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beta - Cyclodextrin

RTECS #: GU2293000

CAS #: 7585-39-9

UPDATE: May 2008 MW: 1,135.12 MF: C42H70O35


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Cycloheptaamylose
  2. Cycloheptaglucan
  3. Cycloheptaglucosan
  4. Cyclomaltoheptaose
  1. Schardinger beta - dextrin
  2. beta - Cycloheptaamylose
  3. beta - Cycloamylose
  4. beta - Dextrin


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 350 gm/kg (multigeneration) Reproductive: Other effects on female

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		REPTED 9,389,1995
oral
rat 		lowest published toxic dose: 155 gm/kg (multigeneration) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		NTIS** OTS0571979


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 330 mg/kg N/R 48THAM 1,109,1982
intraperitoneal
rat 		lethal dose (50 percent kill): 356 mg/kg N/R 48THAM 1,109,1982
intravenous
rat 		lethal dose (50 percent kill): 1,008 mg/kg N/R AJPAA4 83,367,1976
oral
mouse 		lethal dose (50 percent kill): >12,500 mg/kg N/R PSSCBG 11,134,1980
oral
rat 		lethal dose (50 percent kill): 18,800 mg/kg N/R OYYAA2 26,287,1983
oral
rabbit 		lethal dose (50 percent kill): >12,000 mg/kg N/R FEREAC 67,69003,2002
subcutaneous
mouse 		lethal dose (50 percent kill): 412 mg/kg N/R 48THAM 1,109,1982
subcutaneous
rat 		lethal dose (50 percent kill): 3,700 mg/kg N/R OYYAA2 26,287,1983


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 112.5 gm/kg/90 day- continuous Blood: Other changes FEREAC 67,69003,2002
oral
dog 		lowest published toxic dose: 337.6 gm/kg/1 year- continuous Kidney, Ureter, and Bladder: Proteinuria FEREAC 67,69003,2002
oral
rat 		lowest published toxic dose: 634 gm/kg/52 week- continuous Liver: Hepatitis (hepatocellular necrosis), zonal

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		FCTOD7 33,367,1995
oral
rat 		lowest published toxic dose: 3,285 gm/kg/2 year- continuous Skin: After topical application: Dermatitis, allergic

Kidney, Ureter, and Bladder: Changes in both tubules and glomeruli 		FEREAC 67,69003,2002
oral
rat 		lowest published toxic dose: 4.59 gm/kg/7 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Biochemical: Metabolism (intermediary): Lipids including transport 		PHTOEH 92,94,2003
oral
rat 		lowest published toxic dose: 7.35 gm/kg/7 week- continuous Liver: Hepatitis (hepatocellular necrosis), diffuse

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		PHTOEH 92,94,2003
oral
rat 		lowest published toxic dose: 73,500 mg/kg/7 week- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		PHTOEH 92,94,2003
oral
rat 		lowest published toxic dose: 147,000 mg/kg/7 week- continuous Behavioral: Food intake (animal)

Liver: Hepatitis (hepatocellular necrosis), zonal 		PHTOEH 92,94,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JUN2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X2627;
Number of Industries 1;
Total Number of Facilities 21;
Number of Occupations 1;
Total Number of Employees Exposed 123;
Total Number of Female Employees Exposed 123


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
48THAM "Proceedings of the International Symposium on Cyclodextrins, 1st, 1981," Szejtli, J., ed., Hingham, MA, Kluwer Academic Pub., 1982
AJPAA4 American Journal of Pathology. (Lippincott/Harper, Journal Fulfillment Dept., 2350 Virginia Ave., Hagerstown, MD 21740) V.1- 1925-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987-
PSSCBG Pesticide Science. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1970-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-

RTECS Compound Description:
   Reproductive Effector

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