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11 - Deoxycorticosterone, acetate

RTECS #: HG0525000

CAS #: 56-47-3

UPDATE: May 2009 MW: 372.55 MF: C23H32O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. REFERENCES:

SYNONYMS:

  1. 11 - Deoxycorticosterone 21 - acetate
  2. 21 - Acetoxy - 3,20 - diketopregn - 4 - ene
  3. 21 - Hydroxypregn - 4 - ene - 3,20 - dione 21 - acetate
  4. 4 - Pregnene - 3,20 - dione - 21 - ol acetate
  5. Arcort
  6. Bio - Corten
  7. Cortacet
  8. Cortate
  9. Cortenil
  10. Cortesan
  11. Cortexone acetate
  12. Corticosterone, deoxy - , acetate
  13. Cortifar
  14. Cortigen
  15. Cortinaq
  16. Cortiron
  17. Cortivis
  18. Cortixyl
  19. DCA
  20. DOC acetate
  21. DOCA
  22. Decortin
  23. Decosterone
  1. Decostrate
  2. Deoxycortone acetate
  3. Descorterone
  4. Descotone
  5. Desoxycorticosterone acetate
  6. Desoxycortone acetate
  7. Dorcostrin
  8. Doxo
  9. Doxycamon
  10. Krinocorts
  11. Ocriten
  12. Organon's Doca Acetate
  13. Percorten
  14. Percotol
  15. Pregn - 4 - ene - 3,20 - dione, 21 - hydroxy - , acetate
  16. Primocort
  17. Primocortan
  18. Sincortex
  19. Steraq
  20. Syncort
  21. Syncorta
  22. Syncortyl
  23. Unidocan


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
parenteral
rat 		lowest published toxic dose: 316 mg/kg (56 day prior to copulation/1-22 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) PSEBAA 120,238,1965
parenteral
rat 		lowest published toxic dose: 224 mg/kg (56 day prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) PSEBAA 120,238,1965
subcutaneous
rat 		lowest published toxic dose: 1,258 mg/kg (20 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct ENDOAO 28,129,1941
unreported route
rat 		lowest published toxic dose: 16 mg/kg (2 day male) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) ANENAG 24(Suppl 3),1,1963


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
mouse 		lowest published toxic dose: 520 mg/kg/13 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		PSEBAA 83,14,1953


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
rat 		lowest published toxic dose: 200 mg/kg Vascular: BP elevation not characterized in autonomic section JPETAB 321,485,2007
subcutaneous
rat 		lowest published toxic dose: 200 mg/kg Reproductive: Other effects on male TOXIA6 51,1197,2008


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
monkey 		lowest published toxic dose: 3.5 mg/kg/8 week- intermittent Vascular: BP elevation not characterized in autonomic section

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Changes in: K 		PBBHAU 38,55,1991
parenteral
rabbit 		lowest published toxic dose: 35 mg/kg/7 day- intermittent Liver: Other changes ANREAK 113,349,1952
subcutaneous
mouse 		lowest published toxic dose: 450 mg/kg/2 week- intermittent Vascular: BP elevation not characterized in autonomic section EJPHAZ 552,131,2006
subcutaneous
mouse 		lowest published toxic dose: 1,125 mg/kg/5 week- intermittent Vascular: Structural changes in vessels EJPHAZ 552,131,2006
subcutaneous
rat 		lowest published toxic dose: 180 mg/kg/3 week- intermittent Cardiac: Changes in heart weight

Vascular: BP elevation not characterized in autonomic section 		CEXPB9 27,277,2000
subcutaneous
rat 		lowest published toxic dose: 175 mg/kg/2 week- intermittent Vascular: BP elevation not characterized in autonomic section CEXPB9 27,818,2000
subcutaneous
rat 		lowest published toxic dose: 700 mg/kg/8 week- intermittent Vascular: BP elevation not characterized in autonomic section

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		CEXPB9 27,818,2000
subcutaneous
rat 		lowest published toxic dose: 1,400 mg/kg/8 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) CEXPB9 27,818,2000
subcutaneous
rat 		lowest published toxic dose: 30 mg/kg/1 week- intermittent Vascular: BP elevation not characterized in autonomic section BIPBU* 24,1181,2001
subcutaneous
rat 		lowest published toxic dose: 150 mg/kg/5 week- intermittent Cardiac: Changes in heart weight

Vascular: BP elevation not characterized in autonomic section

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		BIPBU* 24,1181,2001
subcutaneous
rat 		lowest published toxic dose: 100 mg/kg/4 week- intermittent Vascular: BP elevation not characterized in autonomic section FCLPH* 17,323,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
CNREA8 17,432,1957


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X5546;
Number of Industries 1;
Total Number of Facilities 17;
Number of Occupations 2;
Total Number of Employees Exposed 968;
Total Number of Female Employees Exposed 494


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
ANENAG Annales d'Endocrinologie. (Masson Editeur, 120 Blvd. Saint-Germain, F-25280 Paris Cedex 06, France) V.1- 1939-
ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08-
BIPBU* Biological & pharmaceutical bulletin. (Pharmaceutical Society of Japan, 2-12-15, Shibuya, Shibuya-ku, Tokyo 150-0002, Japan) V.1- 1993-
CEXPB9 Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917-
FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
PBBHAU Pharmacology, Biochemistry and Behavior. (ANKHO International Inc., P.O. Box 426, Fayetteville, NY 13066) V.1- 1973-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962-

FDA-proprietary drug

RTECS Compound Description:
   Tumorigen
   Drug
   Reproductive Effector

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