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5H - Dibenz (b,f) azepine - 5 - carboxamide

RTECS #: HN8225000

CAS #: 298-46-4

UPDATE: May 2009 MW: 236.29 MF: C15H12N2O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 5 - Carbamoyl - 5H - dibenz (b,f) azepine
  2. 5 - Carbamoyl - 5H - dibenzo (b,f) azepine
  3. 5 - Carbamyl - 5H - dibenzo (b,f) azepine
  4. Amizepin
  5. Biston
  6. CBZ
  7. Carbamazepen
  8. Carbamazepine
  9. Carbazepine
  10. Finlepsin
  1. G 32883
  2. Geigy 32883
  3. Karbamazepin
  4. Neurotol
  5. Stazepine
  6. Tegretal
  7. Tegretol
  8. Telesmin
  9. Timonil


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 440 mg/kg (6-16 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TXAPA9 40,365,1977
oral
mouse 		lowest published toxic dose: 92 gm/kg (2 week male/2 week prior to copulation-18 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		TCMUD8 6,393,1986
oral
mouse 		lowest published toxic dose: 5,628 mg/kg (7-12 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		TJADAB 23,33A,1981
oral
mouse 		lowest published toxic dose: 9,984 mg/kg (8-13 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ARNEAS 36,832,1979
oral
rat 		lowest published toxic dose: 3,600 mg/kg (14 day prior to copulation/1-22 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		TJADAB 29(3),33A,1984
oral
rat 		lowest published toxic dose: 765 mg/kg (9-17 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		EAMJAV 60,407,1983
oral
rat 		lowest published toxic dose: 4,800 mg/kg (7-18 day pregnant) Reproductive: Other developmental abnormalities TJADAB 41,311,1990
oral
rat 		lowest published toxic dose: 7,200 mg/kg (7-18 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TJADAB 41,311,1990
oral
rat 		lowest published toxic dose: 2,400 mg/kg (7-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TJADAB 41,311,1990
oral
woman 		lowest published toxic dose: 96 mg/kg (3 week pregnant) Reproductive: Specific developmental abnormalities: Central nervous system OBGNAS 82,705,1993
oral
woman 		lowest published toxic dose: 3,192 mg/kg (1-38 week pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects 		NEJMAG 320,1661,1989
oral
woman 		lowest published toxic dose: 7,644 mg/kg (1-39 week pregnant) Reproductive: Specific developmental abnormalities: Skin and skin appendages

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system 		NEJMAG 320,1661,1989
oral
woman 		lowest published toxic dose: 1,288 mg/kg (26-42 week pregnant) Reproductive: Specific developmental abnormalities: Skin and skin appendages NRPDDB 16,167,1985
oral
woman 		lowest published toxic dose: 3,492 mg/kg (1-39 week pregnant/17 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic EJPEDT 150,136,1990


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 113.5 mg/kg N/R FATOAO 53,19,1990
intraperitoneal
mouse 		lowest published toxic dose: 100 mg/kg Behavioral: Alteration of operant conditioning APBDAJ 335,129,2002
intraperitoneal
mouse 		lowest published toxic dose: 50 mg/kg Behavioral: Ataxia JPETAB 292,215,2000
intraperitoneal
mouse 		lowest published toxic dose: 8.1 mg/kg Behavioral: Change in motor activity (specific assay) INJPD2 36,306,2004
intraperitoneal
mouse 		lowest published toxic dose: 53.6 mg/kg Behavioral: Change in motor activity (specific assay)

Behavioral: Ataxia 		EURNE* 15,609,2005
intraperitoneal
mouse 		lowest published toxic dose: 5 mg/kg Behavioral: Analgesia EJPHAZ 550,78,2006
intraperitoneal
mouse 		lowest published toxic dose: 4 mg/kg Behavioral: Anticonvulsant AEPPAE 370,99,2004
intraperitoneal
rat 		lethal dose (50 percent kill): 158 mg/kg N/R AIPTAK 202,106,1973
intraperitoneal
rat 		lowest published toxic dose: 10 mg/kg Behavioral: Analgesia EJPHAZ 473,27,2003
intraperitoneal
rat 		lowest published toxic dose: 20 mg/kg Behavioral: Anticonvulsant EURNE* 14,251,2003
intraperitoneal
rat 		lowest published toxic dose: 30 mg/kg Behavioral: Alteration of classical conditioning

