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Cobalt (III) oxide

RTECS #: GG2900000

CAS #: 1308-04-9

UPDATE: February 2009 MW: 165.86 MF: Co2O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. C.I. 77323
  2. Cobalt oxide (8CI,9CI)
  3. Cobalt sesqioxide
  4. Cobalt trioxide
  5. Cobalt peroxide
  1. Cobalt sesquioxide
  2. Cobalt (3+) oxide
  3. Cobaltic oxide
  4. Dicobalt oxide
  5. Dicobalt trioxide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lethal dose (50 percent kill): 5 gm/kg Vascular: Regional or general arteriolar or venous dilation

Liver: Other changes

Blood: Other changes 		INMEAF 15,482,1946
subcutaneous
mouse 		lethal dose (50 percent kill): 2,064 mg/kg N/R ZVKOA6 19,186,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 700 µg/m3/3 hour/13 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Fibrosis (interstitial)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		WDZAEK 4,27,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.02 mg(Co)/m3 DTLVS* TLV/BEI,2007
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed animal carcinogen DTLVS* TLV/BEI,2007
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 52,363,1991
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 52,363,1991
TOXICOLOGY REVIEW
HBTME* ,511,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - HUNGARY time-weighted average 0.1 mg(Co)/m3, short term exposure limit 0.4 mg(Co)/m3, SEP2000
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.05 mg(Co)/m3, 2B carcinogen, APR2007
Occupational Exposure Limit - NORWAY time-weighted average 0.05 mg(Co)/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, JUN2003
Occupational Exposure Limit - SWEDEN time-weighted average 0.05 mg(Co)/m3, Sen, JUN2005
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg(Co)/m3, dust, aerosol, DEC2006


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
HBTME*
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
INMEAF Industrial Medicine. (Chicago, IL) V.1-18, 1932-49. For publisher information, see IOHSA5.
WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987
ZVKOA6 Zhurnal Vsesoyuznogo Khimicheskogo Obshchestva im. D.I. Mendeleeva. Journal of the D.I. Mendeleeva All-Union Chemical Society. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.5- 1960-

Used in electronics and ceramics

RTECS Compound Description:
   Tumorigen

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