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Cyclohexanone, 2 - (o - chlorophenyl) - 2 - (methylamino) - , (+ - ) -

RTECS #: GW1300000

CAS #: 6740-88-1

UPDATE: May 2009 MW: 237.75 MF: C13H16ClNO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 2 - (Methylamino) - 2 - (2 - chlorophenyl) cyclohexanone
  2. 2 - (o - Chlorophenyl) - 2 - (methylamino) - cyclohexanone
  1. Cyclohexanone, 2 - (2 - chlorophenyl) - 2 - (methylamino) - , (+ - ) - (9CI)
  2. Ketamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
parenteral
monkey 		lowest published toxic dose: 1 mg/kg (23 week pregnant) Reproductive: Other effects to embryo or fetus BJANAD 47,917,1975


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
mouse 		lowest published toxic dose: 50 mg/kg Behavioral: Anticonvulsant TOXIA6 40,1667,2002
intramuscular
monkey 		lowest published toxic dose: 10 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Food intake (animal)

Behavioral: Ataxia 		TOXID9 66,261,2002
intraperitoneal
mouse 		lethal dose (50 percent kill): 400 mg/kg N/R BJANAD 55,457,1983
intraperitoneal
mouse 		lowest published toxic dose: 50 mg/kg Behavioral: Analgesia FATOAO 55,17,1992
intraperitoneal
mouse 		lowest published toxic dose: 18.3 mg/kg Behavioral: Anticonvulsant EURNE* 14,163,2003
intraperitoneal
mouse 		lowest published toxic dose: 30 mg/kg Behavioral: Change in motor activity (specific assay)

Biochemical: Metabolism (intermediary): Glycolytic

Biochemical: Metabolism (intermediary): Effect on active transport 		NEROEW 22,400,2000
intraperitoneal
mouse 		lowest published toxic dose: 40 mg/kg Behavioral: Somnolence (general depressed activity) NEROEW 22,400,2000
intraperitoneal
mouse 		lowest published toxic dose: 100 mg/kg Peripheral Nerve and Sensation: Recording from peripheral motor nerve PSCHDL 172,187,2004
intraperitoneal
mouse 		lowest published toxic dose: 10 mg/kg Behavioral: Change in motor activity (specific assay) PHREP* 57,55,2005
intraperitoneal
mouse 		lowest published toxic dose: 100 mg/kg Behavioral: Sleep FTRPAE 75,457,2004
intraperitoneal
rat 		lowest published toxic dose: 50 mg/kg Cardiac: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		FATOAO 52,37,1989
intraperitoneal
rat 		lowest published toxic dose: 25 mg/kg Biochemical: Metabolism (intermediary): Effect on active transport JPETAB 293,8,2000
intraperitoneal
rat 		lowest published toxic dose: 10 mg/kg Brain and Coverings: Other degenerative changes PSCHDL 161,168,2002
intraperitoneal
rat 		lowest published toxic dose: 8 mg/kg Behavioral: Alteration of operant conditioning PSCHDL 161,168,2002
intraperitoneal
rat 		lowest published toxic dose: 15 mg/kg Behavioral: Analgesia EJPHAZ 487,93,2004
intraperitoneal
rat 		lowest published toxic dose: 25 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Change in motor activity (specific assay)

Behavioral: Change in psychophysiological tests 		JPETAB 305,999,2003
intraperitoneal
rat 		lowest published toxic dose: 50 mg/kg Brain and Coverings: Other degenerative changes

Behavioral: Change in motor activity (specific assay)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		EJPHAZ 540,82,2006
intraperitoneal
rat 		lowest published toxic dose: 30 mg/kg Behavioral: Change in motor activity (specific assay) BPBLEO 29,86,2006
intraperitoneal
rat 		lowest published toxic dose: 100 mg/kg Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation 		NSAPCC 372(Suppl 1),94,2006
intravenous
human 		lowest published toxic dose: 0.25 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Analgesia

Gastrointestinal: Nausea or vomiting 		AJEMEN 19,531,2001
intravenous
human 		lowest published toxic dose: 0.3 mg/kg Brain and Coverings: Changes in circulation

Vascular: Measurement of regional blood flow 		NEROEW 25,165,2001
intravenous
human 		lowest published toxic dose: 0.3 mg/kg Behavioral: Toxic psychosis NEROEW 25,455,2001
intravenous
human 		lowest published toxic dose: 0.1 mg/kg Eye: Other eye effects

Behavioral: Change in psychophysiological tests 		NEROEW 23,645,2000
intravenous
human 		lowest published toxic dose: 0.8 mg/kg Behavioral: Alteration of operant conditioning PSCHDL 172,298,2004
intravenous
man 		lowest published toxic dose: 0.5 mg/kg Behavioral: Toxic psychosis

Behavioral: Change in psychophysiological tests

Gastrointestinal: Nausea or vomiting 		NEROEW 25,72,2001
intravenous
man 		lowest published toxic dose: 0.3 mg/kg Brain and Coverings: Changes in surface EEG

