CDC logo, Safer Healthier People CDC HomeCDC SearchCDC Health Topics A-Z
NIOSH - National Institute for Occupational Safety and Health

Search NIOSH  |  NIOSH Home  |  NIOSH Topics  |  Site Index  |  Databases and Information Resources  |  NIOSH Products  |  Contact Us




Colchicine, N - deacetyl - N - methyl -

RTECS #: GH0800000

CAS #: 477-30-5

UPDATE: November 2008 MW: 371.47 MF: C21H25NO5


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. ( - ) - Demecolcine
  2. 6,7 - Dihydro - 1,2,3,10 - tetramethoxy - 7 - (methylamino) - benzo (alpha) heptalen - 9 (5H) - one
  3. Alkaloid H 3, from colchicum antumnale
  4. Benzo (a) heptalen - 9 (5H) - one, 6,7 - dihydro - 1,2,3,10 - tetramethoxy - 7 - (methylamino) - , (S) -
  5. Ciba 12669A
  6. Colcemid
  7. Colchamine
  8. Colchicine, deacetyl - N - methyl -
  9. Colchicine, 7 - deacetamido - 7 - (methylamino) -
  10. Deacetylmethylcolchicine
  11. Deacetyl - N - methylcolchicine
  12. Demecolcine
  13. Desmecolcine
  1. Kolchamin
  2. Kolchicin (Czech)
  3. N - Deacetyl - N - methylcolchicine
  4. N - Desacetylmethylcolchicine
  5. N - Desacetyl - N - methylcolchicine
  6. N - Methyl - N - deacetylcolchicine
  7. N - Methyl - N - desacetylcolchicine
  8. NSC 3096
  9. Omain
  10. Omaine
  11. Reichstein's F
  12. Santavy's substance F
  13. Substance F


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis oral
Drosophila melanogaster 		0.25 mmol/L/6 hour MUTAEX 19,121,2004
cytogenetic analysis hamster lung 40 µg/L MUTAEX 2,23,1987
cytogenetic analysis hamster ovary 15 µg/L CYTGAX 8,158,1969
cytogenetic analysis hamster embryo 10 µg/L CRNGDP 5,89,1984
cytogenetic analysis hamster fibroblast 5 µg/L MUREAV 139,127,1984
cytogenetic analysis human fibroblast 15 µg/L MUREAV 261,57,1991
cytogenetic analysis human other cell types 10 µg/L TSITAQ 12,382,1970
cytogenetic analysis human lymphocyte 0.22 mg/L/24 hour MUREAV 537,117,2003
cytogenetic analysis intraperitoneal
mouse 		1 mg/kg AJANA2 137,67,1973
cytogenetic analysis mouse other cell types 0.3 µmol/L/48 hour MUREAV 617,125,2007
DNA damage oral
Drosophila melanogaster 		0.25 mmol/L/6 hour MUTAEX 19,121,2004
DNA damage human lymphocyte 0.16 mg/L/48 hour MUREAV 607,160,2006
DNA inhibition mouse Ascites tumor 20 mg/L NEOLA4 22,105,1975
unscheduled DNA synthesis hamster lung 1 mg/L CYTBAI 46,79,1986
micronucleus test hamster lung 5 mg/L CYTBAI 46,79,1986
micronucleus test hamster other cell types 1 pph/3 hour (-enzymatic activation step) FCTOD7 39,843,2001
micronucleus test human fibroblast 7,500 ng/L MUREAV 261,57,1991
micronucleus test human lymphocyte 0.1 mg/L/24 hour MUREAV 495,1,2001
micronucleus test human lymphocyte 10 µmol/L/24 hour MUREAV 528,61,2003
micronucleus test intraperitoneal
mouse 		2,500 µg/kg/24 hour MUREAV 23,239,1974
micronucleus test non-mammalian species testis 54 nmol/L MUREAV 247,29,1991
micronucleus test intraperitoneal
rat 		4 mg/kg ARTODN 75,234,2001
gene conversion and mitotic recombination oral
Drosophila melanogaster 		0.25 mmol/L/6 hour MUTAEX 19,121,2004
morphological transform hamster embryo 10 µg/L CRNGDP 5,89,1984
other mutation test systems Drosophila melanogaster other cell types 100 mg/L IJEBA6 22,67,1984
other mutation test systems hamster lung 1 mg/L CYTBAI 46,79,1986
other mutation test systems hamster embryo 100 µg/kg TIVIEQ 4,75,1990
other mutation test systems human fibroblast 20 µg/kg TIVIEQ 4,75,1990
other mutation test systems mouse Ascites tumor 20 mg/L NEOLA4 22,105,1975
other mutation test systems mouse embryo 80 µg/L JCLLAX 83,401,1974
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		1 ppm/7 day MUREAV 23,179,1974
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		0.25 mmol/L/6 hour MUTAEX 19,121,2004
sex chromosome loss and nondisjunction hamster embryo 100 µg/L PAACA3 27,39,1986
sex chromosome loss and nondisjunction hamster other cell types 18 µg/L CGCGBR 12,165,1973
sex chromosome loss and nondisjunction hamster fibroblast 5 µg/L MUREAV 139,127,1984
sex chromosome loss and nondisjunction hamster lung 25 µg/L TCMUD8 8,45,1988
sex chromosome loss and nondisjunction hamster ovary 25 µg/L MUREAV 379,83,1997
sex chromosome loss and nondisjunction human lymphocyte 10 mg/L MUREAV 190,137,1987
sex chromosome loss and nondisjunction human fibroblast 20 µg/L MUREAV 240,241,1990
sex chromosome loss and nondisjunction mammal (species unspecified) 2 µg/L MUREAV 201,423,1988
sex chromosome loss and nondisjunction intraperitoneal
mouse 		37 mg/kg ENMUDM 6,422,1984
sex chromosome loss and nondisjunction non-mammalian species testis 54 nmol/L MUREAV 247,29,1991
sex chromosome loss and nondisjunction non-mammalian species other cell types 27 nmol/L MUREAV 247,29,1991
sperm morphology oral
Drosophila melanogaster 		100 mg/L JULRA7 48,242,1974


