The Registry of Toxic Effects of Chemical Substances

6 - Chromanol, 2,5,7,8 - tetramethyl - 2 - (4,8,12 - trimethyltridecyl) - , acetate, (+) -

RTECS #: GP8280000

CAS #: 58-95-7

UPDATE: August 2008 MW: 472.83 MF: C31H52O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. (+) - alpha - Tocopherol acetate
  2. (+) - alpha - Tocopheryl acetate
  3. (2R,4'R,8'R) - alpha - Tocopheryl acetate
  4. (R,R,R) - alpha - Tocopheryl acetate
  5. Alfacol
  6. Combinal E
  7. Contopheron
  8. Copherol 1250
  9. Covitol 1360
  10. E - Ferol
  11. E - Toplex
  12. ECON
  13. Ecofrol
  14. Endo E dompe
  15. Ephynal acetate
  16. Epsilan - M
  1. Erevit
  2. Evipherol
  3. Fertilvit
  4. Gevex
  5. Juvela
  6. Tocopherex
  7. Tocopherol acetate
  8. Tocophrin
  9. Tofaxin
  10. Tokoferol acetate
  11. Vitamin E acetate
  12. Vitamin Ealpha acetate
  13. alpha - Tocopherol acetate
  14. alpha - Tocopheryl acetate
  15. d - alpha - Tocopherol acetate
  16. d - alpha - Tocopheryl acetate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 5 gm/kg N/R YAKUD5 9,759,1967
intraperitoneal
rat 		lethal dose (50 percent kill): 840 mg/kg N/R IJTOFN 21,51,2002
oral
mouse 		lethal dose (50 percent kill): 5 gm/kg N/R YAKUD5 9,759,1967
oral
rat 		lethal dose (50 percent kill): >16 gm/kg N/R IJTOFN 21,51,2002


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
rat 		lowest published toxic dose: 100 mg/kg/5 day- intermittent Immunological Including Allergic: Increased immune response EKFAE9 59,47,1996
intraperitoneal
rat 		lowest published toxic dose: 80 units/kg/14 day- intermittent Behavioral: Change in motor activity (specific assay)

Biochemical: Metabolism (intermediary): Other proteins

Biochemical: Metabolism (intermediary): Other 		NEROEW 26,397,2002
oral
mouse 		lowest published toxic dose: 7,938 units/kg/9 week- intermittent Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Other changes 		TXCYAC 175,235,2002
oral
mouse 		lowest published toxic dose: 41,958 units/kg/9 week- intermittent Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TXCYAC 175,235,2002
oral
mouse 		lowest published toxic dose: 2,400 mg/kg/30 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects

Biochemical: Metabolism (intermediary): Lipids including transport 		TXCYAC 191,19,2003
oral
mouse 		lowest published toxic dose: 1,383 units/kg/26 week- continuous Tumorigenic: Protects against induction of experimental tumors CRNGDP 26,2179,2005
oral
rat 		lowest published toxic dose: 182 gm/kg/13 week- continuous Liver: Changes in liver weight

Blood: Pigmented or nucleated red blood cells

Blood: Changes in other cell count (unspecified) 		FCTOD7 24,1043,1986
oral
rat 		lowest published toxic dose: 150 mg/kg/5 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases FATOAO 53,52,1990
oral
rat 		lowest published toxic dose: 2,100 mg/kg/3 week- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport

Biochemical: Metabolism (intermediary): Other proteins 		TXCYAC 190,231,2003
oral
rat 		lowest published toxic dose: 1,000 mg/kg/4 week- intermittent Vascular: Structural changes in vessels

Biochemical: Metabolism (intermediary): Lipids including transport 		ARTODN 78,655,2004
oral
rat 		lowest published toxic dose: 31,500 units/kg/10 week- intermittent Endocrine: Hypoglycemia PHMCAA 70,1,2004
oral
rat 		lowest published toxic dose: 96,000 units/kg/32 week- intermittent Endocrine: Hypoglycemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		FCLPH* 19,73,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
IJTOFN 21,51,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80575;
Number of Industries 3;
Total Number of Facilities 149;
Number of Occupations 9;
Total Number of Employees Exposed 8,005
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80575;
Number of Industries 5;
Total Number of Facilities 834;
Number of Occupations 9;
Total Number of Employees Exposed 8,113;
Total Number of Female Employees Exposed 5,676


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992-
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FCLPH* Fundamental & Clinical Pharmacology (Oxford : Blackwell Science) 2001-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
IJTOFN International Journal of Toxicology. (Taylor & Francis, 47 Runway Rd., Suite g, Levittown, PA 19057) V.16- 1997-
NEROEW Neuropsychopharmacology. (Elsevier Science, 655 Avenue of the Americas, New York, NY 10010) V.1- 1987-
PHMCAA Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville Pike, Bethesda, MD 20014) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

RTECS Compound Description:
   Drug

ALT CAS #: 1406-70-8
ALT CAS #: 12741-00-3
ALT CAS #: 26243-95-8
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