Behavioral: Change in psychophysiological tests 		NEROEW 22,293,2000
intravenous
mouse 		lethal dose (50 percent kill): 77 mg/kg Behavioral: General anesthetic JZKEDZ 1,119,1975
intravenous
rat 		lowest published toxic dose: 5 mg/kg Lung, Thorax, or Respiration: Respiratory depression FATOAO 53,35,1990
intravenous
rat 		lowest published toxic dose: 2.5 mg/kg Behavioral: Analgesia FATOAO 51,48,1988
intravenous
rat 		lowest published toxic dose: 10 mg/kg Vascular: BP elevation not characterized in autonomic section FATOAO 51,48,1988
intravenous
rat 		lowest published toxic dose: 50 mg/kg Behavioral: Sleep

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Respiratory depression 		FATOAO 51,48,1988
intravenous
rat 		lowest published toxic dose: 3 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Vascular: BP lowering not characterized in autonomic section 		CYLPDN 22,97,2001
parenteral
rat 		lowest published toxic dose: 10 mg/kg Behavioral: Alteration of classical conditioning FCLPH* 18(Suppl 1),128,2004
subcutaneous
mouse 		lowest published toxic dose: 25 mg/kg Brain and Coverings: Other degenerative changes

Behavioral: Somnolence (general depressed activity)

Behavioral: Alteration of classical conditioning 		TOXID9 44,219,2005
subcutaneous
mouse 		lowest published toxic dose: 5 mg/kg Brain and Coverings: Other degenerative changes

Behavioral: Change in motor activity (specific assay)

Behavioral: Alteration of classical conditioning 		TXCYAC 249,153,2008
subcutaneous
rat 		lowest published toxic dose: 25 mg/kg Brain and Coverings: Other degenerative changes TOXID9 78,61,2004
subcutaneous
rat 		lowest published toxic dose: 12 mg/kg Brain and Coverings: Other degenerative changes

Behavioral: Change in motor activity (specific assay)

Behavioral: Alteration of classical conditioning 		EJPHAZ 544,77,2006
subcutaneous
rat 		lowest published toxic dose: 6 mg/kg Brain and Coverings: Changes in surface EEG

Behavioral: Change in motor activity (specific assay)

Behavioral: Alteration of classical conditioning 		PSCHDL 191,961,2007


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 700 mg/kg/7 day- intermittent Behavioral: Alteration of classical conditioning TOXID9 44,219,2005
oral
rat 		lowest published toxic dose: 23.5 gm/kg/235 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Alteration of operant conditioning

Behavioral: Change in psychophysiological tests 		TOXID9 90,298,2006
unreported route
monkey 		lowest published toxic dose: 40 mg/kg/2 day- intermittent Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Body temperature decrease 		TOXID9 44,414,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
JFSCAS 45,655,2000
TOXICOLOGY REVIEW
TPHSDY 24,634,2003
TOXICOLOGY REVIEW
JOPSEQ 20,143,2006
TOXICOLOGY REVIEW
PSCHDL 192,253,2007
TOXICOLOGY REVIEW
HOKMJ* 13,311,2007
TOXICOLOGY REVIEW
HUTOX* -,493,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X6267;
Number of Industries 1;
Total Number of Facilities 28;
Number of Occupations 2;
Total Number of Employees Exposed 91;
Total Number of Female Employees Exposed 36


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983-
BJANAD British Journal of Anesthesia. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1923-
BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993-
CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980-
EJPHAZ European Journal of Pharmacology. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1967-
EURNE* European Neuropsychopharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Nov.1990-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001-
FTRPAE Fitoterapia. (Inverni della Beffa SpA, via Ripamonti, 99, 20141 Milan, Italy) V.18- 1947-
HOKMJ* Hong Kong Medical Journal (Published by the Hong Kong Academy of Medicine and the Hong Kong Medical Association, 10th Floor, 99 Wong Chuk Hang Road, Aberdeen, Hong Kong, China)-
HUTOX*
JFSCAS Journal of Forensic Sciences. (American Soc. for Testing and Materials, 1916 Race St., Philadelphia, PA 19103) V.1- 1956-
JOPSEQ Journal of Psychopharmacology (Oxford). (Oxford University Press, Great Clarendon St., Oxford OX2 6DP, UK) V.1- 1987-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JZKEDZ Jitchuken Zenrinsho Kenkyuho. Central Institute for Experimental Animals, Research Reports. (Jikken Dobutsu Chuo Kenkyusho, 1433 Nogawa, Takatsu-ku, Kawasaki 211, Japan) V.1- 1975-
NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987-
NSAPCC Naunyn-Schmiedeberg's Archives of Pharmacology. (Springer Verlag, Heidelberger, Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.272- 1972-
PHREP*
PSCHDL Psychopharmacology (Berlin). (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.47- 1976-
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

Used as a general anesthetic

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   Reproductive Effector
   Human Data

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