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 1,800 µg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Eye, ear

Reproductive: Specific developmental abnormalities: Body wall 		AMZOAF 6,551,1966
intraperitoneal
mouse 		lowest published toxic dose: 1,800 µg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) AMZOAF 6,551,1966
subcutaneous
rat 		lowest published toxic dose: 3 mg/kg (7-9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death 		COREAF 247,152,1958
subcutaneous
rabbit 		lowest published toxic dose: 500 µg/kg (12 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death FESTAS 18,7,1967
unreported route
rabbit 		lowest published toxic dose: 2,500 µg/kg (2-26 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) CCPTAY 2,85,1970


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intramuscular
mouse 		lethal dose (50 percent kill): 87 mg/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain JMCMAR 24,257,1981
intraperitoneal
mouse 		lethal dose (50 percent kill): 35 mg/kg N/R AEPPAE 230,559,1957
intravenous
mouse 		lethal dose (50 percent kill): 56 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness

Gastrointestinal: Hypermotility, diarrhea 		PHTXA6 20,284,1957
intravenous
rat 		lethal dose (50 percent kill): 1,700 µg/kg N/R ARZNAD 20,1467,1970
oral
human 		lowest published toxic dose: 200 µg/kg Skin and Appendages: Other: Hair 34ZIAG -,184,1969
oral
mouse 		lethal dose (50 percent kill): 25,530 µg/kg N/R NCISP* JAN1986
parenteral
rat 		lethal dose (50 percent kill): 1,700 µg/kg N/R RRCRBU 52,76,1975


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
JAMAAP 172,1765,1960
TOXICOLOGY REVIEW
DIMON* 39,678,1993
TOXICOLOGY REVIEW
MUREAV 628,67,2007
TOXICOLOGY REVIEW
MUTAEX 18,105,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3189;
Number of Industries 2;
Total Number of Facilities 105;
Number of Occupations 2;
Total Number of Employees Exposed 412;
Total Number of Female Employees Exposed 287


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-whole sex chrom. loss
EPA GENETOX PROGRAM 1988, Positive: D melanogaster-nondisjunction; Mammalian micronucleus


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AJANA2 American Journal of Anatomy. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1-192, 1901-91.
AMZOAF American Zoologist. (American Soc. of Zoologists, Box 2739, California Lutheran College, Thousand Oaks, CA 91360) V.1- 1961-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
CCPTAY Contraception. (Geron-X, Inc., POB 1108, Los Altos, CA 94022) V.1- 1970-
CGCGBR Cytogenetics and Cell Genetics. (S. Karger Pub., Inc., 79 Fifth Ave., New York, NY 10003) V.12- 1973-
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
CYTBAI Cytobios. (Faculty Press, 88 Regent St., Cambridge, UK) V.1- 1969-
CYTGAX Cytogenetics. (Basel, Switzerland) V.1-11, 1962-72. For publisher information, see CGCGBR.
DIMON* Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950-
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
JCLLAX Journal of Cellular Physiology. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.67- 1966-
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963-
JULRA7 Journal of Ultrastructure Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1975-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205)
NEOLA4 Neoplasma. (Karger-Libri, P.O. Box, CH-4009 Basel, Switzerland) V.4- 1957-
PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954-
PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued.
RRCRBU Recent Results in Cancer Research. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1965-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TIVIEQ Toxicology In Vitro. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TSITAQ Tsitologiya. Cytology. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1959-

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data

Click Here for Additional Information about RTECS

NIOSH Home |  NIOSH Search  |  Site Index  |  Topic List |  Contact Us