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5H - Dibenz (b,f) azepine, 5 - (3 - (dimethylamino) propyl) - 10,11 - dihydro -

RTECS #: HO1575000

CAS #: 50-49-7

UPDATE: February 2009 MW: 280.45 MF: C19H24N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1 - (3 - Dimethylaminopropyl) - 4,5 - dihydro - 2,3,6,7 - dibenzazepine
  2. 2,2' - (3 - Dimethylaminopropylimino) bibenzyl
  3. 2,2' - (3 - Dimethylaminopropylimino) dibenzyl
  4. 5,6 - Dihydro - N - (3 - (dimethylamino) propyl) - 11H - dibenz (b,e) azepine
  5. 5 - (3 - (Dimethylamino) propyl) - 10,11 - dihydro - 5H - dibenz (b,f) azepine
  6. 5H - Dibenz (b,f) azepine, 10,11 - dihydro - 5 - (3 - (dimethylamino) propyl) -
  7. Antideprin
  8. Berkomine
  9. Dyna - zina
  10. Dynaprin
  11. Eupramin
  1. Imipramina (Italian)
  2. Imipramine
  3. Intalpram
  4. Melipramin
  5. Melipramine
  6. N - (gamma - Dimethylaminopropyl) iminodibenzyl
  7. Prazepine
  8. Promiben
  9. Surplix
  10. Timolet


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis unreported route
other insects 		10 gm/L JCLBA3 47,182a,1970
DNA damage hamster lung 100 µmol/L/3 hour (-enzymatic activation step) MUREAV 503,21,2002
DNA damage hamster lung 29 µmol/L/3 hour MUREAV 609,47,2006
DNA inhibition unreported route
other insects 		10 gm/L JCLBA3 47,182a,1970
micronucleus test hamster lung 29 µmol/L/3 hour MUREAV 609,47,2006
micronucleus test intraperitoneal
mouse 		75 mg/kg/24 hour IMSCE2 14,1129,1986
sister chromatid exchange intraperitoneal
mouse 		20 mg/kg TOLED5 132,123,2002
sperm morphology intraperitoneal
mouse 		188 mg/kg/5 day- intermittent IMSCE2 14,1129,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraplacental
mouse 		lowest published toxic dose: 80 µg/kg (11 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death 40YJAX -,207,1979
intraplacental
mouse 		lowest published toxic dose: 80 µg/kg (15 day pregnant) Reproductive: Other developmental abnormalities 40YJAX -,207,1979
intraperitoneal
mouse 		lowest published toxic dose: 188 mg/kg (5 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) IMSCE2 14,1129,1986
intraperitoneal
rat 		lowest published toxic dose: 210 mg/kg (21 day prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders REPTED 6,319,1992
oral
mouse 		lowest published toxic dose: 175 mg/kg (7-13 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) OYYAA2 4,855,1970
oral
mouse 		lowest published toxic dose: 87,500 µg/kg (7-13 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) OYYAA2 4,855,1970
oral
rat 		lowest published toxic dose: 75 mg/kg (9-14 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system OYYAA2 4,855,1970
oral
rat 		lowest published toxic dose: 600 mg/kg (60 day male/60 day prior to copulation) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) 		ARZNAD 15,1218,1965
oral
rat 		lowest published toxic dose: 378 mg/kg (21 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Physical 		PSCHDL 56,93,1978
oral
rat 		lowest published toxic dose: 165 mg/kg (14 day prior to copulation/1-19 day pregnant) Reproductive: Effects on newborn: Stillbirth

Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) 		PBBHAU 3,799,1975
oral
rat 		lowest published toxic dose: 40 mg/kg (14-21 day pregnant) Reproductive: Effects on newborn: Behavioral PSYPAG 44,253,1975
oral
rabbit 		lowest published toxic dose: 390 mg/kg (6-18 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		IYKEDH 7,195,1976
subcutaneous
rat 		lowest published toxic dose: 40 mg/kg (18-21 day pregnant) Reproductive: Effects on newborn: Biochemical and metabolic ADBBBW 8,171,1972
subcutaneous
rat 		lowest published toxic dose: 130 mg/kg (8-20 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system 		TJADAB 31,46A,1985
subcutaneous
rat 		lowest published toxic dose: 65 mg/kg (8-20 day pregnant) Reproductive: Effects on newborn: Behavioral TJADAB 31,11B,1985
subcutaneous
rat 		lowest published toxic dose: 15 mg/kg (17-19 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system JPETAB 47,35,1985
subcutaneous
rabbit 		lowest published toxic dose: 55 mg/kg (6-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death ARZNAD 15,1218,1965
subcutaneous
rabbit 		lowest published toxic dose: 255 mg/kg (1-17 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		LANCAO 1,638,1963


