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Cyclohexanesulfamic acid, monosodium salt

RTECS #: GV7350000

CAS #: 139-05-9

UPDATE: February 2008 MW: 201.24 MF: C6H12NO3S•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Assurgrin feinsuss
  2. Assurgrin vollsuss
  3. Asugryn
  4. Cyclamate sodium
  5. Cyclamate, sodium salt
  6. Cyclamic acid sodium salt
  7. Cyclohexanesulphamic acid, monosodium salt
  8. Cyclohexylsulphamate sodium
  9. Cyclohexylsulphamic acid, monosodium salt
  10. Dulzor - Etas
  11. Hachi - Sugar
  12. Ibiosuc
  13. N - Cyklohexylsulfamat sodny (Czech)
  14. Natreen
  15. Natriumzyklamate (German)
  1. Sodium cyclamate
  2. Sodium cyclohexanesulfamate
  3. Sodium cyclohexanesulphamate
  4. Sodium cyclohexyl amidosulphate
  5. Sodium cyclohexyl sulfamate
  6. Sodium cyclohexyl sulphamate
  7. Sodium cyclohexylsulphamidate
  8. Sodium sucaryl
  9. Sucaryl sodium
  10. Sucrum 7
  11. Suessette
  12. Suestamin
  13. Sugarin
  14. Sugaron


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster fibroblast 10 mg/L MUREAV 39,1,1976
cytogenetic analysis hamster lung 500 mg/L HEREAY 70,271,1972
cytogenetic analysis human leukocyte 10 µmol/L/5 hour MUREAV 39,1,1976
cytogenetic analysis human fibroblast 500 mg/L ACYTAN 16,41,1972
cytogenetic analysis oral
rat 		250 mg/kg DBTEAD 19,215,1971
DNA damage oral
mouse 		2 gm/kg MUREAV 519,103,2002
DNA inhibition human HeLa cell 800 µg/L INHEAO 9,188,1971
morphological transform rat other cell types 24 mmol/L CRNGDP 7,2059,1986
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		5 pph SBJODP 1,77,1975


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 180 mg/kg (7 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death IIZAAX 16,330,1964
oral
mouse 		lowest published toxic dose: 420 gm/kg (multigenerations) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		TXCYAC 8,285,1977
oral
mouse 		lowest published toxic dose: 168 gm/kg (multigenerations) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) TXCYAC 8,285,1977
oral
mouse 		lowest published toxic dose: 5 gm/kg (7 day pregnant) Reproductive: Other effects to embryo or fetus ARZNAD 19,923,1969
oral
mouse 		lowest published toxic dose: 252 mg/kg (1-21 day pregnant/21 day after birth) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		DBTEAD 17,103,1969


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
mouse 		lowest published toxic dose: 176 mg/kg Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors

Tumorigenic: Tumors at site of application 		SCIEAS 167,996,1970
oral
monkey 		lowest published toxic dose: 580 gm/kg/5800 day- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Uterine tumors 		TOSCF2 53,33,2000
oral
monkey 		lowest published toxic dose: 556 gm/kg/5560 day- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Reproductive: Tumorigenic effects: Prostate tumors 		TOSCF2 53,33,2000
oral
monkey 		lowest published toxic dose: 2,810 gm/kg/5620 day- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Liver: Tumors 		TOSCF2 53,33,2000
oral
monkey 		lowest published toxic dose: 2,810 gm/kg/5620 day- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Colon tumors 		TOSCF2 53,33,2000
oral
rat 		lowest published toxic dose: 63 gm/kg/9 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Skin and Appendages: Tumors 		CNREA8 37,2943,1977
oral
rat 		toxic dose : 112 gm/kg/8 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Kidney, Ureter, and Bladder: Kidney tumors

Skin and Appendages: Tumors 		CNREA8 37,2943,1977
oral
rat 		toxic dose : 610 gm/kg/87 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors 		CBINA8 11,225,1975


