): 8,900 ng/kg N/R RPTOAN 53,171,1990
subcutaneous
rat 		lowest published toxic dose: 0.87 mg/kg Behavioral: Anticonvulsant FATOAO 54,11,1991
unreported route
frog 		lowest published toxic dose: 0.1 mg/kg Behavioral: Anticonvulsant FATOAO 54,52,1991
unreported route
man 		lowest published toxic dose: 13 µg/kg/4 day- intermittent Behavioral: Change in psychophysiological tests

Vascular: Other changes

Lung, Thorax, or Respiration: Dyspnea 		AHJOA2 106,419,1983
unreported route
rat 		lowest published toxic dose: 0.6 mg/kg Behavioral: Anticonvulsant FATOAO 54,52,1991
unreported route
rat 		lowest published toxic dose: 20 mg/kg Cardiac: Other changes

Biochemical: Metabolism (intermediary): Other proteins 		TOXID9 78,405,2004


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
dog 		lowest published toxic dose: 462 µg/kg/30 day- intermittent Blood: Other changes

Nutritional and Gross Metabolic: Changes in: Cl

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		ARTODN 51,273,1982
intravenous
infant 		lowest published toxic dose: 187.5 µg/kg/3 day- intermittent Cardiac: Arrythmias (indlucing changes in conduction)

Lung, Thorax, or Respiration: Respiratory obstruction

Lung, Thorax, or Respiration: Cyanosis 		CTOXAO 1,51,2005
oral
human 		lowest published toxic dose: 0.353 mg/kg/12 week- intermittent Cardiac: Change in rate CEXPB9 28,446,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
PHJOAV 213,159,1974
TOXICOLOGY REVIEW
85ELDJ -,190,1963
TOXICOLOGY REVIEW
85ELDJ -,54,1963
TOXICOLOGY REVIEW
MUREAV 488,151,2001
TOXICOLOGY REVIEW
TPHSDY 23,358,2002
TOXICOLOGY REVIEW
ASXBA8 9,343,1980
TOXICOLOGY REVIEW
JCAFA* 12,343,2006
TOXICOLOGY REVIEW
ENTOX* -,45,2005
TOXICOLOGY REVIEW
AJEMEN 22,404,2004
TOXICOLOGY REVIEW
MJAUAJ 179,98,2003
TOXICOLOGY REVIEW
HUTOX* -,377,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA Control as low as possible, MAR2004


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84688;
Number of Industries 2;
Total Number of Facilities 110;
Number of Occupations 7;
Total Number of Employees Exposed 2,855
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9128;
Number of Industries 1;
Total Number of Facilities 171;
Number of Occupations 7;
Total Number of Employees Exposed 1,925;
Total Number of Female Employees Exposed 1,628
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84688;
Number of Industries 4;
Total Number of Facilities 848;
Number of Occupations 12;
Total Number of Employees Exposed 21,318;
Total Number of Female Employees Exposed 16,552


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: E coli polA without S9
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963
AFPYAE American Family Physician. (American Academy of Family Physicians, 1740 W. 92nd St., Kansas City, MO 64114) V.2-17, 1962-69; New series: V.2- 1970-
AHJOA2 American Heart Journal. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1925-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
APPHAX Acta Poloniae Pharmaceutica. For English translation, see APPFAR. (Ars Polona, POB 1001, 00-680 Warsaw 1, Poland) V.1- 1937-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
ASXBA8 Archives of Sexual Behavior. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1971-
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
CEXPB9 Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974-
CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968-
CPBTAL Chemical and Pharmaceutical Bulletin. (Japan Pub. Trading Co., USA, 1255 Howard St., San Francisco, CA 94103) V.6- 1958-
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
HUTOX*
JCAFA* Journal of Cardiac Failure (Philadelphia, PA : Churchill Livingstone) V.1- 1994-
JDGRAX Journal of Drug Research. (National Organization for Drug Research and Control, POB 29, Cairo, Egypt) V.2- 1969-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
MJAUAJ Medical Journal of Australia. (Australasian Medical Pub. Co. Ltd., 71-79 Arundel St., Glebe, N.S.W., Australia) V.1- 1914-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
NZMJAX New Zealand Medical Journal. (New Zealand Medical Assoc., P.O. Box 156, Wellington, New Zealand) V.1- 1900-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034, Evanston, IL 60204) V.1- 1948-
PHJOAV Pharmaceutical Journal. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London, SE1 7JN, UK) V.131- 1933-
PLMEAA Planta Medica. (Georg Thieme Verlag, Postfach 732, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.1- 1953-
PLRCAT Pharmacological Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969-
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967-
SIHSD8 Shang-hai I Hsueh. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1978(?)-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Natural Product

ALT CAS #: 36-35-1
ALT CAS #: 8001-36-3
ALT CAS #: 8001-37-4
ALT CAS #: 8001-52-3
ALT CAS #: 11000-95-6
ALT CAS #: 39366-41-1
ALT CAS #: 82476-60-6
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