Behavioral: Change in psychophysiological tests 		EPBEH* 5,857,2004
intraperitoneal
rat 		lowest published toxic dose: 20 mg/kg Behavioral: Antianxiety PSCHDL 180,159,2005
intraperitoneal
rat 		lowest published toxic dose: 60 mg/kg Behavioral: Alteration of operant conditioning PSCHDL 180,159,2005
intraperitoneal
rat 		lowest published toxic dose: 50 mg/kg Brain and Coverings: Changes in surface EEG

Cardiac: EKG changes not diagnostic of above

Lung, Thorax, or Respiration: Other changes 		NRTXDN 29,136,2008
oral
child 		lowest published toxic dose: 65 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Lung, Thorax, or Respiration: Other changes 		JOPDAB 121,295,1992
oral
child 		lowest published toxic dose: 1,050 mg/kg/6 week- intermittent Behavioral: Muscle contraction or spasticity AJPSAO 143,1176,1985
oral
child 		lowest published toxic dose: 19 mg/kg/4 week- intermittent Peripheral Nerve and Sensation: Fasciculations PEDIAU 73,841,1984
oral
child 		lowest published toxic dose: 420 mg/kg/3 week- intermittent Eye: Other eye effects

Behavioral: General anesthetic

Behavioral: Tremor 		JTCTDW 36,109,1998
oral
child 		lowest published toxic dose: 25,926 µg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		YAKUD5 35,320,1993
oral
child 		lowest published toxic dose: 55 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma 		JTCTDW 38,323,2000
oral
dog 		lethal dose (50 percent kill): 5,620 mg/kg N/R 27ZQAG -,63,1972
oral
guinea pig 		lethal dose (50 percent kill): 920 mg/kg N/R 27ZQAG -,63,1972
oral
guinea pig 		lowest published toxic dose: 30 mg/kg Behavioral: Analgesia JPETAB 304,56,2003
oral
human 		lowest published toxic dose: 43 mg/kg Behavioral: Sleep

Behavioral: Hallucinations, distorted perceptions

Gastrointestinal: Nausea or vomiting 		BMJOAE 1,754,1977
oral
human 		lowest published toxic dose: 3.27 mg/kg Behavioral: Change in psychophysiological tests JOPSEQ 17,269,2003
oral
infant 		lowest published toxic dose: 55 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression 		JTCTDW 38,321,2000
oral
man 		lowest published toxic dose: 160 mg/kg/3 week- intermittent Skin: After systemic exposure: Dermatitis, other JCPYDR 5,185,1985
oral
man 		lowest published toxic dose: 253 mg/kg/6 week- intermittent Gastrointestinal: Nausea or vomiting

Liver: Liver function tests impaired 		JCPYDR 6,251,1986
oral
man 		lowest published lethal dose: 54 mg/kg/9 day- intermittent Behavioral: Ataxia

Kidney, Ureter, and Bladder: Urine volume increased

Blood: Angranulocytosis 		CMAJAX 132,1040,1985
oral
man 		lowest published toxic dose: 94 mg/kg/11 day- intermittent Blood: Thrombocytopenia JCPYDR 10,305,1990
oral
man 		lowest published toxic dose: 5.71 mg/kg Behavioral: Convulsions or effect on seizure threshold CTOXAO 40,81,2002
oral
mouse 		lethal dose (50 percent kill): 529 mg/kg N/R FRMCE8 44,595,1989
oral
mouse 		lowest published toxic dose: 0.28 mg/kg Behavioral: Ataxia JPETAB 308,127,2004
oral
mouse 		lowest published toxic dose: 96.5 mg/kg Behavioral: Convulsions or effect on seizure threshold JPETAB 308,127,2004
oral
mouse 		lowest published toxic dose: 10 mg/kg Behavioral: Anticonvulsant JPHSC* 104,56,2007
oral
mouse 		lowest published toxic dose: 20 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Anticonvulsant 		JPHSC* 106,78,2008
oral
rat 		lethal dose (50 percent kill): 1,957 mg/kg Behavioral: Altered sleep time (including change in righting reflex) JKXXAF #79-163823
oral
rat 		lowest published toxic dose: 80 mg/kg Behavioral: Analgesia JPETAB 306,490,2003
oral
rat 		lowest published toxic dose: 5.2 mg/kg Behavioral: Convulsions or effect on seizure threshold JPETAB 308,127,2004
oral
rat 		lowest published toxic dose: 30 mg/kg Behavioral: Ataxia JPETAB 318,1083,2006
oral
rat 		lowest published toxic dose: 40 mg/kg Behavioral: Anticonvulsant AEPPAE 370,99,2004
oral
rabbit 		lethal dose (50 percent kill): 2,680 mg/kg N/R 27ZQAG -,63,1972
oral
woman 		lowest published toxic dose: 112 mg/kg/2 week- intermittent Gastrointestinal: Nausea or vomiting