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
rat 		lowest published toxic dose: 5.7 µg/kg Behavioral: Change in psychophysiological tests EURNE* 14,59,2003
intraperitoneal
mouse 		lethal dose (50 percent kill): 51,600 µg/kg N/R BRXXAA #1460700
intraperitoneal
mouse 		lowest published toxic dose: 10 mg/kg Eye: Mydriasis (pupilliary dilation) FATOAO 44,15,1981
intraperitoneal
mouse 		lowest published toxic dose: 30 mg/kg Behavioral: Antianxiety

Behavioral: Change in psychophysiological tests 		EURNE* 12,S192,2002
intraperitoneal
mouse 		lowest published toxic dose: 16 mg/kg Behavioral: Change in motor activity (specific assay) PSCHDL 153,443,2001
intraperitoneal
mouse 		lowest published toxic dose: 3 mg/kg Behavioral: Antipsychotic EJPHAZ 499,135,2004
intraperitoneal
mouse 		lowest published toxic dose: 15 mg/kg Behavioral: Alteration of classical conditioning JPETAB 319,254,2006
intraperitoneal
mouse 		lowest published toxic dose: 1.25 mg/kg Behavioral: Analgesia EJPHAZ 550,78,2006
intraperitoneal
mouse 		lowest published toxic dose: 15 mg/kg Behavioral: Excitement

Behavioral: Change in psychophysiological tests 		EJPHAZ 555,30,2007
intraperitoneal
mouse 		lowest published toxic dose: 15 mg/kg Behavioral: Change in motor activity (specific assay)

Behavioral: Alteration of classical conditioning 		PHREP* 58,746,2006
intraperitoneal
rat 		lowest published toxic dose: 30 mg/kg Brain and Coverings: Other degenerative changes FATOAO 48,22,1985
intraperitoneal
rat 		lowest published toxic dose: 2.5 mg/kg Behavioral: Alteration of operant conditioning FATOAO 53,13,1990
intraperitoneal
rat 		lethal dose (50 percent kill): 79 mg/kg N/R FATOAO 48,57,1985
intraperitoneal
rat 		lowest published toxic dose: 16 mg/kg Behavioral: Change in motor activity (specific assay) PSCHDL 159,64,2001
intraperitoneal
rat 		lowest published toxic dose: 28.57 µg/kg Behavioral: Change in psychophysiological tests EURNE* 14,59,2003
intraperitoneal
rat 		lowest published toxic dose: 15 mg/kg Behavioral: Excitement

Behavioral: Change in psychophysiological tests 		EJPHAZ 555,30,2007
intraperitoneal
rat 		lowest published toxic dose: 10 mg/kg Behavioral: Alteration of classical conditioning PSCHDL 191,353,2007
intraperitoneal
rat 		lowest published toxic dose: 40 mg/kg Behavioral: Food intake (animal)

Behavioral: Fluid intake 		FTRPAE 77,339,2006
intravenous
cat 		lowest published lethal dose: 20 mg/kg N/R BCFAAI 112,601,1973
intravenous
dog 		lowest published lethal dose: 45 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory depression 		BCFAAI 112,601,1973
intravenous
mouse 		lethal dose (50 percent kill): 21 mg/kg Autonomic Nervous System: Parasympatholytic

Behavioral: Wakefulness

Behavioral: Change in motor activity (specific assay) 		AIPTAK 245,283,1980
intravenous
mouse 		lowest published toxic dose: 8 mg/kg Behavioral: Change in psychophysiological tests JPETAB 299,1027,2001
intravenous
rat 		lethal dose (50 percent kill): 9,300 µg/kg N/R USXXAM #4141993
intravenous
rabbit 		lethal dose (50 percent kill): 18 mg/kg N/R AIPTAK 120,450,1959
oral
cat 		lowest published lethal dose: 100 mg/kg N/R FATOAO 48,57,1985
oral
child 		lethal dose (50 percent kill): 40 mg/kg Behavioral: Hallucinations, distorted perceptions

Behavioral: Change in motor activity (specific assay)

Behavioral: Coma 		HEPHD2 55,527,1980
oral
child 		lowest published toxic dose: 30 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Change in motor activity (specific assay)

Behavioral: Ataxia 		AJDCAI 130,507,1976
oral
child 		lowest published lethal dose: 35 mg/kg Behavioral: Convulsions or effect on seizure threshold

