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Cyclopenta (g) - 2 - benzopyran, 1,3,4,6,7,8 - hexahydro - 4,6,6,7,8,8 - hexamethyl -

RTECS #: GY0790000

CAS #: 1222-05-5

UPDATE: December 2000 MW: 258.44 MF: C18H26O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,3,4,6,7,8 - Hexahydro - 4,6,6,7,8,8 - hexamethyl - cyclopenta - gamma - 2 - benzopyran
  2. Abbalide
  3. Galaxolide 50
  1. Galoxolide
  2. HHCB
  3. Pearlide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg/24 hour moderate FCTXAV 14,793,1976


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 5,500 mg/kg (7-17 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		NTIS** OTS0559129
oral
rat 		lowest published toxic dose: 5,500 mg/kg (7-17 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		TOLED5 111,169,1999


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published lethal dose: 3,250 mg/kg N/R DLRUAJ 94,268,1998
skin
rat 		lethal dose (50 percent kill): >5 gm/kg N/R DLRUAJ 94,268,1998
skin
rabbit 		lethal dose : >3,250 mg/kg N/R DLRUAJ 94,268,1998


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 84 mg/kg/2 week- continuous Liver: Changes in liver weight TOLED5 111,161,1999
oral
rat 		lowest published toxic dose: 4,858 mg/kg/14 day- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOLED5 111,143,1999


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T0055;
Number of Industries 1;
Total Number of Facilities 15;
Number of Occupations 16;
Total Number of Employees Exposed 2,279
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T0055;
Number of Industries 10;
Total Number of Facilities 3,202;
Number of Occupations 11;
Total Number of Employees Exposed 32,968;
Total Number of Female Employees Exposed 20,222


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in fragrance formulations
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
DLRUAJ Deutsche Lebensmittel - Rundschau. (Wissenschaftliche Verlagsgesellschaft Postfach 101061, D-70009 Stutgart, Germany) V. 34 - 42 n.10, 1936-1944, (1944 - 1947 suspended) V 43 n.1- July 1947-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-

Used in fragrance formulations

RTECS Compound Description:
   Reproductive Effector
   Primary Irritant

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