Blood: Thrombocytopenia 		AJPSAO 150,1750,1993
oral
woman 		lowest published toxic dose: 144 mg/kg/2 week- intermittent Blood: Thrombocytopenia

Skin: After systemic exposure: Dermatitis, allergic 		JCLPDE 53,378,1992
oral
woman 		lowest published toxic dose: 28 mg/kg/4 day- intermittent Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Nausea or vomiting

Nutritional and Gross Metabolic: Other changes 		AJPSAO 143,1328,1986
oral
woman 		lowest published toxic dose: 560 mg/kg/4 week- intermittent Blood: Changes in bone marrow not included in above BJCPAT 43,302,1989
oral
woman 		lowest published lethal dose: 1,920 mg/kg/17 week- intermittent Blood: Aplastic anemia AJPSAO 142,974,1985
oral
woman 		lowest published toxic dose: 7,604 mg/kg/69 week- intermittent Behavioral: General anesthetic

Cardiac: EKG changes not diagnostic of above 		JHEJAR 39,469,1998
oral
woman 		lowest published toxic dose: 480 mg/kg Behavioral: Coma

Cardiac: Arrythmias (indlucing changes in conduction)

Lung, Thorax, or Respiration: Respiratory depression 		JTCTDW 38,339,2000
oral
woman 		lowest published toxic dose: 0.8 gm/kg Behavioral: Convulsions or effect on seizure threshold CTOXAO 40,81,2002
subcutaneous
mouse 		lethal dose (50 percent kill): >1 gm/kg N/R ARZNAD 30,477,1980
subcutaneous
rat 		lethal dose (50 percent kill): >1,500 mg/kg N/R ARZNAD 30,477,1980
subcutaneous
rat 		lowest published toxic dose: 0.868 mg/kg Behavioral: Analgesia JPHSC* 100,310,2006


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 300 mg/kg/5 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		BJPCBM 126,1634,1999
oral
human 		lowest published toxic dose: 20 mg/kg/7 day- intermittent Behavioral: Change in psychophysiological tests

Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Nausea or vomiting 		EURNE* 12,255,2002
oral
human 		lowest published toxic dose: 20 mg/kg/8 day- intermittent Behavioral: Somnolence (general depressed activity)

Behavioral: Headache

Blood: Luekopenia 		PSCHDL 159,203,2002
oral
human 		lowest published toxic dose: 71.25 mg/kg/8 day- intermittent Brain and Coverings: Changes in surface EEG

Behavioral: Somnolence (general depressed activity)

Behavioral: Change in psychophysiological tests 		APHRER 38,1816,2004
oral
human 		lowest published toxic dose: 48.6 mg/kg/17 day- intermittent Skin: After systemic exposure: Dermatitis, other

Immunological Including Allergic: Hypersensitivity delayed (multiple organ involvement) 		BJDEAZ 149,165,2003
oral
man 		lowest published toxic dose: 525 mg/kg/5 week- intermittent Skin: After systemic exposure: Dermatitis, allergic

Skin: After systemic exposure: Dermatitis, other 		APHRE* 29,538,1995
oral
man 		lowest published toxic dose: 85.7 mg/kg/30 day- intermittent Skin: After systemic exposure: Photosensitivity

Skin: After systemic exposure: Dermatitis, allergic 		CODEDG 20,260,1989
oral
man 		lowest published toxic dose: 15.71 mg/kg/8 week- intermittent Liver: Other changes

Skin: After systemic exposure: Dermatitis, other

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		APHRER 37,1441,2003
oral
man 		lowest published toxic dose: 0.44 mg/kg/11 week- intermittent Skin: After systemic exposure: Dermatitis, other APHRER 37,1441,2003
oral
man 		: 524.6 mg/kg/61 day- intermittent Brain and Coverings: Changes in surface EEG

