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Cysteine, L -

RTECS #: HA1600000

CAS #: 52-90-4

UPDATE: February 2009 MW: 121.17 MF: C3H7NO2S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2 - Amino - 3 - mercaptopropionic acid
  2. Cystein
  3. Cysteine
  4. Half - cysteine
  5. L - (+) - Cysteine
  6. L - Alanine, 3 - mercapto -
  1. L - Cysteine (9CI)
  2. L - cysteine
  3. MDI - cysteine
  4. NSC - 8746
  5. Thioserine
  6. beta - Mercaptoalanine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 1 mmol/L CALEDQ 5,199,1978
DNA damage mouse other cell types 0.5 mmol/L/1 hour TOSCF2 73,416,2003
DNA damage intracerebral
mouse 		6 mg/kg TOSCF2 73,416,2003
DNA inhibition rat liver 1 mmol/L ABBIA4 166,400,1975
unscheduled DNA synthesis human fibroblast 1 mmol/L CALEDQ 5,199,1978
mutation in microorganisms Escherichia coli 25 mmol/plate (-enzymatic activation step) BZARAZ 32,1146,1979
mutation in microorganisms Escherichia coli 5 mg/plate (+enzymatic activation step) MUREAV 446,205,1999
mutation in microorganisms other microorganisms 25 mmol/plate (-enzymatic activation step) BZARAZ 32,1146,1979
mutation in microorganisms Salmonella typhimurium 30 µmol/plate (+enzymatic activation step) MUREAV 224,89,1989
mutation in microorganisms Salmonella typhimurium 8 µmol/plate (-enzymatic activation step) BCPCA6 34,3725,1985
micronucleus test hamster fibroblast 50 mg/L TOSCF2 58,102,2000
sister chromatid exchange hamster ovary 100 µmol/L MUREAV 68,351,1979
sister chromatid exchange human lymphocyte 10 mg/L MUREAV 372,75,1996


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 100 mg/kg (12 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) PSEBAA 139,62,1972
intravenous
rat 		lowest published toxic dose: 1,000 mg/kg (1 day prior to copulation) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) TOXID9 66,234,2002
oral
mouse 		lowest published toxic dose: 3,600 mg/kg (7-12 day pregnant) Reproductive: Effects on newborn: Physical TOIZAG 24,667,1977
oral
mouse 		lowest published toxic dose: 27,600 mg/kg (23 day prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders ENDOAO 69,331,1961
oral
mouse 		lowest published toxic dose: 6 gm/kg (30 day male) Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands OYYAA2 7,1251,1973


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
mouse 		lowest published toxic dose: 6,058 µg/kg Behavioral: Convulsions or effect on seizure threshold

Biochemical: Metabolism (intermediary): Lipids including transport 		TOSCF2 73,416,2003
intracerebral
mouse 		lowest published toxic dose: 6,058 µg/kg Brain and Coverings: Other degenerative changes

Behavioral: Convulsions or effect on seizure threshold

Biochemical: Metabolism (intermediary): Lipids including transport 		TOSCF2 73,416,2003
intramuscular
rat 		lowest published toxic dose: 5 mg/kg Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		BCLPT* 94,112,2004
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,400 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression 		OYYAA2 7,1251,1973
intraperitoneal
rat 		lethal dose (50 percent kill): 1,620 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression 		OYYAA2 7,1251,1973
intraperitoneal
rat 		lowest published toxic dose: 800 mg/kg Behavioral: Somnolence (general depressed activity) JTPAE7 16,123,2003
intravenous
mouse 		lethal dose (50 percent kill): 1,250 mg/kg N/R YKKZAJ 89,1138,1969
intravenous
rat 		lethal dose (50 percent kill): 1,140 mg/kg N/R JACTDZ 12,113,1993
intravenous
rat 		lowest published toxic dose: 1,000 mg/kg Eye: Ptosis

Behavioral: Tremor

Behavioral: Ataxia 		JTSCDR 28,95,2003
oral
mouse 		lethal dose (50 percent kill): 660 mg/kg N/R ARTODN 41,79,1978
oral
rat 		lethal dose (50 percent kill): 1,890 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Kidney, Ureter, and Bladder: Other changes in urine composition 		AGACBH 4,125,1974
oral
rat 		lethal dose (50 percent kill): 1,890 mg/kg N/R USXXAM #4510338
subcutaneous
mouse 		lethal dose (50 percent kill): 1,360 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression 		OYYAA2 7,1251,1973
subcutaneous
rat 		lethal dose (50 percent kill): 1,550 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression 		OYYAA2 7,1251,1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 22.4 gm/kg/4 week- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation

Related to Chronic Data: Changes in prostate weight 		JTPAE7 16,123,2003
intraperitoneal
rat 		lowest published toxic dose: 11.2 gm/kg/2 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JTPAE7 16,123,2003
intravenous
rat 		lowest published toxic dose: 3,000 mg/kg/3 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain JTSCDR 28,95,2003
intravenous
rat 		lowest published toxic dose: 28,000 mg/kg/28 day- intermittent Brain and Coverings: Changes in brain weight

Cardiac: Changes in heart weight

Related to Chronic Data: Changes in testicular weight 		JTSCDR 28,95,2003
intravenous
rat 		lowest published toxic dose: 2,800 mg/kg/28 day- intermittent Liver: Changes in liver weight

Endocrine: Changes in thyroid weight 		JTSCDR 28,95,2003
intravenous
rat 		lowest published toxic dose: 8,400 mg/kg/28 day- intermittent Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		JTSCDR 28,95,2003
oral
mouse 		lowest published toxic dose: 90 gm/kg/30 day- continuous Lung, Thorax, or Respiration: Other changes

Endocrine: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		OYYAA2 7,1251,1973
oral
rat 		lowest published toxic dose: 150 gm/kg/30 day- continuous Behavioral: Convulsions or effect on seizure threshold

Behavioral: Muscle weakness

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		OYYAA2 7,1251,1973
oral
rat 		lowest published toxic dose: 308 gm/kg/26 week- intermittent Cardiac: Other changes

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes 		OYYAA2 7,1251,1973


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
DPIRDU 3(1),14,1983


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 2 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4773;
Number of Industries 2;
Total Number of Facilities 81;
Number of Occupations 7;
Total Number of Employees Exposed 8,402;
Total Number of Female Employees Exposed 7,734


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951-
AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BCLPT* Basic & clinical pharmacology & toxicology (Copenhagen, Denmark : Nordic Pharmacological Society Oxford, UK : Distributed by Blackwell Munksgaard) V.94- 2004-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BZARAZ Biologicheskii Zhurnal Armenii. Biological Journal of Armenia. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.19- 1966-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
DPIRDU Dangerous Properties of Industrial Materials Report. (Van Nostrand Reinhold, 115 Fifth Ave., New York, NY 10003) V.1- 1981-
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JTPAE7 Journal of Toxicologic Pathology. (Nihon Dokusei Byori Gakkai, editor, 3-25-8 Nishi- shinbashi, Minato-ku, Tokyo 105, Japan) V.1- 1988
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PSEBAA Proceedings of the Society for Experimental Biology and Medicine. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1903/04-
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881-

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Natural Product

ALT CAS #: 4371-52-2
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