Cardiac: Other changes

Lung, Thorax, or Respiration: Dyspnea 		SMWOAS 99,1157,1969
oral
dog 		lowest published lethal dose: 100 mg/kg N/R 27ZQAG -,78,1972
oral
dog 		lowest published toxic dose: 60 mg/kg Eye: Mydriasis (pupilliary dilation)

Behavioral: Excitement

Behavioral: Ataxia 		FATOAO 48,57,1985
oral
human 		lowest published lethal dose: 450 mg/kg Skin: After systemic exposure: Dermatitis, irritative BMJOAE 1,722,1979
oral
human 		lethal dose (50 percent kill): 40 mg/kg N/R PSDTAP 6,171,1965
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 350 mg/kg Behavioral: Anticonvulsant JMCMAR 8,836,1965
oral
mammal (species unspecified) 		lowest published toxic dose: 10 mg/kg Behavioral: Antianxiety NEROEW 27,357,2002
oral
man 		lowest published toxic dose: 71,428 µg/kg/10 day- intermittent Behavioral: Rigidity (includes catalepsy)

Skin and Appendages: Other: Sweating

Nutritional and Gross Metabolic: Body temperature increase 		ICMED9 23,480,1997
oral
man 		lowest published lethal dose: 71 mg/kg Behavioral: Convulsions or effect on seizure threshold

Cardiac: Change in rate

Endocrine: Change in LH 		JTCTDW 19,239,1982
oral
man 		lethal dose (50 percent kill): 30 mg/kg Behavioral: Hallucinations, distorted perceptions

Behavioral: Change in motor activity (specific assay)

Behavioral: Coma 		HEPHD2 55,527,1980
oral
man 		lowest published toxic dose: 5,357 µg/kg/5 day- intermittent Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Changes in REM sleep (human) 		HUPSEC 11,211,1996
oral
man 		lowest published toxic dose: 8 mg/kg/3 day- intermittent Behavioral: Excitement LANCAO 2,568,1959
oral
mouse 		lethal dose (50 percent kill): 188 mg/kg Eye: Ptosis

Behavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Body temperature decrease 		PCJOAU 14,773,1980
oral
mouse 		lowest published toxic dose: 10 mg/kg Behavioral: Antipsychotic FATOAO 47,19,1984
oral
mouse 		lowest published toxic dose: 10 mg/kg Behavioral: Change in motor activity (specific assay)

Behavioral: Analgesia 		FATOAO 53,20,1990
oral
mouse 		lowest published toxic dose: 3 mg/kg Behavioral: Alteration of operant conditioning FATOAO 53,52,1990
oral
mouse 		lowest published toxic dose: 10 mg/kg Behavioral: Change in motor activity (specific assay)

Behavioral: Alteration of operant conditioning 		EKFAE9 56,3,1993
oral
mouse 		lowest published toxic dose: 10 mg/kg Nutritional and Gross Metabolic: Body temperature increase FATOAO 48,10,1985
oral
mouse 		lowest published toxic dose: 25 mg/kg Eye: Mydriasis (pupilliary dilation) FATOAO 48,10,1985
oral
mouse 		lethal dose (50 percent kill): 290 mg/kg N/R FATOAO 48,57,1985
oral
rat 		lethal dose (50 percent kill): 250 mg/kg Eye: Ptosis

Behavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Body temperature decrease 		PCJOAU 14,773,1980
oral
rat 		lethal dose (50 percent kill): 400 mg/kg N/R USXXAM #5401853
oral
rat 		lowest published toxic dose: 10 mg/kg Behavioral: Alteration of operant conditioning EKFAE9 56,3,1993
oral
rat 		lowest published toxic dose: 10 mg/kg Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS PSCHDL 162,323,2002
oral
rat 		lowest published toxic dose: 30 mg/kg Behavioral: Antipsychotic PSCHDL 162,323,2002
oral
rabbit 		lethal dose (50 percent kill): 385 mg/kg N/R ARZNAD 19,1617,1969
oral
woman 		lowest published toxic dose: 150 mg/kg Behavioral: Coma

Cardiac: Other changes

Vascular: BP lowering not characterized in autonomic section 		JTCTDW 33,51,1995
oral
woman 		lowest published lethal dose: 2 mg/kg/1 day Lung, Thorax, or Respiration: Other changes JPPMAB 16,265,1964
oral
woman 		lowest published toxic dose: 3 mg/kg/32 hour- intermittent Skin: After systemic exposure: Photosensitivity JAMAAP 254,357,1985
parenteral
mouse 		lowest published toxic dose: 10 mg/kg Behavioral: Antianxiety PSCHDL 158,241,2001
parenteral
rat 		lowest published toxic dose: 10 mg/kg Behavioral: Antianxiety PSCHDL 158,205,2001
subcutaneous
mouse 		lethal dose (50 percent kill): 195 µg/kg Behavioral: Wakefulness

