RTECS:GM4800000 The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH

The Registry of Toxic Effects of Chemical Substances

Corn oil

RTECS #: GM4800000

CAS #: 8001-30-7

UPDATE: August 2003 MW: N/R MF: N/R

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

SKIN AND EYE IRRITATION DATA:

REPRODUCTIVE EFFECTS DATA:

TUMORIGENIC DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

Maise oil

Maydol

Mazola oil

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
skin
human 300 mg/3 day- intermittent mild 85DKA8 -,127,1977

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intramuscular
rat lowest published toxic dose: 1 mL/kg (1 day prior to copulation) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) EKFAE9 57,49,1994
oral
mouse lowest published toxic dose: 30 gm/kg (15-17 day pregnant) Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system TJADAB 29(2),57A,1984
oral
mouse lowest published toxic dose: 100 mL/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects to embryo or fetus NTIS PB89-122246
oral
rat lowest published toxic dose: 12,500 mg/kg (15-19 day pregnant) Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)

Reproductive: Specific developmental abnormalities: Immune and reticuloendothelial system TJADAB 27,75A,1983
oral
rat lowest published toxic dose: 360 gm/kg (10-22 day pregnant/23 day after birth) Reproductive: Effects on newborn: Biochemical and metabolic DPTHDL 14,135,1989
oral
rat lowest published toxic dose: 50 mL/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other effects to embryo or fetus NTIS PB89-122246
oral
rat lowest published toxic dose: 390 mL/kg (2 week prior to copulation-3 day after birth) Reproductive: Other effects on female

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) TOSCF2 56,156,2000

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
rat lowest published toxic dose: 2,600 mL/kg/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors NTPTR* NTP-TR-426,1994
oral
rat lowest published toxic dose: 1,287,500 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors NTIS PB95-103958

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
intramuscular
rat lowest published toxic dose: 1 mL/kg Reproductive: Maternal effects: Oogenesis

Reproductive: Maternal effects: Uterus, cervix, vagina EKFAE9 57,49,1994
intraperitoneal
mouse lethal dose (50 percent kill): >50 gm/kg N/R NTIS AD691-490
oral
rat lethal dose (50 percent kill): >100 mL/kg N/R IPSTB3 3,93,1976

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
oral
mouse lowest published toxic dose: 91.8 mg/kg/10 day- intermittent Liver: Changes in liver weight NTIS #PB89-122246/AS
oral
mouse lowest published toxic dose: 64.26 mg/kg/7 day- intermittent Behavioral: Food intake (animal) NTIS #PB89-122246/AS
oral
rat lowest published toxic dose: 2,575,000 mg/kg/103 week- intermittent Blood: Leukemia

Endocrine: Adrenal cortex tumors

Tumorigenic: Active as anti-cancer agent NTIS PB95-103958
oral
rat lowest published toxic dose: 315 gm/kg/15 week- continuous Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase PCBPBS 14,1,1980
oral
rat lowest published toxic dose: 240 gm/kg/60 day- continuous Skin and Appendages: Other: Breast

Tumorigenic: Facilitates action of known carcinogens KIDZAK 33,360,1981
oral
rat lowest published toxic dose: 1,200 gm/kg/60 day- continuous Skin and Appendages: Other: Breast

Tumorigenic: Facilitates action of known carcinogens

Biochemical: Metabolism (intermediary): Lipids including transport KIDZAK 33,360,1981
oral
rat lowest published toxic dose: 18.36 mg/kg/4 day- intermittent Behavioral: Food intake (animal) NTIS #PB89-165401/AS

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

N/R N/R N/R

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0850;
Number of Industries 21;
Total Number of Facilities 769;
Number of Occupations 32;
Total Number of Employees Exposed 19,075
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0850;
Number of Industries 34;
Total Number of Facilities 4,529;
Number of Occupations 63;
Total Number of Employees Exposed 154,495;
Total Number of Female Employees Exposed 101,949

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
NTP Carcinogenesis studies (gavage) NTPTR* NTP-TR-426,1994

REFERENCES:
CODEN
REFERENCE

85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977
DPTHDL Developmental Pharmacology and Therapeutics. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.1- 1980-
EKFAE9 Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. (Mezhdunarodnaya Kniga, ul. B. Yakimanka, 39, 117049 Moscow, Russia) V.55- 1992-
IPSTB3 International Polymer Science and Technology. (Rapra Technology Ltd., Shawbury, Shrewsbury, Shropshire SY4 4NR, UK)
KIDZAK Kansai Ika Daigaku Zasshi. Journal of the Kansai Medical University. (Kansai Ika Daigaku Igakkai, 1, Fumizono-cho, Moriguchi, Osaka, Japan) V.8- 1956-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TOSCF2 Toxicological Sciences (Oxford University Press, 6277 Sea Harbor Drive, Orlando, FL 32887 ) V. 41, Jan. 1998-

FDA-over the counter drug

RTECS Compound Description:
   Tumorigen
   Reproductive Effector
   Human Data
   Natural Product
   Primary Irritant

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