CDC logo, Safer Healthier People CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us




Cortisone

RTECS #: GM9020000

CAS #: 53-06-5

UPDATE: August 2007 MW: 360.49 MF: C21H28O5


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. REFERENCES:

SYNONYMS:

  1. 11 - Dehydro - 17 - hydroxycorticosterone
  2. 17 - Hydroxy - 11 - dehydrocorticosterone
  3. 17 - alpha - Hydroxy - 11 - dehydrocorticosterone
  4. 17alpha,21 - Dihydroxypregn - 4 - ene - 3,11,20 - trione
  5. 17alpha,21 - Dihydroxy - 4 - pregnene - 3,11,20 - trione
  6. 4 - Pregnene - 17alpha,21 - diol - 3,11,20 - trione
  7. Adrenalex
  8. Compound E
  9. Cortisate
  1. Cortivite
  2. Cortone
  3. KE
  4. Kendall's compound E
  5. Pregn - 4 - en - 17alpha,21 - diol - 3,11,20 - trione
  6. Pregn - 4 - ene - 3,11,20 - trione, 17,21 - dihydroxy -
  7. Reichstein's substance FA
  8. Wintersteiner's compound F
  9. delta (sup 4) - Pregnene - 17alpha,21 - diol - 3,11,20 - trione


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis parenteral
silkworm 		100 µmol/L ENZYAS 41,183,1971
DNA adduct human liver 2 mmol/L MUREAV 370,49,1996
DNA adduct human liver 2 mmol/L/1 hour MUREAV 370,49,1996
DNA adduct human liver 2 mmol/plate/1 hour MUREAV 370,49,1996
DNA damage mammal (species unspecified) liver 1 mmol/L ENZYAS 41,183,1971
DNA damage mammal (species unspecified) lymphocyte 10 µmol/L ENZYAS 41,183,1971
DNA damage mouse liver 100 µmol/L ENZYAS 41,183,1971
DNA inhibition subcutaneous
rat 		168 mg/kg/3 day- continuous ENDOAO 94,1637,1974
unscheduled DNA synthesis subcutaneous
rat 		168 mg/kg/3 day- continuous ENDOAO 94,1637,1974


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
mouse 		lowest published toxic dose: 400 mg/kg (11-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		JDREAF 50,609,1971
intramuscular
mouse 		lowest published toxic dose: 100 mg/kg (11-12 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) ANREAK 142,479,1962
intramuscular
mouse 		lowest published toxic dose: 300 mg/kg (12 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		JTEHD6 10,541,1982
intramuscular
mouse 		lowest published toxic dose: 300 mg/kg (12 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Physical 		TCMUD8 4,403,1984
intramuscular
rat 		lowest published toxic dose: 110 mg/kg (1-22 day pregnant) Reproductive: Effects on newborn: Delayed effects JCINAO 41,710,1962
intramuscular
rat 		lowest published toxic dose: 225 mg/kg (13-22 day pregnant) Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow) ACENA7 50,104,1965
intramuscular
rat 		lowest published toxic dose: 110 mg/kg (1-22 day pregnant) Reproductive: Specific developmental abnormalities: Endocrine system ACENA7 53,547,1966
intramuscular
rat 		lowest published toxic dose: 82,500 µg/kg (11 day pregnant) Reproductive: Other effects to embryo or fetus

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Biochemical and metabolic 		ACENA7 60,36,1969
intraperitoneal
mouse 		lowest published toxic dose: 400 mg/kg (11-14 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) JDREAF 50,609,1971
intraperitoneal
mouse 		lowest published toxic dose: 200 mg/kg (11 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		JDREAF 45,1767,1966
oral
mouse 		lowest published toxic dose: 500 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 28QFAD -,85,1973
oral
mouse 		lowest published toxic dose: 1 gm/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system JJATDK 5,97,1985
oral
woman 		lowest published toxic dose: 90 mg/kg (90 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system 		AJOGAH 65,227,1953
oral
woman 		lowest published toxic dose: 160 mg/kg (16 week prior to copulation/1-39 week pregnant) Reproductive: Effects on newborn: Other neonatal measures or effects OBGNAS 1,276,1953
parenteral
rat 		lowest published toxic dose: 35 mg/kg (7 day prior to copulation) Reproductive: Maternal effects: Uterus, cervix, vagina JEMEAV 102,347,1955
parenteral
rabbit 		lowest published toxic dose: 32 mg/kg (20-27 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		JOENAK 14,284,1956
subcutaneous
mouse 		lowest published toxic dose: 400 mg/kg (11-14 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		JDREAF 50,609,1971
subcutaneous
rat 		lowest published toxic dose: 500 mg/kg (8-17 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) AGDJAI 18,34,1970
unreported route
mouse 		lowest published toxic dose: 120 mg/kg (1 day prior to copulation) Reproductive: Effects on fertility: Other measures of fertility FESTAS 12,346,1961
unreported route
rat 		lowest published toxic dose: 144 mg/kg (9 day male) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) ANENAG 24(Suppl 3),1,1963
unreported route
rabbit 		lowest published toxic dose: 450 mg/kg (16-30 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) AKGIAO 43(12),10,1967
unreported route
woman 		lowest published toxic dose: 476 mg/kg (1-34 week pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) LANCAO 2,730,1956


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
parenteral
rabbit 		lowest published toxic dose: 35 mg/kg/7 day- intermittent Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Other changes

Liver: Changes in liver weight 		ANREAK 113,349,1952


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
AJOGAH 96,985,1966
TOXICOLOGY REVIEW
PHTHDT 96,23,2002
TOXICOLOGY REVIEW
LANCAO 1,1045,1956
TOXICOLOGY REVIEW
AINCM* 7,63,2006
TOXICOLOGY REVIEW
ENTOX* -,669,2005


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3836;
Number of Industries 1;
Total Number of Facilities 27;
Number of Occupations 1;
Total Number of Employees Exposed 936;
Total Number of Female Employees Exposed 906


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
28QFAD "Laboratory Animals in Drug Testing, Symposium of the 5th International Committee on Laboratory Animals, Hanover, 1972," Speigel, A. ed., Stuttgart, Fed. Rep. Ger., Gustav Fischer Verlag, 1973
ACENA7 Acta Endocrinologica (Copenhagen). (Periodica, Skolegade 12 E, DK-2500 Valby, Denmark) V.1- 1948-
AGDJAI Journal of the Academy of General Dentistry. (Academy of General Dentistry, 211 E. Chicago Ave., Suite 1200, Chicago, IL 60611) V.1- 1952(?)-
AINCM* Anaesthesia and Intensive Care Medicine (Abingdon: Medicine Pub. Co.) V.1- 2000-
AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920-
AKGIAO Akushcherstvo i Ginekologiya (Moscow). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1936-
ANENAG Annales d'Endocrinologie. (Masson Editeur, 120 Blvd. Saint-Germain, F-25280 Paris Cedex 06, France) V.1- 1939-
ANREAK Anatomical Record. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1906/08-
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917-
ENTOX* Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
ENZYAS Enzymologia. (The Hague, Netherlands) V.1-43, 1936-72.
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950-
JCINAO Journal of Clinical Investigation. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1924-
JDREAF Journal of Dental Research. (International Assoc. for Dental Research, 734 15th St., NW, Suite 809, Washington, DC 20005) V.1- 1919-
JEMEAV Journal of Experimental Medicine. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1896-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
OBGNAS Obstetrics and Gynecology. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1953-
PHTHDT Pharmacology and Therapeutics. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 0BW, UK) V.4- 1979-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Human Data
   Hormone

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us