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Cyclacillin

RTECS #: GT8450000

CAS #: 3485-14-1

UPDATE: November 2005 MW: 341.47 MF: C15H23N3O4S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. REFERENCES:

SYNONYMS:

  1. (1 - Aminocyclohexyl) penicillin
  2. 6 - (1 - Aminocyclohexanecarboxamido) penicillanic acid
  3. AC - PC
  4. Aminocyclohexylpenicillin
  5. Ciclacillin
  6. Ciclacillum
  1. Cyclapen
  2. Ultracillin
  3. Vastcillin
  4. WY 4508
  5. Wyvital


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 3,776 mg/kg Liver: Other changes CHTHBK 22,154,1976
intraperitoneal
rat 		lethal dose (50 percent kill): 5,010 mg/kg Liver: Other changes CHTHBK 22,154,1976
oral
dog 		lethal dose (50 percent kill): 2,500 mg/kg Liver: Other changes CHTHBK 22,154,1976
oral
human 		lowest published toxic dose: 210 mg/kg/7 day- intermittent Gastrointestinal: Hypermotility, diarrhea

Gastrointestinal: Other changes

Skin: After systemic exposure: Dermatitis, other 		CHTHBK 22,154,1976
oral
mouse 		lethal dose (50 percent kill): 5,010 mg/kg Liver: Other changes CHTHBK 22,154,1976
oral
rat 		lethal dose (50 percent kill): 5,010 mg/kg Liver: Other changes CHTHBK 22,154,1976
subcutaneous
mouse 		lethal dose (50 percent kill): 7,500 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity) 		TAKHAA 29,117,1970
subcutaneous
rat 		lethal dose (50 percent kill): 6,500 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity) 		TAKHAA 29,117,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 87 gm/kg/26 week- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) TXAPA9 29,1,1974
oral
rat 		lowest published toxic dose: 108 gm/kg/30 day- continuous Behavioral: Food intake (animal)

Kidney, Ureter, and Bladder: Changes in bladder weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TAKHAA 29,117,1970


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
TPHSDY 23,434,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X9351;
Number of Industries 1;
Total Number of Facilities 25;
Number of Occupations 1;
Total Number of Employees Exposed 101;
Total Number of Female Employees Exposed 51


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
CHTHBK Chemotherapy (Basel). (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.13- 1968-
TAKHAA Takeda Kenkyusho Ho. Journal of the Takeda Research Laboratories. (Takeda Yakuhin Kogyo K.K., 2-17-85 Jusohon-machi, Yodogawa-ku, Osaka 532, Japan) V.29- 1970-
TPHSDY Trends in Pharmacological Sciences. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1979-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Human Data

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