RTECS:HP0875000 The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH

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5H - Dibenzo (a,d) cycloheptene - delta (sup 5) - gamma - propylamine, N,N - dimethyl - , hydrochloride

RTECS #: HP0875000

CAS #: 6202-23-9

UPDATE: August 2007 MW: 311.88 MF: C₂₀H₂₁N•ClH

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

ACUTE TOXICITY DATA:

REVIEWS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

REFERENCES:

SYNONYMS:

1 - Propanamine, 3 - (5H - dibenzo (a,d) cyclohepten - 5 - ylidene) - N,N - dimethyl - , hydrochloride

5 - (3 - Dimethylaminopropylidene) - 5H - dibenzo - (a,d) cycloheptene hydrochloride

Cyclobenzaprine hydrochloride

Flexeril

Flexiban

N,N - Dimethyl - 5H - dibenzo (a,d) cycloheptene - delta (sup 5,gamma) - propylamine hydrochloride

Proheptatriene hydrochloride

Proheptatrien monohydrochloride

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intravenous
mouse lethal dose (50 percent kill): 36 mg/kg N/R AIPTAK 144,481,1963
oral
man lowest published toxic dose: 5,714 µg/kg/2 day- intermittent Behavioral: Wakefulness

Behavioral: Euphoria

Behavioral: Hallucinations, distorted perceptions JCLPDE 54,39,1993
oral
mouse lethal dose (50 percent kill): 250 mg/kg N/R 27ZQAG -,87,1972
oral
woman lowest published toxic dose: 1 mg/kg/3 day- intermittent Behavioral: Wakefulness

Behavioral: Euphoria

Behavioral: Hallucinations, distorted perceptions JCLPDE 54,39,1993
oral
woman lowest published toxic dose: 12 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Hallucinations, distorted perceptions

Cardiac: Pulse rate increased without fall in BP JTCTDW 20,281,1983
oral
woman lowest published toxic dose: 8,400 µg/kg/2 week- intermittent Behavioral: General anesthetic JCLPDE 44,151,1983

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
BPCRA* 17,471,2003

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5339;
Number of Industries 1;
Total Number of Facilities 100;
Number of Occupations 2;
Total Number of Employees Exposed 656;
Total Number of Female Employees Exposed 512

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
BPCRA* Best Practice & Research Clinical Anaesthesiology(Elsevier Ltd.) V.13- 1999-
JCLPDE Journal of Clinical Psychiatry. (Physicians Postgraduate Press, Inc., POB 240008, Memphis, TN 38124) V.39- 1978-
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-

Used as a muscle relaxant

FDA-proprietary drug

RTECS Compound Description:
Drug
Human Data

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