Nutritional and Gross Metabolic: Body temperature increase 		PCJOAU 15,412,1981
subcutaneous
mouse 		lowest published toxic dose: 5 mg/kg Behavioral: Stiffness JOPSEQ 15,18,2001
subcutaneous
mouse 		lowest published toxic dose: 2.5 mg/kg Behavioral: Change in psychophysiological tests NEROEW 24,391,2001
subcutaneous
mouse 		lowest published toxic dose: 40 mg/kg Immunological Including Allergic: Increase in cellular immune response

Immunological Including Allergic: Increase in humoral response

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TXCYAC 200,247,2004
subcutaneous
rat 		lethal dose (50 percent kill): 250 mg/kg N/R AIPTAK 148,560,1964
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 455 mg/kg N/R KHFZAN 24(7),27,1990
unreported route
mouse 		lethal dose (50 percent kill): 107 mg/kg Autonomic Nervous System: Smooth muscle relaxant (mechanism undefined, spasmolytic) JMCMAR 10,418,1967
unreported route
mouse 		lowest published toxic dose: 5 mg/kg Behavioral: Change in psychophysiological tests FCLPH* 18,49,2004
unreported route
mouse 		lowest published toxic dose: 10 mg/kg Behavioral: Change in motor activity (specific assay)

Behavioral: Change in psychophysiological tests 		FCLPH* 18,49,2004


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 225 mg/kg/5 day- intermittent Eye: Mydriasis (pupilliary dilation) FATOAO 48,10,1985
intraperitoneal
rat 		lowest published toxic dose: 350 mg/kg/5 week- intermittent Behavioral: Fluid intake EURNE* 11,351,2001
intraperitoneal
rat 		lowest published toxic dose: 120 mg/kg/12 day- intermittent Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in CNS EKFAE9 58,14,1995
intraperitoneal
rat 		lowest published toxic dose: 140 mg/kg/14 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases BJMRDK 34,1265,2001
intraperitoneal
rat 		lowest published toxic dose: 210 mg/kg/3 week- intermittent Behavioral: Food intake (animal) NEROEW 28,694,2003
intraperitoneal
rat 		lowest published toxic dose: 100 mg/kg/10 day- intermittent Behavioral: Alteration of operant conditioning PSCHDL 191,353,2007
intraperitoneal
rat 		lowest published toxic dose: 280 mg/kg/28 day- intermittent Behavioral: Alteration of classical conditioning

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		PSCHDL 191,353,2007
intraperitoneal
rat 		lowest published toxic dose: 218 mg/kg/20 day- intermittent Behavioral: Change in motor activity (specific assay)

Behavioral: Change in psychophysiological tests 		FCLPH* 18(Suppl 1),104,2004
oral
human 		lowest published toxic dose: 88.28 mg/kg/4 week- intermittent Behavioral: Change in motor activity (specific assay)

Behavioral: Change in psychophysiological tests 		EURNE* 12,273,2002
oral
man 		lowest published toxic dose: 782.1 mg/kg/1 year- intermittent Skin: After systemic exposure: Photosensitivity APHRER 37,825,2003
oral
man 		lowest published toxic dose: 1,562.2 mg/kg/2 year- intermittent Brain and Coverings: Other degenerative changes

Skin: After systemic exposure: Dermatitis, other

Biochemical: Metabolism (intermediary): Other 		APHRER 37,825,2003
oral
mouse 		lowest published toxic dose: 90 mg/kg/5 day- intermittent Behavioral: Tremor

Behavioral: Irritability 		FATOAO 48,10,1985
oral
rat 		lowest published toxic dose: 3,600 mg/kg/4 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field AIPTAK 120,450,1959
oral
rat 		lowest published toxic dose: 5,760 mg/kg/22 week- intermittent Cardiac: EKG changes not diagnostic of above

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		ARZNAD 30,1709,1980
oral
rat 		lowest published toxic dose: 210 mg/kg/21 day- intermittent Brain and Coverings: Other degenerative changes

Endocrine: Other changes

Biochemical: Metabolism (intermediary): Other proteins 		NEROEW 24,652,2001
oral
rat 		lowest published toxic dose: 210 mg/kg/14 day- intermittent Behavioral: Change in motor activity (specific assay) BPBLEO 29,1767,2006
subcutaneous
rat 		lowest published toxic dose: 210 mg/kg/21 day- intermittent Brain and Coverings: Recordings from specific areas of CNS NEROEW 22,346,2000
unreported route
human 		lowest published toxic dose: 14.98 mg/kg/7 day- intermittent Cardiac: Change in rate