Behavioral: Convulsions or effect on seizure threshold 		ERPSY* 19,322,2004
oral
rat 		lowest published toxic dose: 630 mg/kg/14 day- intermittent Behavioral: Convulsions or effect on seizure threshold

Behavioral: Withdrawal 		EURNE* 12,S60,2002
oral
rat 		lowest published toxic dose: 9.9 gm/kg/5 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Effect on cyclic nucleotides 		NEROEW 25,729,2001
oral
rat 		lowest published toxic dose: 3.15 gm/kg/14 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Metabolism (intermediary): Other proteins 		NEROEW 22,530,2000
oral
rat 		lowest published toxic dose: 210 mg/kg/7 day- intermittent Behavioral: Change in motor activity (specific assay)

Behavioral: Antianxiety

Behavioral: Alteration of classical conditioning 		JPHPH* 58,253,2007
oral
woman 		lowest published toxic dose: 48 mg/kg/6 day- intermittent Skin: After systemic exposure: Dermatitis, allergic

Immunological Including Allergic: Hypersensitivity delayed (multiple organ involvement)

Nutritional and Gross Metabolic: Body temperature increase 		PEDNE* 22,231,2000
oral
woman 		lowest published toxic dose: 76 mg/kg/2 day- intermittent Behavioral: Convulsions or effect on seizure threshold

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: Na 		APHRER 39,1943,2005
unreported route
child 		lowest published toxic dose: 6,048 mg/kg/24 week- intermittent Behavioral: Somnolence (general depressed activity)

Blood: Luekopenia 		PHREP* 57,646,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
HFHBAG 30,31,1975
TOXICOLOGY REVIEW
EPILAK 16,159,1975
TOXICOLOGY REVIEW
JTCTDW 39,4,2001
TOXICOLOGY REVIEW
NEJMAG 342,186,2000
TOXICOLOGY REVIEW
CTOXAO 39,381,2001
TOXICOLOGY REVIEW
EURNE* 12,361,2002
TOXICOLOGY REVIEW
NEJMAG 343,1608,2000
TOXICOLOGY REVIEW
MUREAV 488,151,2001
TOXICOLOGY REVIEW
TOLED5 144,383,2003
TOXICOLOGY REVIEW
ARPTDI 44,87,2004
TOXICOLOGY REVIEW
TPHSDY 23,113,2002
TOXICOLOGY REVIEW
PHMREP 51,211,2005
TOXICOLOGY REVIEW
EOGRAL 117,10,2004
TOXICOLOGY REVIEW
TPHSDY 24,542,2003
TOXICOLOGY REVIEW
TPHSDY 24,555,2003
TOXICOLOGY REVIEW
REPTED 20,203,2005
TOXICOLOGY REVIEW
EPBEH* 3,S14,2002
TOXICOLOGY REVIEW
EPIRE8 47,155,2001
TOXICOLOGY REVIEW
REPTED 22,214,2006
TOXICOLOGY REVIEW
APHRER 37,1694,2003
TOXICOLOGY REVIEW
JOPSEQ 20,23,2006
TOXICOLOGY REVIEW
JOPSEQ 20,347,2006
TOXICOLOGY REVIEW
EJIME* 17,529,2006
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
AJEMEN 22,404,2004
TOXICOLOGY REVIEW
PAREAQ 56,103,2004
TOXICOLOGY REVIEW
PSBUL* 35,66,2001
TOXICOLOGY REVIEW
PSBUL* 36,130,2002
TOXICOLOGY REVIEW
REPTED 23,125,2007
TOXICOLOGY REVIEW
HPCQA4 38,527,2007
TOXICOLOGY REVIEW
JAADDB 56,181,2007
TOXICOLOGY REVIEW
HUTOX* -,319,1996
TOXICOLOGY REVIEW
REPTED 26,42,2008


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4467;
Number of Industries 2;
Total Number of Facilities 169;
Number of Occupations 5;
Total Number of Employees Exposed 5,295;
Total Number of Female Employees Exposed 3,361


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test


REFERENCES:

