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Decanoic acid

RTECS #: HD9100000

CAS #: 334-48-5

UPDATE: November 2005 MW: 172.30 MF: C10H20O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. 1 - Nonanecarboxylic acid
  2. Capric acid
  3. Caprinic acid
  4. Caprynic acid
  5. Decylic acid
  6. Hexacid 1095
  1. Neo - fat 10
  2. n - Capric acid
  3. n - Decanoic acid
  4. n - Decoic acid
  5. n - Decylic acid


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg/24 hour moderate FCTXAV 17,735,1979
skin
rabbit 		1,00%/24 hour open irritation test severe FEREAC 68,7935,2003


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 14,500 ppb ANYAA9 407,186,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intravenous
mouse 		lethal dose (50 percent kill): 129 mg/kg Behavioral: Convulsions or effect on seizure threshold APTOA6 18,141,1961
oral
mammal (species unspecified) 		lethal dose (50 percent kill): >10 gm/kg N/R FEREAC 68,7935,2003
oral
rat 		lethal dose (50 percent kill): >10 gm/kg N/R AIHAAP 37,251,1976
skin
mammal (species unspecified) 		lethal concentration (50 percent kill): >5 gm/kg N/R FEREAC 68,7935,2003


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 168 gm/kg/6 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Metabolism (intermediary): Lipids including transport 		FEREAC 68,7935,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
FCTOD7 38,79,2000
TOXICOLOGY REVIEW
MUREAV 564,179,2004
TOXICOLOGY REVIEW
AJCDE* 13,21,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84495;
Number of Industries 8;
Total Number of Facilities 270;
Number of Occupations 9;
Total Number of Employees Exposed 2,910
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84495;
Number of Industries 9;
Total Number of Facilities 703;
Number of Occupations 15;
Total Number of Employees Exposed 7,879;
Total Number of Female Employees Exposed 945


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the manufacture of esters for artificial fruit flavors and perfumes
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AJCDE* American Journal of Contact Dermatitis: Official Journal of the American Contact Dermatitis Society (Philadelphia, PA : W.B. Saunders, Harcourt Brace Jovanovich) V.1-14 1990-2003.
ANYAA9 Annals of the New York Academy of Sciences. (New York Academy of Sciences, 2 E. 63rd St., New York, NY 10021) V.1- 1877-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-

Used in the manufacture of esters for artificial fruit flavors and perfumes

RTECS Compound Description:
   Mutagen
   Primary Irritant

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