Vascular: BP elevation not characterized in autonomic section

Biochemical: Neurotransmitters or modulators (putative): Catecholamine levels in sympathetic nerves 		NSAPCC 369(Suppl 1),R159,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
DICPBB 8,690,1974
TOXICOLOGY REVIEW
CRTXB2 1(1),93,1971
TOXICOLOGY REVIEW
CLCHAU 19,361,1973
TOXICOLOGY REVIEW
ARVPAX 5,447,1965
TOXICOLOGY REVIEW
ADVPA3 4,263,1966
TOXICOLOGY REVIEW
FNSCA6 2,67,1973
TOXICOLOGY REVIEW
CTOXAO 2,403,1969
TOXICOLOGY REVIEW
NEJMAG 342,186,2000
TOXICOLOGY REVIEW
MUREAV 488,151,2001
TOXICOLOGY REVIEW
TPHSDY 23,238,2002
TOXICOLOGY REVIEW
TPHSDY 23,519,2002
TOXICOLOGY REVIEW
TPHSDY 23,441,2002
TOXICOLOGY REVIEW
EMMUEG 43,143,2004
TOXICOLOGY REVIEW
EMMUEG 44,163,2004
TOXICOLOGY REVIEW
APHRER 37,825,2003
TOXICOLOGY REVIEW
APHRER 39,141,2005
TOXICOLOGY REVIEW
JOPSEQ 20,19,2006
TOXICOLOGY REVIEW
AINCM* 7,63,2006
TOXICOLOGY REVIEW
EJIME* 17,529,2006
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
ENTOX* -,386,2005
TOXICOLOGY REVIEW
BCLPT* 96,399,2005
TOXICOLOGY REVIEW
BCLPT* 98,304,2006
TOXICOLOGY REVIEW
AJEMEN 22,404,2004
TOXICOLOGY REVIEW
PAREAQ 56,103,2004
TOXICOLOGY REVIEW
PSBUL* 35,66,2001
TOXICOLOGY REVIEW
PSBUL* 36,91,2002
TOXICOLOGY REVIEW
PSBUL* 37,96,2003
TOXICOLOGY REVIEW
MJAUAJ 187,361,2007
TOXICOLOGY REVIEW
JTPAE7 21,9,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4727;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 1;
Total Number of Employees Exposed 103;
Total Number of Female Employees Exposed 52


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Rodent dominant lethal


REFERENCES:

CODEN
REFERENCE
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972
40YJAX "Evaluation of Embryotoxicity, Mutagenicity and Carcinogenicity Risks In New Drugs, Proceedings of the Symposium on Toxicological Testing for Safety of New Drugs, 3rd, Prague, 1976," Benesova, O., et al., eds., Prague, Czechoslovakia, Univerzita Karlova, 1979
ADBBBW Advances in Behavioral Biology. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.1- 1971-
ADVPA3 Advances in Pharmacology. (New York, NY) V.1-6, 1962-68. For publisher information, see AVPCAQ.
AINCM* Anaesthesia and Intensive Care Medicine (Abingdon: Medicine Pub. Co.) V.1- 2000-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
AJDCAI American Journal of Diseases of Children. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1-80(3), 1911-50; V.100- 1960-
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992-
ARVPAX Annual Review of Pharmacology. (Palo Alto, CA) V.1-15, 1961-75. For publisher information, see ARPTDI.
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894-
BCLPT* Basic & clinical pharmacology & toxicology (Copenhagen, Denmark : Nordic Pharmacological Society Oxford, UK : Distributed by Blackwell Munksgaard) V.94- 2004-
BJMRDK Brazilian Journal of Medical and Biological Research. (Associacao Brasileira de Divulgacao Cientifica, Faculdade de Medicina de Ribeirao Preto, USP, 141000 Ribeirao Preto, SP, Brazil) V.14- 1981-
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
BRXXAA British Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231)
CLCHAU Clinical Chemistry (Winston-Salem, NC). (American Assoc. for Clinical Chemistry, 1725 K St., NW, Washington, DC 20006) V.1- 1955-
CRTXB2 CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton, FL 33431) V.1- 1971-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DICPBB Drug Intelligence and Clinical Pharmacy. (POB 42435, Cincinnati, OH 45242) V.3- 1969-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
EJIME* European Journal of Internal Medicine: The Official Journal of the European Federation of Internal Medicine (EFIM) (Elsevier) V.10- 1999-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992-
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ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
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Used as antidepressant

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data

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