CODEN
REFERENCE
27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
AJPSAO American Journal of Psychiatry. (American Psychiatric Assoc., Circulation Dept., 1400 K St., NW, Washington, DC 20005) V.78- 1921-
APBDAJ Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft. (Weinheim, Fed. Rep. Ger.) V.262-304, 1924-71. For publisher information, see ARPMAS.
APHRE* The Annals of pharmacotherapy. (Cincinnati, OH : Harvey Whitney Books Co.) V.26- 1992-
APHRER Annals of Pharmacotherpy. (Harvey Whitney Books Co., POB 42696, Cincinnati, OH 45242) V. 26- 1992-
ARNEAS Archives of Neurology (Chicago). (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.3- 1960-
ARPTDI Annual Review of Pharmacology and Toxicology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.16- 1976-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BJCPAT British Journal of Clinical Practice. (Medical News Group, 1 Bedford St., London WC2E 9HD, UK) V.10(10)- 1956-
BJDEAZ British Journal of Dermatology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.63- 1951-
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968-
BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857-
CMAJAX Canadian Medical Association Journal. (Canadian Medical Assoc., POB 8650, Ottawa, ON K1G 0G8, Canada) V.1- 1911-
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
EAMJAV East African Medical Journal. (P.O. Box 41632, Nairobi, Kenya) V.9- 1932-
EJIME* European Journal of Internal Medicine: The Official Journal of the European Federation of Internal Medicine (EFIM) (Elsevier) V.10- 1999-
EJPEDT European Journal of Pediatrics. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.121- 1975-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EOGRAL European Journal of Obstetrics, Gynecology and Reproductive Biology. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.3- 1973-
EPBEH* Epilepsy & Behavior (San Diego, CA : Academic Press) V.1- 2000-
EPILAK Epilepsia (New York). (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) Ser.1-3: 1909-55; Ser.4: V.1- 1959-
EPIRE8 Epilepsy Research. (Elsevier Science Publishers B.V., POB 1527, 1000 BM, Amsterdam, Netherlands) V.1- 1987-
ERPSY* European psychiatry : the Journal of the Association of European Psychiatrists (Paris : Editions scientifiques Elsevier) V.1- 1991-
EURNE* European Neuropsychopharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Nov.1990-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FRMCE8 Farmaco. (Societa Chimica Italiana, Corso Strada Nova, 86, Casella Postale 227, 27100 Pavia, Italy) V.44- 1989-
HFHBAG Hartford Hospital Bulletin. (Hartford Hospital, 80 Seymour St., Hartford, CT 06115) V.1- 1938/39-
HPCQA4 Human Pathology. (W.B. Saunders Co., W. Washington Sq., Philadelphia, PA 19105) V.1- 1970-
HUTOX*
INJPD2 Indian Journal of Pharmacology. (Dept. of Pharmacology, Baranas Hindu Univ., Varanasi 221 005, India) V.1- 1968(?)-
JAADDB Journal of the American Academy of Dermatology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) 1979-
JCLPDE Journal of Clinical Psychiatry. (Physicians Postgraduate Press, Inc., POB 240008, Memphis, TN 38124) V.39- 1978-
JCPYDR Journal of Clinical Pyschopharmacology. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1981-
JHEJAR Japanese Heart Journal. (Nankodo Co., 42-6 Hongo 3-chome, Bunkyo-ku Tokyo 113, Japan) V.1- 1960-
JKXXAF Japanese Kokai Tokyo Koho Patents. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231)
JOPDAB Journal of Pediatrics. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1932-
JOPSEQ Journal of Psychopharmacology (Oxford). (Oxford University Press, Great Clarendon St., Oxford OX2 6DP, UK) V.1- 1987-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPHPH*
JPHSC*
JTCTDW Journal of Toxicology, Clinical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.19- 1982-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928-
NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987-
NRPDDB Neuropediatrics (Stuttgart). (Hippokrates Verlag GmbH, Postfach 593, D-7000 Stuttgart 1, Fed. Rep. Ger.) V.11- 1980-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
OBGNAS Obstetrics and Gynecology. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1953-
PAREAQ Pharmacological Reviews. (Williams & Wilkins, 428 E. Preston St., Baltimore, MD 21202) V.1- 1949-
PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034, Evanston, IL 60204) V.1- 1948-
PEDNE* Pediatric neurology (New York Ny Elsevier Science Publishing) V.1- 1985-
PHMREP Pharmacological Research. (Academic Press, 24-28 Oval Rd. London NW1 7DX, UK) V.21- 1989-
PHREP*
PSBUL*
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

Used as an analgesic and anticonvulsant

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 105234-21-7
ALT CAS #: 121947-25-9
ALT CAS #: 121985-71-5
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