RTECS:HA6040000 The Registry of Toxic Effects of Chemical Substances

Cytosine, 5 - fluoro -

RTECS #: HA6040000

CAS #: 2022-85-7

UPDATE: August 2007 MW: 129.11 MF: C₄H₄FN₃O

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

MUTATION DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

REFERENCES:

SYNONYMS:

2 - Hydroxy - 4 - amino - 5 - fluoropyrimidine

4 - Amino - 5 - fluoro - 2 (1H) - pyrimidinone

5 - FC

5 - Fluorocystosine

5 - Fluorocytosine

Alcobon

Ancobon

Ancotil

Flucytosine

Ro 2 - 9915

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
DNA inhibition other microorganisms 100 mg/L JMMIAV 12,83,1979
mutation in microorganisms Saccharomyes cerevisiae 8 mg/L (-enzymatic activation step) MGGEAE 146,253,1976
other mutation test systems other microorganisms 100 mg/L JMMIAV 12,83,1979

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intraperitoneal
mouse lethal dose (50 percent kill): 1,190 mg/kg N/R AACHAX -,566,1963
intraperitoneal
rat lethal dose (50 percent kill): 3,811 mg/kg N/R IYKEDH 10,710,1979
intravenous
mouse lethal dose (50 percent kill): 500 mg/kg N/R AACHAX -,566,1963
intravenous
rat lethal dose (50 percent kill): >600 mg/kg N/R IYKEDH 10,710,1979
oral
mouse lethal dose (12 percent kill): 500 mg/kg N/R BAXXDU #2067993
oral
rat lethal dose (50 percent kill): >15 gm/kg N/R NIIRDN 6,699,1982
oral
woman lowest published toxic dose: 1,080 mg/kg/10 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Change in motor activity (specific assay)

Behavioral: Ataxia EJCPAS 51,505,1997
subcutaneous
mouse lethal dose (50 percent kill): 1 gm/kg N/R CHTHBK 25,54,1979
subcutaneous
rat lethal dose (50 percent kill): 3,336 mg/kg N/R YAKUD5 21,935,1979

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
woman lowest published toxic dose: 240 mg/kg/2 day- intermittent Cardiac: Arrythmias (indlucing changes in conduction) CLPTAT 67,323,2000

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

TOXICOLOGY REVIEW
32XPAD -,49,1975
TOXICOLOGY REVIEW
EJIME* 17,529,2006
TOXICOLOGY REVIEW
DIMON* 39,678,1993

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6122;
Number of Industries 1;
Total Number of Facilities 53;
Number of Occupations 2;
Total Number of Employees Exposed 1,033;
Total Number of Female Employees Exposed 480

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

N/R

REFERENCES:
CODEN
REFERENCE

32XPAD "Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975
AACHAX Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI) 1961-70. For publisher information, see AMACCQ.
BAXXDU British UK Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231)
CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968-
CLPTAT Clinical Pharmacology and Therapeutics. (American Society for Clinical Pharmacology and Therapeutics, St. Louis Mo Mosby-Year Book) V.1- 1960-
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
EJCPAS European Journal of Clinical Pharmacology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1970-
EJIME* European Journal of Internal Medicine: The Official Journal of the European Federation of Internal Medicine (EFIM) (Elsevier) V.10- 1999-
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
JMMIAV Journal of Medical Microbiology. (Longman Group UK Ltd., Longman House, Burnt Mill, Harlow, Essex CM20 2JE, UK) V.1- 1968-
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967-
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

Used as an antifungal agent

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Mutagen
   Human Data

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SYNONYMS:
2 - Hydroxy - 4 - amino - 5 - fluoropyrimidine 4 - Amino - 5 - fluoro - 2 (1H) - pyrimidinone 5 - FC 5 - Fluorocystosine 5 - Fluorocytosine	Alcobon Ancobon Ancotil Flucytosine Ro 2 - 9915

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
DNA inhibition	other microorganisms	100 mg/L	JMMIAV 12,83,1979
mutation in microorganisms	Saccharomyes cerevisiae	8 mg/L (-enzymatic activation step)	MGGEAE 146,253,1976
other mutation test systems	other microorganisms	100 mg/L	JMMIAV 12,83,1979

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
intraperitoneal mouse	lethal dose (50 percent kill): 1,190 mg/kg	N/R	AACHAX -,566,1963
intraperitoneal rat	lethal dose (50 percent kill): 3,811 mg/kg	N/R	IYKEDH 10,710,1979
intravenous mouse	lethal dose (50 percent kill): 500 mg/kg	N/R	AACHAX -,566,1963
intravenous rat	lethal dose (50 percent kill): >600 mg/kg	N/R	IYKEDH 10,710,1979
oral mouse	lethal dose (12 percent kill): 500 mg/kg	N/R	BAXXDU #2067993
oral rat	lethal dose (50 percent kill): >15 gm/kg	N/R	NIIRDN 6,699,1982
oral woman	lowest published toxic dose: 1,080 mg/kg/10 day- intermittent	Brain and Coverings: Other degenerative changes Behavioral: Change in motor activity (specific assay) Behavioral: Ataxia	EJCPAS 51,505,1997
subcutaneous mouse	lethal dose (50 percent kill): 1 gm/kg	N/R	CHTHBK 25,54,1979
subcutaneous rat	lethal dose (50 percent kill): 3,336 mg/kg	N/R	YAKUD5 21,935,1979

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
oral woman	lowest published toxic dose: 240 mg/kg/2 day- intermittent	Cardiac: Arrythmias (indlucing changes in conduction)	CLPTAT 67,323,2000

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
TOXICOLOGY REVIEW		32XPAD -,49,1975
TOXICOLOGY REVIEW		EJIME* 17,529,2006
TOXICOLOGY REVIEW		DIMON* 39,678,1993

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
N/R	N/R	N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: X6122; Number of Industries 1; Total Number of Facilities 53; Number of Occupations 2; Total Number of Employees Exposed 1,033; Total Number of Female Employees Exposed 480

REFERENCES:
CODEN	REFERENCE
32XPAD	"Teratology," Berry, C.L., and D.E. Poswillo, eds., New York, Springer, 1975
AACHAX	Antimicrobial Agents and Chemotherapy (1961-70). (Ann Arbor, MI) 1961-70. For publisher information, see AMACCQ.
BAXXDU	British UK Patent Application. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231)
CHTHBK	Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968-
CLPTAT	Clinical Pharmacology and Therapeutics. (American Society for Clinical Pharmacology and Therapeutics, St. Louis Mo Mosby-Year Book) V.1- 1960-
DIMON*	Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
EJCPAS	European Journal of Clinical Pharmacology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1970-
EJIME*	European Journal of Internal Medicine: The Official Journal of the European Federation of Internal Medicine (EFIM) (Elsevier) V.10- 1999-
IYKEDH	Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970-
JMMIAV	Journal of Medical Microbiology. (Longman Group UK Ltd., Longman House, Burnt Mill, Harlow, Essex CM20 2JE, UK) V.1- 1968-
MGGEAE	Molecular and General Genetics. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967-
NIIRDN	Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan)
YAKUD5	Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-