The Registry of Toxic Effects of Chemical Substances

alpha (sup 1 - 24) - Corticotropin

RTECS #: GM7915000

CAS #: 16960-16-0

UPDATE: August 2008 MW: 2,933.92 MF: C136H210N40O31S


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. REFERENCES:

SYNONYMS:

  1. ACTH (1 - 24)
  2. ACTH - alpha (1 - 24)
  3. Actholain
  4. Adrenocorticotropin (1 - 24)
  5. Ba 30920
  6. Ba 36716
  7. Corticotropin - (1 - 24)
  8. Cortrophin S
  9. Cortrosinta
  10. Cortrosyn
  11. Cosyntropin
  12. Nuvacthen depot
  1. Porcine ACTH (1 - 24)
  2. Synacthen
  3. Tetracosactid
  4. Tetracosactide
  5. Tetracosactrin
  6. Tetracosapeptide
  7. alpha (1 - 24) ACTH
  8. beta (1 - 24) ACTH
  9. beta (sup 1 - 24) - Corticotropin
  10. beta - Corticotrophin - (1 - 24) - tetracosapeptide
  11. beta - Corticotropin - (1 - 24) - tetracosapeptide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
rat 		lowest published toxic dose: 60 µg/kg/24 hour Behavioral: Food intake (animal) NSAPCC 369(Suppl 1),R176,2004
intramuscular
woman 		lowest published lethal dose: 5 µg/kg Cardiac: Change in rate

Lung, Thorax, or Respiration: Cyanosis

Lung, Thorax, or Respiration: Other changes 		JAMAAP 237,879,1977


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intracerebral
rat 		lowest published toxic dose: 720 µg/kg/12 day- continuous Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NSAPCC 369(Suppl 1),R176,2004
intramuscular
human 		lowest published toxic dose: 4 mg/kg/4 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Skin: After topical application: Primary irritation

Biochemical: Metabolism (intermediary): Lipids including transport 		BCLPT* 97,86,2005
intramuscular
human 		lowest published toxic dose: 5 mg/kg/17 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Metabolism (intermediary): Lipids including transport 		BCLPT* 97,86,2005


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4549;
Number of Industries 1;
Total Number of Facilities 24;
Number of Occupations 2;
Total Number of Employees Exposed 1,071;
Total Number of Female Employees Exposed 546


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
BCLPT* Basic & clinical pharmacology & toxicology (Copenhagen, Denmark : Nordic Pharmacological Society Oxford, UK : Distributed by Blackwell Munksgaard) V.94- 2004-
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
NSAPCC Naunyn-Schmiedeberg's Archives of Pharmacology. (Springer Verlag, Heidelberger, Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.272- 1972-

FDA-proprietary drug

RTECS Compound Description:
   Drug
   Human Data
   Hormone

ALT CAS #: 35-33-6
ALT CAS #: 17008-05-8
ALT CAS #: 37341-02-9
ALT CAS #: 52051-40-8
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