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 1,154 mg/kg N/R NCIBR* NCI-E-68-1311,1973
intraperitoneal
rat 		lethal dose (50 percent kill): 1,350 mg/kg N/R NCIBR* NCI-E-68-1311,1973
intravenous
mouse 		lethal dose (50 percent kill): 4,800 mg/kg N/R FCTXAV 6,313,1968
intravenous
rat 		lethal dose (50 percent kill): 3,500 mg/kg N/R FCTXAV 6,313,1968
oral
mouse 		lethal dose (50 percent kill): 17 gm/kg N/R FCTXAV 6,313,1968
oral
rat 		lethal dose (50 percent kill): 1,280 mg/kg N/R SRTCAC 36(1-4),10,1989


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
hamster 		lowest published toxic dose: 78,400 mg/kg/8 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field CALEDQ 1,21,1975
oral
mouse 		lowest published toxic dose: 4,704 gm/kg/80 week- continuous Blood: Pigmented or nucleated red blood cells FCTXAV 11,735,1973


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 22,55,1980
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 22,55,1980
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 73,195,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 73,195,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 73,195,1999
TOXICOLOGY REVIEW
IDJOAS 23,328,1973
TOXICOLOGY REVIEW
MUREAV 39,1,1976
TOXICOLOGY REVIEW
AEHLAU 23,6,1971
TOXICOLOGY REVIEW
WMWOA4 121,515,1971
TOXICOLOGY REVIEW
BLFSBY 24,129,1983
TOXICOLOGY REVIEW
BLFSBY 24,253,1983
TOXICOLOGY REVIEW
MUREAV 584,1,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83822;
Number of Industries 1;
Total Number of Facilities 21;
Number of Occupations 2;
Total Number of Employees Exposed 83
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83822;
Number of Industries 2;
Total Number of Facilities 294;
Number of Occupations 9;
Total Number of Employees Exposed 5,265;
Total Number of Female Employees Exposed 4,349


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Negative: D melanogaster-nondisjunction; Rodent dominant lethal
EPA GENETOX PROGRAM 1988, Negative: Host-mediated assay; Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: Cytogenetics-male germ cell
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
ACYTAN Acta Cytologica. (Science Printers and Pub., Inc., 2 Jacklynn Ct., St. Louis, MO 63132) V.1- 1957-
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
BLFSBY Basic Life Sciences. (Plenum Pub. Corp., 223 Spring St., New York, NY 10003) V.1- 1973-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969-
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DBTEAD Diabete. (Le Raincy, France) V.1-22, 1953-74. Discontinued.
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
HEREAY Hereditas (Lund, Sweden). (Gjoerloffsgatan 121, S-261 34 Landskrona, Sweden) V.1- 1947-
IDJOAS International Dental Journal. (A. Sijthoff, 37 Wagenstr, The Hague, Netherlands) V.1- 1950-
IIZAAX Iwate Igaku Zasshi. Journal of the Iwate Medical Association. (c/o Iwate Ika Daigaku, 19-1 Uchimaru, Morioka, 020, Japan) V.1- 1947-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
INHEAO Industrial Health. (National Institute of Industrial Health, 6-21-1 Nagao, Tama-ku, Kawasaki, 213 Japan) V.1- 1963-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCIBR* Progress Report for Contract No. NIH-NCI-E-68-1311, Submitted to the National Cancer Institute by Bio-Research Consultants, Inc. (9 Commercial Ave., Cambridge, MA 02141)
SBJODP Science of Biology Journal. (Springfield, IL) V.1-4, 1975-78(?). Discontinued.
SCIEAS Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC 20005) V.1- 1895-
SRTCAC Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. (Tohoku University, Research Institute for Tuberculosis and Cancer, 4-1 Seiryo-machi, Sendai, Japan) V.1- 1949-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
WMWOA4 Wiener Medizinische Wochenschrift. (Brueder Hollinek, Gallgasse 40, A-1130 Vienna, Austria) V.1- 1851-

Used as a non-nutritive sweetening agent

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

ALT CAS #: 53170-91-5
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